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Volumn 20, Issue 15, 2010, Pages 4376-4381

Carbonic anhydrase inhibitors. the X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

Author keywords

1,3,4 Thiadiazole 2 sulfonamide; Carbonic anhydrase; Enzyme inhibitor; Isoforms I XV; Sulfonamide; X ray crystallography

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; ACETAZOLAMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE XII; ISOLEUCINE; PHENYLALANINE; SULFONAMIDE; VALINE;

EID: 77955424033     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.082     Document Type: Article
Times cited : (69)

References (58)
  • 41
    • 0015239422 scopus 로고
    • 2 concentrations ranged from 1.7 to 17 mM for the determination of the kinetic parameters and inhibition constants. For each inhibitor at least six traces of the initial 5-10% of the reaction have been used for determining the initial velocity. The uncatalyzed rates were determined in the same manner and subtracted from the total observed rates.
    • 15e,16a
    • (1971) J. Biol. Chem. , vol.246 , pp. 2561
    • Khalifah, R.G.1
  • 45
    • 77955425258 scopus 로고    scopus 로고
    • note
    • 27 Complete refinement statistics and model quality are included in Table 2.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.