Conformational heterogeneity in antibody-protein antigen recognition: Implications for high affinity protein complex formation

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 7200-7210

  Addis, Philip W ^a   Hall, Catherine J ^a   Bruton, Shaun ^a   Veverka, Vaclav ^a,c   Wilkinson, Ian C ^a   Muskett, Frederick W ^a   Renshaw, Philip S ^a   Prosser, Christine E ^a,b   Carrington, Bruce ^b   Lawson, Alastair D G ^b   Griffin, Robert ^b   Taylor, Richard J ^b   Waters, Lorna C ^a   Henry, Alistair J ^b   Carr, Mark D ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UCB Celltech   (United Kingdom)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ANTIGENS;

ANTIGEN RECOGNITION; BIOLOGICAL PROCESS; CONFORMATIONAL EXCHANGE; CONFORMATIONAL HETEROGENEITY; HIGH AFFINITY; PROTEIN ANTIGENS; PROTEIN COMPLEXES; PROTEIN-PROTEIN INTERACTIONS;

ANTIBODIES;

ANTIBODY; ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY;

ALPHA HELIX; ANTIBODY PROTEIN ANTIGEN RECOGNITION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; IMMUNE SYSTEM; MOLECULAR DOCKING; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ANTIBODIES; CDR; CONFORMATIONAL HETEROGENEITY; NMR; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN-PROTEIN INTERACTIONS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY;

EID: 84896758400     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.492215     Document Type: Article

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