Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 22, 2013, Pages 9007-9012

  Dickinson, Bryan C ^a   Leconte, Aaron M ^a   Allen, Benjamin ^b,c   Esvelt, Kevin M ^b,c,d   Liu, David R ^a  

^a Department of Chemistry   (United States)

^b Department of Molecular and Cellular Biology ^*  (United States)

^c HARVARD UNIVERSITY   (United States)

^d EMMANUEL COLLEGE   (United States)

Author keywords

Directed evolution; Evolutionary biology; Tape of life

Indexed keywords

RNA POLYMERASE;

ARTICLE; CONTINUOUS EVOLUTION; CONTROLLED STUDY; CONVERGENT EVOLUTION; EPISTASIS; EVOLUTION; GENE INTERACTION; HIGH THROUGHPUT SEQUENCING; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; STOCHASTIC MODEL;

DIRECTED EVOLUTION; EVOLUTIONARY BIOLOGY; TAPE OF LIFE;

ADAPTATION, BIOLOGICAL; BASE SEQUENCE; DIRECTED MOLECULAR EVOLUTION; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; EPISTASIS, GENETIC; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; LUCIFERASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROTEINS; REPRODUCIBILITY OF RESULTS; STOCHASTIC PROCESSES;

EID: 84878427504     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220670110     Document Type: Article

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