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Volumn 32, Issue 3, 2016, Pages 415-432

Host Resistance and Immune Aging

Author keywords

Aging; B cell; Immunosenescence; Inflammation; Innate immunity; T cell

Indexed keywords

INFLUENZA VACCINE; RAPAMYCIN; TOLL LIKE RECEPTOR;

EID: 84969706251     PISSN: 07490690     EISSN: 18798853     Source Type: Journal    
DOI: 10.1016/j.cger.2016.02.007     Document Type: Review
Times cited : (51)

References (128)
  • 1
    • 0034463126 scopus 로고    scopus 로고
    • Epidemiology and unique aspects of aging and infectious diseases
    • 1 Yoshikawa, T.T., Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis 30 (2000), 931–933.
    • (2000) Clin Infect Dis , vol.30 , pp. 931-933
    • Yoshikawa, T.T.1
  • 2
    • 84858020392 scopus 로고    scopus 로고
    • Respiratory impairment and the aging lung: a novel paradigm for assessing pulmonary function
    • 2 Vaz Fragoso, C.A., Gill, T.M., Respiratory impairment and the aging lung: a novel paradigm for assessing pulmonary function. J Gerontol A Biol Sci Med Sci 67 (2012), 264–275.
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 264-275
    • Vaz Fragoso, C.A.1    Gill, T.M.2
  • 3
    • 84902273600 scopus 로고    scopus 로고
    • Cellular signaling in the aging immune system
    • 3 Fulop, T., Le Page, A., Fortin, C., et al. Cellular signaling in the aging immune system. Curr Opin Immunol 29 (2014), 105–111.
    • (2014) Curr Opin Immunol , vol.29 , pp. 105-111
    • Fulop, T.1    Le Page, A.2    Fortin, C.3
  • 4
  • 5
    • 0033163270 scopus 로고    scopus 로고
    • A high plasma concentration of TNF-alpha is associated with dementia in centenarians
    • 5 Bruunsgaard, H., Andersen-Ranberg, K., Jeune, B., et al. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol A Biol Sci Med Sci 54 (1999), M357–M364.
    • (1999) J Gerontol A Biol Sci Med Sci , vol.54 , pp. M357-M364
    • Bruunsgaard, H.1    Andersen-Ranberg, K.2    Jeune, B.3
  • 6
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • 6 Fagiolo, U., Cossarizza, A., Scala, E., et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 23 (1993), 2375–2378.
    • (1993) Eur J Immunol , vol.23 , pp. 2375-2378
    • Fagiolo, U.1    Cossarizza, A.2    Scala, E.3
  • 7
    • 0028998934 scopus 로고
    • Hypercoagulability in centenarians: the paradox of successful aging
    • 7 Mari, D., Mannucci, P.M., Coppola, R., et al. Hypercoagulability in centenarians: the paradox of successful aging. Blood 85 (1995), 3144–3149.
    • (1995) Blood , vol.85 , pp. 3144-3149
    • Mari, D.1    Mannucci, P.M.2    Coppola, R.3
  • 8
    • 0031846354 scopus 로고    scopus 로고
    • Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha
    • 8 Paolisso, G., Rizzo, M.R., Mazziotti, G., et al. Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. Am J Physiol 275 (1998), E294–E299.
    • (1998) Am J Physiol , vol.275 , pp. E294-E299
    • Paolisso, G.1    Rizzo, M.R.2    Mazziotti, G.3
  • 9
    • 77950513758 scopus 로고    scopus 로고
    • Plasma cytokine levels in a population-based study: relation to age and ethnicity
    • 9 Stowe, R.P., Peek, M.K., Cutchin, M.P., et al. Plasma cytokine levels in a population-based study: relation to age and ethnicity. J Gerontol A Biol Sci Med Sci 65 (2010), 429–433.
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 429-433
    • Stowe, R.P.1    Peek, M.K.2    Cutchin, M.P.3
  • 10
    • 0026497223 scopus 로고
    • Increase of plasma IL-6 concentration with age in healthy subjects
    • 10 Wei, J., Xu, H., Davies, J.L., et al. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci 51 (1992), 1953–1956.
    • (1992) Life Sci , vol.51 , pp. 1953-1956
    • Wei, J.1    Xu, H.2    Davies, J.L.3
  • 11
    • 0041878545 scopus 로고    scopus 로고
    • Elevated levels of tumor necrosis factor alpha and mortality in centenarians
    • 11 Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J., et al. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 115 (2003), 278–283.
    • (2003) Am J Med , vol.115 , pp. 278-283
    • Bruunsgaard, H.1    Andersen-Ranberg, K.2    Hjelmborg, J.3
  • 12
    • 0033134682 scopus 로고    scopus 로고
    • Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • 12 Harris, T.B., Ferrucci, L., Tracy, R.P., et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106 (1999), 506–512.
    • (1999) Am J Med , vol.106 , pp. 506-512
    • Harris, T.B.1    Ferrucci, L.2    Tracy, R.P.3
  • 13
    • 0036216138 scopus 로고    scopus 로고
    • Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons
    • 13 Reuben, D.B., Cheh, A.I., Harris, T.B., et al. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J Am Geriatr Soc 50 (2002), 638–644.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 638-644
    • Reuben, D.B.1    Cheh, A.I.2    Harris, T.B.3
  • 14
    • 84904746130 scopus 로고    scopus 로고
    • Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    • 14 Morrisette-Thomas, V., Cohen, A.A., Fulop, T., et al. Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev 139 (2014), 49–57.
    • (2014) Mech Ageing Dev , vol.139 , pp. 49-57
    • Morrisette-Thomas, V.1    Cohen, A.A.2    Fulop, T.3
  • 15
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • 15 Franceschi, C., Bonafe, M., Valensin, S., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908 (2000), 244–254.
    • (2000) Ann N Y Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 16
    • 84876721938 scopus 로고    scopus 로고
    • Immune system, cell senescence, aging and longevity–inflamm-aging reappraised
    • 16 Salvioli, S., Monti, D., Lanzarini, C., et al. Immune system, cell senescence, aging and longevity–inflamm-aging reappraised. Curr Pharm Des 19 (2013), 1675–1679.
