-
1
-
-
0036752519
-
Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms
-
Forloni G, Terreni L, Bertani I, et al. Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms. Neurobiol Aging 2002;23:957-976.
-
(2002)
Neurobiol Aging
, vol.23
, pp. 957-976
-
-
Forloni, G.1
Terreni, L.2
Bertani, I.3
-
2
-
-
84867608942
-
The genetics of Alzheimer disease
-
Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2012;2:a006296.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006296
-
-
Tanzi, R.E.1
-
3
-
-
84945444891
-
Functional significance of TDP-43 mutations in disease
-
Buratti E. Functional significance of TDP-43 mutations in disease. Adv Genet 2015;91:1-53.
-
(2015)
Adv Genet
, vol.91
, pp. 1-53
-
-
Buratti, E.1
-
4
-
-
9044239670
-
Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway
-
Lippa CF, Saunders AM, Smith TW, et al. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology 1996;46:406-412.
-
(1996)
Neurology
, vol.46
, pp. 406-412
-
-
Lippa, C.F.1
Saunders, A.M.2
Smith, T.W.3
-
5
-
-
35048888574
-
A prospective study of familial versus sporadic Parkinson's disease
-
Papapetropoulos S, Adi N, Ellul J, Argyriou AA, Chroni E. A prospective study of familial versus sporadic Parkinson's disease. Neurodegener Dis 2007;4:424-427.
-
(2007)
Neurodegener Dis
, vol.4
, pp. 424-427
-
-
Papapetropoulos, S.1
Adi, N.2
Ellul, J.3
Argyriou, A.A.4
Chroni, E.5
-
6
-
-
80053525105
-
Spatial patterns of β-amyloid (Aβ) deposits in familial and sporadic Alzheimer's disease
-
Armstrong RA. Spatial patterns of β-amyloid (Aβ) deposits in familial and sporadic Alzheimer's disease. Folia Neuropathol 2011;49:153-161.
-
(2011)
Folia Neuropathol
, vol.49
, pp. 153-161
-
-
Armstrong, R.A.1
-
7
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991;30:572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
-
8
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Näslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000 283:1571-1577.
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Näslund, J.1
Haroutunian, V.2
Mohs, R.3
-
9
-
-
0037264120
-
Unfolding the role of protein misfolding in neurodegenerative diseases
-
Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 2003;4:49-60.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 49-60
-
-
Soto, C.1
-
10
-
-
0025733411
-
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures
-
Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol 1991;207:367-368.
-
(1991)
Eur J Pharmacol
, vol.207
, pp. 367-368
-
-
Pike, C.J.1
Walencewicz, A.J.2
Glabe, C.G.3
Cotman, C.W.4
-
11
-
-
0030779130
-
Amidation of beta-amyloid peptide strongly reduced the amyloidogenic activity without alteration of the neurotoxicity
-
Forloni G, Lucca E, Angeretti N, Della Torre P, Salmona M. Amidation of beta-amyloid peptide strongly reduced the amyloidogenic activity without alteration of the neurotoxicity. J Neurochem 1997;69:2048-2054.
-
(1997)
J Neurochem
, vol.69
, pp. 2048-2054
-
-
Forloni, G.1
Lucca, E.2
Angeretti, N.3
Della Torre, P.4
Salmona, M.5
-
12
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 1998;95:6448-6453.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
-
13
-
-
0030614627
-
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
-
Harper JD, Wong SS, Lieber CM, Lansbury PT. Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chem Biol 1997;4:119-125.
-
(1997)
Chem Biol
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.4
-
14
-
-
0033520461
-
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
-
Walsh DM, Hartley DM, Kusumoto Y, et al. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem 1999;274:25945-25952.
-
(1999)
J Biol Chem
, vol.274
, pp. 25945-25952
-
-
Walsh, D.M.1
Hartley, D.M.2
Kusumoto, Y.3
-
15
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002;416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
16
-
-
0034069795
-
Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
-
Chen QS, Kagan BL, Hirakura Y, Xie CW. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 2000;60:65-72.
-
(2000)
J Neurosci Res
, vol.60
, pp. 65-72
-
-
Chen, Q.S.1
Kagan, B.L.2
Hirakura, Y.3
Xie, C.W.4
-
17
-
-
17944368176
-
The "Arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
-
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C. The "Arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 2001;4:887-893.
-
(2001)
Nat Neurosci
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
-
18
-
-
0042838303
-
Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 2003;100:10417-10422.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
Lacor, P.N.4
Lambert, M.P.5
Finch, C.E.6
-
19
-
-
41749096713
-
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia
-
Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H. A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol 2008;63:377-387.
-
(2008)
Ann Neurol
, vol.63
, pp. 377-387
-
-
Tomiyama, T.1
Nagata, T.2
Shimada, H.3
Teraoka, R.4
Fukushima, A.5
Kanemitsu, H.6
-
20
-
-
84856353669
-
High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain
-
Upadhaya AR, Lungrin I, Yamaguchi H, Fändrich M, Thal DR. High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain. J Cell Mol Med 2012;16:287-295.
-
(2012)
J Cell Mol Med
, vol.16
, pp. 287-295
-
-
Upadhaya, A.R.1
Lungrin, I.2
Yamaguchi, H.3
Fändrich, M.4
Thal, D.R.5
-
21
-
-
84861913912
-
AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly
-
Sokolow S, Henkins KM, Bilousova T, et al. AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging 2012;33:1545-1555.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 1545-1555
-
-
Sokolow, S.1
Henkins, K.M.2
Bilousova, T.3
-
22
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A 1999;96:3228-3233.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
-
23
-
-
0032756213
-
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
-
Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 1999;29:177-185.
-
(1999)
Behav Genet
, vol.29
, pp. 177-185
-
-
Holcomb, L.A.1
Gordon, M.N.2
Jantzen, P.3
Hsiao, K.4
Duff, K.5
Morgan, D.6
-
24
-
-
0037266894
-
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
-
Van Dam D, D'Hooge R, Staufenbiel M, Van Ginneken C, Van Meir F, De Deyn PP. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur J Neurosci 2003;17:388-396.
