Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 12, 2007, Pages 4152-4158

  Vitale, Rosa Maria ^a   Pedone, Carlo ^a,b   Amodeo, Pietro ^c   Antel, Jochen ^d   Wurl, Michael ^d   Scozzafava, Andrea ^e   Supuran, Claudiu T ^e   Simone, Giuseppina De ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

^d Solvay Pharmaceuticals GmbH   (Germany)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Anti obesity drug; Carbonic anhydrase; Molecular dynamics

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; CARBONIC ANHYDRASE VA; TOPIRAMATE; UNCLASSIFIED DRUG; ZINC ION; ZONISAMIDE;

ARTICLE; BINDING AFFINITY; DRUG BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; SIMULATION;

AMINO ACID SEQUENCE; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; FRUCTOSE; HUMANS; ISOXAZOLES; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34248220084     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.070     Document Type: Article

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