Impaired functions of peripheral blood monocyte subpopulations in aged humans

Journal of Clinical Immunology

Volumn 30, Issue 6, 2010, Pages 806-813

  Nyugen, Joseph ^a   Agrawal, Sudhanshu ^a   Gollapudi, Sastry ^a   Gupta, Sudhir ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytokines; Monocyte subsets; Signaling; TLR

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AGING; ARTICLE; CELL AGING; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLOGY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKOCYTE FUNCTION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD; BACTERIAL INFECTIONS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 3; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 78651275576     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9448-8     Document Type: Article

References (30)

1. Linton P, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol. 2004;5:133-9.
2. Caruso C, Buffa S, Candore G, Colonna-Romano G, Dunn-Walters D, Kipling D, et al. Mechanisms of immunosenescence. Immun Ageing. 2009;22:6-10.
3. Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis. 2000;31:578-85.
4. Serbina NV, Jia T, Hohl TM, Pamer EG. Monocyte-mediated defense against microbial pathogens. Ann Rev Immunol. 2008;26:421-52.
5. Ziegler-Heitbrock L. The CD14+CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81:584-92.
6. Passlick B, Flieger D, Ziegler-Heitbrock HWL. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood. 1989;74:2527-34.
7. Auffray C, Fogg D, Garfa M, Elain G, Join-Lambert O, Kayal S, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007;317:666-70.
8. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19:71-82.
9. Grage-Griebenow E, Lorenzen D, Fetting R, Flad HD, Ernst M. Phenotypical and functional characterization of Fcγ receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity. Eur J Immunol. 1993;23:3126-35.
10. Wang SV, Mak KL, Chen LY, Chou MP, Ho CK. Heterogeneity of human blood monocytes: two subpopulations with different size, phenotypes, and functions. Immunology. 1992;77:298-303.
11. Tacke F, Randolph GJ. Migratory fate and differentiation of blood monocyte subsets. Immunobiology. 2006;211:609-18.
12. Weber C, Belge KU, van Hundelshausen P, Draude G, Steppich B, Meck M, et al. Differential chemokine receptor expression and functions in human monocyte subpopulations. J Leukoc Biol. 2000;67:699-704.
13. Belge KU, Dayyani F, Horelt A, Siedler M, Frankenberger M, Frankenberger B, et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. J Immunol. 2002;168:3536-42.
14. Mizuno K, Toma T, Tsukiji H, Okamoto H, Yamazaki H, Ohta K, et al. Selective expression of CD16highCCR2-subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation. Clin Exp Immunol. 2005;142:461-70.
15. Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J, Sambhara S. Impaired Toll-like receptor expression and function in aging. J Immunol. 2002;169:4697-701.
16. Takeda K, Kaisho T, Akira S. Toll-like receptors. Ann Rev Immunol. 2002;21:335-76.
17. Kawai T, Akira S. TLR signaling. Sem Immunol. 2007;19:24-32.
18. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004;5:987-95.
19. Jenssens S, Beyaert R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol. 2003;16:637-46.
20. Kim W-K, Sun Y, Do H, Autssier P, Halpern EF, Piatak M Jr., et al. Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage. J Leukoc Biol. 2010;87:557-67.
21. Bruunsgaard H, Pedersen BK. Age-related inflammatory cytokines and diseases. Immunol Allergy Clin North Am. 2003;23:15-39.
22. Krabbe KS, Pedersen BK, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol. 2004;39:687-99.
23. Boehmer ED, Meehan MJ, Cutro BT, Kovacs EJ. Aging negatively skews macrophage TLR2-and TLR4-mediated proinflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev. 2005;26:1305-13.
24. Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. L Leukoc Biol. 2004;75:342-9.
25. Van Duin D, Subhasis M, Thomas V, Ginter S, Montogomery RR, Fikrig E, et al. Age-associated defect in human TLR-1/2 function. J Immunol. 2007;178:970-5.
26. Agarwal A, Agrawal S, Cao JN, Su H, Osann K, GUPTA S. Abberant innate functions of dendritic cells in aged humans: a role of PI3-K signaling pathway. J Immunol. 2007;178:6912-22.
27. Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T, et al. Different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogenactivated protein kinase and c-fos. J Immunol. 2003;171:4984-9.
28. Dillon S, Agrawal S, Banerjee K, Letterio J, Denning TL, Oswald-Richter K, et al. Yeast zymosan, a stimulus for TLR-2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest. 2006;116:916-28.
29. Kopp A, Buechlet C, Bala M, Neumeier M, Scholmerich J, Schaffler A. Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of xetracellular signal-regulated kinase and c-Jin N-terminal kinase but not interferon regulatory factor-3. Endocrinology. 2010;15:1097-108.
30. Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, et al. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR-1 and TLR-2 deficient mice. Nat Med. 2002;8:878-84.