-
(2003)
Eur J Neurosci
, vol.17
, pp. 388-396
-
-
Van Dam, D.1
D'Hooge, R.2
Staufenbiel, M.3
Van Ginneken, C.4
Van Meir, F.5
De Deyn, P.P.6
-
25
-
-
78650505187
-
Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AßPP23 transgenic mice
-
Balducci C, Tonini R, Zianni E, et al. Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AßPP23 transgenic mice. J Alzheimers Dis 2010;21:1367-1381.
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 1367-1381
-
-
Balducci, C.1
Tonini, R.2
Zianni, E.3
-
26
-
-
0025269152
-
Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity
-
De Kosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990;27:457-464.
-
(1990)
Ann Neurol
, vol.27
, pp. 457-464
-
-
De Kosky, S.T.1
Scheff, S.W.2
-
27
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor PN, Buniel MC, Chang L, et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 2004;24:10191-10200.
-
(2004)
J Neurosci
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
-
28
-
-
80051665699
-
Cognitive effects of cell-derived and synthetically derived Aβ oligomers
-
Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA. Cognitive effects of cell-derived and synthetically derived Aβ oligomers. Neurobiol Aging 2011;32:1784-1794.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1784-1794
-
-
Reed, M.N.1
Hofmeister, J.J.2
Jungbauer, L.3
Welzel, A.T.4
Yu, C.5
Sherman, M.A.6
-
29
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?
-
Jarrett JT, Lansbury PT Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 1993;73:1055-1058.
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury, P.T.2
-
30
-
-
0027270578
-
A kinetic model for amyloid formation in the prion diseases: importance of seeding
-
Come JH, Fraser PE, Lansbury PT Jr. A kinetic model for amyloid formation in the prion diseases: importance of seeding. Proc Natl Acad Sci U S A 1993;90:5959-5963.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 5959-5963
-
-
Come, J.H.1
Fraser, P.E.2
Lansbury, P.T.3
-
31
-
-
34548172773
-
Different species of alpha-synuclein oligomers induce calcium influx and seeding
-
Danzer KM, Haasen D, Karow AR, et al. Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci 2007;27:9220-9232.
-
(2007)
J Neurosci
, vol.27
, pp. 9220-9232
-
-
Danzer, K.M.1
Haasen, D.2
Karow, A.R.3
-
32
-
-
78649503285
-
Preparation and characterization of neurotoxic tau oligomers
-
Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry 2010;49:10039-10041.
-
(2010)
Biochemistry
, vol.49
, pp. 10039-10041
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Guerrero-Muoz, M.J.3
Jackson, G.R.4
Kayed, R.5
-
33
-
-
84941785675
-
Prion-like mechanism in amyotrophic lateral sclerosis: are protein aggregates the key?
-
Lee S, Kim HJ. Prion-like mechanism in amyotrophic lateral sclerosis: are protein aggregates the key? Exp Neurobiol 2015;24:1-7.
-
(2015)
Exp Neurobiol
, vol.24
, pp. 1-7
-
-
Lee, S.1
Kim, H.J.2
-
34
-
-
77954385676
-
The propagation of prion-like protein inclusions in neurodegenerative diseases
-
Goedert M, Clavaguera F, Tolnay M. The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci 2010;33:317-325.
-
(2010)
Trends Neurosci
, vol.33
, pp. 317-325
-
-
Goedert, M.1
Clavaguera, F.2
Tolnay, M.3
-
35
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rüb, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
36
-
-
84947038529
-
Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors
-
Klingelhoefer L, Reichmann H Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors. Nat Rev Neurol 2015, 11:625-636.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 625-636
-
-
Klingelhoefer, L.1
Reichmann, H.2
-
37
-
-
84955245033
-
Cell Biology of prions and prionoids: a status report
-
Aguzzi A, Lakkaraju AK. Cell Biology of prions and prionoids: a status report. Trends Cell Biol 2016;26:40-51.
-
(2016)
Trends Cell Biol
, vol.26
, pp. 40-51
-
-
Aguzzi, A.1
Lakkaraju, A.K.2
-
38
-
-
84901822966
-
The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway
-
Chang YJ, Chen YR. The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway. FEBS J 2014;281:2674-2687.
-
(2014)
FEBS J
, vol.281
, pp. 2674-2687
-
-
Chang, Y.J.1
Chen, Y.R.2
-
39
-
-
27644493692
-
Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B. Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem 2005;95:834-847.
-
(2005)
J Neurochem
, vol.95
, pp. 834-847
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
Krantz, C.4
Keller, P.5
Janson, B.6
-
41
-
-
0028855851
-
Dominant and differential deposition of distinct beta-amyloid peptide species, A-Beta(N3-(Pe)), in senile plaques
-
Saido TC, Iwatsubo T, Mann DMA, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A-Beta(N3-(Pe)), in senile plaques. Neuron 1995;14:457-466.
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.A.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
42
-
-
84863762839
-
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
-
Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature 2012;485:651-655.
-
(2012)
Nature
, vol.485
, pp. 651-655
-
-
Nussbaum, J.M.1
Schilling, S.2
Cynis, H.3
Silva, A.4
Swanson, E.5
Wangsanut, T.6
-
43
-
-
84880632451
-
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models
-
Frost JL, Le KX, Cynis H, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol 2013, 183:369-381.
-
(2013)
Am J Pathol
, vol.183
, pp. 369-381
-
-
Frost, J.L.1
Le, K.X.2
Cynis, H.3
-
44
-
-
84903820348
-
Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer's disease
-
Mandler M, Walker L, Santic R, et al. Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer's disease. Acta Neuropathol 2014;128: 67-79.