    • (2013) Curr Pharm Des , vol.19 , pp. 1675-1679
    • Salvioli, S.1    Monti, D.2    Lanzarini, C.3
  • 17
    • 0024397502 scopus 로고
    • Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies
    • 17 Niwa, Y., Kasama, T., Miyachi, Y., et al. Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies. Life Sci 44 (1989), 1655–1664.
    • (1989) Life Sci , vol.44 , pp. 1655-1664
    • Niwa, Y.1    Kasama, T.2    Miyachi, Y.3
  • 18
    • 84892640743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
    • 18 Sapey, E., Greenwood, H., Walton, G., et al. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 123 (2014), 239–248.
    • (2014) Blood , vol.123 , pp. 239-248
    • Sapey, E.1    Greenwood, H.2    Walton, G.3
  • 19
    • 0033958830 scopus 로고    scopus 로고
    • Effect of age on human neutrophil function
    • 19 Wenisch, C., Patruta, S., Daxbock, F., et al. Effect of age on human neutrophil function. J Leukoc Biol 67 (2000), 40–45.
    • (2000) J Leukoc Biol , vol.67 , pp. 40-45
    • Wenisch, C.1    Patruta, S.2    Daxbock, F.3
  • 20
    • 0035216133 scopus 로고    scopus 로고
    • Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
    • 20 Butcher, S.K., Chahal, H., Nayak, L., et al. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 70 (2001), 881–886.
    • (2001) J Leukoc Biol , vol.70 , pp. 881-886
    • Butcher, S.K.1    Chahal, H.2    Nayak, L.3
  • 21
    • 79951722208 scopus 로고    scopus 로고
    • Aging reduces the functionality of anti-pneumococcal antibodies and the killing of streptococcus pneumoniae by neutrophil phagocytosis
    • 21 Simell, B., Vuorela, A., Ekstrom, N., et al. Aging reduces the functionality of anti-pneumococcal antibodies and the killing of streptococcus pneumoniae by neutrophil phagocytosis. Vaccine 29 (2011), 1929–1934.
    • (2011) Vaccine , vol.29 , pp. 1929-1934
    • Simell, B.1    Vuorela, A.2    Ekstrom, N.3
  • 22
    • 84904903325 scopus 로고    scopus 로고
    • Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
    • 22 Hazeldine, J., Harris, P., Chapple, I.L., et al. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell 13 (2014), 690–698.
    • (2014) Aging Cell , vol.13 , pp. 690-698
    • Hazeldine, J.1    Harris, P.2    Chapple, I.L.3
  • 23
    • 33947660464 scopus 로고    scopus 로고
    • GM-CSF activates the JAK/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals
    • 23 Fortin, C.F., Larbi, A., Dupuis, G., et al. GM-CSF activates the JAK/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals. Biogerontology 8 (2007), 173–187.
    • (2007) Biogerontology , vol.8 , pp. 173-187
    • Fortin, C.F.1    Larbi, A.2    Dupuis, G.3
  • 24
    • 33646580485 scopus 로고    scopus 로고
    • Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    • 24 Fortin, C.F., Larbi, A., Lesur, O., et al. Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J Leukoc Biol 79 (2006), 1061–1072.
    • (2006) J Leukoc Biol , vol.79 , pp. 1061-1072
    • Fortin, C.F.1    Larbi, A.2    Lesur, O.3
  • 25
    • 84897842773 scopus 로고    scopus 로고
    • Reduced bioenergetics and Toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
    • 25 Qian, F., Guo, X., Wang, X., et al. Reduced bioenergetics and Toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging (Albany NY) 6 (2014), 131–139.
    • (2014) Aging (Albany NY) , vol.6 , pp. 131-139
    • Qian, F.1    Guo, X.2    Wang, X.3
  • 26
    • 84873442127 scopus 로고    scopus 로고
    • Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation
    • 26 Nomellini, V., Brubaker, A.L., Mahbub, S., et al. Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation. Aging Dis 3 (2012), 234–247.
    • (2012) Aging Dis , vol.3 , pp. 234-247
    • Nomellini, V.1    Brubaker, A.L.2    Mahbub, S.3
  • 27
    • 84866734182 scopus 로고    scopus 로고
    • The three human monocyte subsets: implications for health and disease
    • 27 Wong, K.L., Yeap, W.H., Tai, J.J., et al. The three human monocyte subsets: implications for health and disease. Immunol Res 53 (2012), 41–57.
    • (2012) Immunol Res , vol.53 , pp. 41-57
    • Wong, K.L.1    Yeap, W.H.2    Tai, J.J.3
  • 28
    • 78651275576 scopus 로고    scopus 로고
    • Impaired functions of peripheral blood monocyte subpopulations in aged humans
    • 28 Nyugen, J., Agrawal, S., Gollapudi, S., et al. Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol 30 (2010), 806–813.
    • (2010) J Clin Immunol , vol.30 , pp. 806-813
    • Nyugen, J.1    Agrawal, S.2    Gollapudi, S.3
  • 29
    • 33846208784 scopus 로고    scopus 로고
    • Age-associated defect in human TLR-1/2 function
    • 29 van Duin, D., Mohanty, S., Thomas, V., et al. Age-associated defect in human TLR-1/2 function. J Immunol 178 (2007), 970–975.
    • (2007) J Immunol , vol.178 , pp. 970-975
    • van Duin, D.1    Mohanty, S.2    Thomas, V.3
  • 30
    • 34249107969 scopus 로고    scopus 로고
    • Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults
    • 30 van Duin, D., Allore, H.G., Mohanty, S., et al. Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis 195 (2007), 1590–1597.
    • (2007) J Infect Dis , vol.195 , pp. 1590-1597
    • van Duin, D.1    Allore, H.G.2    Mohanty, S.3
  • 31
    • 84855837075 scopus 로고    scopus 로고
    • Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly
    • 31 Qian, F., Wang, X., Zhang, L., et al. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 11 (2012), 104–110.
