메뉴 건너뛰기




Volumn 67, Issue 18, 2016, Pages 2161-2176

Translation of Human-Induced Pluripotent Stem Cells from Clinical Trial in a Dish to Precision Medicine

Author keywords

drug discovery; human induced pluripotent stem cells; macromedicine; micromedicine; personalized medicine

Indexed keywords

TRANSCRIPTION FACTOR;

EID: 84966638796     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.01.083     Document Type: Review
Times cited : (215)

References (174)
  • 1
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • J.E. Till, and E.A. McCulloch A direct measurement of the radiation sensitivity of normal mouse bone marrow cells Radiat Res 14 1961 213 222
    • (1961) Radiat Res , vol.14 , pp. 213-222
    • Till, J.E.1    McCulloch, E.A.2
  • 2
    • 0000155376 scopus 로고
    • The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles
    • J.B. Gurdon The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles J Embryol Exp Morphol 10 1962 622 640
    • (1962) J Embryol Exp Morphol , vol.10 , pp. 622-640
    • Gurdon, J.B.1
  • 3
    • 0031044215 scopus 로고    scopus 로고
    • Viable offspring derived from fetal and adult mammalian cells
    • [published correction appears in Nature 1997;386:200]
    • I. Wilmut, A.E. Schnieke, J. McWhir, A.J. Kind, and K.H. Campbell Viable offspring derived from fetal and adult mammalian cells [published correction appears in Nature 1997;386:200] Nature 385 1997 810 813
    • (1997) Nature , vol.385 , pp. 810-813
    • Wilmut, I.1    Schnieke, A.E.2    McWhir, J.3    Kind, A.J.4    Campbell, K.H.5
  • 4
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 5
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • [published correction appears in Science 1998;282:1827]
    • J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, and et al. Embryonic stem cell lines derived from human blastocysts [published correction appears in Science 1998;282:1827] Science 282 1998 1145 1147
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3
  • 6
    • 0035797898 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • M. Tada, Y. Takahama, K. Abe, N. Nakatsuji, and T. Tada Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells Curr Biol 11 2001 1553 1558
    • (2001) Curr Biol , vol.11 , pp. 1553-1558
    • Tada, M.1    Takahama, Y.2    Abe, K.3    Nakatsuji, N.4    Tada, T.5
  • 7
    • 0023663888 scopus 로고
    • Expression of a single transfected cDNA converts fibroblasts to myoblasts
    • R.L. Davis, H. Weintraub, and A.B. Lassar Expression of a single transfected cDNA converts fibroblasts to myoblasts Cell 51 1987 987 1000
    • (1987) Cell , vol.51 , pp. 987-1000
    • Davis, R.L.1    Weintraub, H.2    Lassar, A.B.3
  • 8
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 9
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • K. Takahashi, K. Tanabe, M. Ohnuki, and et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 10
    • 48149107133 scopus 로고    scopus 로고
    • Wnt signaling promotes reprogramming of somatic cells to pluripotency
    • A. Marson, R. Foreman, B. Chevalier, and et al. Wnt signaling promotes reprogramming of somatic cells to pluripotency Cell Stem Cell 3 2008 132 135
    • (2008) Cell Stem Cell , vol.3 , pp. 132-135
    • Marson, A.1    Foreman, R.2    Chevalier, B.3
  • 11
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • D. Huangfu, R. Maehr, W. Guo, and et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds Nat Biotech 26 2008 795 797
    • (2008) Nat Biotech , vol.26 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3
  • 12
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • J.T. Dimos, K.T. Rodolfa, K.K. Niakan, and et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons Science 321 2008 1218 1221
    • (2008) Science , vol.321 , pp. 1218-1221
    • Dimos, J.T.1    Rodolfa, K.T.2    Niakan, K.K.3
  • 13
    • 41949098160 scopus 로고    scopus 로고
    • Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    • [published correction appears in Cell 2008;134:365]
    • J. Hanna, S. Markoulaki, P. Schorderet, and et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency [published correction appears in Cell 2008;134:365] Cell 133 2008 250 264
    • (2008) Cell , vol.133 , pp. 250-264
    • Hanna, J.1    Markoulaki, S.2    Schorderet, P.3
  • 14
    • 70349446099 scopus 로고    scopus 로고
    • Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
    • N. Sun, N.J. Panetta, D.M. Gupta, and et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells Proc Natl Acad Sci U S A 106 2009 15720 15725
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15720-15725
    • Sun, N.1    Panetta, N.J.2    Gupta, D.M.3
  • 15
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • J. Yu, M.A. Vodyanik, K. Smuga-Otto, and et al. Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 16
    • 54949136146 scopus 로고    scopus 로고
    • Two supporting factors greatly improve the efficiency of human iPSC generation
    • Y. Zhao, X. Yin, H. Qin, and et al. Two supporting factors greatly improve the efficiency of human iPSC generation Cell Stem Cell 3 2008 475 479
    • (2008) Cell Stem Cell , vol.3 , pp. 475-479
    • Zhao, Y.1    Yin, X.2    Qin, H.3
  • 17
    • 64749083939 scopus 로고    scopus 로고
    • PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
    • K. Woltjen, I.P. Michael, P. Mohseni, and et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells Nature 458 2009 766 770
    • (2009) Nature , vol.458 , pp. 766-770
    • Woltjen, K.1    Michael, I.P.2    Mohseni, P.3
  • 18
    • 58549096370 scopus 로고    scopus 로고
    • Reprogramming of murine and human somatic cells using a single polycistronic vector
    • [published corrections appear in Proc Natl Acad Sci U S A 2009;106:5449 and Proc Natl Acad Sci U S A 2009;106:11818]
    • B.W. Carey, S. Markoulaki, J. Hanna, and et al. Reprogramming of murine and human somatic cells using a single polycistronic vector [published corrections appear in Proc Natl Acad Sci U S A 2009;106:5449 and Proc Natl Acad Sci U S A 2009;106:11818] Proc Natl Acad Sci U S A 106 2009 157 162
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 157-162
    • Carey, B.W.1    Markoulaki, S.2    Hanna, J.3
  • 19
    • 77649275936 scopus 로고    scopus 로고
    • A nonviral minicircle vector for deriving human iPS cells
    • F. Jia, K.D. Wilson, N. Sun, and et al. A nonviral minicircle vector for deriving human iPS cells Nat Methods 7 2010 197 199
    • (2010) Nat Methods , vol.7 , pp. 197-199
    • Jia, F.1    Wilson, K.D.2    Sun, N.3
  • 20
    • 49449096588 scopus 로고    scopus 로고
    • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
    • M. Wernig, C.J. Lengner, J. Hanna, and et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types Nat Biotechnol 26 2008 916 924
    • (2008) Nat Biotechnol , vol.26 , pp. 916-924
    • Wernig, M.1    Lengner, C.J.2    Hanna, J.3
  • 21
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • L. Warren, P.D. Manos, T. Ahfeldt, and et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 7 2010 618 630
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3
  • 22
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • [published correction appears in Cell Stem Cell 2009;4:581]
    • H. Zhou, S. Wu, J.Y. Joo, and et al. Generation of induced pluripotent stem cells using recombinant proteins [published correction appears in Cell Stem Cell 2009;4:581] Cell Stem Cell 4 2009 381 384
    • (2009) Cell Stem Cell , vol.4 , pp. 381-384
    • Zhou, H.1    Wu, S.2    Joo, J.Y.3
  • 23
    • 84868007347 scopus 로고    scopus 로고
    • Activation of innate immunity is required for efficient nuclear reprogramming
    • J. Lee, N. Sayed, A. Hunter, and et al. Activation of innate immunity is required for efficient nuclear reprogramming Cell 151 2012 547 558
    • (2012) Cell , vol.151 , pp. 547-558
    • Lee, J.1    Sayed, N.2    Hunter, A.3
  • 24
    • 84881256653 scopus 로고    scopus 로고
    • Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
