Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity

Journal of Molecular Neuroscience

Volumn 51, Issue 3, 2013, Pages 967-975

  Daixing, Zhou ^a   Chengye, Zhan ^a   Qiang, Zhong ^a   Shusheng, Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Mitochondrial dysfunction; Oxidative stress; p53; Parkinson's disease; Sestrin 2 (SESN2)

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; PROTEIN; PROTEIN P53; RNA; SELEGILINE; SESTRIN 2; UNCLASSIFIED DRUG;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MESENCEPHALON; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION;

1-METHYL-4-PHENYLPYRIDINIUM; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL LINE, TUMOR; FEMALE; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCEPHALON; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84885957317     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0081-x     Document Type: Article

References (22)

1. Alves da Costa C, Checler F (2011) Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism? Cell Signal 23(6):963-968
2. Bove J, Perier C (2012) Neurotoxin-based models of Parkinson's disease. Neuroscience 211:51-76
3. Budanov AV, Karin M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451-460
4. Budanov AV, Shoshani T, Faerman A et al (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21:6017-6031
5. Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304:596-600
6. Dauer W, Przedborski S (2003) Parkinson's disease: mechanisms and models. Neuron 39:889-909
7. Duan W, Zhu X, Ladenheim B et al (2002) p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol 52:597-606
8. Essler S, Dehne N, Brüne B (2009) Role of sestrin2 in peroxide signaling in macrophages. FEBS Lett 583:3531-3535
9. Exner N, Lutz AK, Haass C, Winklhofer KF (2012) Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J 31(14):3038-3062
10. Giordano S, Lee J, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PLoS One 7(9):e44610
11. Jackson-Lewis V, Przedborski S (2007) Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2(1):141-151
12. Kim JR, Lee SR, Chung HJ et al (2003) Identification of amyloid β-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid β-peptide toxicity. Exp Mol Med 35:403-411
13. Kopin IJ, Markey SP (1988) MPTP toxicity: implications for research in Parkinson's disease. Annu Rev Neurosci 11:81-96
14. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE et al (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327:1223-1228
15. Liu SY, Lee YJ, Lee TC (2011) Association of platelet-derived growth factor receptor β accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. FEBS Lett 585(12):1853-1858
16. Maiuri MC, Malik SA, Morselli E et al (2009) Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 8:1571-1576
17. Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36:2503-2508
18. Papadia S, Soriano FX, Léveillé F et al (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11(4):476-487
19. Soontornniyomkij V, Soontornniyomkij B, Moore DJ et al (2012) Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. J Neuroimmune Pharmacol 7:579-590
20. Tobón-Velasco JC, Carmona-Aparicio L, Ali SF, Santamaría A (2010) Biomarkers of cell damage induced by oxidative stress in Parkinson's disease and related models. Cent Nerv Syst Agents Med Chem 10(4):278-286
21. Vyas I, Heikkila RE, Nicklas WJ (1986) Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium. J Neurochem 46:1501-1507
22. Zhuang J, Ma W, Lago CU, Hwang PM (2012) Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology? Free Radic Biol Med 53(6):1279-1285