-
2
-
-
82255175484
-
Vaccines for the twenty-first century society
-
Rappuoli, R., Mandl, C. W., Black, S. & De Gregorio, E. Vaccines for the twenty-first century society. Nature Rev. Immunol. 11, 865-872 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.11
, pp. 865-872
-
-
Rappuoli, R.1
Mandl, C.W.2
Black, S.3
De Gregorio, E.4
-
3
-
-
84871036375
-
Global and regionalmortality from235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
-
Lozano, R. et al. Global and regionalmortality from235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
-
(2012)
Lancet
, vol.380
, pp. 2095-2128
-
-
Lozano, R.1
-
4
-
-
84871099014
-
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
-
Murray, C. J. et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223 (2012).
-
(2012)
Lancet
, vol.380
, pp. 2197-2223
-
-
Murray, C.J.1
-
5
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209-2220 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
-
6
-
-
84871037616
-
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants
-
The RTS,S Clinical Trials Partnership.
-
The RTS,S Clinical Trials Partnership. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N. Engl. J. Med. 367, 2284-2295 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 2284-2295
-
-
-
7
-
-
84875382846
-
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: A randomised, placebo-controlled phase 2b trial
-
Tameris, M. D. et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 381, 1021-1028 (2013).
-
(2013)
Lancet
, vol.381
, pp. 1021-1028
-
-
Tameris, M.D.1
-
8
-
-
84155162558
-
Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis
-
Osterholm, M. T., Kelley, N. S., Sommer, A. & Belongia, E. A. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect. Dis. 12, 36-44 (2012).
-
(2012)
Lancet Infect. Dis.
, vol.12
, pp. 36-44
-
-
Osterholm, M.T.1
Kelley, N.S.2
Sommer, A.3
Belongia, E.A.4
-
9
-
-
84876804736
-
The global distribution and burden of dengue
-
Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504-507 (2013).
-
(2013)
Nature
, vol.496
, pp. 504-507
-
-
Bhatt, S.1
-
10
-
-
84876735541
-
Strategic priorities for respiratory syncytial virus (RSV) vaccine development
-
Anderson, L. J. et al. Strategic priorities for respiratory syncytial virus (RSV) vaccine development. Vaccine 31 (Suppl. 2), B209-B215 (2013).
-
(2013)
Vaccine
, vol.31
, Issue.SUPPL. 2
-
-
Anderson, L.J.1
-
11
-
-
85172633842
-
-
U.S. Food and Drug Administration. Vaccines, Blood & Biologics
-
U.S. Food and Drug Administration. Vaccines, Blood & Biologics http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/
-
-
-
-
12
-
-
0036719574
-
Antibodies, viruses and vaccines
-
Burton, D. R. Antibodies, viruses and vaccines. Nature Rev. Immunol. 2, 706-713 (2002).
-
(2002)
Nature Rev. Immunol
, vol.2
, pp. 706-713
-
-
Burton, D.R.1
-
13
-
-
84863774072
-
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
-
Burton, D. R., Poignard, P., Stanfield, R. L. & Wilson, I. A. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 337, 183-186 (2012).
-
(2012)
Science
, vol.337
, pp. 183-186
-
-
Burton, D.R.1
Poignard, P.2
Stanfield, R.L.3
Wilson, I.A.4
-
14
-
-
34047143155
-
Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract
-
Wu, H. et al. Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract. J. Mol. Biol. 368, 652-665 (2007).
-
(2007)
J. Mol. Biol.
, vol.368
, pp. 652-665
-
-
Wu, H.1
-
15
-
-
76349122922
-
Structural basis of respiratory syncytial virus neutralization by motavizumab
-
McLellan, J. S. et al. Structural basis of respiratory syncytial virus neutralization by motavizumab. Nature Struct. Mol. Biol. 17, 248-250 (2010).
-
(2010)
Nature Struct. Mol. Biol.
, vol.17
, pp. 248-250
-
-
McLellan, J.S.1
-
16
-
-
77956317558
-
Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
-
Correia, B. E. et al. Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure 18, 1116-1126 (2010).
