메뉴 건너뛰기




Volumn 5, Issue , 2014, Pages

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ISOPROTEIN; DNA; HISTONE;

EID: 84924367822     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6288     Document Type: Article
Times cited : (245)

References (69)
  • 1
    • 64249107059 scopus 로고    scopus 로고
    • Evidence for cardiomyocyte renewal in humans
    • Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98-102 (2009).
    • (2009) Science , vol.324 , pp. 98-102
    • Bergmann, O.1
  • 2
    • 84872611623 scopus 로고    scopus 로고
    • Mammalian heart renewal by pre-existing cardiomyocytes
    • Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433-436 (2013).
    • (2013) Nature , vol.493 , pp. 433-436
    • Senyo, S.E.1
  • 3
    • 77649087980 scopus 로고    scopus 로고
    • Return to the fetal gene program: A suggested metabolic link to gene expression in the heart
    • Taegtmeyer, H., Sen, S. & Vela, D. Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann. NY Acad. Sci. 1188, 191-198 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1188 , pp. 191-198
    • Taegtmeyer, H.1    Sen, S.2    Vela, D.3
  • 4
    • 0038069065 scopus 로고    scopus 로고
    • Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart
    • Siedner, S. et al. Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J. Physiol. 548, 493-505 (2003).
    • (2003) J. Physiol. , vol.548 , pp. 493-505
    • Siedner, S.1
  • 5
    • 33746861905 scopus 로고    scopus 로고
    • + sensitivity due to titin and troponin-i isoform switching are not critically triggered by birth
    • + sensitivity due to titin and troponin-i isoform switching are not critically triggered by birth. Am. J. Physiol. Heart Circ. Physiol. 291, H496-H506 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. H496-H506
    • Krüger, M.1    Kohl, T.2    Linke, W.A.3
  • 6
    • 84860340270 scopus 로고    scopus 로고
    • A cardiac microrna governs systemic energy homeostasis by regulation of med13
    • Grueter, C. E. et al. A cardiac microrna governs systemic energy homeostasis by regulation of med13. Cell 149, 671-683 (2012).
    • (2012) Cell , vol.149 , pp. 671-683
    • Grueter, C.E.1
  • 7
    • 84881192460 scopus 로고    scopus 로고
    • Bet bromodomains mediate transcriptional pause release in heart failure
    • Anand, P. et al. Bet bromodomains mediate transcriptional pause release in heart failure. Cell 154, 569-582 (2013).
    • (2013) Cell , vol.154 , pp. 569-582
    • Anand, P.1
  • 8
    • 84867073340 scopus 로고    scopus 로고
    • Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage
    • Wamstad, J. A. et al. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151, 206-220 (2012).
    • (2012) Cell , vol.151 , pp. 206-220
    • Wamstad, J.A.1
  • 9
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • Zhang, C. L. et al. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110, 479-488 (2002).
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1
  • 10
    • 84885021247 scopus 로고    scopus 로고
    • Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues
    • Hon, G. C. et al. Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat. Genet. 45, 1198-1206 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1198-1206
    • Hon, G.C.1
  • 11
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 12
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones, P. A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 13, 484-492 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 13
    • 79956330964 scopus 로고    scopus 로고
    • Cpg islands and the regulation of transcription
    • Deaton, A. M. & Bird, A. Cpg islands and the regulation of transcription. Genes Dev. 25, 1010-1022 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 14
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: Roles in mammalian development
    • Smith, Z. D. & Meissner, A. DNA methylation: Roles in mammalian development. Nat. Rev. Genet. 14, 204-220 (2013).
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 15
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik, W., Dean, W. & Walter, J. Epigenetic reprogramming in mammalian development. Science 293, 1089-1093 (2001).
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 16
    • 83855163995 scopus 로고    scopus 로고
    • Uncovering the role of 5-hydroxymethylcytosine in the epigenome
    • Branco, M. R., Ficz, G. & Reik, W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat. Rev. Genet. 13, 7-13 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 7-13
    • Branco, M.R.1    Ficz, G.2    Reik, W.3
  • 17
    • 84874746425 scopus 로고    scopus 로고
    • Alterations in cardiac DNA methylation in human dilated cardiomyopathy
    • Haas, J. et al. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol. Med. 5, 413-429 (2013).
    • (2013) EMBO Mol. Med. , vol.5 , pp. 413-429
    • Haas, J.1
  • 18
    • 82355180985 scopus 로고    scopus 로고
    • Distinct epigenomic features in end-stage failing human hearts
    • Movassagh, M. et al. Distinct epigenomic features in end-stage failing human hearts. Circulation 124, 2411-2422 (2011).
