Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2314-2318

  Biswas, Shyamasri ^a   Carta, Fabrizio ^b   Scozzafava, Andrea ^b   McKenna, Robert ^a   Supuran, Claudiu T ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Adamantyl; Benzenesulfonamide; Carbonic anhydrase; Isoform selective inhibitor; X ray crystallography

Indexed keywords

1,3,4 THIADIAZOLESULFONAMIDE DERIVATIVE; 4 (1 ADAMANTYLCARBOXAMIDOMETHYL)BENZENESULFONAMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADAMANTANE; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIADIAZOLES;

EID: 84875700273     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.022     Document Type: Article

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