    • P. Hou, Y. Li, X. Zhang, and et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds Science 341 2013 651 654
    • (2013) Science , vol.341 , pp. 651-654
    • Hou, P.1    Li, Y.2    Zhang, X.3
  • 25
    • 84936791706 scopus 로고    scopus 로고
    • Hurdles to clinical translation of human induced pluripotent stem cells
    • E. Neofytou, C.G. O'Brien, L.A. Couture, and J.C. Wu Hurdles to clinical translation of human induced pluripotent stem cells J Clin Invest 125 2015 2551 2557
    • (2015) J Clin Invest , vol.125 , pp. 2551-2557
    • Neofytou, E.1    O'Brien, C.G.2    Couture, L.A.3    Wu, J.C.4
  • 26
    • 84942985344 scopus 로고    scopus 로고
    • Current status of pluripotent stem cells: Moving the first therapies to the clinic
    • E.A. Kimbrel, and R. Lanza Current status of pluripotent stem cells: moving the first therapies to the clinic Nat Rev Drug Discov 14 2015 681 692
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 681-692
    • Kimbrel, E.A.1    Lanza, R.2
  • 27
    • 84862907693 scopus 로고    scopus 로고
    • Production of de novo cardiomyocytes: Human pluripotent stem cell differentiation and direct reprogramming
    • P.W. Burridge, G. Keller, J.D. Gold, and J.C. Wu Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming Cell Stem Cell 10 2012 16 28
    • (2012) Cell Stem Cell , vol.10 , pp. 16-28
    • Burridge, P.W.1    Keller, G.2    Gold, J.D.3    Wu, J.C.4
  • 28
    • 84903196154 scopus 로고    scopus 로고
    • Human stem cells for modeling heart disease and for drug discovery
    • E. Matsa, P.W. Burridge, and J.C. Wu Human stem cells for modeling heart disease and for drug discovery Sci Transl Med 6 2014 239ps6
    • (2014) Sci Transl Med , vol.6 , pp. 239ps6
    • Matsa, E.1    Burridge, P.W.2    Wu, J.C.3
  • 29
    • 84905242471 scopus 로고    scopus 로고
    • Chemically defined generation of human cardiomyocytes
    • P.W. Burridge, E. Matsa, P. Shukla, and et al. Chemically defined generation of human cardiomyocytes Nat Methods 11 2014 855 860
    • (2014) Nat Methods , vol.11 , pp. 855-860
    • Burridge, P.W.1    Matsa, E.2    Shukla, P.3
  • 30
    • 84923762812 scopus 로고    scopus 로고
    • A new initiative on precision medicine
    • F.S. Collins, and H. Varmus A new initiative on precision medicine N Engl J Med 372 2015 793 795
    • (2015) N Engl J Med , vol.372 , pp. 793-795
    • Collins, F.S.1    Varmus, H.2
  • 31
    • 84871586080 scopus 로고    scopus 로고
    • A molecular roadmap of reprogramming somatic cells into iPS cells
    • J.M. Polo, E. Anderssen, R.M. Walsh, and et al. A molecular roadmap of reprogramming somatic cells into iPS cells Cell 151 2012 1617 1632
    • (2012) Cell , vol.151 , pp. 1617-1632
    • Polo, J.M.1    Anderssen, E.2    Walsh, R.M.3
  • 32
    • 84866369892 scopus 로고    scopus 로고
    • Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
    • Y. Buganim, D.A. Faddah, A.W. Cheng, and et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase Cell 150 2012 1209 1222
    • (2012) Cell , vol.150 , pp. 1209-1222
    • Buganim, Y.1    Faddah, D.A.2    Cheng, A.W.3
  • 33
    • 84885619736 scopus 로고    scopus 로고
    • Deterministic direct reprogramming of somatic cells to pluripotency
    • [published correction appears in Nature 2015;520:710]
    • Y. Rais, A. Zviran, S. Geula, and et al. Deterministic direct reprogramming of somatic cells to pluripotency [published correction appears in Nature 2015;520:710] Nature 502 2013 65 70
    • (2013) Nature , vol.502 , pp. 65-70
    • Rais, Y.1    Zviran, A.2    Geula, S.3
  • 34
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    • M.H. Chin, M.J. Mason, W. Xie, and et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell Stem Cell 5 2009 111 123
    • (2009) Cell Stem Cell , vol.5 , pp. 111-123
    • Chin, M.H.1    Mason, M.J.2    Xie, W.3
  • 35
    • 77957325592 scopus 로고    scopus 로고
    • Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells
    • Z. Ghosh, K.D. Wilson, Y. Wu, S. Hu, T. Quertermous, and J.C. Wu Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells PLoS One 5 2010 e8975
    • (2010) PLoS One , vol.5 , pp. e8975
    • Ghosh, Z.1    Wilson, K.D.2    Wu, Y.3    Hu, S.4    Quertermous, T.5    Wu, J.C.6
  • 36
    • 64349106730 scopus 로고    scopus 로고
    • Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
    • J. Deng, R. Shoemaker, B. Xie, and et al. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming Nat Biotechnol 27 2009 353 360
    • (2009) Nat Biotechnol , vol.27 , pp. 353-360
    • Deng, J.1    Shoemaker, R.2    Xie, B.3
  • 37
    • 79551677421 scopus 로고    scopus 로고
    • Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
    • C. Bock, E. Kiskinis, G. Verstappen, and et al. Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines Cell 144 2011 439 452
    • (2011) Cell , vol.144 , pp. 439-452
    • Bock, C.1    Kiskinis, E.2    Verstappen, G.3
  • 38
    • 77956260872 scopus 로고    scopus 로고
    • Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
    • M.G. Guenther, G.M. Frampton, F. Soldner, and et al. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells Cell Stem Cell 7 2010 249 257
    • (2010) Cell Stem Cell , vol.7 , pp. 249-257
    • Guenther, M.G.1    Frampton, G.M.2    Soldner, F.3
  • 39
    • 77956247114 scopus 로고    scopus 로고
    • Lab-specific gene expression signatures in pluripotent stem cells
    • A.M. Newman, and J.B. Cooper Lab-specific gene expression signatures in pluripotent stem cells Cell Stem Cell 7 2010 258 262
    • (2010) Cell Stem Cell , vol.7 , pp. 258-262
    • Newman, A.M.1    Cooper, J.B.2
  • 40
    • 84947252379 scopus 로고    scopus 로고
    • A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
    • J. Choi, S. Lee, W. Mallard, and et al. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs Nat Biotech 33 2015 1173 1181
    • (2015) Nat Biotech , vol.33 , pp. 1173-1181
    • Choi, J.1    Lee, S.2    Mallard, W.3
  • 41
    • 84921890530 scopus 로고    scopus 로고
    • Therapeutic transdifferentiation: Can we generate cardiac tissue rather than scar after myocardial injury?
    • N. Sayed, W.T. Wong, and J.P. Cooke Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury? Methodist Debakey Cardiovasc J 9 2013 210 212
    • (2013) Methodist Debakey Cardiovasc J , vol.9 , pp. 210-212
    • Sayed, N.1    Wong, W.T.2    Cooke, J.P.3
  • 43
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • P. Huang, Z. He, S. Ji, and et al. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors Nature 475 2011 386 389
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3
  • 44
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • M. Ieda, J.D. Fu, P. Delgado-Olguin, and et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors Cell 142 2010 375 386
    • (2010) Cell , vol.142 , pp. 375-386
    • Ieda, M.1    Fu, J.D.2    Delgado-Olguin, P.3
  • 45
    • 84865286051 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels
    • A. Margariti, B. Winkler, E. Karamariti, and et al. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels Proc Natl Acad Sci U S A 109 2012 13793 13798
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 13793-13798
    • Margariti, A.1    Winkler, B.2    Karamariti, E.3
  • 46
    • 84924906921 scopus 로고    scopus 로고
    • Transdifferentiation of human fibroblasts to endothelial cells: Role of innate immunity
    • N. Sayed, W.T. Wong, F. Ospino, and et al. Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity Circulation 131 2015 300 309
    • (2015) Circulation , vol.131 , pp. 300-309
    • Sayed, N.1    Wong, W.T.2    Ospino, F.3
  • 47
    • 85027957068 scopus 로고    scopus 로고
    • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5
    • J.X. Chen, M. Krane, M.A. Deutsch, and et al. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5 Circ Res 111 2012 50 55
    • (2012) Circ Res , vol.111 , pp. 50-55
    • Chen, J.X.1    Krane, M.2    Deutsch, M.A.3
  • 48
    • 84940790627 scopus 로고    scopus 로고
    • Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: Where do we stand?
