Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

eLife

Volumn 4, Issue AUGUST2015, 2015, Pages

  Kaltenbach, Miriam ^a,b   Jackson, Colin J ^c   Campbell, Eleanor C ^c   Hollfelder, Florian ^b   Tokuriki, Nobuhiko ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRIESTERASE; ARYLESTERASE; CARBOXYLESTERASE;

AGAR GEL ELECTROPHORESIS; AGROBACTERIUM TUMEFACIENS; ANIMAL CELL; ARTICLE; BACTERIUM MUTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE; GENE MUTATION; GENETIC INCOMPATIBILITY; GENETIC VARIABILITY; GENOTYPE; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; DIRECTED MOLECULAR EVOLUTION; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; PHENOTYPE;

CARBOXYLIC ESTER HYDROLASES; CATALYTIC DOMAIN; DIRECTED MOLECULAR EVOLUTION; GENOTYPE; MUTATION; PHENOTYPE; PHOSPHORIC TRIESTER HYDROLASES; SELECTION, GENETIC;

EID: 84943792201     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.06492     Document Type: Article

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