-
(2014)
Acta Neuropathol
, vol.128
, pp. 67-79
-
-
Mandler, M.1
Walker, L.2
Santic, R.3
-
45
-
-
84903756361
-
Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores
-
Gillman AL, Jang H, Lee J, et al. Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores. J Phys Chem B 2014;118:7335-7344.
-
(2014)
J Phys Chem B
, vol.118
, pp. 7335-7344
-
-
Gillman, A.L.1
Jang, H.2
Lee, J.3
-
46
-
-
0242424155
-
Self-assembly of Abeta(1-42) into globular neurotoxins
-
Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry 2003;42:12749-12760.
-
(2003)
Biochemistry
, vol.42
, pp. 12749-12760
-
-
Chromy, B.A.1
Nowak, R.J.2
Lambert, M.P.3
Viola, K.L.4
Chang, L.5
Velasco, P.T.6
-
47
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006;440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
-
48
-
-
84877293577
-
Brain amyloid-β oligomers in ageing and Alzheimer's disease
-
Lesné SE, Sherman MA, Grant M, et al. Brain amyloid-β oligomers in ageing and Alzheimer's disease. Brain 2013;136:1383-1398.
-
(2013)
Brain
, vol.136
, pp. 1383-1398
-
-
Lesné, S.E.1
Sherman, M.A.2
Grant, M.3
-
49
-
-
84937640921
-
quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration
-
Liu P, Reed MN, Kotilinek LA, et al. quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration. Cell Rep 2015;11:1760-1771.
-
(2015)
Cell Rep
, vol.11
, pp. 1760-1771
-
-
Liu, P.1
Reed, M.N.2
Kotilinek, L.A.3
-
50
-
-
85012093582
-
Seeking a mechanism for the toxicity of oligomeric α-synuclein
-
Roberts HL, Brown DR. Seeking a mechanism for the toxicity of oligomeric α-synuclein. Biomolecules 2015;5:282-305.
-
(2015)
Biomolecules
, vol.5
, pp. 282-305
-
-
Roberts, H.L.1
Brown, D.R.2
-
51
-
-
84860389674
-
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
-
Lee J, Culyba EK, Powers ET, Kelly JW. Amyloid-β forms fibrils by nucleated conformational conversion of oligomers. Nat Chem Biol 2011;7:602-609.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 602-609
-
-
Lee, J.1
Culyba, E.K.2
Powers, E.T.3
Kelly, J.W.4
-
52
-
-
84949641876
-
mechanism of nucleated conformational conversion of Aβ42
-
4197-4120
-
Fu Z, Aucoin D, Davis J, Van Nostrand WE, Smith SO. mechanism of nucleated conformational conversion of Aβ42. Biochemistry 2015;54:4197-4120.
-
(2015)
Biochemistry
, vol.54
-
-
Fu, Z.1
Aucoin, D.2
Davis, J.3
Van Nostrand, W.E.4
Smith, S.O.5
-
53
-
-
84863799510
-
Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity
-
Ladiwala AR, Litt J, Kane RS, Aucoin DS, Smith SO, Ranjan S. Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity. J Biol Chem 2012;287:24765-24773.
-
(2012)
J Biol Chem
, vol.287
, pp. 24765-24773
-
-
Ladiwala, A.R.1
Litt, J.2
Kane, R.S.3
Aucoin, D.S.4
Smith, S.O.5
Ranjan, S.6
-
54
-
-
80053289958
-
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
-
Zampagni M, Cascella R, Casamenti F, Grossi C, Evangelisti E, Wright D. A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells. J Cell Mol Med 2011;15:2106-2116.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 2106-2116
-
-
Zampagni, M.1
Cascella, R.2
Casamenti, F.3
Grossi, C.4
Evangelisti, E.5
Wright, D.6
-
55
-
-
84878954521
-
Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N
-
Tatini F, Pugliese AM, Traini C, et al. Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N. Neurobiol Aging 2013;34:2100-2109.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2100-2109
-
-
Tatini, F.1
Pugliese, A.M.2
Traini, C.3
-
56
-
-
84894039447
-
Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation
-
Tsigelny IF, Sharikov Y, Kouznetsova VL, et al. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis 2014;39:583-600.
-
(2014)
J Alzheimers Dis
, vol.39
, pp. 583-600
-
-
Tsigelny, I.F.1
Sharikov, Y.2
Kouznetsova, V.L.3
-
57
-
-
0027191973
-
Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35
-
Forloni G, Chiesa R, Smiroldo S, et al. Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35. Neuroreport 1993;4:523-526.
-
(1993)
Neuroreport
, vol.4
, pp. 523-526
-
-
Forloni, G.1
Chiesa, R.2
Smiroldo, S.3
-
58
-
-
33745253950
-
Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway
-
Malaplate-Armand C, Florent-Béchard S, Youssef I, et al. Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. Neurobiol Dis 2006;23:178-189.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 178-189
-
-
Malaplate-Armand, C.1
Florent-Béchard, S.2
Youssef, I.3
-
59
-
-
84857642949
-
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
-
Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012;15:349-357.
-
(2012)
Nat Neurosci
, vol.15
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
60
-
-
77149138009
-
Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice
-
Chakravarthy B, Gaudet C, Ménard M, et al. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis 2010;19:915-925.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 915-925
-
-
Chakravarthy, B.1
Gaudet, C.2
Ménard, M.3
-
61
-
-
0035875962
-
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
-
Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 2001;21:4125-4133.
-
(2001)
J Neurosci
, vol.21
, pp. 4125-4133
-
-
Dineley, K.T.1
Westerman, M.2
Bui, D.3
Bell, K.4
Ashe, K.H.5
Sweatt, J.D.6
-
62
-
-
0034006944
-
Beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
-
Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB. Beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 2000;275:5626-5632.
