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Volumn 473, Issue 14, 2016, Pages 2023-2032

Structure and function of carbonic anhydrases

Author keywords

Carbonic anhydrase; CO2 capture; Drug; Enzyme inhibitor; Metalloenzyme; X ray crystallography

Indexed keywords

ANTICONVULSIVE AGENT; ANTIGLAUCOMA AGENT; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; CARBONATE DEHYDRATASE; DIURETIC AGENT; METAL ION; NUCLEOPHILE; CARBON DIOXIDE; CARBONATE DEHYDRATASE INHIBITOR;

EID: 84971609633     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160115     Document Type: Review
Times cited : (736)

References (87)
  • 1
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • CrossRef PubMed
    • Supuran, C. T. (2008) Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov. 7, 168-181 CrossRef PubMed
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 2
    • 0033593062 scopus 로고    scopus 로고
    • Carbonic anhydrase is an ancient enzyme widespread in prokaryotes
    • CrossRef PubMed
    • Smith, K. S., Jakubzick, C., Whittam, T. S. And Ferry, J. G. (1999) Carbonic anhydrase is an ancient enzyme widespread in prokaryotes. Proc. Natl. Acad. Sci. U. S. A. 96, 15184-15189 CrossRef PubMed
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 15184-15189
    • Smith, K.S.1    Jakubzick, C.2    Whittam, T.S.3    Ferry, J.G.4
  • 3
    • 40449131050 scopus 로고    scopus 로고
    • Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms
    • CrossRef PubMed
    • Xu, Y., Feng, L., Jeffrey, P. D., Shi, Y. And Morel, F. M. (2008) Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature 452, 56-61 CrossRef PubMed
    • (2008) Nature , vol.452 , pp. 56-61
    • Xu, Y.1    Feng, L.2    Jeffrey, P.D.3    Shi, Y.4    Morel, F.M.5
  • 4
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • CrossRef PubMed
    • Neri, D. And Supuran, C. T. (2011) Interfering with pH regulation in tumours as a therapeutic strategy. Nat. Rev. Drug Discov. 10, 767-777 CrossRef PubMed
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 5
    • 84906101635 scopus 로고    scopus 로고
    • An overview of the alpha-, beta-and gamma-carbonic anhydrases from bacteria: Can bacterial carbonic anhydrases shed new light on evolution of bacteria
    • CrossRef PubMed
    • Capasso, C. And Supuran, C. T. (2015) An overview of the alpha-, beta-and gamma-carbonic anhydrases from bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria J. Enzyme Inhib. Med. Chem. 30, 325-332 CrossRef PubMed
    • (2015) J. Enzyme Inhib. Med. Chem. , vol.30 , pp. 325-332
    • Capasso, C.1    Supuran, C.T.2
  • 6
    • 84924867437 scopus 로고    scopus 로고
    • The eta-class carbonic anhydrases as drug targets for antimalarial agents
    • CrossRef PubMed
    • Supuran, C. T. And Capasso, C. (2015) The eta-class carbonic anhydrases as drug targets for antimalarial agents. Expert Opin. Ther. Targets 19, 551-563 CrossRef PubMed
    • (2015) Expert Opin. Ther. Targets , vol.19 , pp. 551-563
    • Supuran, C.T.1    Capasso, C.2
  • 7
    • 84865850354 scopus 로고    scopus 로고
    • Structure-based drug discovery of carbonic anhydrase inhibitors
    • CrossRef PubMed
    • Supuran, C. T. (2012) Structure-based drug discovery of carbonic anhydrase inhibitors. J. Enzyme Inhib. Med. Chem. 27, 759-772 CrossRef PubMed
    • (2012) J. Enzyme Inhib. Med. Chem. , vol.27 , pp. 759-772
    • Supuran, C.T.1
  • 8
    • 84865962997 scopus 로고    scopus 로고
    • Bacterial carbonic anhydrases as drug targets: Towards novel antibiotics
    • CrossRef PubMed
    • Supuran, C. T. (2011) Bacterial carbonic anhydrases as drug targets: Towards novel antibiotics Front. Pharmacol. 2, 34 CrossRef PubMed
    • (2011) Front. Pharmacol. , vol.2 , pp. 34
    • Supuran, C.T.1
  • 9
    • 84913594655 scopus 로고    scopus 로고
    • Biochemical characterization of the-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA
    • CrossRef PubMed
    • Del Prete, S., Vullo, D., De Luca, V., Supuran, C. T. And Capasso, C. (2014) Biochemical characterization of the-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA. J. Enzyme Inhib. Med. Chem. 29, 906-911 CrossRef PubMed
    • (2014) J. Enzyme Inhib. Med. Chem. , vol.29 , pp. 906-911
    • Del Prete, S.1    Vullo, D.2    De Luca, V.3    Supuran, C.T.4    Capasso, C.5
  • 11
    • 58149330109 scopus 로고    scopus 로고
    • Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans
    • CrossRef PubMed
    • Schlicker, C., Hall, R. A., Vullo, D., Middelhaufe, S., Gertz, M., Supuran, C. T., Muhlschlegel, F. A. And Steegborn, C. (2009) Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. J. Mol. Biol. 385, 1207-1220 CrossRef PubMed
    • (2009) J. Mol. Biol. , vol.385 , pp. 1207-1220
    • Schlicker, C.1    Hall, R.A.2    Vullo, D.3    Middelhaufe, S.4    Gertz, M.5    Supuran, C.T.6    Muhlschlegel, F.A.7    Steegborn, C.8
