Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

Cell Death and Differentiation

Volumn 20, Issue 4, 2013, Pages 611-619

  Ben Sahra, I ^a,b,d   Dirat, B ^a,b   Laurent, K ^a,b   Puissant, A ^a,e   Auberger, P ^a,b   Budanov, A ^c   Tanti, J F ^a,b   Bost, F ^a,b  

^a CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

2 deoxyglucose; AMPK; Apoptosis; Cell metabolism; Metformin; Sestrin

Indexed keywords

DEOXYGLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN KINASE B; PROTEIN P53; SESTRIN2 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ENERGETIC STRESS; ENERGY METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; UPREGULATION;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; CASPASES; CELL LINE; DEOXYGLUCOSE; HUMANS; METFORMIN; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

MAMMALIA;

EID: 84874945405     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.157     Document Type: Article

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