-
(2000)
J Biol Chem
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'Andrea, M.R.3
Peterson, P.A.4
Shank, R.P.5
Reitz, A.B.6
-
63
-
-
0035836747
-
Beta-amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
-
Liu Q, Kawai H, Berg DK. Beta-amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci U S A 2001;98:4734-4739.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4734-4739
-
-
Liu, Q.1
Kawai, H.2
Berg, D.K.3
-
64
-
-
84939251603
-
A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity
-
Liu Q, Xie X, Emadi S, Sierks MR, Wu J. A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity. Neuropharmacology 2015;97:457-463.
-
(2015)
Neuropharmacology
, vol.97
, pp. 457-463
-
-
Liu, Q.1
Xie, X.2
Emadi, S.3
Sierks, M.R.4
Wu, J.5
-
65
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005;8:1051-1058.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
-
66
-
-
79955769953
-
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
-
Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 2011;31:6627-6638.
-
(2011)
J Neurosci
, vol.31
, pp. 6627-6638
-
-
Li, S.1
Jin, M.2
Koeglsperger, T.3
Shepardson, N.E.4
Shankar, G.M.5
Selkoe, D.J.6
-
67
-
-
84920842347
-
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease
-
Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener 2014;14;9:48.
-
(2014)
Mol Neurodegener
, vol.14
, Issue.9
, pp. 48
-
-
Tu, S.1
Okamoto, S.2
Lipton, S.A.3
Xu, H.4
-
68
-
-
0030723983
-
Gilchrest BA Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease
-
Yaar M, Zhai S, Pilch PF, et al. Gilchrest BA Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest 1997;100:2333-2340.
-
(1997)
J Clin Invest
, vol.100
, pp. 2333-2340
-
-
Yaar, M.1
Zhai, S.2
Pilch, P.F.3
-
69
-
-
84865602955
-
Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-β peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus
-
Ito S, Ménard M, Atkinson T, et al. Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-β peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus. J Alzheimers Dis 2012;31:493-506.
-
(2012)
J Alzheimers Dis
, vol.31
, pp. 493-506
-
-
Ito, S.1
Ménard, M.2
Atkinson, T.3
-
70
-
-
69249202594
-
Inhibition of LTP by beta amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway
-
Wang QW, Rowan MJ, Anwyl R. Inhibition of LTP by beta amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway. Neurobiol Aging 2009;30:1608-1613.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1608-1613
-
-
Wang, Q.W.1
Rowan, M.J.2
Anwyl, R.3
-
71
-
-
84875717632
-
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers
-
Li S, Jin M, Zhang D, et al. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron 2013;77:929-941.
-
(2013)
Neuron
, vol.77
, pp. 929-941
-
-
Li, S.1
Jin, M.2
Zhang, D.3
-
72
-
-
78650970378
-
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
-
Cissé M, Halabisky B, Harris J, et al. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 2011;469:47-52.
-
(2011)
Nature
, vol.469
, pp. 47-52
-
-
Cissé, M.1
Halabisky, B.2
Harris, J.3
-
73
-
-
84903978323
-
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease
-
Fu AK, Hung KW, Huang H, et al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A 2014;111:9959-9964.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 9959-9964
-
-
Fu, A.K.1
Hung, K.W.2
Huang, H.3
-
74
-
-
84879616001
-
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease
-
Kam TI, Song S, Gwon Y, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. J Clin Invest 2013;123:2791-2802.
-
(2013)
J Clin Invest
, vol.123
, pp. 2791-2802
-
-
Kam, T.I.1
Song, S.2
Gwon, Y.3
-
75
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
-
De Felice FG, Vieira MN, Bomfim TR, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009;106:1971-1976.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
-
76
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
-
Bomfim TR, Forny-Germano L, Sathler LB, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J Clin Invest 2012;122:1339-1353.
-
(2012)
J Clin Invest
, vol.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
-
77
-
-
67650729973
-
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
-
Ma QL, Yang F, Rosario ER, et al. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci 2009;29:9078-9089.
-
(2009)
J Neurosci
, vol.29
, pp. 9078-9089
-
-
Ma, Q.L.1
Yang, F.2
Rosario, E.R.3
-
78
-
-
84926312823
-
Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
-
Viola KL, Klein WL. Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol 2015;129:183-206.
-
(2015)
Acta Neuropathol
, vol.129
, pp. 183-206
-
-
Viola, K.L.1
Klein, W.L.2
-
79
-
-
61349201380
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
-
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009;457:1128-1132.
-
(2009)
Nature
, vol.457
, pp. 1128-1132
-
-
Laurén, J.1
Gimbel, D.A.2
Nygaard, H.B.3
Gilbert, J.W.4
Strittmatter, S.M.5
-
80
-
-
84901260237
-
Interaction between prion protein and Aβ amyloid fibrils revisited
-
Nieznanski K, Surewicz K, Chen S, Nieznanska H, Surewicz WK. Interaction between prion protein and Aβ amyloid fibrils revisited. ACS Chem Neurosci 2014;5:340-345.
-
(2014)
ACS Chem Neurosci
, vol.5
, pp. 340-345
-
-
Nieznanski, K.1
Surewicz, K.2
Chen, S.3
Nieznanska, H.4
Surewicz, W.K.5
-
81
-
-
84915798275
-
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)
-
Ganzinger KA, Narayan P, Qamar SS, et al. Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C). Chembiochem 2014;15:2515-2521.
-
(2014)
Chembiochem
, vol.15
, pp. 2515-2521
-
-
Ganzinger, K.A.1
Narayan, P.2
Qamar, S.S.3
-
82
-
-
76649093635
-
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
-
Balducci C, Beeg M, Stravalaci M, et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci U S A 2010;107:2295-2300.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2295-2300
-
-
Balducci, C.1
Beeg, M.2
Stravalaci, M.3
-
83
-
-
84875174182
-
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
-
Fluharty BR, Biasini E, Stravalaci M, et al. An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo. J Biol Chem 2013;288:7857-7866.