  • 12
    • 77954218410 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors
    • CrossRef PubMed
    • Supuran, C. T. (2010) Carbonic anhydrase inhibitors. Bioorg. Med. Chem. Lett. 20, 3467-3474 CrossRef PubMed
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3467-3474
    • Supuran, C.T.1
  • 13
    • 84858420920 scopus 로고    scopus 로고
    • (In)organic anions as carbonic anhydrase inhibitors
    • CrossRef PubMed
    • De Simone, G. And Supuran, C. T. (2012) (In)organic anions as carbonic anhydrase inhibitors. J. Inorg. Biochem. 111, 117-129 CrossRef PubMed
    • (2012) J. Inorg. Biochem. , vol.111 , pp. 117-129
    • De Simone, G.1    Supuran, C.T.2
  • 14
    • 84906960520 scopus 로고    scopus 로고
    • Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-the-carbonic anhydrases
    • 24 CrossRef
    • Del Prete, S., Vullo, D., Fisher, G. M., Andrews, K. T., Poulsen, S. A., Capasso, C. And Supuran, C. T. (2014) Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-the-carbonic anhydrases. Bioorg. Med. Chem. Lett. 15, 4389-4396, 24 CrossRef
    • (2014) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4389-4396
    • Del Prete, S.1    Vullo, D.2    Fisher, G.M.3    Andrews, K.T.4    Poulsen, S.A.5    Capasso, C.6    Supuran, C.T.7
  • 15
    • 0015747374 scopus 로고
    • Plant carbonic anhydrase. Properties and carbon dioxide hydration kinetics
    • CrossRef PubMed
    • Pocker, Y. And Ng, S. Y. (1973) Plant carbonic anhydrase. Properties and carbon dioxide hydration kinetics. Biochemistry 12, 5127-5134 CrossRef PubMed
    • (1973) Biochemistry , vol.12 , pp. 5127-5134
    • Pocker, Y.1    Ng, S.Y.2
  • 16
    • 0021223305 scopus 로고
    • Chemical properties, distribution, and physiology of plant and algal carbonic anhydrases
    • CrossRef PubMed
    • Graham, D., Reed, M. L., Patterson, B. D., Hockley, D. G. And Dwyer, M. R. (1984) Chemical properties, distribution, and physiology of plant and algal carbonic anhydrases. Ann. N. Y. Acad. Sci. 429, 222-237 CrossRef PubMed
    • (1984) Ann. N. Y. Acad. Sci. , vol.429 , pp. 222-237
    • Graham, D.1    Reed, M.L.2    Patterson, B.D.3    Hockley, D.G.4    Dwyer, M.R.5
  • 17
    • 34249672418 scopus 로고    scopus 로고
    • Malarial parasite carbonic anhydrase and its inhibitors
    • CrossRef PubMed
    • Krungkrai, J., Krungkrai, S. R. And Supuran, C. T. (2007) Malarial parasite carbonic anhydrase and its inhibitors. Curr. Top. Med. Chem. 7, 909-917 CrossRef PubMed
    • (2007) Curr. Top. Med. Chem. , vol.7 , pp. 909-917
    • Krungkrai, J.1    Krungkrai, S.R.2    Supuran, C.T.3
  • 18
    • 84874988656 scopus 로고    scopus 로고
    • Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the-carbonic anhydrase family enzymes
    • CrossRef PubMed
    • Ogawa, T., Noguchi, K., Saito, M., Nagahata, Y., Kato, H., Ohtaki, A., Nakayama, H., Dohmae, N., Matsushita, Y., Odaka, M. et al. (2013) Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the-carbonic anhydrase family enzymes. J. Am. Chem. Soc. 135, 3818-3825 CrossRef PubMed
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 3818-3825
    • Ogawa, T.1    Noguchi, K.2    Saito, M.3    Nagahata, Y.4    Kato, H.5    Ohtaki, A.6    Nakayama, H.7    Dohmae, N.8    Matsushita, Y.9    Odaka, M.10
  • 20
    • 0032708011 scopus 로고    scopus 로고
    • Carbonic anhydrase catalyzes cyanamide hydration to urea: Is it mimicking the physiological reaction
    • CrossRef
    • Briganti, F., Mangani, S., Scozzafava, A., Vernaglione, G. And Supuran, C. T. (1999) Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction J. Biol. Inorg. Chem. 4, 528-536 CrossRef
    • (1999) J. Biol. Inorg. Chem. , vol.4 , pp. 528-536
    • Briganti, F.1    Mangani, S.2    Scozzafava, A.3    Vernaglione, G.4    Supuran, C.T.5
  • 21
    • 0034633939 scopus 로고    scopus 로고
    • Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction
    • CrossRef PubMed
    • Guerri, A., Briganti, F., Scozzafava, A., Supuran, C. T. And Mangani, S. (2000) Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction. Biochemistry 39, 12391-12397 CrossRef PubMed
    • (2000) Biochemistry , vol.39 , pp. 12391-12397
    • Guerri, A.1    Briganti, F.2    Scozzafava, A.3    Supuran, C.T.4    Mangani, S.5
  • 22
    • 0007530501 scopus 로고
    • The catalytic versatility of carbonic anhydrase from erythrocytes. The enzymatic catalyzed hydration of acetaldehyde
    • CrossRef PubMed
    • Pocker, Y. And Meany, J. E. (1965) The catalytic versatility of carbonic anhydrase from erythrocytes. The enzymatic catalyzed hydration of acetaldehyde. J. Am. Chem. Soc. 87, 1809-1811 CrossRef PubMed
    • (1965) J. Am. Chem. Soc. , vol.87 , pp. 1809-1811
    • Pocker, Y.1    Meany, J.E.2
  • 23
    • 0013843449 scopus 로고
