메뉴 건너뛰기




Volumn 507, Issue 7491, 2014, Pages 201-206

Proof of principle for epitope-focused vaccine design

(27)  Correia, Bruno E a,b,c   Bates, John T d   Loomis, Rebecca J e   Baneyx, Gretchen a   Carrico, Chris f   Jardine, Joseph G a,c   Rupert, Peter f   Correnti, Colin f   Kalyuzhniy, Oleksandr a,c   Vittal, Vinayak a   Connell, Mary J e   Stevens, Eric a   Schroeter, Alexandria a   Chen, Man g   MacPherson, Skye a,c   Serra, Andreia M a,c   Adachi, Yumiko a,c   Holmes, Margaret A f   Li, Yuxing c   Klevit, Rachel E a   more..


Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RESPIRATORY SYNCYTIAL VIRUS VACCINE;

EID: 84896315237     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12966     Document Type: Article
Times cited : (424)

References (39)
  • 3
    • 84871036375 scopus 로고    scopus 로고
    • Global and regionalmortality from235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano, R. et al. Global and regionalmortality from235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1
  • 4
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Murray, C. J. et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223 (2012).
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.1
  • 5
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209-2220 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1
  • 6
    • 84871037616 scopus 로고    scopus 로고
    • A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants
    • The RTS,S Clinical Trials Partnership.
    • The RTS,S Clinical Trials Partnership. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N. Engl. J. Med. 367, 2284-2295 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 2284-2295
  • 7
    • 84875382846 scopus 로고    scopus 로고
    • Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: A randomised, placebo-controlled phase 2b trial
    • Tameris, M. D. et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 381, 1021-1028 (2013).
    • (2013) Lancet , vol.381 , pp. 1021-1028
    • Tameris, M.D.1
  • 8
    • 84155162558 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis
    • Osterholm, M. T., Kelley, N. S., Sommer, A. & Belongia, E. A. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect. Dis. 12, 36-44 (2012).
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 36-44
    • Osterholm, M.T.1    Kelley, N.S.2    Sommer, A.3    Belongia, E.A.4
  • 9
    • 84876804736 scopus 로고    scopus 로고
    • The global distribution and burden of dengue
    • Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504-507 (2013).
    • (2013) Nature , vol.496 , pp. 504-507
    • Bhatt, S.1
  • 10
    • 84876735541 scopus 로고    scopus 로고
    • Strategic priorities for respiratory syncytial virus (RSV) vaccine development
    • Anderson, L. J. et al. Strategic priorities for respiratory syncytial virus (RSV) vaccine development. Vaccine 31 (Suppl. 2), B209-B215 (2013).
    • (2013) Vaccine , vol.31 , Issue.SUPPL. 2
    • Anderson, L.J.1
  • 11
    • 85172633842 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Vaccines, Blood & Biologics
    • U.S. Food and Drug Administration. Vaccines, Blood & Biologics http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/
  • 12
    • 0036719574 scopus 로고    scopus 로고
    • Antibodies, viruses and vaccines
    • Burton, D. R. Antibodies, viruses and vaccines. Nature Rev. Immunol. 2, 706-713 (2002).
    • (2002) Nature Rev. Immunol , vol.2 , pp. 706-713
    • Burton, D.R.1
  • 13
    • 84863774072 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
    • Burton, D. R., Poignard, P., Stanfield, R. L. & Wilson, I. A. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 337, 183-186 (2012).
    • (2012) Science , vol.337 , pp. 183-186
    • Burton, D.R.1    Poignard, P.2    Stanfield, R.L.3    Wilson, I.A.4
  • 14
    • 34047143155 scopus 로고    scopus 로고
    • Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract
    • Wu, H. et al. Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract. J. Mol. Biol. 368, 652-665 (2007).
    • (2007) J. Mol. Biol. , vol.368 , pp. 652-665
    • Wu, H.1
  • 15
    • 76349122922 scopus 로고    scopus 로고