-
(2013)
J Biol Chem
, vol.288
, pp. 7857-7866
-
-
Fluharty, B.R.1
Biasini, E.2
Stravalaci, M.3
-
84
-
-
84874626947
-
The neurodegeneration in Alzheimer disease and the prion protein
-
Forloni G, Sclip A, Borsello T, Balducci C. The neurodegeneration in Alzheimer disease and the prion protein. Prion 2013;7:60-65.
-
(2013)
Prion
, vol.7
, pp. 60-65
-
-
Forloni, G.1
Sclip, A.2
Borsello, T.3
Balducci, C.4
-
85
-
-
84884630099
-
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
-
Kim T, Vidal GS, Djurisic M, et al. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 2013;341:1399-1404.
-
(2013)
Science
, vol.341
, pp. 1399-1404
-
-
Kim, T.1
Vidal, G.S.2
Djurisic, M.3
-
86
-
-
84953346346
-
The binding receptors of aβ: an alternative therapeutic target for alzheimer's disease
-
Xia M, Cheng X, Yi R, Gao D, Xiong J. The binding receptors of aβ: an alternative therapeutic target for alzheimer's disease. Mol Neurobiol 2016;53:455-471.
-
(2016)
Mol Neurobiol
, vol.53
, pp. 455-471
-
-
Xia, M.1
Cheng, X.2
Yi, R.3
Gao, D.4
Xiong, J.5
-
87
-
-
0031789960
-
Lewy body diseases and multiple system atrophy as alpha-synucleinopathies
-
Goedert M, Spillantini MG. Lewy body diseases and multiple system atrophy as alpha-synucleinopathies. Mol Psychiatry 1998;3:462-465.
-
(1998)
Mol Psychiatry
, vol.3
, pp. 462-465
-
-
Goedert, M.1
Spillantini, M.G.2
-
88
-
-
41149141259
-
Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
-
Parkkinen L, Pirttilä T, Alafuzoff I. Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol 2008;115:399-407.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 399-407
-
-
Parkkinen, L.1
Pirttilä, T.2
Alafuzoff, I.3
-
89
-
-
84978829327
-
Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases
-
published online ahead of print November 3
-
Ruffmann C, Calboli FC, Bravi I, et al. Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases [published online ahead of print November 3, 2015]. Neuropathol Appl Neurobiol. doi: 10.1111/nan.12294.
-
(2015)
Neuropathol Appl Neurobiol
-
-
Ruffmann, C.1
Calboli, F.C.2
Bravi, I.3
-
90
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
-
Tu PH, Galvin JE, Baba M, et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann Neurol 1998;44:415-422.
-
(1998)
Ann Neurol
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
Galvin, J.E.2
Baba, M.3
-
91
-
-
0024496060
-
An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination
-
Bancher C, Lassmann H, Budka H, et al. An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J Neuropathol Exp Neurol 1989;48:81-93.
-
(1989)
J Neuropathol Exp Neurol
, vol.48
, pp. 81-93
-
-
Bancher, C.1
Lassmann, H.2
Budka, H.3
-
92
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
-
93
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14:467-475.
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
-
94
-
-
0141499226
-
The role of alpha-synuclein in Parkinson's disease: insights from animal models
-
Maries E, Dass B, Collier TJ, Kordower JH, Steece-Collier K. The role of alpha-synuclein in Parkinson's disease: insights from animal models. Nat Rev Neurosci 2003;4:727-738.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 727-738
-
-
Maries, E.1
Dass, B.2
Collier, T.J.3
Kordower, J.H.4
Steece-Collier, K.5
-
95
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway KA, Harper JD, Lansbury PT. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 1998;4:1318-1320.
-
(1998)
Nat Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
96
-
-
0036415838
-
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
-
Lashuel HA, Petre BM, Wall J, et al. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 2002; 322:1089-1102.
-
(2002)
J Mol Biol
, vol.322
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
-
97
-
-
84928170240
-
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
-
Chen SW, Drakulic S, Deas E, et al. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proc Natl Acad Sci U S A 2015;112:E1994-E2003.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. E1994-E2003
-
-
Chen, S.W.1
Drakulic, S.2
Deas, E.3
-
98
-
-
84899889312
-
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
-
Rockenstein E, Nuber S, Overk CR, et al. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain 2014;137:1496-1513.
-
(2014)
Brain
, vol.137
, pp. 1496-1513
-
-
Rockenstein, E.1
Nuber, S.2
Overk, C.R.3
-
99
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades N, Cohen SI, Deas E, et al. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 2012;149:1048-1059.
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
Cohen, S.I.2
Deas, E.3
-
100
-
-
84952637945
-
Post-translational modification of α-synuclein in Parkinson's disease
-
published online ahead of print June 14
-
Barrett PJ, Greenamyre TJ Post-translational modification of α-synuclein in Parkinson's disease [published online ahead of print June 14, 2015]. Brain Res.
-
(2015)
Brain Res
-
-
Barrett, P.J.1
Greenamyre, T.J.2
-
101
-
-
0034674376
-
Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects
-
Borghi R, Marchese R, Negro A, et al. Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci Lett 2000;287:65-67.
-
(2000)
Neurosci Lett
, vol.287
, pp. 65-67
-
-
Borghi, R.1
Marchese, R.2
Negro, A.3
-
102
-
-
33748932543
-
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy
-
Lee PH, Lee G, Park HJ, Bang OY, Joo IS, Huh K. The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. J Neural Transm (Vienna) 2006;113:1435-1439.
-
(2006)
J Neural Transm (Vienna)
, vol.113
, pp. 1435-1439
-
-
Lee, P.H.1
Lee, G.2
Park, H.J.3
Bang, O.Y.4
Joo, I.S.5
Huh, K.6
-
103
-
-
33645833848
-
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
-
El-Agnaf OM, Salem SA, Paleologou KE, et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 2006;20:419-425.
-
(2006)
FASEB J
, vol.20
, pp. 419-425
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
-
104
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li JY, Englund E, Holton JL, et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008;14:501-503.
-
(2008)
Nat Med
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
-
105
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008;14:504-506.