    • The catalytic versatility of erythrocyte carbonic anhydrase. The enzyme-catalyzed hydrolysis of para-nitrophenyl acetate
    • CrossRef PubMed
    • Pocker, Y. And Stone, J. T. (1965) The catalytic versatility of erythrocyte carbonic anhydrase. The enzyme-catalyzed hydrolysis of para-nitrophenyl acetate. J. Am. Chem. Soc. 87, 5497-5498 CrossRef PubMed
    • (1965) J. Am. Chem. Soc. , vol.87 , pp. 5497-5498
    • Pocker, Y.1    Stone, J.T.2
  • 24
    • 77957876033 scopus 로고    scopus 로고
    • Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of-but not of-,-and-carbonic anhydrases
    • CrossRef PubMed
    • Innocenti, A. And Supuran, C. T. (2010) Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of-but not of-,-and-carbonic anhydrases. Bioorg. Med. Chem. Lett. 20, 6208-6212 CrossRef PubMed
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6208-6212
    • Innocenti, A.1    Supuran, C.T.2
  • 25
    • 41149141063 scopus 로고    scopus 로고
    • Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates
    • CrossRef PubMed
    • Innocenti, A., Scozzafava, A., Parkkila, S., Puccetti, L., De Simone, G. And Supuran, C. T. (2008) Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates. Bioorg. Med. Chem. Lett. 18, 2267-2271 CrossRef PubMed
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2267-2271
    • Innocenti, A.1    Scozzafava, A.2    Parkkila, S.3    Puccetti, L.4    De Simone, G.5    Supuran, C.T.6
  • 26
    • 84870560662 scopus 로고    scopus 로고
    • Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity
    • CrossRef PubMed
    • Kazancioglu, E. A., Güney, M., Şentürk, M. And Supuran, C. T. (2012) Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity. J. Enzyme Inhib. Med. Chem. 27, 880-885 CrossRef PubMed
    • (2012) J. Enzyme Inhib. Med. Chem. , vol.27 , pp. 880-885
    • Kazancioglu, E.A.1    Güney, M.2    Şentürk, M.3    Supuran, C.T.4
  • 28
    • 84655175049 scopus 로고    scopus 로고
    • 5-and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors
    • CrossRef PubMed
    • Carta, F., Maresca, A., Scozzafava, A. And Supuran, C. T. (2012) 5-and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors. Bioorg. Med. Chem. Lett. 22, 267-270 CrossRef PubMed
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 267-270
    • Carta, F.1    Maresca, A.2    Scozzafava, A.3    Supuran, C.T.4
  • 29
    • 84924744865 scopus 로고    scopus 로고
    • Carbonic anhydrases possess thioesterase activity
    • CrossRef PubMed
    • Tanc, M., Carta, F., Scozzafava, A. And Supuran, C. T. (2015)-Carbonic anhydrases possess thioesterase activity. ACS Med. Chem. Lett. 6, 292-295 CrossRef PubMed
    • (2015) ACS Med. Chem. Lett. , vol.6 , pp. 292-295
    • Tanc, M.1    Carta, F.2    Scozzafava, A.3    Supuran, C.T.4
  • 30
    • 0031049560 scopus 로고    scopus 로고
    • Is cyanate a carbonic anhydrase substrate
    • CrossRef PubMed
    • Supuran, C. T., Conroy, C. W. And Maren, T. H. (1997) Is cyanate a carbonic anhydrase substrate Proteins 27, 272-278 CrossRef PubMed
    • (1997) Proteins , vol.27 , pp. 272-278
    • Supuran, C.T.1    Conroy, C.W.2    Maren, T.H.3
  • 31
    • 84863501358 scopus 로고    scopus 로고
    • Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms
    • CrossRef PubMed
    • Alterio, V., Di Fiore, A., D'Ambrosio, K., Supuran, C. T. And De Simone, G. (2012) Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms Chem. Rev. 112, 4421-4468 CrossRef PubMed
    • (2012) Chem. Rev. , vol.112 , pp. 4421-4468
    • Alterio, V.1    Di Fiore, A.2    D'Ambrosio, K.3    Supuran, C.T.4    De Simone, G.5
  • 33
    • 84925498524 scopus 로고    scopus 로고
    • The zinc coordination pattern in the-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families
    • CrossRef PubMed
    • De Simone, G., Di Fiore, A., Capasso, C. And Supuran, C. T. (2015) The zinc coordination pattern in the-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families. Bioorg. Med. Chem. Lett. 25, 1385-1389 CrossRef PubMed
    • (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 1385-1389
    • De Simone, G.1    Di Fiore, A.2    Capasso, C.3    Supuran, C.T.4
  • 34
    • 1342282973 scopus 로고    scopus 로고
    • A role for iron in an ancient carbonic anhydrase
    • CrossRef PubMed
    • Tripp, B. C., Bell, 3rd, C. B., Cruz, F., Krebs, C. And Ferry, J. G. (2004) A role for iron in an ancient carbonic anhydrase. J. Biol. Chem. 279, 6683-6687 CrossRef PubMed
    • (2004) J. Biol. Chem. , vol.279 , pp. 6683-6687
    • Tripp, B.C.1    Bell, C.B.2    Cruz, F.3    Krebs, C.4    Ferry, J.G.5
  • 36
    • 0024218271 scopus 로고
    • Refined structure of human carbonic anhydrase II at 2. 0 A resolution
    • CrossRef PubMed
    • Eriksson, A. E., Jones, T. A. And Liljas, A. (1988) Refined structure of human carbonic anhydrase II at 2. 0 A resolution. Proteins 4, 274-282 CrossRef PubMed
