Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Cell Reports

Volumn 9, Issue 4, 2014, Pages 1281-1291

  Parmigiani, Anita ^a   Nourbakhsh, Aida ^a   Ding, Boxiao ^a   Wang, Wei ^b,c   Kim, YoungChul ^b,c   Akopiants, Konstantin ^d   Guan, Kun Liang ^b,c   Karin, Michael ^b   Budanov, AndreiV ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; PROTEIN GATOR1; PROTEIN GATOR2; ROTENONE; SESTRINS; TUNICAMYCIN; UNCLASSIFIED DRUG; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; S6 KINASE; SESN2 PROTEIN, HUMAN; SESTRIN 2 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; LYSOSOME; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN TRANSPORT;

AMINO ACIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; LYSOSOMES; MICE; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; ROTENONE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUNICAMYCIN;

EID: 84912128530     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.10.019     Document Type: Article

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