    • (2012) Aging Cell , vol.11 , pp. 104-110
    • Qian, F.1    Wang, X.2    Zhang, L.3
  • 32
    • 84940897919 scopus 로고    scopus 로고
    • Flagellin-dependent TLR5/Caveolin-1 as a promising immune activator in immunosenescence
    • 32 Lim, J.S., Nguyen, K.C., Nguyen, C.T., et al. Flagellin-dependent TLR5/Caveolin-1 as a promising immune activator in immunosenescence. Aging Cell 14 (2015), 907–915.
    • (2015) Aging Cell , vol.14 , pp. 907-915
    • Lim, J.S.1    Nguyen, K.C.2    Nguyen, C.T.3
  • 33
    • 84866449395 scopus 로고    scopus 로고
    • Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function
    • 33 Hearps, A.C., Martin, G.E., Angelovich, T.A., et al. Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 11 (2012), 867–875.
    • (2012) Aging Cell , vol.11 , pp. 867-875
    • Hearps, A.C.1    Martin, G.E.2    Angelovich, T.A.3
  • 34
    • 79251538661 scopus 로고    scopus 로고
    • Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity
    • 34 Merino, A., Buendia, P., Martin-Malo, A., et al. Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity. J Immunol 186 (2011), 1809–1815.
    • (2011) J Immunol , vol.186 , pp. 1809-1815
    • Merino, A.1    Buendia, P.2    Martin-Malo, A.3
  • 35
    • 77953669656 scopus 로고    scopus 로고
    • Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
    • 35 Seidler, S., Zimmermann, H.W., Bartneck, M., et al. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol, 11, 2010, 30.
    • (2010) BMC Immunol , vol.11 , pp. 30
    • Seidler, S.1    Zimmermann, H.W.2    Bartneck, M.3
  • 36
    • 84927750142 scopus 로고    scopus 로고
    • Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults
    • 36 Mohanty, S., Joshi, S.R., Ueda, I., et al. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis 211 (2015), 1174–1184.
    • (2015) J Infect Dis , vol.211 , pp. 1174-1184
    • Mohanty, S.1    Joshi, S.R.2    Ueda, I.3
  • 37
    • 84904388288 scopus 로고    scopus 로고
    • Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults
    • 37 Markofski, M.M., Flynn, M.G., Carrillo, A.E., et al. Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults. Eur J Appl Physiol 114 (2014), 1737–1748.
    • (2014) Eur J Appl Physiol , vol.114 , pp. 1737-1748
    • Markofski, M.M.1    Flynn, M.G.2    Carrillo, A.E.3
  • 38
    • 55549108701 scopus 로고    scopus 로고
    • Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?
    • 38 Timmerman, K.L., Flynn, M.G., Coen, P.M., et al. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?. J Leukoc Biol 84 (2008), 1271–1278.
    • (2008) J Leukoc Biol , vol.84 , pp. 1271-1278
    • Timmerman, K.L.1    Flynn, M.G.2    Coen, P.M.3
  • 39
    • 77951886965 scopus 로고    scopus 로고
    • Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response
    • 39 Panda, A., Qian, F., Mohanty, S., et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 184 (2010), 2518–2527.
    • (2010) J Immunol , vol.184 , pp. 2518-2527
    • Panda, A.1    Qian, F.2    Mohanty, S.3
  • 40
    • 84892580313 scopus 로고    scopus 로고
    • Impaired secretion of interferons by dendritic cells from aged subjects to influenza: role of histone modifications
    • 40 Prakash, S., Agrawal, S., Cao, J.N., et al. Impaired secretion of interferons by dendritic cells from aged subjects to influenza: role of histone modifications. Age (Dordr) 35 (2013), 1785–1797.
    • (2013) Age (Dordr) , vol.35 , pp. 1785-1797
    • Prakash, S.1    Agrawal, S.2    Cao, J.N.3
  • 41
    • 79955001064 scopus 로고    scopus 로고
    • Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus
    • 41 Qian, F., Wang, X., Zhang, L., et al. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis 203 (2011), 1415–1424.
    • (2011) J Infect Dis , vol.203 , pp. 1415-1424
    • Qian, F.1    Wang, X.2    Zhang, L.3
  • 42
    • 84907000995 scopus 로고    scopus 로고
    • Alterations in gene array patterns in dendritic cells from aged humans
    • 42 Cao, J.N., Agrawal, A., Sharman, E., et al. Alterations in gene array patterns in dendritic cells from aged humans. PLoS One, 9, 2014, e106471.
    • (2014) PLoS One , vol.9 , pp. e106471
    • Cao, J.N.1    Agrawal, A.2    Sharman, E.3
  • 43
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • 43 Agrawal, A., Agrawal, S., Cao, J.N., et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 178 (2007), 6912–6922.
    • (2007) J Immunol , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3
  • 44
    • 60549108257 scopus 로고    scopus 로고
    • Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
    • 44 Agrawal, A., Tay, J., Ton, S., et al. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol 182 (2009), 1138–1145.
    • (2009) J Immunol , vol.182 , pp. 1138-1145
    • Agrawal, A.1    Tay, J.2    Ton, S.3
  • 45
    • 84907005509 scopus 로고    scopus 로고
    • Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state
    • 45 Prakash, S., Agrawal, S., Vahed, H., et al. Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. Mucosal Immunol 7 (2014), 1386–1394.
    • (2014) Mucosal Immunol , vol.7 , pp. 1386-1394
    • Prakash, S.1    Agrawal, S.2    Vahed, H.3
  • 46
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells–a proposal for uniform nomenclature
    • 46 Spits, H., Artis, D., Colonna, M., et al. Innate lymphoid cells–a proposal for uniform nomenclature. Nat Rev Immunol 13 (2013), 145–149.
    • (2013) Nat Rev Immunol , vol.13 , pp. 145-149
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 47
    • 84914158785 scopus 로고    scopus 로고
    • Proinflammatory status influences NK cells subsets in the elderly
    • 47 Campos, C., Pera, A., Lopez-Fernandez, I., et al. Proinflammatory status influences NK cells subsets in the elderly. Immunol Lett 162 (2014), 298–302.
