Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition

Biochemistry

Volumn 55, Issue 15, 2016, Pages 2197-2213

  Liang, Yu ^a   Guttman, Miklos ^a   Davenport, Thaddeus M ^a,b   Hu, Shiu Lok ^a   Lee, Kelly K ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BINDING SITES; BINS; CRYSTALLOGRAPHY; DYNAMICS; EPITOPES; MASS SPECTROMETRY; POLYPEPTIDES; STABILITY; STRUCTURAL DYNAMICS; X RAY CRYSTALLOGRAPHY;

ANTIBODY RECOGNITION; ANTIBODY-ANTIGEN INTERACTIONS; CONFORMATIONAL EPITOPES; CONFORMATIONAL FLEXIBILITY; CORECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; STRUCTURAL COMPLEMENTARITY; STRUCTURAL STABILITIES;

ANTIBODIES;

CD4 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 120; ANTIGEN ANTIBODY COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; PROTEIN BINDING;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGENICITY; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; CHEMICAL STRUCTURE; CHEMISTRY; HEK293 CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MOLECULAR DOCKING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIGEN-ANTIBODY COMPLEX; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, CD4; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HEK293 CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84966350741     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01354     Document Type: Article

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