    • (1988) Proteins , vol.4 , pp. 274-282
    • Eriksson, A.E.1    Jones, T.A.2    Liljas, A.3
  • 37
    • 0026351203 scopus 로고
    • Structural properties of human carbonic anhydrase II at pH 9. 5
    • CrossRef PubMed
    • Nair, S. K. And Christianson, D. W. (1991) Structural properties of human carbonic anhydrase II at pH 9. 5. Biochem. Biophys. Res. Commun. 181, 579-584 CrossRef PubMed
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 579-584
    • Nair, S.K.1    Christianson, D.W.2
  • 38
    • 84897535939 scopus 로고    scopus 로고
    • Crystal structure of two tetrameric carbonic anhydrases from the filamentous ascomycete Sordariamacrospora
    • CrossRef PubMed
    • Lehneck, R., Neumann, P., Vullo, D., Elleuche, S., Supuran, C. T., Ficner, R. And Pöggeler, S. (2014) Crystal structure of two tetrameric carbonic anhydrases from the filamentous ascomycete Sordariamacrospora. FEBS J. 281, 1759-1772 CrossRef PubMed
    • (2014) FEBS J. , vol.281 , pp. 1759-1772
    • Lehneck, R.1    Neumann, P.2    Vullo, D.3    Elleuche, S.4    Supuran, C.T.5    Ficner, R.6    Pöggeler, S.7
  • 39
    • 84948799389 scopus 로고    scopus 로고
    • Crystal structure and kinetic studies of a tetrameric type II-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
    • CrossRef PubMed
    • Ferraroni, M., Del Prete, S., Vullo, D., Capasso, C. And Supuran, CT. (2015) Crystal structure and kinetic studies of a tetrameric type II-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Acta Crystallogr. D Biol. Crystallogr. 71, 2449-2456 CrossRef PubMed
    • (2015) Acta Crystallogr. D Biol. Crystallogr. , vol.71 , pp. 2449-2456
    • Ferraroni, M.1    Del Prete, S.2    Vullo, D.3    Capasso, C.4    Supuran, C.T.5
  • 40
    • 0034599484 scopus 로고    scopus 로고
    • The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases
    • CrossRef PubMed
    • Kimber, M. S. And Pai, E. F. (2000) The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases. EMBO J. 19, 1407-1418 CrossRef PubMed
    • (2000) EMBO J. , vol.19 , pp. 1407-1418
    • Kimber, M.S.1    Pai, E.F.2
  • 41
    • 0035971165 scopus 로고    scopus 로고
    • Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum
    • CrossRef PubMed
    • Strop, P., Smith, K. S., Iverson, T. M., Ferry, J. G. And Rees, D. C. (2001) Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum. J. Biol. Chem. 276, 10299-10305 CrossRef PubMed
    • (2001) J. Biol. Chem. , vol.276 , pp. 10299-10305
    • Strop, P.1    Smith, K.S.2    Iverson, T.M.3    Ferry, J.G.4    Rees, D.C.5
  • 42
    • 33645687432 scopus 로고    scopus 로고
    • Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase
    • CrossRef PubMed
    • Cronk, J. D., Rowlett, R. S., Zhang, K. Y., Tu, C., Endrizzi, J. A., Lee, J., Gareiss, P. C. And Preiss, J. R. (2006) Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase. Biochemistry 45, 4351-4361 CrossRef PubMed
    • (2006) Biochemistry , vol.45 , pp. 4351-4361
    • Cronk, J.D.1    Rowlett, R.S.2    Zhang, K.Y.3    Tu, C.4    Endrizzi, J.A.5    Lee, J.6    Gareiss, P.C.7    Preiss, J.R.8
  • 43
    • 0035059355 scopus 로고    scopus 로고
    • Crystal structure of E. Coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity
    • CrossRef PubMed
    • Cronk, J. D., Endrizzi, J. A., Cronk, M. R., O'Neill, J. W. And Zhang, K. Y. (2001) Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity. Protein Sci. 10, 911-922 CrossRef PubMed
    • (2001) Protein Sci. , vol.10 , pp. 911-922
    • Cronk, J.D.1    Endrizzi, J.A.2    Cronk, M.R.3    O'Neill, J.W.4    Zhang, K.Y.5
  • 44
    • 0034050126 scopus 로고    scopus 로고
    • X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO2 hydration
    • CrossRef PubMed
    • Mitsuhashi, S., Mizushima, T., Yamashita, E., Yamamoto, M., Kumasaka, T., Moriyama, H., Ueki, T., Miyachi, S. And Tsukihara, T. (2000) X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO2 hydration. J. Biol. Chem. 275, 5521-5526 CrossRef PubMed
    • (2000) J. Biol. Chem. , vol.275 , pp. 5521-5526
    • Mitsuhashi, S.1    Mizushima, T.2    Yamashita, E.3    Yamamoto, M.4    Kumasaka, T.5    Moriyama, H.6    Ueki, T.7    Miyachi, S.8    Tsukihara, T.9
  • 45
    • 0016345760 scopus 로고
    • Chemical and biological evolution of nucleotide-binding protein
    • CrossRef PubMed
    • Rossmann, M. G., Moras, D. And Olsen, K. W. (1974) Chemical and biological evolution of nucleotide-binding protein. Nature 250, 194-199 CrossRef PubMed
    • (1974) Nature , vol.250 , pp. 194-199
    • Rossmann, M.G.1    Moras, D.2    Olsen, K.W.3
  • 46
    • 1642500161 scopus 로고    scopus 로고
    • A novel evolutionary lineage of carbonic anhydrase (epsilon class) is a component of the carboxysome shell
    • CrossRef PubMed
