Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

Cell

Volumn 163, Issue 7, 2015, Pages 1702-1715

  De Taeye, Steven W ^a   Ozorowski, Gabriel ^b   Torrents De La Peña, Alba ^a   Guttman, Miklos ^c   Julien, Jean Philippe ^b,i,j   Van Den Kerkhof, Tom L G M ^a   Burger, Judith A ^a   Pritchard, Laura K ^d   Pugach, Pavel ^e   Yasmeen, Anila ^e   Crampton, Jordan ^f   Hu, Joyce ^f   Bontjer, Ilja ^a   Torres, Jonathan L ^b   Arendt, Heather ^g   Destefano, Joanne ^g   Koff, Wayne C ^g   Schuitemaker, Hanneke ^a,k   Eggink, Dirk ^a   Berkhout, Ben ^a   Dean, Hansi ^g   Labranche, Celia ^h   Crotty, Shane ^f   Crispin, Max ^d   Montefiori, David C ^h   Klasse, P J ^e   Lee, Kelly K ^c   Moore, John P ^e   Wilson, Ian A ^b   Ward, Andrew B ^b   Sanders, Rogier W ^a,e   more..

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^g INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^h DUKE UNIVERSITY MEDICAL CENTER   (United States)

ⁱ HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

^k Janssen Research and Development   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMC008 SOSIP.664 TRIMER; B41 SOSIP.664 TRIMER; BG505 SOSIP.664 TRIMER; CD4 ANTIGEN; CD4 IMMUNOGLOBULIN G2; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; ZM197M SOSIP.664 TRIMER; GLYCOPROTEIN GP 41; IMMUNOGLOBULIN G;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DISSOCIATION CONSTANT; DISULFIDE BOND; ENTHALPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; HYDROPHOBICITY; IMMUNOGENICITY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN QUATERNARY STRUCTURE; RABBIT MODEL; THERMOSTABILITY; VACCINATION; VIRUS NEUTRALIZATION; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; GENETICS; IMMUNOLOGY; MOLECULAR MODEL; MUTAGENESIS; RABBITS AND HARES;

AIDS VACCINES; ANIMALS; ANTIBODIES, NEUTRALIZING; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; HIV ENVELOPE PROTEIN GP41; HIV-1; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; RABBITS;

EID: 84950267324     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.11.056     Document Type: Article

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