A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Sanders, Rogier W ^a,b   Derking, Ronald ^b   Cupo, Albert ^a   Julien, Jean Philippe ^c   Yasmeen, Anila ^a   de Val, Natalia ^c   Kim, Helen J ^c   Blattner, Claudia ^c   de la Peña, Alba Torrents ^b   Korzun, Jacob ^a   Golabek, Michael ^a   de los Reyes, Kevin ^a   Ketas, Thomas J ^a   van Gils, Marit J ^b   King, C Richter ^d   Wilson, Ian A ^c   Ward, Andrew B ^c   Klasse, P J ^a   Moore, John P ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 140; MONOCLONAL ANTIBODY; MONOMER; NEUTRALIZING ANTIBODY; NITRILOTRIACETATE NICKEL; VIRUS SPIKE PROTEIN; GP140 ENVELOPE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MUTANT PROTEIN; PEPTIDE FRAGMENT; PROTEIN AGGREGATE; VIRUS ENVELOPE PROTEIN;

AFFINITY CHROMATOGRAPHY; ANTIGENICITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOTHERMAL TITRATION CALORIMETRY; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE; VIRUS NEUTRALIZATION; VIRUS SPIKE; VIRUS TYPING; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HIV INFECTIONS; IMMUNOLOGY; METABOLISM; MOLECULAR WEIGHT; PROTEIN STABILITY; SOLUBILITY;

AIDS VACCINES; AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MOLECULAR WEIGHT; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; SOLUBILITY;

EID: 84884678235     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003618     Document Type: Article

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