    • So, A. K., Espie, G. S., Williams, E. B., Shively, J. M., Heinhorst, S. And Cannon, G. C. (2004) A novel evolutionary lineage of carbonic anhydrase (epsilon class) is a component of the carboxysome shell. J. Bacteriol. 186, 623-630 CrossRef PubMed
    • (2004) J. Bacteriol. , vol.186 , pp. 623-630
    • So, A.K.1    Espie, G.S.2    Williams, E.B.3    Shively, J.M.4    Heinhorst, S.5    Cannon, G.C.6
  • 47
    • 33646365079 scopus 로고    scopus 로고
    • The structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two
    • CrossRef PubMed
    • Sawaya, M. R., Cannon, G. C., Heinhorst, S., Tanaka, S., Williams, E. B., Yeates, T. O. And Kerfeld, C. A. (2006) The structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two. J. Biol. Chem. 281, 7546-7555 CrossRef PubMed
    • (2006) J. Biol. Chem. , vol.281 , pp. 7546-7555
    • Sawaya, M.R.1    Cannon, G.C.2    Heinhorst, S.3    Tanaka, S.4    Williams, E.B.5    Yeates, T.O.6    Kerfeld, C.A.7
  • 48
    • 0028234521 scopus 로고
    • A carbonic anhydrase from the archaeon Methanosarcina thermophila
    • CrossRef PubMed
    • Alber, B. E. And Ferry, J. G. (1994) A carbonic anhydrase from the archaeon Methanosarcina thermophila. Proc. Natl. Acad. Sci. U. S. A. 91, 6909-6913 CrossRef PubMed
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 6909-6913
    • Alber, B.E.1    Ferry, J.G.2
  • 49
    • 0029874435 scopus 로고    scopus 로고
    • A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila
    • PubMed
    • Kisker, C., Schindelin, H., Alber, B. E., Ferry, J. G. And Rees, D. C. (1996) A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J. 15, 2323-2330 PubMed
    • (1996) EMBO J. , vol.15 , pp. 2323-2330
    • Kisker, C.1    Schindelin, H.2    Alber, B.E.3    Ferry, J.G.4    Rees, D.C.5
  • 50
    • 0034622579 scopus 로고    scopus 로고
    • A closer look at the active site of gamma-class carbonic anhydrases: High-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila
    • CrossRef PubMed
    • Iverson, T. M., Alber, B. E., Kisker, C., Ferry, J. G. And Rees, D. C. (2000) A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila. Biochemistry 39, 9222-9231 CrossRef PubMed
    • (2000) Biochemistry , vol.39 , pp. 9222-9231
    • Iverson, T.M.1    Alber, B.E.2    Kisker, C.3    Ferry, J.G.4    Rees, D.C.5
  • 51
    • 77249103054 scopus 로고    scopus 로고
    • Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM
    • CrossRef PubMed
    • Pena, K. L., Castel, S. E., de Araujo, C., Espie, G. S. And Kimber, M. S. (2010) Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM. Proc. Natl. Acad. Sci. U. S. A. 107, 2455-2460 CrossRef PubMed
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 2455-2460
    • Pena, K.L.1    Castel, S.E.2    De Araujo, C.3    Espie, G.S.4    Kimber, M.S.5
  • 53
    • 84879407175 scopus 로고    scopus 로고
    • Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors
    • CrossRef PubMed
    • De Simone, G., Alterio, V. And Supuran, C. T. (2013) Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors. Expert Opin. Drug Discov. 8, 793-810 CrossRef PubMed
    • (2013) Expert Opin. Drug Discov. , vol.8 , pp. 793-810
    • De Simone, G.1    Alterio, V.2    Supuran, C.T.3
  • 54
    • 79954992410 scopus 로고    scopus 로고
    • Chemical rescue of enzymes: Proton transfer in mutants of human carbonic anhydrase II
    • CrossRef PubMed
    • Maupin, C. M., Castillo, N., Taraphder, S., Tu, C., McKenna, R., Silverman, D. N. And Voth, G. A. (2011) Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II. J. Am. Chem. Soc. 133, 6223-6234 CrossRef PubMed
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 6223-6234
    • Maupin, C.M.1    Castillo, N.2    Taraphder, S.3    Tu, C.4    McKenna, R.5    Silverman, D.N.6    Voth, G.A.7
  • 55
    • 0030772018 scopus 로고    scopus 로고
    • Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes i and II with histamine
    • CrossRef PubMed
    • Briganti, F., Mangani, S., Orioli, P., Scozzafava, A., Vernaglione, G. And Supuran, C. T. (1997) Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry 36, 10384-10392 CrossRef PubMed
    • (1997) Biochemistry , vol.36 , pp. 10384-10392
    • Briganti, F.1    Mangani, S.2    Orioli, P.3    Scozzafava, A.4    Vernaglione, G.5    Supuran, C.T.6
  • 56
    • 70349199011 scopus 로고    scopus 로고
    • The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as an intrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors
    • CrossRef PubMed
    • Innocenti, A., Pastorekova, S., Pastorek, J., Scozzafava, A., De Simone, G. And Supuran, C. T. (2009) The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as an intrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors. Bioorg. Med. Chem. Lett. 19, 5825-5828 CrossRef PubMed
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5825-5828