    • (2011) Circulation , vol.124 , pp. 2411-2422
    • Movassagh, M.1
  • 19
    • 33645964973 scopus 로고    scopus 로고
    • Cardiac regeneration: Repopulating the heart
    • Rubart, M. & Field, L. J. Cardiac regeneration: repopulating the heart. Annu. Rev. Physiol. 68, 29-49 (2006).
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 29-49
    • Rubart, M.1    Field, L.J.2
  • 20
    • 78649462103 scopus 로고    scopus 로고
    • Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover
    • Bergmann, O. et al. Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover. Exp. Cell Res. 317, 188-194 (2011).
    • (2011) Exp. Cell Res. , vol.317 , pp. 188-194
    • Bergmann, O.1
  • 21
    • 84355163093 scopus 로고    scopus 로고
    • DNA-binding factors shape the mouse methylome at distal regulatory regions
    • Stadler, M. B. et al. DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature 480, 490-495 (2011).
    • (2011) Nature , vol.480 , pp. 490-495
    • Stadler, M.B.1
  • 22
    • 84882884517 scopus 로고    scopus 로고
    • Charting a dynamic DNA methylation landscape of the human genome
    • Ziller, M. J. et al. Charting a dynamic DNA methylation landscape of the human genome. Nature 500, 477-481 (2013).
    • (2013) Nature , vol.500 , pp. 477-481
    • Ziller, M.J.1
  • 23
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934-947 (2013).
    • (2013) Cell , vol.155 , pp. 934-947
    • Hnisz, D.1
  • 24
    • 78650758676 scopus 로고    scopus 로고
    • Histone h3k27ac separates active from poised enhancers and predicts developmental state
    • Creyghton, M. P. et al. Histone h3k27ac separates active from poised enhancers and predicts developmental state. Proc. Natl Acad. Sci. USA 107, 21931-21936 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1
  • 25
    • 84883059229 scopus 로고    scopus 로고
    • Expression of isl1 during mouse development
    • Zhuang, S. et al. Expression of isl1 during mouse development. Gene Expr. Patterns 13, 407-412 (2013).
    • (2013) Gene Expr. Patterns , vol.13 , pp. 407-412
    • Zhuang, S.1
  • 26
    • 84877696605 scopus 로고    scopus 로고
    • Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos
    • Jiang, L. et al. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell 153, 773-784 (2013).
    • (2013) Cell , vol.153 , pp. 773-784
    • Jiang, L.1
  • 27
    • 33748621746 scopus 로고    scopus 로고
    • Making or breaking the heart: From lineage determination to morphogenesis
    • Srivastava, D. Making or breaking the heart: from lineage determination to morphogenesis. Cell 126, 1037-1048 (2006).
    • (2006) Cell , vol.126 , pp. 1037-1048
    • Srivastava, D.1
  • 28
    • 84856707310 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 regulates normal development of the mouse heart
    • He, A. et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ. Res. 110, 406-415 (2012).
    • (2012) Circ. Res. , vol.110 , pp. 406-415
    • He, A.1
  • 29
    • 84862777974 scopus 로고    scopus 로고
    • Epigenetic repression of cardiac progenitor gene expression by ezh2 is required for postnatal cardiac homeostasis
    • Delgado-Olguin, P. et al. Epigenetic repression of cardiac progenitor gene expression by ezh2 is required for postnatal cardiac homeostasis. Nat. Genet. 44, 343-347 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 343-347
    • Delgado-Olguin, P.1
  • 30
    • 77952371023 scopus 로고    scopus 로고
    • Cardiomyocyte cell cycle control and growth estimation in vivo-an analysis based on cardiomyocyte nuclei
    • Walsh, S., Ponten, A., Fleischmann, B. K. & Jovinge, S. Cardiomyocyte cell cycle control and growth estimation in vivo-an analysis based on cardiomyocyte nuclei. Cardiovasc. Res. 86, 365-373 (2010).
    • (2010) Cardiovasc. Res. , vol.86 , pp. 365-373
    • Walsh, S.1    Ponten, A.2    Fleischmann, B.K.3    Jovinge, S.4
  • 31
    • 84867009100 scopus 로고    scopus 로고
    • Direct visualization of cell division using high-resolution imaging of m-phase of the cell cycle
    • Hesse, M. et al. Direct visualization of cell division using high-resolution imaging of m-phase of the cell cycle. Nat. Commun. 3, 1076 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 1076
    • Hesse, M.1
  • 32
    • 84892690160 scopus 로고    scopus 로고
    • Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions
    • Feldmann, A. et al. Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions. PLoS Genet. 9, e1003994 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. e1003994
    • Feldmann, A.1
  • 33
    • 84879663784 scopus 로고    scopus 로고
    • Global epigenomic reconfiguration during mammalian brain development
    • Lister, R. et al. Global epigenomic reconfiguration during mammalian brain development. Science 341, 1237905 (2013).