-
(2008)
Nat Med
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
106
-
-
33749020837
-
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
-
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006;313:1781-1784.
-
(2006)
Science
, vol.313
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
Coomaraswamy, J.2
Bolmont, T.3
-
107
-
-
43249085326
-
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
-
Mendez I, Viñuela A, Astradsson A, et al. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med 2008;14:507-509.
-
(2008)
Nat Med
, vol.14
, pp. 507-509
-
-
Mendez, I.1
Viñuela, A.2
Astradsson, A.3
-
108
-
-
84862609075
-
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
-
Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 2012;209:975-986.
-
(2012)
J Exp Med
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.6
-
109
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk KC, Kehm V, Carroll J, et al. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012;338:949-953.
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
-
111
-
-
84934983329
-
α-synuclein strains cause distinct synucleinopathies after local and systemic administration
-
Peelaerts W, Bousset L, Van der Perren A, et al. α-synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 2015;522:340-344.
-
(2015)
Nature
, vol.522
, pp. 340-344
-
-
Peelaerts, W.1
Bousset, L.2
Van der Perren, A.3
-
112
-
-
84904636970
-
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
-
Sacino AN, Brooks M, Thomas MA, et al. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A 2014;111:10732-10737.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 10732-10737
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
-
113
-
-
84947997820
-
transmission of soluble and insoluble α-synuclein to mice
-
Jones DR, Delenclos M, Baine AT, et al. transmission of soluble and insoluble α-synuclein to mice. J Neuropathol Exp Neurol 2015;74:1158-1169.
-
(2015)
J Neuropathol Exp Neurol
, vol.74
, pp. 1158-1169
-
-
Jones, D.R.1
Delenclos, M.2
Baine, A.T.3
-
114
-
-
84941068345
-
Alpha-synuclein propagation: new insights from animal models
-
Dehay B, Vila M, Bezard E, Brundin P, Kordower JH. Alpha-synuclein propagation: new insights from animal models. Mov Disord 2016;31:161-168.
-
(2016)
Mov Disord
, vol.31
, pp. 161-168
-
-
Dehay, B.1
Vila, M.2
Bezard, E.3
Brundin, P.4
Kordower, J.H.5
-
115
-
-
84863229691
-
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo
-
Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J Neurosci 2012;32:3301-3305.
-
(2012)
J Neurosci
, vol.32
, pp. 3301-3305
-
-
Colla, E.1
Jensen, P.H.2
Pletnikova, O.3
Troncoso, J.C.4
Glabe, C.5
Lee, M.K.6
-
116
-
-
0029257497
-
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?
-
Han H, Weinreb PH, Lansbury PT Jr. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol 1995;2:163-169.
-
(1995)
Chem Biol
, vol.2
, pp. 163-169
-
-
Han, H.1
Weinreb, P.H.2
Lansbury, P.T.3
-
117
-
-
0034017710
-
Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo
-
Forloni G, Bertani I, Calella AM, Thaler F, Invernizzi R. Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Ann Neurol 2000;47:632-640.
-
(2000)
Ann Neurol
, vol.47
, pp. 632-640
-
-
Forloni, G.1
Bertani, I.2
Calella, A.M.3
Thaler, F.4
Invernizzi, R.5
-
118
-
-
9444272812
-
Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70
-
Albani D, Peverelli E, Rametta R, et al. Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70. FASEB J 2004;18:1713-1715.
-
(2004)
FASEB J
, vol.18
, pp. 1713-1715
-
-
Albani, D.1
Peverelli, E.2
Rametta, R.3
-
119
-
-
84924269795
-
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity
-
Batelli S, Invernizzi RW, Negro A, et al. The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity. Neurodegener Dis 2015;15:13-23.
-
(2015)
Neurodegener Dis
, vol.15
, pp. 13-23
-
-
Batelli, S.1
Invernizzi, R.W.2
Negro, A.3
-
120
-
-
84905494974
-
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease
-
Zondler L, Miller-Fleming L, Repici M, et al. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death Dis 2014;5:e1350.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1350
-
-
Zondler, L.1
Miller-Fleming, L.2
Repici, M.3
-
121
-
-
84971466169
-
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation
-
Diógenes MJ, Dias RB, Rombo DM, et al. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J Neurosci 2012;22:32-40.
-
(2012)
J Neurosci
, vol.22
, pp. 32-40
-
-
Diógenes, M.J.1
Dias, R.B.2
Rombo, D.M.3
-
122
-
-
84942038566
-
Alpha-synuclein produces early behavioral alterations via striatal cholinergic synaptic dysfunction by interacting with glun2d n-methyl-d-aspartate receptor subunit
-
Tozzi A, de Iure A, Bagetta V, et al. Alpha-synuclein produces early behavioral alterations via striatal cholinergic synaptic dysfunction by interacting with glun2d n-methyl-d-aspartate receptor subunit. Biol Psychiatry 2016;79:402-414.
-
(2016)
Biol Psychiatry
, vol.79
, pp. 402-414
-
-
Tozzi, A.1
de Iure, A.2
Bagetta, V.3
-
123
-
-
84920920653
-
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
-
Eschbach J, von Einem B, Müller K, et al. Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Ann Neurol 2015;77:15-32.
-
(2015)
Ann Neurol
, vol.77
, pp. 15-32
-
-
Eschbach, J.1
von Einem, B.2
Müller, K.3
-
124
-
-
84971448635
-
Adenosine a2a receptors modulate α-synuclein aggregation and toxicity
-
published online ahead of print November 2
-
Ferreira DG, Batalha VL, Vicente Miranda H, et al. Adenosine a2a receptors modulate α-synuclein aggregation and toxicity [published online ahead of print November 2, 2015]. Cereb Cortex.
-
(2015)
Cereb Cortex
-
-
Ferreira, D.G.1
Batalha, V.L.2
Vicente Miranda, H.3
-
125
-
-
77949912389
-
Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein
-
Ebrahim AS, Ko LW, Yen SH. Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein. Neurosci Lett 2010;473:120-125.
