Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

Aging Cell

Volumn 11, Issue 5, 2012, Pages 751-759

  Hazeldine, Jon ^a   Hampson, Peter ^a   Lord, Janet M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Aging; Apoptosis; Cell death; Cellular immunology; Human

Indexed keywords

CD69 ANTIGEN; GRANZYME B; PERFORIN; PROTEIN P46;

ADULT; AGE DISTRIBUTION; AGED; AGING; ANTIGEN EXPRESSION; ARTICLE; COCULTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; LYMPHOCYTE ACTIVATION; LYSOSOME; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION;

ADULT; AGED; AGING; APOPTOSIS; CELL DEATH; CELL DEGRANULATION; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HUMANS; IMMUNOLOGICAL SYNAPSES; K562 CELLS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PERFORIN; RECEPTORS, NATURAL KILLER CELL; YOUNG ADULT;

EID: 84866443820     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00839.x     Document Type: Article

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