    • A.D. Ebert, S. Diecke, I.Y. Chen, and J.C. Wu Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? EMBO Mol Med 7 2015 1090 1103
    • (2015) EMBO Mol Med , vol.7 , pp. 1090-1103
    • Ebert, A.D.1    Diecke, S.2    Chen, I.Y.3    Wu, J.C.4
  • 49
    • 84878852415 scopus 로고    scopus 로고
    • Modeling human disease with pluripotent stem cells: From genome association to function
    • F.T. Merkle, and K. Eggan Modeling human disease with pluripotent stem cells: from genome association to function Cell Stem Cell 12 2013 656 668
    • (2013) Cell Stem Cell , vol.12 , pp. 656-668
    • Merkle, F.T.1    Eggan, K.2
  • 50
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • I.H. Park, N. Arora, H. Huo, and et al. Disease-specific induced pluripotent stem cells Cell 134 2008 877 886
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.H.1    Arora, N.2    Huo, H.3
  • 51
    • 77953443251 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
    • X. Carvajal-Vergara, A. Sevilla, S.L. D'Souza, and et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome Nature 465 2010 808 812
    • (2010) Nature , vol.465 , pp. 808-812
    • Carvajal-Vergara, X.1    Sevilla, A.2    D'Souza, S.L.3
  • 52
    • 77953879152 scopus 로고    scopus 로고
    • Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases
    • M.C.N. Marchetto, B. Winner, and F.H. Gage Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases Hum Mol Genet 19 2010 R71 R76
    • (2010) Hum Mol Genet , vol.19 , pp. R71-R76
    • Marchetto, M.C.N.1    Winner, B.2    Gage, F.H.3
  • 53
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    • A. Moretti, M. Bellin, A. Welling, and et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome N Engl J Med 363 2010 1397 1409
    • (2010) N Engl J Med , vol.363 , pp. 1397-1409
    • Moretti, A.1    Bellin, M.2    Welling, A.3
  • 54
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • I. Itzhaki, L. Maizels, I. Huber, and et al. Modelling the long QT syndrome with induced pluripotent stem cells Nature 471 2011 225 229
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3
  • 55
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • E. Matsa, D. Rajamohan, E. Dick, and et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation Eur Heart J 32 2011 952 962
    • (2011) Eur Heart J , vol.32 , pp. 952-962
    • Matsa, E.1    Rajamohan, D.2    Dick, E.3
  • 56
    • 79955583972 scopus 로고    scopus 로고
    • Derivation of human induced pluripotent stem cells for cardiovascular disease modeling
    • K. Narsinh, K.H. Narsinh, and J.C. Wu Derivation of human induced pluripotent stem cells for cardiovascular disease modeling Circ Res 108 2011 1146 1156
    • (2011) Circ Res , vol.108 , pp. 1146-1156
    • Narsinh, K.1    Narsinh, K.H.2    Wu, J.C.3
  • 57
    • 84875880689 scopus 로고    scopus 로고
    • An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells
    • A. Filareto, S. Parker, R. Darabi, and et al. An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells Nat Commun 4 2013 1549
    • (2013) Nat Commun , vol.4 , pp. 1549
    • Filareto, A.1    Parker, S.2    Darabi, R.3
  • 58
    • 84928994904 scopus 로고    scopus 로고
    • Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy
    • B. Lin, Y. Li, L. Han, and et al. Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy Dis Model Mech 8 2015 457 466
    • (2015) Dis Model Mech , vol.8 , pp. 457-466
    • Lin, B.1    Li, Y.2    Han, L.3
  • 59
    • 67650095306 scopus 로고    scopus 로고
    • Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
    • Á. Raya, I. Rodríguez-Pizà, G. Guenechea, and et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells Nature 460 2009 53 59
    • (2009) Nature , vol.460 , pp. 53-59
    • Raya, Á.1    Rodríguez-Pizà, I.2    Guenechea, G.3
  • 60
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • A. Urbach, O. Bar-Nur, G.Q. Daley, and N. Benvenisty Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells Cell Stem Cell 6 2010 407 411
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 61
    • 84938206204 scopus 로고    scopus 로고
    • Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations
    • A. Novak, L. Barad, A. Lorber, and et al. Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations J Cell Mol Med 19 2015 2006 2018
    • (2015) J Cell Mol Med , vol.19 , pp. 2006-2018
    • Novak, A.1    Barad, L.2    Lorber, A.3
  • 62
    • 84872026086 scopus 로고    scopus 로고
    • Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells
    • F. Lan, A.S. Lee, P. Liang, and et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells Cell Stem Cell 12 2013 101 113
    • (2013) Cell Stem Cell , vol.12 , pp. 101-113
    • Lan, F.1    Lee, A.S.2    Liang, P.3
  • 63
    • 84872506168 scopus 로고    scopus 로고
    • Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
    • C.W. Siu, Y.K. Lee, J.C. Ho, and et al. Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells Aging (Albany NY) 4 2012 803 822
    • (2012) Aging (Albany NY) , vol.4 , pp. 803-822
    • Siu, C.W.1    Lee, Y.K.2    Ho, J.C.3
  • 64
    • 84860156650 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
    • N. Sun, M. Yazawa, J. Liu, and et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy Sci Transl Med 4 2012 130ra47
    • (2012) Sci Transl Med , vol.4 , pp. 130ra47
    • Sun, N.1    Yazawa, M.2    Liu, J.3
  • 65
    • 84937022594 scopus 로고    scopus 로고
    • Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-adrenergic signaling in an iPSC model of dilated cardiomyopathy
    • H. Wu, J. Lee, L.G. Vincent, and et al. Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-adrenergic signaling in an iPSC model of dilated cardiomyopathy Cell Stem Cell 17 2015 89 100
    • (2015) Cell Stem Cell , vol.17 , pp. 89-100
    • Wu, H.1    Lee, J.2    Vincent, L.G.3
  • 66
    • 84940491378 scopus 로고    scopus 로고
    • Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
    • J.T. Hinson, A. Chopra, N. Nafissi, and et al. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy Science 349 2015 982 986
    • (2015) Science , vol.349 , pp. 982-986
    • Hinson, J.T.1    Chopra, A.2    Nafissi, N.3
  • 67
    • 84875276852 scopus 로고    scopus 로고
    • Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel des mutation identified by whole exome sequencing
    • [published correction appears in Hum Mol Genet 2014;23:2332-3]
    • H.F. Tse, J.C. Ho, S.W. Choi, and et al. Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing [published correction appears in Hum Mol Genet 2014;23:2332-3] Hum Mol Genet 22 2013 1395 1403
    • (2013) Hum Mol Genet , vol.22 , pp. 1395-1403
    • Tse, H.F.1    Ho, J.C.2    Choi, S.W.3
  • 68
    • 84928966984 scopus 로고    scopus 로고
    • Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
    • I. Karakikes, F. Stillitano, M. Nonnenmacher, and et al. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy Nat Commun 6 2015 6955
    • (2015) Nat Commun , vol.6 , pp. 6955
    • Karakikes, I.1    Stillitano, F.2    Nonnenmacher, M.3
  • 69
    • 84945580024 scopus 로고    scopus 로고
    • Contractile defect caused by mutation in MYBPC3 revealed under conditions optimized for human PSC-cardiomyocyte function
    • M.J. Birket, M.C. Ribeiro, G. Kosmidis, and et al. Contractile defect caused by mutation in MYBPC3 revealed under conditions optimized for human PSC-cardiomyocyte function Cell Rep 13 2015 733 745
    • (2015) Cell Rep , vol.13 , pp. 733-745
    • Birket, M.J.1    Ribeiro, M.C.2    Kosmidis, G.3
  • 70
    • 84902087268 scopus 로고    scopus 로고
    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
    • G. Wang, M.L. McCain, L. Yang, and et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies Nat Med 20 2014 616 623
    • (2014) Nat Med , vol.20 , pp. 616-623
    • Wang, G.1    McCain, M.L.2    Yang, L.3
  • 71
    • 84905157663 scopus 로고    scopus 로고
    • Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing
    • Y. Wang, P. Liang, F. Lan, and et al. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing J Am Coll Cardiol 64 2014 451 459
    • (2014) J Am Coll Cardiol , vol.64 , pp. 451-459
    • Wang, Y.1    Liang, P.2    Lan, F.3
  • 72
    • 84887150722 scopus 로고    scopus 로고
    • Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