    • Structural basis of respiratory syncytial virus neutralization by motavizumab
    • McLellan, J. S. et al. Structural basis of respiratory syncytial virus neutralization by motavizumab. Nature Struct. Mol. Biol. 17, 248-250 (2010).
    • (2010) Nature Struct. Mol. Biol. , vol.17 , pp. 248-250
    • McLellan, J.S.1
  • 16
    • 77956317558 scopus 로고    scopus 로고
    • Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
    • Correia, B. E. et al. Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure 18, 1116-1126 (2010).
    • (2010) Structure , vol.18 , pp. 1116-1126
    • Correia, B.E.1
  • 17
    • 78149242586 scopus 로고    scopus 로고
    • Elicitation of structure-specific antibodies by epitope scaffolds
    • Ofek, G. et al. Elicitation of structure-specific antibodies by epitope scaffolds. Proc. Natl Acad. Sci. USA 107, 17880-17887 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 17880-17887
    • Ofek, G.1
  • 18
    • 79958059341 scopus 로고    scopus 로고
    • Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope fromrespiratory syncytial virus
    • McLellan, J. S. et al. Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope fromrespiratory syncytial virus. J. Mol. Biol. 409, 853-866 (2011).
    • (2011) J. Mol. Biol. , vol.409 , pp. 853-866
    • McLellan, J.S.1
  • 19
    • 80054836686 scopus 로고    scopus 로고
    • Computation-guided backbone grafting of a discontinuousmotif onto a protein scaffold
    • Azoitei, M. L. et al. Computation-guided backbone grafting of a discontinuousmotif onto a protein scaffold. Science 334, 373-376 (2011).
    • (2011) Science , vol.334 , pp. 373-376
    • Azoitei, M.L.1
  • 20
    • 84855258847 scopus 로고    scopus 로고
    • Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope
    • Azoitei, M. L. et al. Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope. J. Mol. Biol. 415, 175-192 (2012).
    • (2012) J. Mol. Biol. , vol.415 , pp. 175-192
    • Azoitei, M.L.1
  • 21
    • 0345306764 scopus 로고    scopus 로고
    • Design of a novel globular protein fold with atomic-level accuracy
    • Kuhlman, B. et al. Design of a novel globular protein fold with atomic-level accuracy. Science 302, 1364-1368 (2003).
    • (2003) Science , vol.302 , pp. 1364-1368
    • Kuhlman, B.1
  • 22
    • 84868611622 scopus 로고    scopus 로고
    • Principles for designing ideal protein structures
    • Koga, N. et al. Principles for designing ideal protein structures. Nature 491, 222-227 (2012).
    • (2012) Nature , vol.491 , pp. 222-227
    • Koga, N.1
  • 23
    • 78650414310 scopus 로고    scopus 로고
    • Computational protein design using flexible backbone remodeling and resurfacing: Case studies in structure-based antigen design
    • Correia, B. E. et al. Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design. J. Mol. Biol. 405, 284-297 (2011).
    • (2011) J. Mol. Biol. , vol.405 , pp. 284-297
    • Correia, B.E.1
  • 24
    • 79751502456 scopus 로고    scopus 로고
    • Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab
    • Zhu, Q. et al. Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab. J. Infect. Dis. 203, 674-682 (2011).
    • (2011) J. Infect. Dis. , vol.203 , pp. 674-682
    • Zhu, Q.1
  • 25
    • 0023546339 scopus 로고
    • Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein
    • Clarke, B. E. et al. Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein. Nature 330, 381-384 (1987).
    • (1987) Nature , vol.330 , pp. 381-384
    • Clarke, B.E.1
  • 26
    • 0037135661 scopus 로고    scopus 로고
    • A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses
    • Jegerlehner, A. et al. A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine 20, 3104-3112 (2002).
    • (2002) Vaccine , vol.20 , pp. 3104-3112
    • Jegerlehner, A.1
  • 27
    • 84876288773 scopus 로고    scopus 로고
    • Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea
    • Jafri, H. S.,Wu, X., Makari, D.&Henrickson, K. J. Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea. Pediatr. Infect. Dis. J. 32, 335-340 (2013).
    • (2013) Pediatr. Infect. Dis. J. , vol.32 , pp. 335-340
    • Jafri, H.S.1    Wu, X.2    Makari, D.3    Henrickson, K.J.4