-
(2010)
Structure
, vol.18
, pp. 1116-1126
-
-
Correia, B.E.1
-
17
-
-
78149242586
-
Elicitation of structure-specific antibodies by epitope scaffolds
-
Ofek, G. et al. Elicitation of structure-specific antibodies by epitope scaffolds. Proc. Natl Acad. Sci. USA 107, 17880-17887 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 17880-17887
-
-
Ofek, G.1
-
18
-
-
79958059341
-
Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope fromrespiratory syncytial virus
-
McLellan, J. S. et al. Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope fromrespiratory syncytial virus. J. Mol. Biol. 409, 853-866 (2011).
-
(2011)
J. Mol. Biol.
, vol.409
, pp. 853-866
-
-
McLellan, J.S.1
-
19
-
-
80054836686
-
Computation-guided backbone grafting of a discontinuousmotif onto a protein scaffold
-
Azoitei, M. L. et al. Computation-guided backbone grafting of a discontinuousmotif onto a protein scaffold. Science 334, 373-376 (2011).
-
(2011)
Science
, vol.334
, pp. 373-376
-
-
Azoitei, M.L.1
-
20
-
-
84855258847
-
Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope
-
Azoitei, M. L. et al. Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope. J. Mol. Biol. 415, 175-192 (2012).
-
(2012)
J. Mol. Biol.
, vol.415
, pp. 175-192
-
-
Azoitei, M.L.1
-
21
-
-
0345306764
-
Design of a novel globular protein fold with atomic-level accuracy
-
Kuhlman, B. et al. Design of a novel globular protein fold with atomic-level accuracy. Science 302, 1364-1368 (2003).
-
(2003)
Science
, vol.302
, pp. 1364-1368
-
-
Kuhlman, B.1
-
22
-
-
84868611622
-
Principles for designing ideal protein structures
-
Koga, N. et al. Principles for designing ideal protein structures. Nature 491, 222-227 (2012).
-
(2012)
Nature
, vol.491
, pp. 222-227
-
-
Koga, N.1
-
23
-
-
78650414310
-
Computational protein design using flexible backbone remodeling and resurfacing: Case studies in structure-based antigen design
-
Correia, B. E. et al. Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design. J. Mol. Biol. 405, 284-297 (2011).
-
(2011)
J. Mol. Biol.
, vol.405
, pp. 284-297
-
-
Correia, B.E.1
-
24
-
-
79751502456
-
Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab
-
Zhu, Q. et al. Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab. J. Infect. Dis. 203, 674-682 (2011).
-
(2011)
J. Infect. Dis.
, vol.203
, pp. 674-682
-
-
Zhu, Q.1
-
25
-
-
0023546339
-
Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein
-
Clarke, B. E. et al. Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein. Nature 330, 381-384 (1987).
-
(1987)
Nature
, vol.330
, pp. 381-384
-
-
Clarke, B.E.1
-
26
-
-
0037135661
-
A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses
-
Jegerlehner, A. et al. A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine 20, 3104-3112 (2002).
-
(2002)
Vaccine
, vol.20
, pp. 3104-3112
-
-
Jegerlehner, A.1
-
27
-
-
84876288773
-
Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea
-
Jafri, H. S.,Wu, X., Makari, D.&Henrickson, K. J. Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea. Pediatr. Infect. Dis. J. 32, 335-340 (2013).
-
(2013)
Pediatr. Infect. Dis. J.
, vol.32
, pp. 335-340
-
-
Jafri, H.S.1
Wu, X.2
Makari, D.3
Henrickson, K.J.4
-
28
-
-
84863915210
-
High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site
-
Sundling, C. et al. High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site. Sci. Transl. Med. 4, 142ra196 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Sundling, C.1
-
29
-
-
84861315738
-
Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site
-
Wen, X. et al. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nature Struct. Mol. Biol. 19, 461-463 (2012).
-
(2012)
Nature Struct. Mol. Biol.