    • D. Ma, H. Wei, Y. Zhao, and et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells Int J Cardiol 168 2013 5277 5286
    • (2013) Int J Cardiol , vol.168 , pp. 5277-5286
    • Ma, D.1    Wei, H.2    Zhao, Y.3
  • 73
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • M. Yazawa, B. Hsueh, X. Jia, and et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome Nature 471 2011 230 234
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1    Hsueh, B.2    Jia, X.3
  • 74
    • 84874741888 scopus 로고    scopus 로고
    • Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    • C. Kim, J. Wong, J. Wen, and et al. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs Nature 494 2013 105 110
    • (2013) Nature , vol.494 , pp. 105-110
    • Kim, C.1    Wong, J.2    Wen, J.3
  • 75
    • 84962932527 scopus 로고    scopus 로고
    • Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient
    • Y. Sato, H. Kobayashi, T. Higuchi, and et al. Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient Mol Ther Methods Clin Dev 2 2015 15023
    • (2015) Mol Ther Methods Clin Dev , vol.2 , pp. 15023
    • Sato, Y.1    Kobayashi, H.2    Higuchi, T.3
  • 76
    • 84905719998 scopus 로고    scopus 로고
    • Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells
    • Y.K. Lee, P.W. Ho, R. Schick, and et al. Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells Pflugers Arch 466 2014 1831 1844
    • (2014) Pflugers Arch , vol.466 , pp. 1831-1844
    • Lee, Y.K.1    Ho, P.W.2    Schick, R.3
  • 77
    • 85021857725 scopus 로고    scopus 로고
    • Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells
    • P.W. Burridge, A. Holmström, and J.C. Wu Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells Curr Protoc Hum Genet 87 2015 21.3.1 21.3.15
    • (2015) Curr Protoc Hum Genet , vol.87 , pp. 2131-21315
    • Burridge, P.W.1    Holmström, A.2    Wu, J.C.3
  • 78
    • 84887949485 scopus 로고    scopus 로고
    • Patient-specific stem cells and cardiovascular drug discovery
    • N.M. Mordwinkin, A.S. Lee, and J.C. Wu Patient-specific stem cells and cardiovascular drug discovery JAMA 310 2013 2039 2040
    • (2013) JAMA , vol.310 , pp. 2039-2040
    • Mordwinkin, N.M.1    Lee, A.S.2    Wu, J.C.3
  • 79
    • 84865254838 scopus 로고    scopus 로고
    • Disease characterization using LQTS-specific induced pluripotent stem cells
    • T. Egashira, S. Yuasa, T. Suzuki, and et al. Disease characterization using LQTS-specific induced pluripotent stem cells Cardiovasc Res 95 2012 419 429
    • (2012) Cardiovasc Res , vol.95 , pp. 419-429
    • Egashira, T.1    Yuasa, S.2    Suzuki, T.3
  • 80
    • 84858040591 scopus 로고    scopus 로고
    • Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
    • A.L. Lahti, V.J. Kujala, H. Chapman, and et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture Dis Model Mech 5 2012 220 230
    • (2012) Dis Model Mech , vol.5 , pp. 220-230
    • Lahti, A.L.1    Kujala, V.J.2    Chapman, H.3
  • 81
    • 84858129398 scopus 로고    scopus 로고
    • Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
    • C.B. Jung, A. Moretti, M. Mederos y Schnitzler, and et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia EMBO Mol Med 4 2012 180 191
    • (2012) EMBO Mol Med , vol.4 , pp. 180-191
    • Jung, C.B.1    Moretti, A.2    Mederos Y Schnitzler, M.3
  • 82
    • 84857547828 scopus 로고    scopus 로고
    • Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation
    • A. Novak, L. Barad, N. Zeevi-Levin, and et al. Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation J Cell Mol Med 16 2012 468 482
    • (2012) J Cell Mol Med , vol.16 , pp. 468-482
    • Novak, A.1    Barad, L.2    Zeevi-Levin, N.3
  • 83
    • 84903202996 scopus 로고    scopus 로고
    • Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy
    • [published correction appears in Sci Transl Med 2014;6:261er6]
    • A. Asimaki, S. Kapoor, E. Plovie, and et al. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy [published correction appears in Sci Transl Med 2014;6:261er6] Sci Transl Med 6 2014 240ra74
    • (2014) Sci Transl Med , vol.6 , pp. 240ra74
    • Asimaki, A.1    Kapoor, S.2    Plovie, E.3
  • 84
    • 84883791986 scopus 로고    scopus 로고
    • Screening drug-induced arrhythmia using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
    • [published correction appears in Circulation 2014;129:e452]
    • E.G. Navarrete, P. Liang, F. Lan, and et al. Screening drug-induced arrhythmia using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays [published correction appears in Circulation 2014;129:e452] Circulation 128 2013 S3 S13
    • (2013) Circulation , vol.128 , pp. S3-S13
    • Navarrete, E.G.1    Liang, P.2    Lan, F.3
  • 85
    • 84876526111 scopus 로고    scopus 로고
    • Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    • P. Liang, F. Lan, A.S. Lee, and et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity Circulation 127 2013 1677 1691
    • (2013) Circulation , vol.127 , pp. 1677-1691
    • Liang, P.1    Lan, F.2    Lee, A.S.3
  • 86
    • 84919764228 scopus 로고    scopus 로고
    • Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
    • F.M. Drawnel, S. Boccardo, M. Prummer, and et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells Cell Rep 9 2014 810 821
    • (2014) Cell Rep , vol.9 , pp. 810-821
    • Drawnel, F.M.1    Boccardo, S.2    Prummer, M.3
  • 87
    • 84907140891 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform
    • A. Sharma, C. Marceau, R. Hamaguchi, and et al. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform Circ Res 115 2014 556 566
    • (2014) Circ Res , vol.115 , pp. 556-566
    • Sharma, A.1    Marceau, C.2    Hamaguchi, R.3
  • 88
    • 84907587769 scopus 로고    scopus 로고
    • RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model
    • P. Aggarwal, A. Turner, A. Matter, and et al. RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model PLoS One 9 2014 e108051
    • (2014) PLoS One , vol.9 , pp. e108051
    • Aggarwal, P.1    Turner, A.2    Matter, A.3
  • 89
    • 84908377652 scopus 로고    scopus 로고
    • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
    • A.D. Ebert, K. Kodo, P. Liang, and et al. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system Sci Transl Med 6 2014 255ra130
    • (2014) Sci Transl Med , vol.6 , pp. 255ra130
    • Ebert, A.D.1    Kodo, K.2    Liang, P.3
  • 90
    • 84872016692 scopus 로고    scopus 로고
    • Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
    • X. Lian, J. Zhang, S.M. Azarin, and et al. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions Nat Protoc 8 2013 162 175
    • (2013) Nat Protoc , vol.8 , pp. 162-175
    • Lian, X.1    Zhang, J.2    Azarin, S.M.3
  • 91
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • J. Zhang, G.F. Wilson, A.G. Soerens, and et al. Functional cardiomyocytes derived from human induced pluripotent stem cells Circ Res 104 2009 e30 e41
    • (2009) Circ Res , vol.104 , pp. e30-e41
    • Zhang, J.1    Wilson, G.F.2    Soerens, A.G.3
  • 92
    • 84894160639 scopus 로고    scopus 로고
    • Engineering adolescence: Maturation of human pluripotent stem cell-derived cardiomyocytes
    • X. Yang, L. Pabon, and C.E. Murry Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes Circ Res 114 2014 511 523
    • (2014) Circ Res , vol.114 , pp. 511-523
    • Yang, X.1    Pabon, L.2    Murry, C.E.3
  • 93
    • 84940033414 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived cardiomyocytes: Insights into molecular, cellular, and functional phenotypes
    • I. Karakikes, M. Ameen, V. Termglinchan, and J.C. Wu Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes Circ Res 117 2015 80 88
    • (2015) Circ Res , vol.117 , pp. 80-88
    • Karakikes, I.1    Ameen, M.2    Termglinchan, V.3    Wu, J.C.4
  • 94
    • 0345303845 scopus 로고    scopus 로고
    • Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes
    • M. Snir, I. Kehat, A. Gepstein, and et al. Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes Am J Physiol Heart Circ Physiol 285 2003 H2355 H2363
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H2355-H2363
    • Snir, M.1    Kehat, I.2    Gepstein, A.3
  • 95
    • 84934292637 scopus 로고    scopus 로고
    • Immaturity of human stem-cell-derived cardiomyocytes in culture: Fatal flaw or soluble problem?