-
(2010)
Neurosci Lett
, vol.473
, pp. 120-125
-
-
Ebrahim, A.S.1
Ko, L.W.2
Yen, S.H.3
-
126
-
-
84920920653
-
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
-
Eschbach J, von Einem B, Müller K, et al. Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Ann Neurol 2015;77:15-32.
-
(2015)
Ann Neurol
, vol.77
, pp. 15-32
-
-
Eschbach, J.1
von Einem, B.2
Müller, K.3
-
127
-
-
79958091447
-
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
-
Fellner L, Jellinger KA, Wenning GK, Stefanova N. Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts. Acta Neuropathol 2011;121:675-679.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 675-679
-
-
Fellner, L.1
Jellinger, K.A.2
Wenning, G.K.3
Stefanova, N.4
-
128
-
-
84949725441
-
Glia and alpha-synuclein in neurodegeneration: a complex interaction
-
Brück D, Wenning GK, Stefanova N, Fellner L. Glia and alpha-synuclein in neurodegeneration: a complex interaction. Neurobiol Dis 2016;85:262-274.
-
(2016)
Neurobiol Dis
, vol.85
, pp. 262-274
-
-
Brück, D.1
Wenning, G.K.2
Stefanova, N.3
Fellner, L.4
-
129
-
-
79951948479
-
Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
-
Alvarez-Erviti L, Couch Y, Richardson J, Cooper JM, Wood MJ. Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line. Neurosci Res 2011;69:337-342.
-
(2011)
Neurosci Res
, vol.69
, pp. 337-342
-
-
Alvarez-Erviti, L.1
Couch, Y.2
Richardson, J.3
Cooper, J.M.4
Wood, M.J.5
-
130
-
-
40849118624
-
Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia
-
Klegeris A, Pelech S, Giasson BI, et al. Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol Aging 2008;29:739-752.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 739-752
-
-
Klegeris, A.1
Pelech, S.2
Giasson, B.I.3
-
131
-
-
82155168545
-
The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
-
Couch Y, Alvarez-Erviti L, Sibson NR, Wood MJ, Anthony DC. The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation. J Neuroinflammation 2011;8:166.
-
(2011)
J Neuroinflammation
, vol.8
, pp. 166
-
-
Couch, Y.1
Alvarez-Erviti, L.2
Sibson, N.R.3
Wood, M.J.4
Anthony, D.C.5
-
132
-
-
0028171374
-
Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
-
Mogi M, Harada M, Kondo T, et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 1994;180:147-150.
-
(1994)
Neurosci Lett
, vol.180
, pp. 147-150
-
-
Mogi, M.1
Harada, M.2
Kondo, T.3
-
133
-
-
84907209549
-
Inflammatory response in Parkinson's disease
-
Yan J, Fu Q, Cheng L, et al. Inflammatory response in Parkinson's disease. Mol Med Rep 2014;10:2223-2233.
-
(2014)
Mol Med Rep
, vol.10
, pp. 2223-2233
-
-
Yan, J.1
Fu, Q.2
Cheng, L.3
-
134
-
-
84876407781
-
Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population
-
Nie K, Zhang Y, Gan R, et al. Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population. Neurosci Lett 2013;541:111-115.
-
(2013)
Neurosci Lett
, vol.541
, pp. 111-115
-
-
Nie, K.1
Zhang, Y.2
Gan, R.3
-
135
-
-
84938221814
-
Inflammation is genetically implicated in Parkinson's disease
-
Dzamko N, Geczy CL, Halliday GM. Inflammation is genetically implicated in Parkinson's disease. Neuroscience 2015;302:89-102.
-
(2015)
Neuroscience
, vol.302
, pp. 89-102
-
-
Dzamko, N.1
Geczy, C.L.2
Halliday, G.M.3
-
136
-
-
84923207477
-
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
-
Allen Reish HE, Standaert DG. Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. J Parkinsons Dis 2015;5:1-19.
-
(2015)
J Parkinsons Dis
, vol.5
, pp. 1-19
-
-
Allen Reish, H.E.1
Standaert, D.G.2
-
137
-
-
84903699375
-
In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches
-
Balducci C, Forloni G. In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches. Curr Pharm Des 2014;20:2491-2505.
-
(2014)
Curr Pharm Des
, vol.20
, pp. 2491-2505
-
-
Balducci, C.1
Forloni, G.2
-
138
-
-
46649115352
-
Recall and recognition of verbal paired associates in early Alzheimer's disease
-
Lowndes GJ, Saling MM, Ames D, Chiu E, Gonzalez LM, Savage GR. Recall and recognition of verbal paired associates in early Alzheimer's disease. J Int Neuropsychol Soc 2008;14:591-600.
-
(2008)
J Int Neuropsychol Soc
, vol.14
, pp. 591-600
-
-
Lowndes, G.J.1
Saling, M.M.2
Ames, D.3
Chiu, E.4
Gonzalez, L.M.5
Savage, G.R.6
-
139
-
-
84878489705
-
Memantine rescues transient cognitive impairment caused by high-molecular-weight Aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers
-
Figueiredo CP1, Clarke JR, Ledo JH, et al. Memantine rescues transient cognitive impairment caused by high-molecular-weight Aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers J Neurosci 2013;33:9626-9634.
-
(2013)
J Neurosci
, vol.33
, pp. 9626-9634
-
-
Figueiredo, C.P.1
Clarke, J.R.2
Ledo, J.H.3
-
140
-
-
84875174182
-
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
-
Fluharty BR, Biasini E, Stravalaci M, et al. An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo. J Biol Chem 2013;288:7857-7866.