    • (2014) Immunol Lett , vol.162 , pp. 298-302
    • Campos, C.1    Pera, A.2    Lopez-Fernandez, I.3
  • 48
    • 84898828587 scopus 로고    scopus 로고
    • Effect of age and CMV on NK cell subpopulations
    • 48 Campos, C., Pera, A., Sanchez-Correa, B., et al. Effect of age and CMV on NK cell subpopulations. Exp Gerontol 54 (2014), 130–137.
    • (2014) Exp Gerontol , vol.54 , pp. 130-137
    • Campos, C.1    Pera, A.2    Sanchez-Correa, B.3
  • 49
    • 0033026570 scopus 로고    scopus 로고
    • NK phenotypic markers and IL2 response in NK cells from elderly people
    • 49 Borrego, F., Alonso, M.C., Galiani, M.D., et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol 34 (1999), 253–265.
    • (1999) Exp Gerontol , vol.34 , pp. 253-265
    • Borrego, F.1    Alonso, M.C.2    Galiani, M.D.3
  • 50
    • 33845625260 scopus 로고    scopus 로고
    • Ageing is associated with a decline in peripheral blood CD56bright NK cells
    • 50 Chidrawar, S.M., Khan, N., Chan, Y.L., et al. Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun Ageing, 3, 2006, 10.
    • (2006) Immun Ageing , vol.3 , pp. 10
    • Chidrawar, S.M.1    Khan, N.2    Chan, Y.L.3
  • 51
    • 77953914911 scopus 로고    scopus 로고
    • Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset
    • 51 Hayhoe, R.P., Henson, S.M., Akbar, A.N., et al. Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset. Hum Immunol 71 (2010), 676–681.
    • (2010) Hum Immunol , vol.71 , pp. 676-681
    • Hayhoe, R.P.1    Henson, S.M.2    Akbar, A.N.3
  • 52
    • 77957803871 scopus 로고    scopus 로고
    • Human NK cells display major phenotypic and functional changes over the life span
    • 52 Le Garff-Tavernier, M., Beziat, V., Decocq, J., et al. Human NK cells display major phenotypic and functional changes over the life span. Aging Cell 9 (2010), 527–535.
    • (2010) Aging Cell , vol.9 , pp. 527-535
    • Le Garff-Tavernier, M.1    Beziat, V.2    Decocq, J.3
  • 53
    • 84899686409 scopus 로고    scopus 로고
    • Shaping of NK cell subsets by aging
    • 53 Solana, R., Campos, C., Pera, A., et al. Shaping of NK cell subsets by aging. Curr Opin Immunol 29 (2014), 56–61.
    • (2014) Curr Opin Immunol , vol.29 , pp. 56-61
    • Solana, R.1    Campos, C.2    Pera, A.3
  • 54
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
    • 54 Solana, R., Tarazona, R., Gayoso, I., et al. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol 24 (2012), 331–341.
    • (2012) Semin Immunol , vol.24 , pp. 331-341
    • Solana, R.1    Tarazona, R.2    Gayoso, I.3
  • 55
    • 84866443820 scopus 로고    scopus 로고
    • Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity
    • 55 Hazeldine, J., Hampson, P., Lord, J.M., Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity. Aging Cell 11 (2012), 751–759.
    • (2012) Aging Cell , vol.11 , pp. 751-759
    • Hazeldine, J.1    Hampson, P.2    Lord, J.M.3
  • 56
    • 0034916891 scopus 로고    scopus 로고
    • Association between natural killer cell activity and infection in immunologically normal elderly people
    • 56 Ogata, K., An, E., Shioi, Y., et al. Association between natural killer cell activity and infection in immunologically normal elderly people. Clin Exp Immunol 124 (2001), 392–397.
    • (2001) Clin Exp Immunol , vol.124 , pp. 392-397
    • Ogata, K.1    An, E.2    Shioi, Y.3
  • 57
    • 70249116821 scopus 로고    scopus 로고
    • Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan
    • 57 Abu-Taha, M., Rius, C., Hermenegildo, C., et al. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J Immunol 183 (2009), 1393–1402.
    • (2009) J Immunol , vol.183 , pp. 1393-1402
    • Abu-Taha, M.1    Rius, C.2    Hermenegildo, C.3
  • 58
    • 30344449759 scopus 로고    scopus 로고
    • Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
    • 58 Maggio, M., Basaria, S., Ble, A., et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J Clin Endocrinol Metab 91 (2006), 345–347.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 345-347
    • Maggio, M.1    Basaria, S.2    Ble, A.3
  • 59
    • 77952958199 scopus 로고    scopus 로고
    • Dehydroepiandrosterone as a regulator of immune cell function
    • 59 Hazeldine, J., Arlt, W., Lord, J.M., Dehydroepiandrosterone as a regulator of immune cell function. J Steroid Biochem Mol Biol 120:2–3 (2010), 127–136.
    • (2010) J Steroid Biochem Mol Biol , vol.120 , Issue.2-3 , pp. 127-136
    • Hazeldine, J.1    Arlt, W.2    Lord, J.M.3
  • 60
    • 84938906516 scopus 로고    scopus 로고
    • Gene expression markers of age-related inflammation in two human cohorts
    • 60 Pilling, L.C., Joehanes, R., Melzer, D., et al. Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol 70 (2015), 37–45.
    • (2015) Exp Gerontol , vol.70 , pp. 37-45
    • Pilling, L.C.1    Joehanes, R.2    Melzer, D.3
  • 61
    • 83755178932 scopus 로고    scopus 로고
    • Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
    • 61 Lumeng, C.N., Liu, J., Geletka, L., et al. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol 187 (2011), 6208–6216.