    • C.C. Veerman, G. Kosmidis, C.L. Mummery, S. Casini, A.O. Verkerk, and M. Bellin Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem? Stem Cells Dev 24 2015 1035 1052
    • (2015) Stem Cells Dev , vol.24 , pp. 1035-1052
    • Veerman, C.C.1    Kosmidis, G.2    Mummery, C.L.3    Casini, S.4    Verkerk, A.O.5    Bellin, M.6
  • 96
    • 84872876842 scopus 로고    scopus 로고
    • Cardiomyocyte proliferation contributes to heart growth in young humans
    • M. Mollova, K. Bersell, S. Walsh, and et al. Cardiomyocyte proliferation contributes to heart growth in young humans Proc Natl Acad Sci U S A 110 2013 1446 1451
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1446-1451
    • Mollova, M.1    Bersell, K.2    Walsh, S.3
  • 97
    • 84880227000 scopus 로고    scopus 로고
    • Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
    • S.D. Lundy, W.Z. Zhu, M. Regnier, and M.A. Laflamme Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells Stem Cells Dev 22 2013 1991 2002
    • (2013) Stem Cells Dev , vol.22 , pp. 1991-2002
    • Lundy, S.D.1    Zhu, W.Z.2    Regnier, M.3    Laflamme, M.A.4
  • 98
    • 84884364320 scopus 로고    scopus 로고
    • Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype
    • C.Y. Ivashchenko, G.C. Pipes, I.M. Lozinskaya, and et al. Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype Am J Physiol Heart Circ Physiol 305 2013 H913 H922
    • (2013) Am J Physiol Heart Circ Physiol , vol.305 , pp. H913-H922
    • Ivashchenko, C.Y.1    Pipes, G.C.2    Lozinskaya, I.M.3
  • 100
    • 84908052815 scopus 로고    scopus 로고
    • Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes
    • F.B. Bedada, S.S.K. Chan, S.K. Metzger, and et al. Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes Stem Cell Reports 3 2014 594 605
    • (2014) Stem Cell Reports , vol.3 , pp. 594-605
    • Bedada, F.B.1    Chan, S.S.K.2    Metzger, S.K.3
  • 101
    • 80455164810 scopus 로고    scopus 로고
    • High purity human-induced pluripotent stem cell-derived cardiomyocytes: Electrophysiological properties of action potentials and ionic currents
    • J. Ma, L. Guo, S.J. Fiene, and et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents Am J Physiol Heart Circ Physiol 301 2011 H2006 H2017
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. H2006-H2017
    • Ma, J.1    Guo, L.2    Fiene, S.J.3
  • 102
    • 84863213874 scopus 로고    scopus 로고
    • Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease
    • R.P. Davis, S. Casini, C.W. van den Berg, and et al. Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease Circulation 125 2012 3079 3091
    • (2012) Circulation , vol.125 , pp. 3079-3091
    • Davis, R.P.1    Casini, S.2    Van Den Berg, C.W.3
  • 104
    • 84926165142 scopus 로고    scopus 로고
    • Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology
    • H.D. Devalla, V. Schwach, J.W. Ford, and et al. Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology EMBO Mol Med 7 2015 394 410
    • (2015) EMBO Mol Med , vol.7 , pp. 394-410
    • Devalla, H.D.1    Schwach, V.2    Ford, J.W.3
  • 105
    • 84862285036 scopus 로고    scopus 로고
    • Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers
    • P. Lee, M. Klos, C. Bollensdorff, and et al. Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers Circ Res 110 2012 1556 1563
    • (2012) Circ Res , vol.110 , pp. 1556-1563
    • Lee, P.1    Klos, M.2    Bollensdorff, C.3
  • 106
    • 84899620475 scopus 로고    scopus 로고
    • Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart
    • A. Vreeker, L. van Stuijvenberg, T.J. Hund, P.J. Mohler, P.G. Nikkels, and T.A. van Veen Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart PLoS One 9 2014 e94722
    • (2014) PLoS One , vol.9 , pp. e94722
    • Vreeker, A.1    Van Stuijvenberg, L.2    Hund, T.J.3    Mohler, P.J.4    Nikkels, P.G.5    Van Veen, T.A.6
  • 107
    • 79953655401 scopus 로고    scopus 로고
    • Calcium handling in human induced pluripotent stem cell derived cardiomyocytes
    • I. Itzhaki, S. Rapoport, I. Huber, and et al. Calcium handling in human induced pluripotent stem cell derived cardiomyocytes PLoS One 6 2011 e18037
    • (2011) PLoS One , vol.6 , pp. e18037
    • Itzhaki, I.1    Rapoport, S.2    Huber, I.3
  • 108
    • 35748931742 scopus 로고    scopus 로고
    • Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes
    • O. Binah, K. Dolnikov, O. Sadan, and et al. Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes J Electrocardiol 40 Suppl 2007 S192 S196
    • (2007) J Electrocardiol , vol.40 , pp. S192-S196
    • Binah, O.1    Dolnikov, K.2    Sadan, O.3
  • 109
    • 37349045754 scopus 로고    scopus 로고
    • Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: Insights for driven maturation
    • J. Liu, J.D. Fu, C.W. Siu, and R.A. Li Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: insights for driven maturation Stem Cells 25 2007 3038 3044
    • (2007) Stem Cells , vol.25 , pp. 3038-3044
    • Liu, J.1    Fu, J.D.2    Siu, C.W.3    Li, R.A.4
  • 110
    • 79960023610 scopus 로고    scopus 로고
    • Growth of engineered human myocardium with mechanical loading and vascular coculture
    • N.L. Tulloch, V. Muskheli, M.V. Razumova, and et al. Growth of engineered human myocardium with mechanical loading and vascular coculture Circ Res 109 2011 47 59
    • (2011) Circ Res , vol.109 , pp. 47-59
    • Tulloch, N.L.1    Muskheli, V.2    Razumova, M.V.3
  • 111
    • 84857762746 scopus 로고    scopus 로고
    • Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue
    • J. Synnergren, C. Améen, A. Jansson, and P. Sartipy Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue Physiol Genomics 44 2012 245 258
    • (2012) Physiol Genomics , vol.44 , pp. 245-258
    • Synnergren, J.1    Améen, C.2    Jansson, A.3    Sartipy, P.4
  • 112
    • 65349152532 scopus 로고    scopus 로고
    • Force frequency relationship of the human ventricle increases during early postnatal development
    • R.F. Wiegerinck, A. Cojoc, C.M. Zeidenweber, and et al. Force frequency relationship of the human ventricle increases during early postnatal development Pediatr Res 65 2009 414 419
    • (2009) Pediatr Res , vol.65 , pp. 414-419
    • Wiegerinck, R.F.1    Cojoc, A.2    Zeidenweber, C.M.3
  • 113
    • 84893395943 scopus 로고    scopus 로고
    • Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes
    • W. Keung, K.R. Boheler, and R.A. Li Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes Stem Cell Res Ther 5 2014 17
    • (2014) Stem Cell Res Ther , vol.5 , pp. 17
    • Keung, W.1    Boheler, K.R.2    Li, R.A.3
  • 114
    • 27744563079 scopus 로고    scopus 로고
    • The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells
