Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5663-5668

  Kwon, Young Do ^a   Finzi, Andrés ^b   Wu, Xueling ^a   Dogo Isonagie, Cajetan ^d   Lee, Lawrence K ^e   Moore, Lucas R ^f   Schmidt, Stephen D ^a   Stuckey, Jonathan ^a   Yang, Yongping ^a   Zhou, Tongqing ^a   Zhu, Jiang ^a   Vicic, David A ^f,g   Debnath, Asim K ^h   Shapiro, Lawrence ^a,i   Bewley, Carole A ^d   Mascola, John R ^a   Sodroski, Joseph G ^b,c   Kwong, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^f UNIVERSITY OF ARKANSAS   (United States)

^g UNIVERSITY OF HAWAII   (United States)

^h NEW YORK BLOOD CENTER   (United States)

ⁱ Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Conformational equilibrium; Viral evasion; X ray crystallography

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120;

ARTICLE; CELL STRAIN HEK293; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; VIRUS CORE;

ANTIGENS, CD4; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84859561617     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112391109     Document Type: Article

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