    • (2011) J Immunol , vol.187 , pp. 6208-6216
    • Lumeng, C.N.1    Liu, J.2    Geletka, L.3
  • 62
    • 84966397603 scopus 로고    scopus 로고
    • JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
    • 62 Xu, M., Tchkonia, T., Ding, H., et al. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc Natl Acad Sci U S A 112 (2015), E6301–E6310.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E6301-E6310
    • Xu, M.1    Tchkonia, T.2    Ding, H.3
  • 63
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • 63 Tchkonia, T., Zhu, Y., van Deursen, J., et al. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 123 (2013), 966–972.
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    van Deursen, J.3
  • 64
    • 84872527628 scopus 로고    scopus 로고
    • mTOR is a key modulator of ageing and age-related disease
    • 64 Johnson, S.C., Rabinovitch, P.S., Kaeberlein, M., mTOR is a key modulator of ageing and age-related disease. Nature 493 (2013), 338–345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 65
    • 84940587703 scopus 로고    scopus 로고
    • mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
    • 65 Herranz, N., Gallage, S., Mellone, M., et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol 17 (2015), 1205–1217.
    • (2015) Nat Cell Biol , vol.17 , pp. 1205-1217
    • Herranz, N.1    Gallage, S.2    Mellone, M.3
  • 66
    • 84938751873 scopus 로고    scopus 로고
    • mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1a translation
    • 66 Laberge, R.M., Sun, Y., Orjalo, A.V., et al. mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1a translation. Nat Cell Biol 17 (2015), 1049–1061.
    • (2015) Nat Cell Biol , vol.17 , pp. 1049-1061
    • Laberge, R.M.1    Sun, Y.2    Orjalo, A.V.3
  • 67
    • 84883785478 scopus 로고    scopus 로고
    • Late-life rapamycin treatment reverses age-related heart dysfunction
    • 67 Flynn, J.M., O'Leary, M.N., Zambataro, C.A., et al. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell 12 (2013), 851–862.
    • (2013) Aging Cell , vol.12 , pp. 851-862
    • Flynn, J.M.1    O'Leary, M.N.2    Zambataro, C.A.3
  • 68
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • 68 Harrison, D.E., Strong, R., Sharp, Z.D., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460 (2009), 392–395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3
  • 69
    • 84902203576 scopus 로고    scopus 로고
    • mTOr signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia
    • 69 Xie, L., Sun, F., Wang, J., et al. mTOr signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia. J Immunol 192 (2014), 6009–6019.
    • (2014) J Immunol , vol.192 , pp. 6009-6019
    • Xie, L.1    Sun, F.2    Wang, J.3
  • 70
    • 84919756169 scopus 로고    scopus 로고
    • mTOR inhibition improves immune function in the elderly
    • 70 Mannick, J.B., Del Giudice, G., Lattanzi, M., et al. mTOR inhibition improves immune function in the elderly. Sci Transl Med, 6, 2014, 268ra179.
    • (2014) Sci Transl Med , vol.6 , pp. 268ra179
    • Mannick, J.B.1    Del Giudice, G.2    Lattanzi, M.3
  • 71
    • 84859864546 scopus 로고    scopus 로고
    • Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the vitality 90+ study
    • 71 Jylhava, J., Jylha, M., Lehtimaki, T., et al. Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the vitality 90+ study. Exp Gerontol 47 (2012), 372–378.
    • (2012) Exp Gerontol , vol.47 , pp. 372-378
    • Jylhava, J.1    Jylha, M.2    Lehtimaki, T.3
  • 72
    • 79251593840 scopus 로고    scopus 로고
    • Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the vitality 90+ study
    • 72 Jylhava, J., Kotipelto, T., Raitala, A., et al. Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the vitality 90+ study. Mech Ageing Dev 132 (2011), 20–26.
    • (2011) Mech Ageing Dev , vol.132 , pp. 20-26
    • Jylhava, J.1    Kotipelto, T.2    Raitala, A.3
  • 73
    • 84877808128 scopus 로고    scopus 로고
    • Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty
    • 73 Jylhava, J., Nevalainen, T., Marttila, S., et al. Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell 12 (2013), 388–397.
    • (2013) Aging Cell , vol.12 , pp. 388-397
    • Jylhava, J.1    Nevalainen, T.2    Marttila, S.3
  • 74
    • 84924943590 scopus 로고    scopus 로고
    • Mitochondrial DNA released by trauma induces neutrophil extracellular traps
    • 74 Itagaki, K., Kaczmarek, E., Lee, Y.T., et al. Mitochondrial DNA released by trauma induces neutrophil extracellular traps. PLoS One, 10, 2015, e0120549.
    • (2015) PLoS One , vol.10 , pp. e0120549
    • Itagaki, K.1    Kaczmarek, E.2    Lee, Y.T.3
  • 75
    • 84899513393 scopus 로고    scopus 로고
    • Circulating mitochondrial DNA increases with age and is a familiar trait: implications for “inflamm-aging
    • 75 Pinti, M., Cevenini, E., Nasi, M., et al. Circulating mitochondrial DNA increases with age and is a familiar trait: implications for “inflamm-aging”. Eur J Immunol 44 (2014), 1552–1562.
    • (2014) Eur J Immunol , vol.44 , pp. 1552-1562
    • Pinti, M.1    Cevenini, E.2    Nasi, M.3
  • 76
    • 84900437811 scopus 로고    scopus 로고
    • Mitochondrial DAMPS induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction
    • 76 Fernandez-Ruiz, I., Arnalich, F., Cubillos-Zapata, C., et al. Mitochondrial DAMPS induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction. PLoS One, 9, 2014, e95073.
    • (2014) PLoS One , vol.9 , pp. e95073
    • Fernandez-Ruiz, I.1    Arnalich, F.2    Cubillos-Zapata, C.3
  • 77
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • 77 Shimada, K., Crother, T.R., Karlin, J., et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36 (2012), 401–414.
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1    Crother, T.R.2    Karlin, J.3
  • 78
    • 84927724336 scopus 로고    scopus 로고
    • Initiation and perpetuation of nlrp3 inflammasome activation and assembly
    • 78 Elliott, E.I., Sutterwala, F.S., Initiation and perpetuation of nlrp3 inflammasome activation and assembly. Immunol Rev 265 (2015), 35–52.