    • J.C. St John, J. Ramalho-Santos, H.L. Gray, and et al. The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells Cloning Stem Cells 7 2005 141 153
    • (2005) Cloning Stem Cells , vol.7 , pp. 141-153
    • St John, J.C.1    Ramalho-Santos, J.2    Gray, H.L.3
  • 116
    • 85047677277 scopus 로고
    • Developmental changes in energy substrate use by the heart
    • G.D. Lopaschuk, R.L. Collins-Nakai, and T. Itoi Developmental changes in energy substrate use by the heart Cardiovasc Res 26 1992 1172 1180
    • (1992) Cardiovasc Res , vol.26 , pp. 1172-1180
    • Lopaschuk, G.D.1    Collins-Nakai, R.L.2    Itoi, T.3
  • 117
    • 84859958334 scopus 로고    scopus 로고
    • Contractile properties of early human embryonic stem cell-derived cardiomyocytes: Beta-adrenergic stimulation induces positive chronotropy and lusitropy but not inotropy
    • F. Pillekamp, M. Haustein, M. Khalil, and et al. Contractile properties of early human embryonic stem cell-derived cardiomyocytes: beta-adrenergic stimulation induces positive chronotropy and lusitropy but not inotropy Stem Cells Dev 21 2012 2111 2121
    • (2012) Stem Cells Dev , vol.21 , pp. 2111-2121
    • Pillekamp, F.1    Haustein, M.2    Khalil, M.3
  • 118
    • 84922599592 scopus 로고    scopus 로고
    • Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells
    • G. Földes, E. Matsa, J. Kriston-Vizi, and et al. Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells Stem Cell Reports 3 2014 905 914
    • (2014) Stem Cell Reports , vol.3 , pp. 905-914
    • Földes, G.1    Matsa, E.2    Kriston-Vizi, J.3
  • 119
    • 55949086081 scopus 로고    scopus 로고
    • Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes
    • J.G. Jacot, A.D. McCulloch, and J.H. Omens Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes Biophys J 95 2008 3479 3487
    • (2008) Biophys J , vol.95 , pp. 3479-3487
    • Jacot, J.G.1    McCulloch, A.D.2    Omens, J.H.3
  • 120
    • 84951784669 scopus 로고    scopus 로고
    • Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies
    • E. Tzatzalos, O.J. Abilez, P. Shukla, and J.C. Wu Engineered heart tissues and induced pluripotent stem cells: macro- and microstructures for disease modeling, drug screening, and translational studies Adv Drug Deliv Rev 96 2016 234 244
    • (2016) Adv Drug Deliv Rev , vol.96 , pp. 234-244
    • Tzatzalos, E.1    Abilez, O.J.2    Shukla, P.3    Wu, J.C.4
  • 121
    • 81155134381 scopus 로고    scopus 로고
    • Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes
    • J.D. Fu, S.N. Rushing, D.K. Lieu, and et al. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes PLoS One 6 2011 e27417
    • (2011) PLoS One , vol.6 , pp. e27417
    • Fu, J.D.1    Rushing, S.N.2    Lieu, D.K.3
  • 122
    • 78649366701 scopus 로고    scopus 로고
    • Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: Role for miR-499
    • K.D. Wilson, S. Hu, S. Venkatasubrahmanyam, and et al. Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499 Circ Cardiovasc Genet 3 2010 426 435
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 426-435
    • Wilson, K.D.1    Hu, S.2    Venkatasubrahmanyam, S.3
  • 123
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • C.L. Zhang, T.A. McKinsey, S. Chang, C.L. Antos, J.A. Hill, and E.N. Olson Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy Cell 110 2002 479 488
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1    McKinsey, T.A.2    Chang, S.3    Antos, C.L.4    Hill, J.A.5    Olson, E.N.6
  • 124
    • 84924367822 scopus 로고    scopus 로고
    • Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease
    • R. Gilsbach, S. Preissl, B.A. Grüning, and et al. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease Nat Commun 5 2014 5288
    • (2014) Nat Commun , vol.5 , pp. 5288
    • Gilsbach, R.1    Preissl, S.2    Grüning, B.A.3
  • 125
    • 84930224849 scopus 로고    scopus 로고
    • Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes
    • K.T. Kuppusamy, D.C. Jones, H. Sperber, and et al. Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes Proc Natl Acad Sci U S A 112 2015 E2785 E2794
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E2785-E2794
    • Kuppusamy, K.T.1    Jones, D.C.2    Sperber, H.3
  • 126
    • 79151484284 scopus 로고    scopus 로고
    • Modulation of human embryonic stem cell-derived cardiomyocyte growth: A testbed for studying human cardiac hypertrophy?
    • G. Földes, M. Mioulane, J.S. Wright, and et al. Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy? J Mol Cell Cardiol 50 2011 367 376
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 367-376
    • Földes, G.1    Mioulane, M.2    Wright, J.S.3
  • 128
    • 84898778301 scopus 로고    scopus 로고
    • A guide to genome engineering with programmable nucleases
    • H. Kim, and J.S. Kim A guide to genome engineering with programmable nucleases Nat Rev Genet 15 2014 321 334
    • (2014) Nat Rev Genet , vol.15 , pp. 321-334
    • Kim, H.1    Kim, J.S.2
  • 129
    • 84873800970 scopus 로고    scopus 로고
    • Genome-scale engineering for systems and synthetic biology
    • K.M. Esvelt, and H.H. Wang Genome-scale engineering for systems and synthetic biology Mol Syst Biol 9 2013 641
    • (2013) Mol Syst Biol , vol.9 , pp. 641
    • Esvelt, K.M.1    Wang, H.H.2
  • 130
    • 84890563877 scopus 로고    scopus 로고
    • Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome
    • M. Bellin, S. Casini, R.P. Davis, and et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome EMBO J 32 2013 3161 3175
    • (2013) EMBO J , vol.32 , pp. 3161-3175
    • Bellin, M.1    Casini, S.2    Davis, R.P.3
  • 131
    • 84907200149 scopus 로고    scopus 로고
    • Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
    • C. Long, J.R. McAnally, J.M. Shelton, A.A. Mireault, R. Bassel-Duby, and E.N. Olson Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA Science 345 2014 1184 1188
    • (2014) Science , vol.345 , pp. 1184-1188
    • Long, C.1    McAnally, J.R.2    Shelton, J.M.3    Mireault, A.A.4    Bassel-Duby, R.5    Olson, E.N.6
  • 132
    • 84923106217 scopus 로고    scopus 로고
    • Therapeutic genome editing: Prospects and challenges
    • D.B.T. Cox, R.J. Platt, and F. Zhang Therapeutic genome editing: prospects and challenges Nat Med 21 2015 121 131
    • (2015) Nat Med , vol.21 , pp. 121-131
    • Cox, D.B.T.1    Platt, R.J.2    Zhang, F.3
  • 133
    • 84966524195 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01344993. NCT01345006. NCT01469832. NCT01625559. NCT01674829. NCT01691261. NCT02122159. NCT02286089. NCT02464956. Available at:. Accessed February 27, 2016
    • ClinicalTrials.gov. NCT01344993. NCT01345006. NCT01469832. NCT01625559. NCT01674829. NCT01691261. NCT02122159. NCT02286089. NCT02464956. Available at: https://clinicaltrials.gov. Accessed February 27, 2016.