    • Innocenti, A.1    Pastorekova, S.2    Pastorek, J.3    Scozzafava, A.4    De Simone, G.5    Supuran, C.T.6
  • 57
    • 84946401900 scopus 로고    scopus 로고
    • Carbon dioxide "trapped" in a-carbonic anhydrase
    • CrossRef PubMed
    • Aggarwal, M., Chua, T. K., Pinard, M. A., Szebenyi, D. M. And McKenna, R. (2015) Carbon dioxide "trapped" in a-carbonic anhydrase. Biochemistry 54, 6631-6638 CrossRef PubMed
    • (2015) Biochemistry , vol.54 , pp. 6631-6638
    • Aggarwal, M.1    Chua, T.K.2    Pinard, M.A.3    Szebenyi, D.M.4    McKenna, R.5
  • 58
    • 33749039202 scopus 로고    scopus 로고
    • Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L-and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton transfer processes within the active site of an enzyme
    • CrossRef PubMed
    • Temperini, C., Scozzafava, A., Vullo, D. And Supuran, C. T. (2006) Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L-and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme. Chemistry 12, 7057-7066 CrossRef PubMed
    • (2006) Chemistry , vol.12 , pp. 7057-7066
    • Temperini, C.1    Scozzafava, A.2    Vullo, D.3    Supuran, C.T.4
  • 59
    • 33646751543 scopus 로고    scopus 로고
    • Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L-and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: Stereospecific recognition within the active site of an enzyme and its consequences for the drug design
    • CrossRef PubMed
    • Temperini, C., Vullo, D., Scozzafava, A. And Supuran, C. T. (2006) Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L-and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. 49, 3019-3027 CrossRef PubMed
    • (2006) J. Med. Chem. , vol.49 , pp. 3019-3027
    • Temperini, C.1    Vullo, D.2    Scozzafava, A.3    Supuran, C.T.4
  • 60
    • 33846283799 scopus 로고    scopus 로고
    • Carbonic anhydrase activators: L-adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII and XIV
    • CrossRef PubMed
    • Temperini, C., Innocenti, A., Scozzafava, A., Mastrolorenzo, A. And Supuran, C. T. (2007) Carbonic anhydrase activators: L-adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII and XIV. Bioorg. Med. Chem. Lett. 17, 628-635 CrossRef PubMed
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 628-635
    • Temperini, C.1    Innocenti, A.2    Scozzafava, A.3    Mastrolorenzo, A.4    Supuran, C.T.5
  • 61
    • 84961206327 scopus 로고    scopus 로고
    • How many carbonic anhydrase inhibition mechanisms exist
    • CrossRef PubMed
    • Supuran, C. T. (2016) How many carbonic anhydrase inhibition mechanisms exist J. Enzyme Inhib. Med. Chem. 31, 345-360 CrossRef PubMed
    • (2016) J. Enzyme Inhib. Med. Chem. , vol.31 , pp. 345-360
    • Supuran, C.T.1
  • 62
    • 84941930903 scopus 로고    scopus 로고
    • Hit recycling: Discovery of a potent carbonic anhydrase inhibitor by in silico target fishing
    • CrossRef PubMed
    • Mori, M., Cau, Y., Vignaroli, G., Laurenzana, I., Caivano, A., Vullo, D., Supuran, C. T. And Botta, M. (2015) Hit recycling: discovery of a potent carbonic anhydrase inhibitor by in silico target fishing. ACS Chem. Biol. 10, 1964-1969 CrossRef PubMed
    • (2015) ACS Chem. Biol. , vol.10 , pp. 1964-1969
    • Mori, M.1    Cau, Y.2    Vignaroli, G.3    Laurenzana, I.4    Caivano, A.5    Vullo, D.6    Supuran, C.T.7    Botta, M.8
  • 63
    • 12444339728 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, v and IX with carboxylates
    • CrossRef PubMed
    • Innocenti, A., Vullo, D., Scozzafava, A., Casey, J. R. And Supuran, C. T. (2005) Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V and IX with carboxylates. Bioorg. Med. Chem. Lett. 15, 573-578 CrossRef PubMed
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 573-578
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Casey, J.R.4    Supuran, C.T.5
  • 64
    • 0034609778 scopus 로고    scopus 로고
    • Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
    • CrossRef PubMed
    • Scozzafava, A. And Supuran, C. T. (2000) Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J. Med. Chem. 43, 3677-3687 CrossRef PubMed
    • (2000) J. Med. Chem. , vol.43 , pp. 3677-3687
    • Scozzafava, A.1    Supuran, C.T.2
  • 65
    • 84864690761 scopus 로고    scopus 로고
    • Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors
    • CrossRef
    • Di Fiore, A., Maresca, A., Supuran, C. T. And De Simone, G. (2012) Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors. Chem. Commun. 48, 8838-8840 CrossRef
    • (2012) Chem. Commun. , vol.48 , pp. 8838-8840
    • Di Fiore, A.1    Maresca, A.2    Supuran, C.T.3    De Simone, G.4
  • 66
    • 84874604544 scopus 로고    scopus 로고
    • Dithiocarbamates strongly inhibit the-class carbonic anhydrases from Mycobacterium tuberculosis
    • CrossRef PubMed