    • (2015) Immunol Rev , vol.265 , pp. 35-52
    • Elliott, E.I.1    Sutterwala, F.S.2
  • 79
    • 61749099391 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity in mice is dependent on TLR9 and the NALP3 inflammasome
    • 79 Imaeda, A.B., Watanabe, A., Sohail, M.A., et al. Acetaminophen-induced hepatotoxicity in mice is dependent on TLR9 and the NALP3 inflammasome. J Clin Invest 119 (2009), 305–314.
    • (2009) J Clin Invest , vol.119 , pp. 305-314
    • Imaeda, A.B.1    Watanabe, A.2    Sohail, M.A.3
  • 80
    • 73949118676 scopus 로고    scopus 로고
    • Necrotic cells trigger a sterile inflammatory response through the NLRP3 inflammasome
    • 80 Iyer, S.S., Pulskens, W.P., Sadler, J.J., et al. Necrotic cells trigger a sterile inflammatory response through the NLRP3 inflammasome. Proc Natl Acad Sci U S A 106 (2009), 20388–20393.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20388-20393
    • Iyer, S.S.1    Pulskens, W.P.2    Sadler, J.J.3
  • 81
    • 68149170478 scopus 로고    scopus 로고
    • Cutting edge: necrosis activates the NLRP3 inflammasome
    • 81 Li, H., Ambade, A., Re, F., Cutting edge: necrosis activates the NLRP3 inflammasome. J Immunol 183 (2009), 1528–1532.
    • (2009) J Immunol , vol.183 , pp. 1528-1532
    • Li, H.1    Ambade, A.2    Re, F.3
  • 82
    • 84885167222 scopus 로고    scopus 로고
    • Canonical NLRP3 inflammasome links systemic low-grade inflammation to functional decline in aging
    • 82 Youm, Y.H., Grant, R.W., McCabe, L.R., et al. Canonical NLRP3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 18 (2013), 519–532.
    • (2013) Cell Metab , vol.18 , pp. 519-532
    • Youm, Y.H.1    Grant, R.W.2    McCabe, L.R.3
  • 83
    • 84904646033 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
    • 83 Baroja-Mazo, A., Martin-Sanchez, F., Gomez, A.I., et al. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15 (2014), 738–748.
    • (2014) Nat Immunol , vol.15 , pp. 738-748
    • Baroja-Mazo, A.1    Martin-Sanchez, F.2    Gomez, A.I.3
  • 84
    • 84904692363 scopus 로고    scopus 로고
    • The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
    • 84 Franklin, B.S., Bossaller, L., De Nardo, D., et al. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol 15 (2014), 727–737.
    • (2014) Nat Immunol , vol.15 , pp. 727-737
    • Franklin, B.S.1    Bossaller, L.2    De Nardo, D.3
  • 85
    • 84885402793 scopus 로고    scopus 로고
    • The effect of age on thymic function
    • 85 Palmer, D.B., The effect of age on thymic function. Front Immunol, 4, 2013, 316.
    • (2013) Front Immunol , vol.4 , pp. 316
    • Palmer, D.B.1
  • 86
    • 84857416171 scopus 로고    scopus 로고
    • Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
    • 86 den Braber, I., Mugwagwa, T., Vrisekoop, N., et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36 (2012), 288–297.
    • (2012) Immunity , vol.36 , pp. 288-297
    • den Braber, I.1    Mugwagwa, T.2    Vrisekoop, N.3
  • 87
    • 70349664158 scopus 로고    scopus 로고
    • Evidence of premature immune aging in patients thymectomized during early childhood
    • 87 Sauce, D., Larsen, M., Fastenackels, S., et al. Evidence of premature immune aging in patients thymectomized during early childhood. J Clin Invest 119 (2009), 3070–3078.
    • (2009) J Clin Invest , vol.119 , pp. 3070-3078
    • Sauce, D.1    Larsen, M.2    Fastenackels, S.3
  • 88
    • 59249090000 scopus 로고    scopus 로고
    • Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
    • 88 Chidrawar, S., Khan, N., Wei, W., et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol 155 (2009), 423–432.
    • (2009) Clin Exp Immunol , vol.155 , pp. 423-432
    • Chidrawar, S.1    Khan, N.2    Wei, W.3
  • 89
    • 78650925501 scopus 로고    scopus 로고
    • Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
    • 89 Litjens, N.H., de Wit, E.A., Betjes, M.G., Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun Ageing, 8, 2011, 2.
    • (2011) Immun Ageing , vol.8 , pp. 2
    • Litjens, N.H.1    de Wit, E.A.2    Betjes, M.G.3
  • 90
    • 0032957642 scopus 로고    scopus 로고
    • Role of cytomegalovirus in the T cell changes seen in elderly individuals
    • 90 Looney, R.J., Falsey, A., Campbell, D., et al. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol 90 (1999), 213–219.
    • (1999) Clin Immunol , vol.90 , pp. 213-219
    • Looney, R.J.1    Falsey, A.2    Campbell, D.3
  • 91
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor g1 (KLRG1)
    • 91 Ouyang, Q., Wagner, W.M., Voehringer, D., et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor g1 (KLRG1). Exp Gerontol 38 (2003), 911–920.
    • (2003) Exp Gerontol , vol.38 , pp. 911-920
    • Ouyang, Q.1    Wagner, W.M.2    Voehringer, D.3
  • 92
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    • 92 Wikby, A., Johansson, B., Olsson, J., et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 37 (2002), 445–453.
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3
  • 93
    • 47849130092 scopus 로고    scopus 로고
    • Cytomegalovirus reactivation in critically ill immunocompetent patients
    • 93 Limaye, A.P., Kirby, K.A., Rubenfeld, G.D., et al. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 300 (2008), 413–422.
    • (2008) JAMA , vol.300 , pp. 413-422
    • Limaye, A.P.1    Kirby, K.A.2    Rubenfeld, G.D.3
  • 94
    • 84896501298 scopus 로고    scopus 로고
    • Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
    • 94 Wertheimer, A.M., Bennett, M.S., Park, B., et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol 192 (2014), 2143–2155.