  • 134
    • 70349873363 scopus 로고    scopus 로고
    • Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration
    • B. Lu, C. Malcuit, S. Wang, and et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration Stem Cells 27 2009 2126 2135
    • (2009) Stem Cells , vol.27 , pp. 2126-2135
    • Lu, B.1    Malcuit, C.2    Wang, S.3
  • 135
    • 84893748014 scopus 로고    scopus 로고
    • Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
    • H. Kamao, M. Mandai, S. Okamoto, and et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application Stem Cell Reports 2 2014 205 218
    • (2014) Stem Cell Reports , vol.2 , pp. 205-218
    • Kamao, H.1    Mandai, M.2    Okamoto, S.3
  • 136
    • 84902476568 scopus 로고    scopus 로고
    • The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa
    • T. Yoshida, Y. Ozawa, K. Suzuki, and et al. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa Mol Brain 7 2014 45
    • (2014) Mol Brain , vol.7 , pp. 45
    • Yoshida, T.1    Ozawa, Y.2    Suzuki, K.3
  • 137
    • 84870382316 scopus 로고    scopus 로고
    • Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa
    • Y. Li, Y.T. Tsai, C.W. Hsu, and et al. Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa Mol Med 18 2012 1312 1319
    • (2012) Mol Med , vol.18 , pp. 1312-1319
    • Li, Y.1    Tsai, Y.T.2    Hsu, C.W.3
  • 138
    • 79955904906 scopus 로고    scopus 로고
    • In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins
    • H. Liu, Y. Kim, S. Sharkis, L. Marchionni, and Y.Y. Jang In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins Sci Transl Med 3 2011 82ra39
    • (2011) Sci Transl Med , vol.3 , pp. 82ra39
    • Liu, H.1    Kim, Y.2    Sharkis, S.3    Marchionni, L.4    Jang, Y.Y.5
  • 139
    • 80053628732 scopus 로고    scopus 로고
    • Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
    • S. Nori, Y. Okada, A. Yasuda, and et al. Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice Proc Natl Acad Sci U S A 108 2011 16825 16830
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16825-16830
    • Nori, S.1    Okada, Y.2    Yasuda, A.3
  • 140
    • 84859011844 scopus 로고    scopus 로고
    • Comparison of potentials of stem cells isolated from tendon and bone marrow for musculoskeletal tissue engineering
    • Q. Tan, P.P.Y. Lui, Y.F. Rui, and Y.M. Wong Comparison of potentials of stem cells isolated from tendon and bone marrow for musculoskeletal tissue engineering Tissue Eng Part A 18 2011 840 851
    • (2011) Tissue Eng Part A , vol.18 , pp. 840-851
    • Tan, Q.1    Lui, P.P.Y.2    Rui, Y.F.3    Wong, Y.M.4
  • 141
    • 84879694584 scopus 로고    scopus 로고
    • Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation
    • N. Suzuki, S. Yamazaki, T. Yamaguchi, and et al. Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation Mol Ther 21 2013 1424 1431
    • (2013) Mol Ther , vol.21 , pp. 1424-1431
    • Suzuki, N.1    Yamazaki, S.2    Yamaguchi, T.3
  • 142
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    • M.A. Laflamme, K.Y. Chen, A.V. Naumova, and et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nat Biotechnol 25 2007 1015 1024
    • (2007) Nat Biotechnol , vol.25 , pp. 1015-1024
    • Laflamme, M.A.1    Chen, K.Y.2    Naumova, A.V.3
  • 143
    • 35548974727 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts
    • O. Caspi, I. Huber, I. Kehat, and et al. Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts J Am Coll Cardiol 50 2007 1884 1893
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1884-1893
    • Caspi, O.1    Huber, I.2    Kehat, I.3
  • 144
    • 55649098531 scopus 로고    scopus 로고
    • Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes
    • F. Cao, R.A. Wagner, K.D. Wilson, and et al. Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes PLoS One 3 2008 e3474
    • (2008) PLoS One , vol.3 , pp. e3474
    • Cao, F.1    Wagner, R.A.2    Wilson, K.D.3
  • 145
    • 84866150446 scopus 로고    scopus 로고
    • Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
    • Y. Shiba, S. Fernandes, W.Z. Zhu, and et al. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Nature 489 2012 322 325
    • (2012) Nature , vol.489 , pp. 322-325
    • Shiba, Y.1    Fernandes, S.2    Zhu, W.Z.3
  • 146
    • 84919460805 scopus 로고    scopus 로고
    • Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells
    • [published correction appears in Cell Stem Cell 2015;16:102]
    • L. Ye, Y.H. Chang, Q. Xiong, and et al. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells [published correction appears in Cell Stem Cell 2015;16:102] Cell Stem Cell 15 2014 750 761
    • (2014) Cell Stem Cell , vol.15 , pp. 750-761
    • Ye, L.1    Chang, Y.H.2    Xiong, Q.3
  • 147
    • 84902312015 scopus 로고    scopus 로고
    • Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
    • J.J.H. Chong, X. Yang, C.W. Don, and et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts Nature 510 2014 273 277
    • (2014) Nature , vol.510 , pp. 273-277
    • Chong, J.J.H.1    Yang, X.2    Don, C.W.3
  • 148
    • 84904596460 scopus 로고    scopus 로고
    • Embryonic stem cell-derived cardiac myocytes are not ready for human trials
    • M.E. Anderson, J. Goldhaber, S.R. Houser, M. Puceat, and M.A. Sussman Embryonic stem cell-derived cardiac myocytes are not ready for human trials Circ Res 115 2014 335 338
    • (2014) Circ Res , vol.115 , pp. 335-338
    • Anderson, M.E.1    Goldhaber, J.2    Houser, S.R.3    Puceat, M.4    Sussman, M.A.5
  • 149
    • 84924845270 scopus 로고    scopus 로고
    • Letter by Murry et al regarding article, "embryonic stem cell-derived cardiac myocytes are not ready for human trials."