    • (2013) Science , vol.341 , pp. 1237905
    • Lister, R.1
  • 34
    • 84891372425 scopus 로고    scopus 로고
    • Large conserved domains of low DNA methylation maintained by dnmt3a
    • Jeong, M. et al. Large conserved domains of low DNA methylation maintained by dnmt3a. Nat. Genet. 46, 17-23 (2013).
    • (2013) Nat. Genet. , vol.46 , pp. 17-23
    • Jeong, M.1
  • 35
    • 84878282421 scopus 로고    scopus 로고
    • Epigenomic analysis of multilineage differentiation of human embryonic stem cells
    • Xie, W. et al. Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell 153, 1134-1148 (2013).
    • (2013) Cell , vol.153 , pp. 1134-1148
    • Xie, W.1
  • 36
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 37
    • 84857467013 scopus 로고    scopus 로고
    • Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
    • Kobayashi, H. et al. Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet. 8, e1002440 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002440
    • Kobayashi, H.1
  • 38
    • 64349091471 scopus 로고    scopus 로고
    • Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
    • Ball, M. P. et al. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat. Biotechnol. 27, 361-368 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 361-368
    • Ball, M.P.1
  • 39
    • 84906302982 scopus 로고    scopus 로고
    • Short sequences can efficiently recruit histone h3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
    • Jermann, P., Hoerner, L., Burger, L. & Schübeler, D. Short sequences can efficiently recruit histone h3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Proc. Natl Acad. Sci. USA 111, E3415-E3421 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E3415-E3421
    • Jermann, P.1    Hoerner, L.2    Burger, L.3    Schübeler, D.4
  • 40
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases dnmt3a and dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases dnmt3a and dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 41
    • 0035166852 scopus 로고    scopus 로고
    • Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of galphaq/galpha11 in cardiomyocytes
    • Wettschureck, N. et al. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of galphaq/galpha11 in cardiomyocytes. Nat. Med. 7, 1236-1240 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 1236-1240
    • Wettschureck, N.1
  • 42
    • 79953224745 scopus 로고    scopus 로고
    • Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function
    • Lother, A. et al. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension 57, 746-754 (2011).
    • (2011) Hypertension , vol.57 , pp. 746-754
    • Lother, A.1
  • 44
    • 85044697058 scopus 로고    scopus 로고
    • Isolation and culture of neonatal mouse cardiomyocytes
    • Ehler, E., Moore-Morris, T. & Lange, S. Isolation and culture of neonatal mouse cardiomyocytes. J. Vis. Exp. doi: 10.3791/50134 (2013).
    • (2013) J. Vis. Exp.
    • Ehler, E.1    Moore-Morris, T.2    Lange, S.3
  • 45
    • 33846225093 scopus 로고    scopus 로고
    • Isolation and culture of adult mouse cardiac myocytes
    • O'Connell, T. D., Rodrigo, M. C. & Simpson, P. C. Isolation and culture of adult mouse cardiac myocytes. Methods Mol. Biol. 357, 271-296 (2007).
    • (2007) Methods Mol. Biol. , vol.357 , pp. 271-296
    • O'Connell, T.D.1    Rodrigo, M.C.2    Simpson, P.C.3
  • 46
    • 84864462544 scopus 로고    scopus 로고
    • A map of the cis-regulatory sequences in the mouse genome
    • Shen, Y. et al. A map of the cis-regulatory sequences in the mouse genome. Nature 488, 116-120 (2012).
    • (2012) Nature , vol.488 , pp. 116-120
    • Shen, Y.1
  • 47
    • 75949108066 scopus 로고    scopus 로고
    • Galaxy: A web-based genome analysis tool for experimentalists
    • Chapter 19: Unit 19 10 11-Unit 19 10 21
    • Blankenberg, D. et al. Galaxy: a web-based genome analysis tool for experimentalists. Curr. Protoc. Mol. Biol. Chapter 19: Unit 19 10 11-Unit 19 10 21 (2010).
    • (2010) Curr. Protoc. Mol. Biol.
    • Blankenberg, D.1
  • 48
    • 25844449770 scopus 로고    scopus 로고
    • Galaxy: A platform for interactive large-scale genome analysis
    • Giardine, B. et al. Galaxy: a platform for interactive large-scale genome analysis. Genome Res. 15, 1451-1455 (2005).
    • (2005) Genome Res. , vol.15 , pp. 1451-1455
    • Giardine, B.1
  • 49
    • 77955801615 scopus 로고    scopus 로고
    • Galaxy: A comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences
    • Goecks, J., Nekrutenko, A., Taylor, J. & Galaxy, T. Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol. 11, R86 (2010).