    • (2014) J Immunol , vol.192 , pp. 2143-2155
    • Wertheimer, A.M.1    Bennett, M.S.2    Park, B.3
  • 95
    • 32044433093 scopus 로고    scopus 로고
    • Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly
    • 95 Hadrup, S.R., Strindhall, J., Kollgaard, T., et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 176 (2006), 2645–2653.
    • (2006) J Immunol , vol.176 , pp. 2645-2653
    • Hadrup, S.R.1    Strindhall, J.2    Kollgaard, T.3
  • 96
    • 0037103256 scopus 로고    scopus 로고
    • Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    • 96 Khan, N., Shariff, N., Cobbold, M., et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 169 (2002), 1984–1992.
    • (2002) J Immunol , vol.169 , pp. 1984-1992
    • Khan, N.1    Shariff, N.2    Cobbold, M.3
  • 97
    • 0037825764 scopus 로고    scopus 로고
    • Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old
    • 97 Ouyang, Q., Wagner, W.M., Wikby, A., et al. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 23 (2003), 247–257.
    • (2003) J Clin Immunol , vol.23 , pp. 247-257
    • Ouyang, Q.1    Wagner, W.M.2    Wikby, A.3
  • 98
    • 1642503829 scopus 로고    scopus 로고
    • Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly
    • 98 Ouyang, Q., Wagner, W.M., Zheng, W., et al. Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp Gerontol 39 (2004), 607–613.
    • (2004) Exp Gerontol , vol.39 , pp. 607-613
    • Ouyang, Q.1    Wagner, W.M.2    Zheng, W.3
  • 99
    • 77951889646 scopus 로고    scopus 로고
    • Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status
    • 99 Vescovini, R., Biasini, C., Telera, A.R., et al. Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol 184 (2010), 3242–3249.
    • (2010) J Immunol , vol.184 , pp. 3242-3249
    • Vescovini, R.1    Biasini, C.2    Telera, A.R.3
  • 100
    • 84897530472 scopus 로고    scopus 로고
    • Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling
    • 100 Britanova, O.V., Putintseva, E.V., Shugay, M., et al. Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling. J Immunol 192 (2014), 2689–2698.
    • (2014) J Immunol , vol.192 , pp. 2689-2698
    • Britanova, O.V.1    Putintseva, E.V.2    Shugay, M.3
  • 101
    • 84907001176 scopus 로고    scopus 로고
    • Diversity and clonal selection in the human T-cell repertoire
    • 101 Qi, Q., Liu, Y., Cheng, Y., et al. Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A 111 (2014), 13139–13144.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 13139-13144
    • Qi, Q.1    Liu, Y.2    Cheng, Y.3
  • 102
    • 84936980441 scopus 로고    scopus 로고
    • Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach
    • 102 Laydon, D.J., Bangham, C.R., Asquith, B., Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach. Phil Trans R Soc B, 370, 2015, 20140291.
    • (2015) Phil Trans R Soc B , vol.370 , pp. 20140291
    • Laydon, D.J.1    Bangham, C.R.2    Asquith, B.3
  • 103
    • 67649407892 scopus 로고    scopus 로고
    • CD28(-) T cells: their role in the age-associated decline of immune function
    • 103 Weng, N.P., Akbar, A.N., Goronzy, J., CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol 30 (2009), 306–312.
    • (2009) Trends Immunol , vol.30 , pp. 306-312
    • Weng, N.P.1    Akbar, A.N.2    Goronzy, J.3
  • 104
    • 0141449956 scopus 로고    scopus 로고
    • Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production
    • 104 Topp, M.S., Riddell, S.R., Akatsuka, Y., et al. Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. J Exp Med 198 (2003), 947–955.
    • (2003) J Exp Med , vol.198 , pp. 947-955
    • Topp, M.S.1    Riddell, S.R.2    Akatsuka, Y.3
  • 105
    • 84876732591 scopus 로고    scopus 로고
    • T cell replicative senescence in human aging
    • 105 Chou, J.P., Effros, R.B., T cell replicative senescence in human aging. Curr Pharm Des 19 (2013), 1680–1698.
    • (2013) Curr Pharm Des , vol.19 , pp. 1680-1698
    • Chou, J.P.1    Effros, R.B.2
  • 106
    • 84878384176 scopus 로고    scopus 로고
    • Increased T-Bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
    • 106 Dolfi, D.V., Mansfield, K.D., Polley, A.M., et al. Increased T-Bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. J Leukoc Biol 93 (2013), 825–836.
    • (2013) J Leukoc Biol , vol.93 , pp. 825-836
    • Dolfi, D.V.1    Mansfield, K.D.2    Polley, A.M.3
  • 107
    • 75949118701 scopus 로고    scopus 로고
    • KLRG1–more than a marker for T cell senescence
    • 107 Henson, S.M., Akbar, A.N., KLRG1–more than a marker for T cell senescence. Age (Dordr) 31 (2009), 285–291.
    • (2009) Age (Dordr) , vol.31 , pp. 285-291
    • Henson, S.M.1    Akbar, A.N.2
  • 108
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • 108 Li, G., Yu, M., Lee, W.W., et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med 18 (2012), 1518–1524.
    • (2012) Nat Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3
  • 109
    • 84859574715 scopus 로고    scopus 로고
    • Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
    • 109 Yu, M., Li, G., Lee, W.W., et al. Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A 109 (2012), E879–E888.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E879-E888
    • Yu, M.1    Li, G.2    Lee, W.W.3
  • 110
    • 84907011926 scopus 로고    scopus 로고
    • P38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells
    • 110 Henson, S.M., Lanna, A., Riddell, N.E., et al. P38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells. J Clin Invest 124 (2014), 4004–4016.
    • (2014) J Clin Invest , vol.124 , pp. 4004-4016
    • Henson, S.M.1    Lanna, A.2    Riddell, N.E.3
  • 111
    • 84922056020 scopus 로고    scopus 로고
    • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
    • 111 Lanna, A., Henson, S.M., Escors, D., et al. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol 15 (2014), 965–972.