-
(2013)
J Biol Chem
, vol.288
, pp. 7857-7866
-
-
Fluharty, B.R.1
Biasini, E.2
Stravalaci, M.3
-
141
-
-
84930458042
-
The continuing failure of bexarotene in Alzheimer's disease mice
-
Balducci C, Paladini A, Micotti E, et al. The continuing failure of bexarotene in Alzheimer's disease mice. J Alzheimers Dis 2015;46:471-482.
-
(2015)
J Alzheimers Dis
, vol.46
, pp. 471-482
-
-
Balducci, C.1
Paladini, A.2
Micotti, E.3
-
142
-
-
84884204132
-
Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research
-
Morris GP, Clark IA, Zinn R, Vissel B. Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol Learn Mem 2013;105:40-53.
-
(2013)
Neurobiol Learn Mem
, vol.105
, pp. 40-53
-
-
Morris, G.P.1
Clark, I.A.2
Zinn, R.3
Vissel, B.4
-
144
-
-
84862908978
-
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases
-
Martin ZS, Neugebauer V, Dineley KT, et al. α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem 2012;120:440-452.
-
(2012)
J Neurochem
, vol.120
, pp. 440-452
-
-
Martin, Z.S.1
Neugebauer, V.2
Dineley, K.T.3
-
145
-
-
84865202477
-
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation
-
Diógenes MJ, Dias RB, Rombo DM, et al. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J Neurosci 2012;32:11750-11762.
-
(2012)
J Neurosci
, vol.32
, pp. 11750-11762
-
-
Diógenes, M.J.1
Dias, R.B.2
Rombo, D.M.3
-
147
-
-
84939194020
-
The diagnostic and differential diagnosis utility of cerebrospinal fluid α -synuclein levels in Parkinson's disease: a meta-analysis
-
Zhou B, Wen M, Yu WF, Zhang CL, Jiao L. The diagnostic and differential diagnosis utility of cerebrospinal fluid α -synuclein levels in Parkinson's disease: a meta-analysis. Parkinsons Dis 2015;2015:567386.
-
(2015)
Parkinsons Dis
, vol.2015
, pp. 567386
-
-
Zhou, B.1
Wen, M.2
Yu, W.F.3
Zhang, C.L.4
Jiao, L.5
-
148
-
-
84925624029
-
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
-
Yang T, O'Malley TT, Kanmert D, et al. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimers Res Ther 2015;7:14.
-
(2015)
Alzheimers Res Ther
, vol.7
, pp. 14
-
-
Yang, T.1
O'Malley, T.T.2
Kanmert, D.3
-
149
-
-
80053129900
-
The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins
-
Manzoni C, Colombo L, Bigini P, et al. The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins. PLoS ONE 2011;6:e24909.
-
(2011)
PLoS ONE
, vol.6
, pp. e24909
-
-
Manzoni, C.1
Colombo, L.2
Bigini, P.3
-
150
-
-
84955392178
-
Immunotherapeutic approaches targeting amyloid-β, α-synuclein, and tau for the treatment of neurodegenerative disorders
-
Valera E, Spencer B, Masliah E. Immunotherapeutic approaches targeting amyloid-β, α-synuclein, and tau for the treatment of neurodegenerative disorders. Neurotherapeutics 2016 13:179-189.
-
(2016)
Neurotherapeutics
, vol.13
, pp. 179-189
-
-
Valera, E.1
Spencer, B.2
Masliah, E.3
-
151
-
-
84885961431
-
Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice
-
Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG. Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice. J Neurochem 2013;126:473-482.
-
(2013)
J Neurochem
, vol.126
, pp. 473-482
-
-
Rasool, S.1
Martinez-Coria, H.2
Wu, J.W.3
LaFerla, F.4
Glabe, C.G.5
-
152
-
-
84950288771
-
antibody against small aggregated peptide specifically recognizes toxic aβ-42 oligomers in Alzheimer's disease
-
Bodani RU, Sengupta U, Castillo-Carranza DL, et al. antibody against small aggregated peptide specifically recognizes toxic aβ-42 oligomers in Alzheimer's disease. ACS Chem Neurosci 2015;6:1981-1989.
-
(2015)
ACS Chem Neurosci
, vol.6
, pp. 1981-1989
-
-
Bodani, R.U.1
Sengupta, U.2
Castillo-Carranza, D.L.3
-
153
-
-
84901502442
-
Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum
-
Meli G, Lecci A, Manca A, et al. Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nat Commun 2014;5:3867.
-
(2014)
Nat Commun
, vol.5
, pp. 3867
-
-
Meli, G.1
Lecci, A.2
Manca, A.3
-
154
-
-
84902177925
-
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
-
Lindström V, Fagerqvist T, Nordström E, et al. Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice. Neurobiol Dis 2014;69:134-143.
-
(2014)
Neurobiol Dis
, vol.69
, pp. 134-143
-
-
Lindström, V.1
Fagerqvist, T.2
Nordström, E.3
-
155
-
-
84944450004
-
Preventive study in subjects at risk of fatal familial insomnia: Innovative approach to rare diseases
-
Forloni G, Tettamanti M, Lucca U, et al. Preventive study in subjects at risk of fatal familial insomnia: Innovative approach to rare diseases. Prion 2015;9:75-79.
-
(2015)
Prion
, vol.9
, pp. 75-79
-
-
Forloni, G.1
Tettamanti, M.2
Lucca, U.3
-
156
-
-
84950154375
-
Neuropathology of α-synuclein propagation and braak hypothesis
-
McCann H, Cartwright H, Halliday GM. Neuropathology of α-synuclein propagation and braak hypothesis. Mov Disord 2016;31:152-160.
-
(2016)
Mov Disord
, vol.31
, pp. 152-160
-
-
McCann, H.1
Cartwright, H.2
Halliday, G.M.3
-
157
-
-
84875687780
-
One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli
-
Caldinelli L, Albani D, Pollegioni L. One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli. BMC Biotechnol 2013;13:32.
-
(2013)
BMC Biotechnol
, vol.13
, pp. 32
-
-
Caldinelli, L.1
Albani, D.2
Pollegioni, L.3
|