    • (2010) Genome Biol. , vol.11 , pp. R86
    • Goecks, J.1    Nekrutenko, A.2    Taylor, J.3    Galaxy, T.4
  • 50
    • 79957868920 scopus 로고    scopus 로고
    • Bismark: A flexible aligner and methylation caller for bisulfite-seq applications
    • Krueger, F. & Andrews, S. R. Bismark: a flexible aligner and methylation caller for bisulfite-seq applications. Bioinformatics 27, 1571-1572 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1571-1572
    • Krueger, F.1    Andrews, S.R.2
  • 51
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memoryefficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).
    • (2009) Genome Biol. , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 52
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and samtools
    • Li, H. et al. The sequence alignment/map format and samtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 53
    • 77951770756 scopus 로고    scopus 로고
    • Bedtools: A flexible suite of utilities for comparing genomic features
    • Quinlan, A. R. & Hall, I. M. Bedtools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841-842 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 841-842
    • Quinlan, A.R.1    Hall, I.M.2
  • 54
    • 78651271733 scopus 로고    scopus 로고
    • Integrative genomics viewer
    • Robinson, J. T. et al. Integrative genomics viewer. Nat. Biotechnol. 29, 24-26 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 24-26
    • Robinson, J.T.1
  • 55
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
    • (2004) Genome Biol. , vol.5 , pp. R80
    • Gentleman, R.C.1
  • 56
    • 84900988020 scopus 로고    scopus 로고
    • Deeptools: A flexible platform for exploring deep-sequencing data
    • Ramirez, F., Dundar, F., Diehl, S., Gruning, B. A. & Manke, T. Deeptools: a flexible platform for exploring deep-sequencing data. Nucleic Acids Res. 42, W187-W191 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. W187-W191
    • Ramirez, F.1    Dundar, F.2    Diehl, S.3    Gruning, B.A.4    Manke, T.5
  • 57
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and b cell identities
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and b cell identities. Mol. Cell 38, 576-589 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 58
    • 34548561572 scopus 로고    scopus 로고
    • Pyrosequencing protocol using a universal biotinylated primer for mutation detection and snp genotyping
    • Royo, J. L., Hidalgo, M. & Ruiz, A. Pyrosequencing protocol using a universal biotinylated primer for mutation detection and snp genotyping. Nat. Protoc. 2, 1734-1739 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 1734-1739
    • Royo, J.L.1    Hidalgo, M.2    Ruiz, A.3
  • 59
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • Tost, J. & Gut, I. G. DNA methylation analysis by pyrosequencing. Nat. Protoc. 2, 2265-2275 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 60
    • 77952214662 scopus 로고    scopus 로고
    • Great improves functional interpretation of cis-regulatory regions
    • McLean, C. Y. et al. Great improves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28, 495-501 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 495-501
    • McLean, C.Y.1
  • 61
    • 64549104807 scopus 로고    scopus 로고
    • Cluego: A cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
    • Bindea, G. et al. Cluego: a cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25, 1091-1093 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1091-1093
    • Bindea, G.1
  • 63
    • 84891771466 scopus 로고    scopus 로고
    • The ucsc genome browser database: 2014 update
    • Karolchik, D. et al. The ucsc genome browser database: 2014 update. Nucleic Acids Res. 42, D764-D770 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D764-D770
    • Karolchik, D.1
  • 64
    • 84876996918 scopus 로고    scopus 로고
    • Tophat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
    • Kim, D. et al. Tophat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).
    • (2013) Genome Biol. , vol.14 , pp. R36
    • Kim, D.1
  • 65
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell, C. et al. Transcript assembly and quantification by rna-seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-515 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1
  • 66
    • 77952333999 scopus 로고    scopus 로고
    • Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload
    • Gilsbach, R. et al. Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovasc. Res. 86, 432-442 (2010).
    • (2010) Cardiovasc. Res. , vol.86 , pp. 432-442
    • Gilsbach, R.1
  • 67
    • 84872112391 scopus 로고    scopus 로고
    • Cell type-specific chromatin immunoprecipitation from multicellular complex samples using bits-chip
    • Bonn, S. et al. Cell type-specific chromatin immunoprecipitation from multicellular complex samples using bits-chip. Nat. Protoc. 7, 978-994 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 978-994
    • Bonn, S.1
  • 68
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with bowtie 2
    • Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with bowtie 2. Nat. Methods 9, 357-359 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 69
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of chip-seq (macs)
    • Zhang, Y. et al. Model-based analysis of chip-seq (macs). Genome Biol. 9, R137 (2008).
    • (2008) Genome Biol. , vol.9 , pp. R137
    • Zhang, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.