HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

Nature

Volumn 420, Issue 6916, 2002, Pages 678-682

  Kwong, Peter D ^a,c   Doyle, Michael L ^d,m   Casper, David J ^d   Cicala, Claudia ^b   Leavitt, Stephanie A ^e   Majeed, Shahzad ^a,c   Steenbeke, Tavis D ^b   Venturi, Miro ^a   Chaiken, Irwin ^f   Fung, Michael ^g   Katinger, Hermann ^h   Parren, Paul W I H ⁱ   Robinson, James ^j   Van Ryk, Donald ^f   Wang, Liping ^k   Burton, Dennis R ⁱ   Freire, Ernesto ^e   Wyatt, Richard ^a,k   Sodroski, Joseph ^k,l   Hendrickson, Wayne A ^c   Arthos, James ^b   more..

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d GLAXOSMITHKLINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g Cell Biology   (United States)

^h UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

ⁱ SCRIPPS RESEARCH INSTITUTE   (United States)

^j TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k DANA FARBER CANCER INSTITUTE   (United States)

^l HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^m BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ENTROPY; IMMUNOLOGY;

NEUTRALIZATION;

VIRUSES;

GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY; VIRUS RECEPTOR; CD4 ANTIGEN; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; HUMAN IMMUNODEFICIENCY VIRUS;

ANTIGEN BINDING; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; THERMODYNAMICS; VIRUS ISOLATION; VIRUS NEUTRALIZATION; ANTIBODY AFFINITY; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; ENTROPY; GLYCOSYLATION; HUMAN; IMMUNOLOGY; METABOLISM; SERODIAGNOSIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ANTIBODY AFFINITY; ANTIGENS, CD4; BINDING SITES; CALORIMETRY; ENTROPY; EPITOPES; GLYCOSYLATION; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PROTEIN CONFORMATION; RECEPTORS, HIV;

EID: 0037069682     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01188     Document Type: Article

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