Effect of age and CMV on NK cell subpopulations

Experimental Gerontology

Volumn 54, Issue , 2014, Pages 130-137

  Campos, Carmen ^a   Pera, Alejandra ^a   Sanchez Correa, Beatriz ^b   Alonso, Corona ^a   Lopez Fernandez, Isabel ^c   Morgado, Sara ^b   Tarazona, Raquel ^b   Solana, Rafael ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF EXTREMADURA   (Spain)

^c Residencia Municipal de Mayores de Torrecampo   (Spain)

Author keywords

CD57; CD94; Granzyme; Immunosenescence; Natural Killer cells; NKG2A; NKG2C; Perforin

Indexed keywords

CD56 ANTIGEN; CD57 ANTIGEN; GRANZYME; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY D; PERFORIN;

ADULT; AGED; CYTOMEGALOVIRUS INFECTION; ENZYMOLOGY; FEMALE; HUMAN; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; MALE; METABOLISM; NATURAL KILLER CELL; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD56; ANTIGENS, CD57; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; MALE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY D; PERFORIN; YOUNG ADULT;

EID: 84898828587     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.01.008     Document Type: Article

References (50)

1. Almeida-Oliveira A., Smith-Carvalho M., Porto L.C., Cardoso-Oliveira J., Ribeiro A.S., Falcao R.R., Abdelhay E., Bouzas L.F., Thuler L.C., Ornellas M.H., Diamond H.R. Age-related changes in natural killer cell receptors from childhood through old age. Hum. Immunol. 2011, 72:319-329.
2. Beziat V., Duffy D., Quoc S.N., Le Garff-Tavernier M., Decocq J., Combadiere B., Debre P., Vieillard V. CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation. J. Immunol. 2011, 186:6753-6761.
3. Bjorkstrom N.K., Ljunggren H.G., Sandberg J.K. CD56 negative NK cells: origin, function, and role in chronic viral disease. Trends Immunol. 2010, 31:401-406.
4. Bjorkstrom N.K., Riese P., Heuts F., Andersson S., Fauriat C., Ivarsson M.A., Bjorklund A.T., Flodstrom-Tullberg M., Michaelsson J., Rottenberg M.E., Guzman C.A., Ljunggren H.G., Malmberg K.J. Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK cell differentiation uncoupled from NK cell education. Blood 2010, 116:3853-3864.
5. Borrego F., Alonso M.C., Galiani M.D., Carracedo J., Ramirez R., Ostos B., Pena J., Solana R. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp. Gerontol. 1999, 34:253-265.
6. Camous X., Pera A., Solana R., Larbi A. NK cells in healthy aging and age-associated diseases. J. Biomed. Biotechnol. 2012, 2012:195956.
7. Cannon M.J., Schmid D.S., Hyde T.B. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev. Med. Virol. 2010, 20:202-213.
8. Chidrawar S.M., Khan N., Chan Y.L., Nayak L., Moss P.A. Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun. Ageing 2006, 3:10.
9. Cooper M.A., Fehniger T.A., Caligiuri M.A. The biology of human natural killer-cell subsets. Trends Immunol. 2001, 22:633-640.
10. DelaRosa O., Pawelec G., Peralbo E., Wikby A., Mariani E., Mocchegiani E., Tarazona R., Solana R. Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 2006, 7:471-481.
11. Della C.M., Falco M., Podesta M., Locatelli F., Moretta L., Frassoni F., Moretta A. Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?. Blood 2012, 119:399-410.
12. deOry F., Ramirez R., Garcia C.L., Leon P., Sagues M.J., Sanz J.C. Is there a change in cytomegalovirus seroepidemiology in Spain?. Eur. J. Epidemiol. 2004, 19:85-89.
13. Derhovanessian E., Larbi A., Pawelec G. Biomarkers of human immunosenescence: impact of cytomegalovirus infection. Curr. Opin. Immunol. 2009, 21:440-445.