  • 28
    • 84863915210 scopus 로고    scopus 로고
    • High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site
    • Sundling, C. et al. High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site. Sci. Transl. Med. 4, 142ra196 (2012).
    • (2012) Sci. Transl. Med. , vol.4
    • Sundling, C.1
  • 29
    • 84861315738 scopus 로고    scopus 로고
    • Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site
    • Wen, X. et al. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nature Struct. Mol. Biol. 19, 461-463 (2012).
    • (2012) Nature Struct. Mol. Biol. , vol.19 , pp. 461-463
    • Wen, X.1
  • 30
    • 78650905964 scopus 로고    scopus 로고
    • ROSETTA3: Anobject-orientedsoftware suite for the simulation and design of macromolecules
    • Leaver-Fay, A. et al.ROSETTA3: anobject-orientedsoftware suite for the simulation and design of macromolecules. Methods Enzymol. 487, 545-574 (2011).
    • (2011) Methods Enzymol , vol.487 , pp. 545-574
    • Leaver-Fay, A.1
  • 32
    • 77957296071 scopus 로고    scopus 로고
    • RosettaHoles2: A volumetric packing measure for protein structure refinement and validation
    • Sheffler, W. & Baker, D. RosettaHoles2: a volumetric packing measure for protein structure refinement and validation. Protein Sci. 19, 1991-1995 (2010).
    • (2010) Protein Sci. , vol.19 , pp. 1991-1995
    • Sheffler, W.1    Baker, D.2
  • 33
    • 0033994775 scopus 로고    scopus 로고
    • HELANAL: A program to characterize helix geometry in proteins
    • Bansal, M., Kumar, S. & Velavan, R. HELANAL: a program to characterize helix geometry in proteins. J. Biomol. Struct. Dyn. 17, 811-819 (2000).
    • (2000) J. Biomol. Struct. Dyn. , vol.17 , pp. 811-819
    • Bansal, M.1    Kumar, S.2    Velavan, R.3
  • 34
    • 34548819311 scopus 로고    scopus 로고
    • Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions
    • Greenfield, N. J. Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions. Nature Protocols 1, 2527-2535 (2007).
    • (2007) Nature Protocols , vol.1 , pp. 2527-2535
    • Greenfield, N.J.1
  • 35
    • 34548817291 scopus 로고    scopus 로고
    • Determination of the folding of proteins as a function of denaturants, osmolytes or ligands using circular dichroism
    • Greenfield, N. J. Determination of the folding of proteins as a function of denaturants, osmolytes or ligands using circular dichroism. Nature Protocols 1, 2733-2741 (2007).
    • (2007) Nature Protocols , vol.1 , pp. 2733-2741
    • Greenfield, N.J.1
  • 36
    • 0029400480 scopus 로고
    • NMRPipe: A multidimensional spectral processing systembased on UNIX pipes
    • Delaglio, F. et al. NMRPipe: a multidimensional spectral processing systembased on UNIX pipes. J. Biomol. NMR 6, 277-293 (1995).
    • (1995) J. Biomol. NMR , vol.6 , pp. 277-293
    • Delaglio, F.1
  • 37
    • 34249765651 scopus 로고
    • A.NMR view: A computer programfor the visualization and analysis of NMR data
    • Johnson, B. A.& Blevins, R. A.NMR View: a computer programfor the visualization and analysis of NMR data. J. Biomol. NMR 4, 603-614 (1994).
    • (1994) J. Biomol. NMR , vol.4 , pp. 603-614
    • Johnson, B.A.1    Blevins, R.2
  • 38
    • 0025052448 scopus 로고
    • Enhanced pulmonary histopathology is observed in cotton rats immunized with formalininactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization
    • Murphy, B. R., Sotnikov, A. V., Lawrence, L. A., Banks, S. M. & Prince, G. A. Enhanced pulmonary histopathology is observed in cotton rats immunized with formalininactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization. Vaccine 8, 497-502 (1990).
    • (1990) Vaccine , vol.8 , pp. 497-502
    • Murphy, B.R.1    Sotnikov, A.V.2    Lawrence, L.A.3    Banks, S.M.4    Prince, G.A.5
  • 39
    • 77958456819 scopus 로고    scopus 로고
    • A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate
    • Chen, M. et al. A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate. J. Immunol. Methods 362, 180-184 (2010).
    • (2010) J. Immunol. Methods , vol.362 , pp. 180-184
    • Chen, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.