Semi-Automated Data Processing of Hydrogen Exchange Mass Spectra Using HX-Express

Journal of the American Society for Mass Spectrometry

Volumn 17, Issue 12, 2006, Pages 1700-1703

  Weis, David D ^a   Engen, John R ^a   Kass, Ignatius J ^b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER AIDED ANALYSIS; DATA REDUCTION; DEUTERIUM; HYDROGEN; ION EXCHANGE; QUALITY CONTROL;

HX-EXPRESS; HYDROGEN EXCHANGE MASS SPECTROMETRY; MASS SPECTRAL DATA; NUMERIC DISPLAYS;

MASS SPECTROMETRY;

DEUTERIUM; HYDROGEN;

ANALYTIC METHOD; ARTICLE; AUTOMATION; DATA ANALYSIS; DEUTERIUM HYDROGEN EXCHANGE; HYDROGEN EXCHANGE MASS SPECTROMETRY; INFORMATION PROCESSING; MASS SPECTROMETRY; MATHEMATICAL ANALYSIS; QUALITY CONTROL;

ALGORITHMS; COMPUTER SIMULATION; DEUTERIUM EXCHANGE MEASUREMENT; HYDROGEN; MODELS, CHEMICAL; MODELS, MOLECULAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOFTWARE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; USER-COMPUTER INTERFACE;

EID: 33751337111     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2006.07.025     Document Type: Article

References (5)

1. Wales T.E., and Engen J.R. Hydrogen Exchange Mass Spectrometry for the Analysis of Protein Dynamics. Mass Spectrom. Rev. 25 (2006) 158-170
2. Weis, D. D., Hotchko, M., Wales, T. E., Ten Eyck, L. F., Engen, J. R. Identification and Characterization of EX1 Kinetics in H/D Exchange Mass Spectrometry by Peak Width Analysis. J. Am. Soc. Mass Spectrom.2006, in press.
3. Garcia R.A., Pantazatos D., and Villarreal F.J. Hydrogen/Deuterium Exchange Mass Spectrometry for Investigating Protein-Ligand Interactions. Assay Drug Dev. Technol. 2 (2004) 81-91
4. Hotchko M., Anand G.S., Komives E.A., and Ten Eyck L.F. Automated Extraction of Backbone Deuteration Levels from Amide H/(2)H Mass Spectrometry Experiments. Protein Sci. 15 (2006) 583-601
5. Chik J.K., Vande Graaf J.L., and Schriemer D.C. Quantitating the Statistical Distribution of Deuterium Incorporation to Extend the Utility of H/D Exchange MS Data. Anal. Chem. 78 (2006) 207-214