Erratum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes (Scientific Reports (2015) 5 (9502) DOI: 10.1038/srep09502);Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Kim, Jeong Sig ^a,b   Ro, Seung Hyun ^a   Kim, Myungjin ^a   Park, Hwan Woo ^a   Semple, Ian A ^a   Park, Haeli ^a   Cho, Uhn Soo ^a   Wang, Wei ^c   Guan, Kun Liang ^c   Karin, Michael ^c   Lee, Jun Hee ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Soonchunhyang University   (South Korea)

^c San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; SESN2 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; DROSOPHILA; FIBROBLAST; GENETICS; HEK293 CELL LINE; HUMAN; INTRACELLULAR MEMBRANE; INTRACELLULAR SPACE; LYSOSOME; METABOLISM; MOUSE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; DROSOPHILA; FIBROBLASTS; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; INTRACELLULAR MEMBRANES; INTRACELLULAR SPACE; LYSOSOMES; MICE; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84961291783     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14029     Document Type: Erratum

References (37)

1. Zoncu, R., Efeyan, A. & Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12, 21-35 (2011).
2. Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev 18, 1926-1945 (2004).
3. Lee, J. H., Budanov, A. V. & Karin, M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 18, 792-801 (2013).
4. Lee, J. H. et al. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab 16, 311-321 (2012).
5. Lee, J. H. et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327, 1223-1228 (2010).
6. Park, H. W. et al. Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5, 4233 (2014).
7. Budanov, A. V. & Karin, M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134, 451-460 (2008).
8. Hardie, D. G., Ross, F. A. & Hawley, S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13, 251-262 (2012).
9. Sanli, T., Linher-Melville, K., Tsakiridis, T. & Singh, G. Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One 7, e32035 (2012).
10. Bar-Peled, L. et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340, 1100-1106 (2013).
11. Schurmann, A., Brauers, A., Massmann, S., Becker, W. & Joost, H. G. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem 270, 28982-28988 (1995).
12. Sancak, Y. et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (2008).
13. Efeyan, A. et al. RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice. Dev Cell 29, 321-329 (2014).
14. Wei, Y. & Lilly, M. A. The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Cell Death Differ, 21, 1460-1468 (2014).
15. Panchaud, N., Peli-Gulli, M. P. & De Virgilio, C. Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Sci Signal 6, ra42 (2013).
16. Panchaud, N., Peli-Gulli, M. P. & De Virgilio, C. SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Cell Cycle 12, 2948-2952 (2013).
17. Neklesa, T. K. & Davis, R. W. A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. PLoS Genet 5, e1000515 (2009).
18. Zhao, B. et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25, 51-63 (2011).
19. Budanov, A. V., Lee, J. H. & Karin, M. Stressin' Sestrins take an aging fight. EMBO Mol Med 2, 388-400 (2010).
20. Bar-Peled, L. & Sabatini, D. M. Regulation of mTORC1 by amino acids. Trends Cell Biol 24, 400-406 (2014).
21. Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S. & Sabatini, D. M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303 (2010).
22. Bar-Peled, L., Schweitzer, L. D., Zoncu, R. & Sabatini, D. M. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208 (2012).
23. Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P. & Guan, K. L. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10, 935-945 (2008).
24. Bruning, A., Rahmeh, M. & Friese, K. Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation. Mol Oncol 7, 1012-1018 (2013).
25. Bae, S. H. et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab 17, 73-84 (2013).
26. Ben-Sahra, I. et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ 20, 611-619 (2013).
27. Inoki, K., Zhu, T. & Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (2003).
28. Gwinn, D. M. et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30, 214-226 (2008).
29. Tsun, Z. Y. et al. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell 52, 495-505 (2013).
30. Chantranupong, L. et al. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep 9, 1-8 (2014).
31. Parmigiani, A. et al. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9, 1281-1291 (2014).
32. Peng, M., Yin, N. & Li, M. O. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell 159, 122-133 (2014).
33. Ro, S. H. et al. Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1. FEBS J 281, 3816-3827 (2014).
34. Laderoute, K. R. et al. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 26, 5336-5347 (2006).
35. Horbinski, C., Stachowiak, M. K., Higgins, D. & Finnegan, S. G. Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina. BMC Neurosci 2, 2 (2001).
36. Castro, A. F., Rebhun, J. F. & Quilliam, L. A. Measuring Ras-family GTP levels in vivo - running hot and cold. Methods 37, 190-196 (2005).
37. Ro, S. H. et al. Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes. Autophagy 9, 2103-2114 (2013).