Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories

PLoS Computational Biology

Volumn 7, Issue 9, 2011, Pages

  Guthrie, Violeta Beleva ^a   Allen, Jennifer ^b   Camps, Manel ^b   Karchin, Rachel ^a  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOLOGY; FORECASTING;

ANTIBIOTIC SELECTIONS; CO-EVOLUTION; CRITICAL GOAL; EVOLUTIONARY BIOLOGY; MODULAR STRUCTURES; MULTIPLE MUTATIONS; NETWORK MODELS; NOVEL FUNCTIONS; TRIPLE MUTANTS; Β-LACTAMASE;

TRAJECTORIES;

ANTIBIOTIC AGENT; BETA LACTAMASE TEM 1; CEFOTAXIME; MUTANT PROTEIN; PROTEIN; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE TEM-1;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; COEVOLUTION; CONTROLLED STUDY; EPISTASIS; EVOLUTIONARY ADAPTATION; MUTATION; NONHUMAN; PHYLOGENY; PREDICTION; STATISTICAL ANALYSIS; ADAPTATION; BACTERIAL GENE; BIOLOGICAL MODEL; DRUG EFFECT; ESCHERICHIA COLI; GENETIC DATABASE; GENETIC EPISTASIS; GENETICS; MOLECULAR EVOLUTION; SEQUENCE ALIGNMENT;

ADAPTATION, BIOLOGICAL; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFOTAXIME; DATABASES, GENETIC; EPISTASIS, GENETIC; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; GENES, BACTERIAL; MODELS, GENETIC; MUTATION; SEQUENCE ALIGNMENT;

EID: 80053445930     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002184     Document Type: Article

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