, vol.19
, pp. 461-463
-
-
Wen, X.1
-
30
-
-
78650905964
-
ROSETTA3: Anobject-orientedsoftware suite for the simulation and design of macromolecules
-
Leaver-Fay, A. et al.ROSETTA3: anobject-orientedsoftware suite for the simulation and design of macromolecules. Methods Enzymol. 487, 545-574 (2011).
-
(2011)
Methods Enzymol
, vol.487
, pp. 545-574
-
-
Leaver-Fay, A.1
-
31
-
-
1642464839
-
Protein structure predictionusing Rosetta
-
Rohl, C.A.,Strauss, C. E., Misura, K. M.&Baker, D. Protein structure predictionusing Rosetta. Methods Enzymol. 383, 66-93 (2004).
-
(2004)
Methods Enzymol.
, vol.383
, pp. 66-93
-
-
Rohl, C.A.1
Strauss, C.E.2
Misura, K.M.3
Baker, D.4
-
32
-
-
77957296071
-
RosettaHoles2: A volumetric packing measure for protein structure refinement and validation
-
Sheffler, W. & Baker, D. RosettaHoles2: a volumetric packing measure for protein structure refinement and validation. Protein Sci. 19, 1991-1995 (2010).
-
(2010)
Protein Sci.
, vol.19
, pp. 1991-1995
-
-
Sheffler, W.1
Baker, D.2
-
33
-
-
0033994775
-
HELANAL: A program to characterize helix geometry in proteins
-
Bansal, M., Kumar, S. & Velavan, R. HELANAL: a program to characterize helix geometry in proteins. J. Biomol. Struct. Dyn. 17, 811-819 (2000).
-
(2000)
J. Biomol. Struct. Dyn.
, vol.17
, pp. 811-819
-
-
Bansal, M.1
Kumar, S.2
Velavan, R.3
-
34
-
-
34548819311
-
Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions
-
Greenfield, N. J. Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions. Nature Protocols 1, 2527-2535 (2007).
-
(2007)
Nature Protocols
, vol.1
, pp. 2527-2535
-
-
Greenfield, N.J.1
-
35
-
-
34548817291
-
Determination of the folding of proteins as a function of denaturants, osmolytes or ligands using circular dichroism
-
Greenfield, N. J. Determination of the folding of proteins as a function of denaturants, osmolytes or ligands using circular dichroism. Nature Protocols 1, 2733-2741 (2007).
-
(2007)
Nature Protocols
, vol.1
, pp. 2733-2741
-
-
Greenfield, N.J.1
-
36
-
-
0029400480
-
NMRPipe: A multidimensional spectral processing systembased on UNIX pipes
-
Delaglio, F. et al. NMRPipe: a multidimensional spectral processing systembased on UNIX pipes. J. Biomol. NMR 6, 277-293 (1995).
-
(1995)
J. Biomol. NMR
, vol.6
, pp. 277-293
-
-
Delaglio, F.1
-
37
-
-
34249765651
-
A.NMR view: A computer programfor the visualization and analysis of NMR data
-
Johnson, B. A.& Blevins, R. A.NMR View: a computer programfor the visualization and analysis of NMR data. J. Biomol. NMR 4, 603-614 (1994).
-
(1994)
J. Biomol. NMR
, vol.4
, pp. 603-614
-
-
Johnson, B.A.1
Blevins, R.2
-
38
-
-
0025052448
-
Enhanced pulmonary histopathology is observed in cotton rats immunized with formalininactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization
-
Murphy, B. R., Sotnikov, A. V., Lawrence, L. A., Banks, S. M. & Prince, G. A. Enhanced pulmonary histopathology is observed in cotton rats immunized with formalininactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization. Vaccine 8, 497-502 (1990).
-
(1990)
Vaccine
, vol.8
, pp. 497-502
-
-
Murphy, B.R.1
Sotnikov, A.V.2
Lawrence, L.A.3
Banks, S.M.4
Prince, G.A.5
-
39
-
-
77958456819
-
A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate
-
Chen, M. et al. A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate. J. Immunol. Methods 362, 180-184 (2010).
-
(2010)
J. Immunol. Methods
, vol.362
, pp. 180-184
-
-
Chen, M.1
|