A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Science

Volumn 349, Issue 6254, 2015, Pages 1301-1306

  Impagliazzo, Antonietta ^c   Milder, Fin ^c   Kuipers, Harmjan ^c   Wagner, Michelle V ^d   Zhu, Xueyong ^b   Hoffman, Ryan M B ^b   Van Meersbergen, Ruud ^c   Huizingh, Jeroen ^c   Wanningen, Patrick ^c   Verspuij, Johan ^c   De Man, Martijn ^c   Ding, Zhaoqing ^d   Apetri, Adrian ^c   Kükrer, Basak ^c   Sneekes Vriese, Eveline ^a   Tomkiewicz, Danuta ^c   Laursen, Nick S ^e   Lee, Peter S ^b   Zakrzewska, Anna ^c   Dekking, Liesbeth ^c   Tolboom, Jeroen ^c   Tettero, Lisanne ^c   Van Meerten, Sander ^c   Yu, Wenli ^b   Koudstaal, Wouter ^c   Goudsmit, Jaap ^c   Ward, Andrew B ^b   Meijberg, Wim ^c   Wilson, Ian A ^c   Radoševic, Katarina ^f   more..

^a CRUCELL HOLLAND BV   (Netherlands)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Janssen Research and Development   (Netherlands)

^d JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^e AARHUS UNIVERSITY   (Denmark)

^f SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIGEN; EPITOPE; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; NEUTRALIZING ANTIBODY; H1N1 VIRUS HEMAGGLUTININ; VIRUS ANTIBODY;

ANTIBODY; ANTIGEN; INFLUENZA; PRIMATE; RODENT; VACCINE; VIRUS;

ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONFORMATION; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CRYSTAL STRUCTURE; DEGLYCOSYLATION; DEUTERIUM HYDROGEN EXCHANGE; DISSOCIATION CONSTANT; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H5N1); INFLUENZA VIRUS; MACACA FASCICULARIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SEASONAL INFLUENZA; SIZE EXCLUSION CHROMATOGRAPHY; VIRUS NEUTRALIZATION; WEIGHT REDUCTION; ANIMAL; CHEMISTRY; IMMUNOLOGY; INFLUENZA, HUMAN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

MACACA FASCICULARIS; MUS; PRIMATES;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84941873935     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7263     Document Type: Article

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