Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV

Journal of Medicinal Chemistry

Volumn 54, Issue 11, 2011, Pages 3977-3981

  Hen, Naama ^a   Bialer, Meir ^a   Yagen, Boris ^a   Maresca, Alfonso ^b   Aggarwal, Mayank ^c   Robbins, Arthur H ^c   McKenna, Robert ^c   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC CARBOXYLIC ACID; ANTICONVULSIVE AGENT; AROMATIC AMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; ISOENZYME; SULFANILAMIDE; SULFONAMIDE;

ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HYDROPHOBICITY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTICONVULSANTS; BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; EPILEPSY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 79958174646     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200209n     Document Type: Article

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