    • C.E. Murry, J.J.H. Chong, and M.A. Laflamme Letter by Murry et al regarding article, "Embryonic stem cell-derived cardiac myocytes are not ready for human trials." Circ Res 115 2014 e28 e29
    • (2014) Circ Res , vol.115 , pp. e28-e29
    • Murry, C.E.1    Chong, J.J.H.2    Laflamme, M.A.3
  • 151
    • 84938956437 scopus 로고    scopus 로고
    • Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold
    • V. Bellamy, V. Vanneaux, A. Bel, and et al. Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold J Heart Lung Transplant 34 2015 1198 1207
    • (2015) J Heart Lung Transplant , vol.34 , pp. 1198-1207
    • Bellamy, V.1    Vanneaux, V.2    Bel, A.3
  • 152
    • 84939612938 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: First clinical case report
    • P. Menasché, V. Vanneaux, A. Hagège, and et al. Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report Eur Heart J 36 2015 2011 2017
    • (2015) Eur Heart J , vol.36 , pp. 2011-2017
    • Menasché, P.1    Vanneaux, V.2    Hagège, A.3
  • 153
    • 84908110213 scopus 로고    scopus 로고
    • Cardiac tissue slice transplantation as a model to assess tissue-engineered graft thickness, survival, and function
    • J. Riegler, A. Gillich, Q. Shen, J.D. Gold, and J.C. Wu Cardiac tissue slice transplantation as a model to assess tissue-engineered graft thickness, survival, and function Circulation 130 11 Suppl 1 2014 S77 S86
    • (2014) Circulation , vol.130 , Issue.11 , pp. S77-S86
    • Riegler, J.1    Gillich, A.2    Shen, Q.3    Gold, J.D.4    Wu, J.C.5
  • 155
    • 84884805212 scopus 로고    scopus 로고
    • Patching the heart: Cardiac repair from within and outside
    • L. Ye, W.H. Zimmermann, D.J. Garry, and J. Zhang Patching the heart: cardiac repair from within and outside Circ Res 113 2013 922 932
    • (2013) Circ Res , vol.113 , pp. 922-932
    • Ye, L.1    Zimmermann, W.H.2    Garry, D.J.3    Zhang, J.4
  • 156
    • 84864882528 scopus 로고    scopus 로고
    • Bioenergetic and functional consequences of cellular therapy: Activation of endogenous cardiovascular progenitor cells
    • Q. Xiong, L. Ye, P. Zhang, and et al. Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells Circ Res 111 2012 455 468
    • (2012) Circ Res , vol.111 , pp. 455-468
    • Xiong, Q.1    Ye, L.2    Zhang, P.3
  • 157
    • 84874663191 scopus 로고    scopus 로고
    • Functional consequences of human induced pluripotent stem cell therapy: Myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling
    • Q. Xiong, L. Ye, P. Zhang, and et al. Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling Circulation 127 2013 997 1008
    • (2013) Circulation , vol.127 , pp. 997-1008
    • Xiong, Q.1    Ye, L.2    Zhang, P.3
  • 158
    • 85047288953 scopus 로고    scopus 로고
    • Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model
    • J. Riegler, M. Tiburcy, A. Ebert, and et al. Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model Circ Res 117 2015 720 730
    • (2015) Circ Res , vol.117 , pp. 720-730
    • Riegler, J.1    Tiburcy, M.2    Ebert, A.3
  • 159
    • 79952144860 scopus 로고    scopus 로고
    • A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling
    • Q. Xiong, K.L. Hill, Q. Li, and et al. A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling Stem Cells 29 2011 367 375
    • (2011) Stem Cells , vol.29 , pp. 367-375
    • Xiong, Q.1    Hill, K.L.2    Li, Q.3
  • 160
    • 84873569528 scopus 로고    scopus 로고
    • Current status of drug screening and disease modelling in human pluripotent stem cells
    • D. Rajamohan, E. Matsa, S. Kalra, and et al. Current status of drug screening and disease modelling in human pluripotent stem cells Bioessays 35 2013 281 298
    • (2013) Bioessays , vol.35 , pp. 281-298
    • Rajamohan, D.1    Matsa, E.2    Kalra, S.3
  • 161
    • 84938937843 scopus 로고    scopus 로고
    • Finding the rhythm of sudden cardiac death: New opportunities using induced pluripotent stem cell-derived cardiomyocytes
    • K. Sallam, Y. Li, P.T. Sager, S.R. Houser, and J.C. Wu Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes Circ Res 116 2015 1989 2004
    • (2015) Circ Res , vol.116 , pp. 1989-2004
    • Sallam, K.1    Li, Y.2    Sager, P.T.3    Houser, S.R.4    Wu, J.C.5
  • 162
    • 74749088503 scopus 로고    scopus 로고
    • Spending on new drug development
    • C.P. Adams, and V.V. Brantner Spending on new drug development Health Econ 19 2010 130 141
    • (2010) Health Econ , vol.19 , pp. 130-141
    • Adams, C.P.1    Brantner, V.V.2
  • 163
    • 70049093343 scopus 로고    scopus 로고
    • Role of hERG potassium channel assays in drug development
    • B.T. Priest, I.M. Bell, and M.L. Garcia Role of hERG potassium channel assays in drug development Channels (Austin) 2 2008 87 93
    • (2008) Channels (Austin) , vol.2 , pp. 87-93
    • Priest, B.T.1    Bell, I.M.2    Garcia, M.L.3
  • 164
    • 33745153776 scopus 로고    scopus 로고
    • The cardiac hERG/IKr potassium channel as pharmacological target: Structure, function, regulation, and clinical applications
    • D. Thomas, C.A. Karle, and J. Kiehn The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications Curr Pharm Des 12 2006 2271 2283
    • (2006) Curr Pharm des , vol.12 , pp. 2271-2283
    • Thomas, D.1    Karle, C.A.2    Kiehn, J.3
  • 165
    • 76749151845 scopus 로고    scopus 로고
    • Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
    • S.R. Braam, L. Tertoolen, A. van de Stolpe, T. Meyer, R. Passier, and C.L. Mummery Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes Stem Cell Res 4 2010 107 116
    • (2010) Stem Cell Res , vol.4 , pp. 107-116
    • Braam, S.R.1    Tertoolen, L.2    Van De Stolpe, A.3    Meyer, T.4    Passier, R.5    Mummery, C.L.6
  • 166
    • 77952281479 scopus 로고    scopus 로고
    • Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes
    • M.K. Jonsson, G. Duker, C. Tropp, and et al. Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes Stem Cell Res 4 2010 189 200
    • (2010) Stem Cell Res , vol.4 , pp. 189-200
    • Jonsson, M.K.1    Duker, G.2    Tropp, C.3
  • 167
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization
    • J.Q. He, Y. Ma, Y. Lee, J.A. Thomson, and T.J. Kamp Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization Circ Res 93 2003 32 39
    • (2003) Circ Res , vol.93 , pp. 32-39
    • He, J.Q.1    Ma, Y.2    Lee, Y.3    Thomson, J.A.4    Kamp, T.J.5
  • 168
    • 84877794737 scopus 로고    scopus 로고
    • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes
    • D. Zhang, I.Y. Shadrin, J. Lam, H.Q. Xian, H.R. Snodgrass, and N. Bursac Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes Biomaterials 34 2013 5813 5820
    • (2013) Biomaterials , vol.34 , pp. 5813-5820
    • Zhang, D.1    Shadrin, I.Y.2    Lam, J.3    Xian, H.Q.4    Snodgrass, H.R.5    Bursac, N.6
  • 169
    • 84948752224 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of human cardiac reprogramming and differentiation in regenerative medicine
    • P.W. Burridge, A. Sharma, and J.C. Wu Genetic and epigenetic regulation of human cardiac reprogramming and differentiation in regenerative medicine Annu Rev Genet 49 2015 461 484
    • (2015) Annu Rev Genet , vol.49 , pp. 461-484
    • Burridge, P.W.1    Sharma, A.2    Wu, J.C.3
  • 170
    • 84924405787 scopus 로고    scopus 로고
    • Human iPSC-based cardiac microphysiological system for drug screening applications
    • A. Mathur, P. Loskill, K. Shao, and et al. Human iPSC-based cardiac microphysiological system for drug screening applications Sci Rep 5 2015 8883
    • (2015) Sci Rep , vol.5 , pp. 8883
    • Mathur, A.1    Loskill, P.2    Shao, K.3
  • 171
    • 80052487012 scopus 로고    scopus 로고
    • Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes
    • L. Guo, R.M.C. Abrams, J.E. Babiarz, and et al. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes Toxicol Sci 123 2011 281 289
    • (2011) Toxicol Sci , vol.123 , pp. 281-289
    • Guo, L.1    Abrams, R.M.C.2    Babiarz, J.E.3
  • 172
    • 84898608302 scopus 로고    scopus 로고
    • IPS cells: A game changer for future medicine
    • H. Inoue, N. Nagata, H. Kurokawa, and S. Yamanaka iPS cells: a game changer for future medicine EMBO J 33 2014 409 417
    • (2014) EMBO J , vol.33 , pp. 409-417
    • Inoue, H.1    Nagata, N.2    Kurokawa, H.3    Yamanaka, S.4
  • 173
    • 84928727557 scopus 로고    scopus 로고
    • Induced pluripotent stem cells
    • K.D. Wilson, and J.C. Wu Induced pluripotent stem cells JAMA 313 2015 1613 1614
    • (2015) JAMA , vol.313 , pp. 1613-1614
    • Wilson, K.D.1    Wu, J.C.2
  • 174
    • 84892930341 scopus 로고    scopus 로고
    • Cardiac stem cell biology: Glimpse of the past, present, and future
    • E. Matsa, K. Sallam, and J.C. Wu Cardiac stem cell biology: glimpse of the past, present, and future Circ Res 114 2014 21 27
    • (2014) Circ Res , vol.114 , pp. 21-27
    • Matsa, E.1    Sallam, K.2    Wu, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.