Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange

Journal of Virology

Volumn 84, Issue 19, 2010, Pages 10311-10321

  Kong, Leopold ^a,b   Huang, Chih Chin ^a   Coales, Stephen J ^c   Molnar, Kathleen S ^c   Skinner, Jeff ^a   Hamuro, Yoshitomo ^c   Kwong, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ExSAR Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DEUTERIUM; GLYCOPROTEIN GP 120; HYDROGEN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND; PEPTIDE FRAGMENT;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; ENTROPY; HUMAN IMMUNODEFICIENCY VIRUS 1; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE; VIRUS ENTRY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANTIGENS, CD4; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; HIV ENVELOPE PROTEIN GP120; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; IN VITRO TECHNIQUES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS;

EID: 77956819789     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00688-10     Document Type: Article

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