    • Maresca, A., Carta, F., Vullo, D. And Supuran, C. T. (2013) Dithiocarbamates strongly inhibit the-class carbonic anhydrases from Mycobacterium tuberculosis. J. Enzyme Inhib. Med. Chem. 28, 407-411 CrossRef PubMed
    • (2013) J. Enzyme Inhib. Med. Chem. , vol.28 , pp. 407-411
    • Maresca, A.1    Carta, F.2    Vullo, D.3    Supuran, C.T.4
  • 67
    • 84857420193 scopus 로고    scopus 로고
    • Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo
    • CrossRef PubMed
    • Carta, F., Aggarwal, M., Maresca, A., Scozzafava, A., McKenna, R., Masini, E. And Supuran, C. T. (2012) Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo. J. Med. Chem. 55, 1721-1730 CrossRef PubMed
    • (2012) J. Med. Chem. , vol.55 , pp. 1721-1730
    • Carta, F.1    Aggarwal, M.2    Maresca, A.3    Scozzafava, A.4    McKenna, R.5    Masini, E.6    Supuran, C.T.7
  • 68
    • 0027949918 scopus 로고
    • Two-site binding of phenol in the active site of human carbonic anhydrase II: Structural implications for substrate association
    • CrossRef
    • Nair, S. K., Ludwig, P. A. And Christianson, D. W. (1994) Two-site binding of phenol in the active site of human carbonic anhydrase II: structural implications for substrate association. J. Am. Chem. Soc. 116, 3659-3660 CrossRef
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 3659-3660
    • Nair, S.K.1    Ludwig, P.A.2    Christianson, D.W.3
  • 69
    • 77955391402 scopus 로고    scopus 로고
    • Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule
    • CrossRef PubMed
    • Carta, F., Temperini, C., Innocenti, A., Scozzafava, A., Kaila, K. And Supuran, C. T. (2010) Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J. Med. Chem. 53, 5511-5522 CrossRef PubMed
    • (2010) J. Med. Chem. , vol.53 , pp. 5511-5522
    • Carta, F.1    Temperini, C.2    Innocenti, A.3    Scozzafava, A.4    Kaila, K.5    Supuran, C.T.6
  • 71
    • 84872343989 scopus 로고    scopus 로고
    • Sulfocoumarins (1, 2-benzoxathiine-2, 2-dioxides): A class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases
    • CrossRef PubMed
    • Tars, K., Vullo, D., Kazaks, A., Leitans, J., Lends, A., Grandane, A., Zalubovskis, R., Scozzafava, A. And Supuran, C. T. (2013) Sulfocoumarins (1, 2-benzoxathiine-2, 2-dioxides): A class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases. J. Med. Chem. 56, 293-300 CrossRef PubMed
    • (2013) J. Med. Chem. , vol.56 , pp. 293-300
    • Tars, K.1    Vullo, D.2    Kazaks, A.3    Leitans, J.4    Lends, A.5    Grandane, A.6    Zalubovskis, R.7    Scozzafava, A.8    Supuran, C.T.9
  • 72
    • 67749116253 scopus 로고    scopus 로고
    • Non-zinc mediated inhibition of carbonic anhydrases: Coumarins are a new class of suicide inhibitors
    • CrossRef PubMed
    • Maresca, A., Temperini, C., Vu, H., Pham, N. B., Poulsen, S. A., Scozzafava, A., Quinn, R. J. And Supuran, C. T. (2009) Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. 131, 3057-3062 CrossRef PubMed
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 3057-3062
    • Maresca, A.1    Temperini, C.2    Vu, H.3    Pham, N.B.4    Poulsen, S.A.5    Scozzafava, A.6    Quinn, R.J.7    Supuran, C.T.8
  • 73
    • 74849118851 scopus 로고    scopus 로고
    • Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins
    • CrossRef PubMed
    • Maresca, A., Temperini, C., Pochet, L., Masereel, B., Scozzafava, A. And Supuran, C. T. (2010) Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J. Med. Chem. 53, 335-344 CrossRef PubMed
    • (2010) J. Med. Chem. , vol.53 , pp. 335-344
    • Maresca, A.1    Temperini, C.2    Pochet, L.3    Masereel, B.4    Scozzafava, A.5    Supuran, C.T.6
  • 74
    • 84055176334 scopus 로고    scopus 로고
    • Glycosylcoumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors
    • CrossRef PubMed
    • Touisni, N., Maresca, A., McDonald, P. C., Lou, Y., Scozzafava, A., Dedhar, S., Winum, J. Y. And Supuran, C. T. (2011) Glycosylcoumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. J. Med. Chem. 54, 8271-8277 CrossRef PubMed
    • (2011) J. Med. Chem. , vol.54 , pp. 8271-8277
    • Touisni, N.1    Maresca, A.2    McDonald, P.C.3    Lou, Y.4    Scozzafava, A.5    Dedhar, S.6    Winum, J.Y.7    Supuran, C.T.8
  • 75
    • 84879662265 scopus 로고    scopus 로고
    • Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors
    • CrossRef PubMed
    • Bonneau, A., Maresca, A., Winum, J. Y. And Supuran, C. T. (2013) Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors. J. Enzyme Inhib. Med. Chem. 28, 397-401 CrossRef PubMed
    • (2013) J. Enzyme Inhib. Med. Chem. , vol.28 , pp. 397-401
    • Bonneau, A.1    Maresca, A.2    Winum, J.Y.3    Supuran, C.T.4
  • 78
    • 84878083885 scopus 로고    scopus 로고
    • Antiglaucoma carbonic anhydrase inhibitors: A patent review
    • CrossRef PubMed