14. Gayoso I., Peralbo E., Sanchez-Correa B., Morgado S., Casado J.G., Tarazona R., Solana R. Phenotypic analysis of human NK cells in healthy elderly. 2nd European Congress of Immunology - ECI 2009, 105-109. Medimond SRL, Pianoro, Italy. R.E. Schmidt (Ed.).
15. Gayoso I., Sanchez-Correa B., Campos C., Alonso C., Pera A., Casado J.G., Morgado S., Tarazona R., Solana R. Immunosenescence of human natural killer cells. J. Innate. Immun. 2011, 3:337-343.
16. Gonzalez V.D., Falconer K., Bjorkstrom N.K., Blom K.G., Weiland O., Ljunggren H.G., Alaeus A., Sandberg J.K. Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment. J. Immunol. 2009, 183:6612-6618.
17. Grubeck-Loebenstein B., Della B.S., Iorio A.M., Michel J.P., Pawelec G., Solana R. Immunosenescence and vaccine failure in the elderly. Aging Clin. Exp. Res. 2009, 21:201-209.
18. Guma M., Angulo A., Vilches C., Gomez-Lozano N., Malats N., Lopez-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 2004, 104:3664-3671.
19. Guma M., Cabrera C., Erkizia I., Bofill M., Clotet B., Ruiz L., Lopez-Botet M. Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients. J. Infect. Dis. 2006, 194:38-41.
20. Hayhoe R.P., Henson S.M., Akbar A.N., Palmer D.B. Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset. Hum. Immunol. 2010, 71:676-681.
21. Hazeldine J., Hampson P., Lord J.M. Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity. Aging Cell. 2012, 11:751-759.
22. Koch S., Solana R., Dela R.O., Pawelec G. Human cytomegalovirus infection and T cell immunosenescence: a mini review. Mech. Ageing Dev. 2006, 127:538-543.
23. Koch S., Larbi A., Ozcelik D., Solana R., Gouttefangeas C., Attig S., Wikby A., Strindhall J., Franceschi C., Pawelec G. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann. N. Y. Acad. Sci. 2007, 1114:23-35.
24. Larbi A., Franceschi C., Mazzatti D., Solana R., Wikby A., Pawelec G. Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) 2008, 23:64-74.
25. Le Garff-Tavernier M., Beziat V., Decocq J., Siguret V., Gandjbakhch F., Pautas E., Debre P., Merle-Beral H., Vieillard V. Human NK cells display major phenotypic and functional changes over the life span. Aging Cell. 2010, 9:527-535.
26. Lopez-Verges S., Milush J.M., Pandey S., York V.A., rakawa-Hoyt J., Pircher H., Norris P.J., Nixon D.F., Lanier L.L. CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK cell subset. Blood 2010, 116:3865-3874.
27. Lopez-Verges S., Milush J.M., Schwartz B.S., Pando M.J., Jarjoura J., York V.A., Houchins J.P., Miller S., Kang S.M., Norris P.J., Nixon D.F., Lanier L.L. Expansion of a unique CD57NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:14725-14732.
28. Lutz C.T., Moore M.B., Bradley S., Shelton B.J., Lutgendorf S.K. Reciprocal age related change in natural killer cell receptors for MHC class I. Mech. Ageing Dev. 2005, 126:722-731.
29. Mariani E., Mariani A.R., Meneghetti A., Tarozzi A., Cocco L., Facchini A. Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity. Int. Immunol. 1998, 10:981-989.
30. Mariani E., Pulsatelli L., Neri S., Dolzani P., Meneghetti A., Silvestri T., Ravaglia G., Forti P., Cattini L., Facchini A. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Exp. Gerontol. 2002, 37:219-226.
31. Mavilio D., Lombardo G., Benjamin J., Kim D., Follman D., Marcenaro E., O'Shea M.A., Kinter A., Kovacs C., Moretta A., Fauci A.S. Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:2886-2891.