    • (2014) Nat Immunol , vol.15 , pp. 965-972
    • Lanna, A.1    Henson, S.M.2    Escors, D.3
  • 112
    • 59049088629 scopus 로고    scopus 로고
    • B-cell diversity decreases in old age and is correlated with poor health status
    • 112 Gibson, K.L., Wu, Y.C., Barnett, Y., et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 8 (2009), 18–25.
    • (2009) Aging Cell , vol.8 , pp. 18-25
    • Gibson, K.L.1    Wu, Y.C.2    Barnett, Y.3
  • 113
    • 84892778834 scopus 로고    scopus 로고
    • Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires
    • 113 Wang, C., Liu, Y., Xu, L.T., et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J Immunol 192 (2014), 603–611.
    • (2014) J Immunol , vol.192 , pp. 603-611
    • Wang, C.1    Liu, Y.2    Xu, L.T.3
  • 114
    • 33747052004 scopus 로고    scopus 로고
    • Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue
    • 114 Kolar, G.R., Mehta, D., Wilson, P.C., et al. Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand J Immunol 64 (2006), 314–324.
    • (2006) Scand J Immunol , vol.64 , pp. 314-324
    • Kolar, G.R.1    Mehta, D.2    Wilson, P.C.3
  • 116
    • 79960997012 scopus 로고    scopus 로고
    • Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    • 116 Sasaki, S., Sullivan, M., Narvaez, C.F., et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest 121 (2011), 3109–3119.
    • (2011) J Clin Invest , vol.121 , pp. 3109-3119
    • Sasaki, S.1    Sullivan, M.2    Narvaez, C.F.3
  • 117
    • 78649641896 scopus 로고    scopus 로고
    • Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
    • 117 Frasca, D., Diaz, A., Romero, M., et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine 28 (2010), 8077–8084.
    • (2010) Vaccine , vol.28 , pp. 8077-8084
    • Frasca, D.1    Diaz, A.2    Romero, M.3
  • 118
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • 118 Frasca, D., Landin, A.M., Lechner, S.C., et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol 180 (2008), 5283–5290.
    • (2008) J Immunol , vol.180 , pp. 5283-5290
    • Frasca, D.1    Landin, A.M.2    Lechner, S.C.3
  • 119
    • 84940121847 scopus 로고    scopus 로고
    • MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals
    • 119 Frasca, D., Diaz, A., Romero, M., et al. MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals. J Immunol 195 (2015), 2134–2140.
    • (2015) J Immunol , vol.195 , pp. 2134-2140
    • Frasca, D.1    Diaz, A.2    Romero, M.3
  • 120
    • 84898802132 scopus 로고    scopus 로고
    • High TNF-alpha levels in resting B cells negatively correlate with their response
    • 120 Frasca, D., Diaz, A., Romero, M., et al. High TNF-alpha levels in resting B cells negatively correlate with their response. Exp Gerontol 54 (2014), 116–122.
    • (2014) Exp Gerontol , vol.54 , pp. 116-122
    • Frasca, D.1    Diaz, A.2    Romero, M.3
  • 121
    • 84924501653 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
    • 121 Frasca, D., Diaz, A., Romero, M., et al. Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine. Vaccine 33 (2015), 1433–1439.
    • (2015) Vaccine , vol.33 , pp. 1433-1439
    • Frasca, D.1    Diaz, A.2    Romero, M.3
  • 122
    • 84927711067 scopus 로고    scopus 로고
    • Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
    • 122 Metcalf, T.U., Cubas, R.A., Ghneim, K., et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 14 (2015), 421–432.
    • (2015) Aging Cell , vol.14 , pp. 421-432
    • Metcalf, T.U.1    Cubas, R.A.2    Ghneim, K.3
  • 123
    • 84925141335 scopus 로고    scopus 로고
    • Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination
    • 123 Thakar, J., Mohanty, S., West, A.P., et al. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY) 7 (2015), 38–52.
    • (2015) Aging (Albany NY) , vol.7 , pp. 38-52
    • Thakar, J.1    Mohanty, S.2    West, A.P.3
  • 124
    • 84876516949 scopus 로고    scopus 로고
    • Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
    • 124 Furman, D., Jojic, V., Kidd, B., et al. Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol, 9, 2013, 659.
    • (2013) Mol Syst Biol , vol.9 , pp. 659
    • Furman, D.1    Jojic, V.2    Kidd, B.3
  • 125
    • 84928041345 scopus 로고    scopus 로고
    • Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock
    • 125 Vanzant, E.L., Hilton, R.E., Lopez, C.M., et al. Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock. Crit Care, 19, 2015, 77.
    • (2015) Crit Care , vol.19 , pp. 77
    • Vanzant, E.L.1    Hilton, R.E.2    Lopez, C.M.3
  • 126
    • 84928728856 scopus 로고    scopus 로고
    • Aging and DNA methylation
    • 126 Jung, M., Pfeifer, G.P., Aging and DNA methylation. BMC Biol, 13, 2015, 7.
    • (2015) BMC Biol , vol.13 , pp. 7
    • Jung, M.1    Pfeifer, G.P.2
  • 127
    • 84926674860 scopus 로고    scopus 로고
    • DNA methylation age of blood predicts all-cause mortality in later life
    • 127 Marioni, R.E., Shah, S., McRae, A.F., et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol, 16, 2015, 25.
    • (2015) Genome Biol , vol.16 , pp. 25
    • Marioni, R.E.1    Shah, S.2    McRae, A.F.3
  • 128
    • 84928419459 scopus 로고    scopus 로고
    • The microbiota and microbiome in aging: potential implications in health and age-related diseases
    • 128 Zapata, H.J., Quagliarello, V.J., The microbiota and microbiome in aging: potential implications in health and age-related diseases. J Am Geriatr Soc 63 (2015), 776–781.
    • (2015) J Am Geriatr Soc , vol.63 , pp. 776-781
    • Zapata, H.J.1    Quagliarello, V.J.2


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