    • Masini, E., Carta, F., Scozzafava, A. And Supuran, C. T. (2013) Antiglaucoma carbonic anhydrase inhibitors: A patent review. Expert Opin. Ther. Pat. 23, 705-716 CrossRef PubMed
    • (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 705-716
    • Masini, E.1    Carta, F.2    Scozzafava, A.3    Supuran, C.T.4
  • 79
    • 84878072961 scopus 로고    scopus 로고
    • Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013)
    • CrossRef PubMed
    • Carta, F. And Supuran, C. T. (2013) Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013). Expert Opin. Ther. Pat. 23, 681-691 CrossRef PubMed
    • (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 681-691
    • Carta, F.1    Supuran, C.T.2
  • 80
    • 84858966345 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity
    • CrossRef PubMed
    • Supuran, C. T. (2012) Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. Expert Opin. Emerg. Drugs 17, 11-15 CrossRef PubMed
    • (2012) Expert Opin. Emerg. Drugs , vol.17 , pp. 11-15
    • Supuran, C.T.1
  • 81
    • 84878062801 scopus 로고    scopus 로고
    • Ant obesity carbonic anhydrase inhibitors: A literature and patent review
    • CrossRef PubMed
    • Scozzafava, A., Supuran, C. T. And Carta, F. (2013) Ant obesity carbonic anhydrase inhibitors: A literature and patent review. Expert Opin. Ther. Pat. 23, 725-735 CrossRef PubMed
    • (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 725-735
    • Scozzafava, A.1    Supuran, C.T.2    Carta, F.3
  • 82
    • 84937899167 scopus 로고    scopus 로고
    • The safety and clinical efficacy of acetazolamide for the treatment of idiopathic intracranial hypertension
    • CrossRef PubMed
    • Supuran, C. T. (2015) The safety and clinical efficacy of acetazolamide for the treatment of idiopathic intracranial hypertension. Expert Rev. Neurother. 15, 851-856 CrossRef PubMed
    • (2015) Expert Rev. Neurother. , vol.15 , pp. 851-856
    • Supuran, C.T.1
  • 83
    • 84878067755 scopus 로고    scopus 로고
    • Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013)
    • CrossRef PubMed
    • Monti, S. M., Supuran, C. T. And De Simone, G. (2013) Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013). Expert Opin. Ther. Pat. 23, 737-749 CrossRef PubMed
    • (2013) Expert Opin. Ther. Pat. , vol.23 , pp. 737-749
    • Monti, S.M.1    Supuran, C.T.2    De Simone, G.3
  • 84
    • 79952808077 scopus 로고    scopus 로고
    • Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
    • CrossRef PubMed
    • Pacchiano, F., Carta, F., McDonald, P. C., Lou, Y., Vullo, D., Scozzafava, A., Dedhar, S. And Supuran, C. T. (2011) Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J. Med. Chem. 54, 1896-1902 CrossRef PubMed
    • (2011) J. Med. Chem. , vol.54 , pp. 1896-1902
    • Pacchiano, F.1    Carta, F.2    McDonald, P.C.3    Lou, Y.4    Vullo, D.5    Scozzafava, A.6    Dedhar, S.7    Supuran, C.T.8
  • 85
    • 84878089506 scopus 로고    scopus 로고
    • Carbonic anhydrases: From biomedical applications of the inhibitors and activators to biotechnologic use for CO2 capture
    • CrossRef PubMed
    • Supuran, C. T. (2013) Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnologic use for CO2 capture. J. Enzyme Inhib. Med. Chem. 28, 229-230 CrossRef PubMed
    • (2013) J. Enzyme Inhib. Med. Chem. , vol.28 , pp. 229-230
    • Supuran, C.T.1
  • 86
    • 84878321519 scopus 로고    scopus 로고
    • Biomimetic CO2 capture using a highly thermostable bacterial-carbonic anhydrase immobilized on a polyurethane foam
    • CrossRef PubMed
    • Migliardini, F., De Luca, V., Carginale, V., Rossi, M., Corbo, P., Supuran, C. T. And Capasso, C. (2014) Biomimetic CO2 capture using a highly thermostable bacterial-carbonic anhydrase immobilized on a polyurethane foam. J. Enzyme Inhib. Med. Chem. 29, 146-150 CrossRef PubMed
    • (2014) J. Enzyme Inhib. Med. Chem. , vol.29 , pp. 146-150
    • Migliardini, F.1    De Luca, V.2    Carginale, V.3    Rossi, M.4    Corbo, P.5    Supuran, C.T.6    Capasso, C.7
  • 87
    • 84951775554 scopus 로고    scopus 로고
    • Recombinant thermoactive phosphoenolpyruvate carboxylase (PEPC) from Thermosynechococcus elongatus and its coupling with mesophilic/thermophilic bacterial carbonic anhydrases (CAs) for the conversion of CO2 to oxaloacetate
    • CrossRef PubMed
    • Del Prete, S., De Luca, V., Capasso, C., Supuran, C. T. And Carginale, V. (2016) Recombinant thermoactive phosphoenolpyruvate carboxylase (PEPC) from Thermosynechococcus elongatus and its coupling with mesophilic/thermophilic bacterial carbonic anhydrases (CAs) for the conversion of CO2 to oxaloacetate. Bioorg. Med. Chem. 24, 220-225 CrossRef PubMed
    • (2016) Bioorg. Med. Chem. , vol.24 , pp. 220-225
    • Del Prete, S.1    De Luca, V.2    Capasso, C.3    Supuran, C.T.4    Carginale, V.5


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