Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 21, 2015, Pages E2785-E2794

  Kuppusamy, Kavitha T ^a,b   Jones, Daniel C ^c   Sperber, Henrik ^a,b   Madan, Anup ^d   Fischer, Karin A ^a,b   Rodriguez, Marita L ^c   Pabon, Lil ^a   Zhu, Wei Zhong ^a   Tulloch, Nathaniel L ^a   Yang, Xiulan ^a   Sniadecki, Nathan J ^c,e   Laflamme, Michael A ^a   Ruzzo, Walter L ^a,c,f   Murry, Charles E ^a,e   Ruohola Baker, Hannele ^a,b,e  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c University of Washington   (United States)

^d LABORATORY CORPORATION OF AMERICA   (United States)

^e University of Washington   (United States)

^f Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Cardiac maturation; HESC cardiomyocyte; Let 7; Metabolism; MicroRNA

Indexed keywords

MICRORNA; MICRORNA LET 7; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; MIRNLET7 MICRORNA, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; FATTY ACID METABOLISM; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL DERIVED CARDIOMYOCYTE; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SARCOMERE LENGTH; SIGNAL TRANSDUCTION; UPREGULATION; ADULT; BIOLOGICAL MODEL; CELL LINE; CYTOLOGY; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; HEART CONTRACTION; METABOLISM; PHYSIOLOGY; TISSUE ENGINEERING;

METAZOA;

ADULT; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; ENERGY METABOLISM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICRORNAS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; UP-REGULATION;

EID: 84930224849     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424042112     Document Type: Article

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