Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30091-30099

  Zhang, Donna D ^a   Lo, Shih Ching ^a   Sun, Zheng ^a   Habib, Geetha M ^b   Lieberman, Michael W ^b   Hannink, Mark ^a,c  

^a University of Missouri   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; BIOSYNTHESIS; CELLS; MOLECULAR BIOLOGY; OXIDATION;

PROTEASOME; PROTEASOME-INDEPENDENT PATHWAY; SARCOSIN; UBIQUITINATION;

PROTEINS;

ADAPTOR PROTEIN; BTB KELCH PROTEIN; CUL3 PROTEIN; CYTOPLASM PROTEIN; ENC1 PROTEIN; GAN1 PROTEIN; GLUTATHIONE; KEAP1 PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; QUINONE DERIVATIVE; SARCOSIN; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL PROTECTION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE ACTIVATION; GENE FUNCTION; GLUTATHIONE METABOLISM; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REGULATORY MECHANISM; STEADY STATE; UBIQUITINATION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CHITIN; COS CELLS; CULLIN PROTEINS; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; GENETIC VECTORS; GLUTATHIONE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; QUINONES; RECOMBINANT PROTEINS; TRANS-ACTIVATORS; TRANSFECTION; UBIQUITIN;

EID: 24044466764     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501279200     Document Type: Article

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