Elicitation of structure-specific antibodies by epitope scaffolds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 42, 2010, Pages 17880-17887

  Ofek, Gilad ^a   Guenaga, F Javier ^a,c   Schief, William R ^b   Skinner, Jeff ^a   Baker, David ^b   Wyatt, Richard ^a,c   Kwong, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Computational design; Epitope transplantation; Structural mimicry

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 41; MOLECULAR SCAFFOLD; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY 2F5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY STRUCTURE; ANTIGEN SPECIFICITY; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MATHEMATICAL ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP41; IMMUNE SERA; MICE; MOLECULAR SEQUENCE DATA;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78149242586     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004728107     Document Type: Article

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