Novel dihydropyrimidines and its pyrazole derivatives: Synthesis and pharmacological screening

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1882-1891

  Ramesh, B ^a   Bhalgat, Chetan M ^a  

^a Sri Adichunchanagiri College of Pharmacy   (India)

Author keywords

Anthelmintic activity; Anti inflammatory activity; Antimicrobial activity; Antioxidant activity; Dihydropyrimidine; Pyrazole fused pyrimidine

Indexed keywords

1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 4 THIEN 2 YL 1,6 DIHYDROPYRIMIDINE; 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 4 THIEN 2 YL 1,6 DIHYDROPYRIMIDINE; 2 HYDRAZINO 4 (2 HYDROXYPHENYL) 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 CHLOROPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 CHLOROPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 FLUOROYPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 FURYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 FURYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2 HYDROXYPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2,4 DIHYDROXYPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (2,4 DIHYDROXYPHENYL)) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (3,4 DIMETHOXYPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (3,4 DIMETHOXYPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (4 CHLOROPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (4 CHLOROPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (4 METHOXYPHENYL) 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 (4 METHOXYPHENYL) 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 [4 (DIMETHYLAMINO)PHENYL] 1 METHYL 2 (METHYLTHIO) 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 4 [4 (DIMETHYLAMINO)PHENYL] 2 HYDRAZINO 1 METHYL 5 CYNO 6 OXO 1,6 DIHYDROPYRIMIDINE; 5 AMINO 4 ETHEYLCORBOXYLATY 1 [5 CYANO 4 (4 METHOXYPHENYL) 1 METHYL 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL] 1H PYRAZOLE; 5 AMINO 4 ETHEYLCORBOXYLATY 1 [5 CYANO 4 (METHOXYPHENYL) 1 METHYL 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL] 1H PYRAZOLE; ETHYL 5 AMINO 1 (5 CYANO 1 METHYL 6 OXO 4 THIEN 2 YL 1,6 DIHYDROPYRIMIDIN 2 YL) 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 5 AMINO 1 [5 CYANO 4 (2 FURYL) 1 METHYL 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL] 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 5 AMINO 1 [5 CYANO 4 (2 HYDROXYPHENYL) 1 METHYL 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL] 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 5 AMINO 1 [5 CYANO 4 (2,4 DIHYDROXYPHENYL) 1 METHYL 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL] 1H PYRAZOLE 4 CARBOXYLATE; HYDRAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTHELMINTIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTHELMINTICS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BACTERIA; DRUG EVALUATION, PRECLINICAL; FUNGI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OLIGOCHAETA; PYRAZOLES; PYRIMIDINES; STEREOISOMERISM;

EID: 79953214524     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.052     Document Type: Article

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