Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13793-13798

  Margariti, Andriana ^a   Winkler, Bernhard ^a   Karamariti, Eirini ^a   Zampetaki, Anna ^a   Tsai, Tsung Neng ^a   Baban, Dilair ^b   Ragoussis, Jiannis ^b   Huang, Yi ^c   Han, Jing Dong J ^c   Zeng, Lingfang ^a   Hu, Yanhua ^a   Xu, Qingbo ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Shear stress; Stem cell therapy; Vascular tissue engineering

Indexed keywords

CD31 ANTIGEN; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; SET TRANSLOCATION SIMILAR PROTEIN; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CELL DIFFERENTIATION; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SOMATIC CELL; TISSUE ENGINEERING;

ANIMALS; ANTIGENS, CD; AORTA; CADHERINS; CELL DIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, SCID; MODELS, GENETIC; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR REPROGRAMMING; PROMOTER REGIONS, GENETIC; STEM CELLS; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 84865286051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205526109     Document Type: Article

References (30)

1. Takahashi K, Okita K, Nakagawa M, Yamanaka S (2007) Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2:3081-3089.
2. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
3. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science 322:949-953.
4. Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
5. Maherali N, et al. (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1:55-70.
6. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317.
7. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K (2008) Induced pluripotent stem cells generated without viral integration. Science 322:945-949.
8. Chang CW, et al. (2009) Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 27: 1042-1049.
9. Sommer CA, et al. (2010) Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells 28:64-74.
10. Zhou H, et al. (2009) Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4:381-384.
11. Warren L, et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7:618-630.
12. Desponts C, Ding S (2010) Using small molecules to improve generation of induced pluripotent stem cells from somatic cells. Methods Mol Biol 636:207-218.
13. Li W, Ding S (2010) Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci 31:36-45.
14. Park SW, et al. (2010) Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways. Blood 116:5762-5772.
15. Dambrot C, Passier R, Atsma D, Mummery CL (2011) Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models. Biochem J 434:25-35.
16. Kattman SJ, et al. (2011) Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8:228-240.
17. Li Z, Hu S, Ghosh Z, Han Z, Wu JC (2011) Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells. Stem Cells Dev 20:1701-1710.
18. Kaji K, et al. (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775.
19. Szabo E, et al. (2010) Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468:521-526.
20. Tursun B, Patel T, Kratsios P, Hobert O (2011) Direct conversion of C. elegans germ cells into specific neuron types. Science 331:304-308.
21. Son EY, et al. (2011) Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 9:205-218.
22. Ieda M, et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142:375-386.
23. Efe JA, et al. (2011) Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 13:215-222.
24. Jaenisch R, Young R (2008) Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132:567-582.
25. Zhou Q, Melton DA (2008) Extreme makeover: converting one cell into another. Cell Stem Cell 3:382-388.
26. Welstead GG, Schorderet P, Boyer LA (2008) The reprogramming language of pluripotency. Curr Opin Genet Dev 18:123-129.
27. Carmeliet P, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.
28. Carmeliet P, et al. (1999) Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98:147-157.
29. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (2003) Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112:659-672.
30. Zeng L, et al. (2009) Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci USA 106:8326-8331.