Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 5990-5998

  Vitale, Rosa Maria ^a   Alterio, Vincenzo ^b   Innocenti, Alessio ^c   Winum, Jean Yves ^d   Monti, Simona Maria ^b   De Simone, Giuseppina ^b   Supuran, Claudiu T ^b  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d INSTITUT CHARLES GERHARDT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC COMPOUND; BIS SULFAMATE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOENZYME; ISOENZYME 2; ISOENZYME 9; SULFAMIC ACID; SULFONAMIDE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 70349650688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900641r     Document Type: Article

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