6-substituted sulfocoumarins are selective carbonic anhdydrase IX and XII Inhibitors with significant cytotoxicity against colorectal cancer cells

Journal of Medicinal Chemistry

Volumn 58, Issue 9, 2015, Pages 3975-3983

  Grandane, Aiga ^a   Tanc, Muhammet ^b   Di Cesare Mannelli, Lorenzo ^b   Carta, Fabrizio ^b   Ghelardini, Carla ^b   Žalubovskis, Raivis ^a   Supuran, Claudiu T ^b  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(2,2 DIOXO 2H 2LAMBDA 6 BENZO[E][1,2]OXATHIIN 6 YL)TRIMETHYL AMMONIUM IODIDE; 1,2 BENZOXATHIINE 6 CARBONITRILE 2,2 DIOXIDE; 2 BROMO N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)BENZAMIDE; 2 FORMYL 4 METHOXYPHENYL METHANESULFONATE; 6 METHOXY 1,2 BENZOXATHIINE 2,2 DIOXIDE; CARBONATE DEHYDRATASE INHIBITOR; COUMARIN DERIVATIVE; CYTOTOXIC AGENT; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL) 2 IODOBENZAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL) 2 PHENYLACETAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL) 2,2 DIMETHYLPROPANAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL) 4 METHYLBENZAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)ACETAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)BENZAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)FURAN 2 CARBOXAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)PYRIDINE 3 CARBOXAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)PYRIDINE 4 CARBOXAMIDE; N (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL)THIOPHENE 2 CARBOXAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG; 2-BROMO-N-(2,2-DIOXIDO-1,2-BENZOXATHIIN-6-YL)BENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE XII; ISOENZYME; N-(2,2-DIOXIDO-1,2-BENZOXATHIIN-6-YL)BENZAMIDE; SULFOXIDE; TUMOR ANTIGEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HT 29 CELL LINE; HUMAN; HUMAN CELL; HYPOXIA; SONOGASHIRA REACTION; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; CHEMISTRY; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BENZAMIDES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL HYPOXIA; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYCLIC S-OXIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOENZYMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84929352933     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00523     Document Type: Article

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