32. Monsivais-Urenda A., Noyola-Cherpitel D., Hernandez-Salinas A., Garcia-Sepulveda C., Romo N., Baranda L., Lopez-Botet M., Gonzalez-Amaro R. Influence of human cytomegalovirus infection on the NK cell receptor repertoire in children. Eur. J. Immunol. 2010, 40:1418-1427.
33. Muntasell A., Vilches C., Angulo A., Lopez-Botet M. Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host-pathogen interaction. Eur. J. Immunol. 2013, 43:1133-1141.
34. Muntasell A., López-Montañés M., Vera A., Heredia G., Romo N., Peñafiel J., Moraru M., Vila J., Vilches C., López-Botet M. NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus. Eur. J. Immunol. 2013, 43:3268-3278.
35. Noyola D.E., Fortuny C., Muntasell A., Noguera-Julian A., Munoz-Almagro C., Alarcon A., Juncosa T., Moraru M., Vilches C., Lopez-Botet M. Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children. Eur. J. Immunol. 2012, 42:3256-3266.
36. Pawelec G., Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011, 157:175-179.
37. Pawelec G., Akbar A., Caruso C., Solana R., Grubeck-Loebenstein B., Wikby A. Human immunosenescence: is it infectious?. Immunol. Rev. 2005, 205:257-268.
38. Pawelec G., McElhaney J.E., Aiello A.E., Derhovanessian E. The impact of CMV infection on survival in older humans. Curr. Opin. Immunol. 2012, 24:507-511.
39. Poli A., Michel T., Theresine M., Andres E., Hentges F., Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 2009, 126:458-465.
40. Sanchez-Correa B., Morgado S., Gayoso I., Bergua J.M., Casado J.G., Arcos M.J., Bengochea M.L., Duran E., Solana R., Tarazona R. Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands. Cancer Immunol. Immunother. 2011, 60:1195-1205.
41. Sanchez-Correa B., Gayoso I., Bergua J.M., Casado J.G., Morgado S., Solana R., Tarazona R. Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients. Immunol. Cell Biol. 2012, 90:109-115.
42. Shilling H.G., Young N., Guethlein L.A., Cheng N.W., Gardiner C.M., Tyan D., Parham P. Genetic control of human NK cell repertoire. J. Immunol. 2002, 169:239-247.
43. Solana R., Mariani E. NK and NK/T cells in human senescence. Vaccine 2000, 18:1613-1620.
44. Solana R., Pawelec G., Tarazona R. Aging and innate immunity. Immunity 2006, 24:491-494.
45. Solana R., Tarazona R., Gayoso I., Lesur O., Dupuis G., Fulop T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin. Immunol. 2012, 24:331-341.
46. Tarazona R., Casado J.G., DelaRosa O., Torre-Cisneros J., Villanueva J.L., Sanchez B., Galiani M.D., Gonzalez R., Solana R., Pena J. Selective depletion of CD56(dim) NK cell subsets and maintenance of CD56(bright) NK cells in treatment-naive HIV-1-seropositive individuals. J. Clin. Immunol. 2002, 22:176-183.
47. Tarazona R., Gayoso I., Alonso C., Pita-Lopez M.L., Peralbo E., Casado J.G., Sanchez-Correa B., Morgado S., Solana R. NK cells in human ageing. Handbook on Immunosenescence 2009, 533-546. Springer. T. Fulop, C. Franceschi, K. Hirokawa, G. Pawelec (Eds.).
48. Wang J., Geiger H., Rudolph K.L. Immunoaging induced by hematopoietic stem cell aging. Curr. Opin. Immunol. 2011, 23:532-536.
49. Wikby A., Ferguson F., Forsey R., Thompson J., Strindhall J., Lofgren S., Nilsson B.O., Ernerudh J., Pawelec G., Johansson B. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J. Gerontol. A Biol. Sci. Med. Sci. 2005, 60:556-565.
50. Wu Z., Sinzger C., Frascaroli G., Reichel J., Bayer C., Wang L., Schirmbeck R., Mertens T. Human cytomegalovirus-induced NKG2C(hi) CD57(hi) natural killer cells are effectors dependent on humoral antiviral immunity. J. Virol. 2013, 87:7717-7725.