Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

Science

Volumn 341, Issue 6152, 2013, Pages 1399-1404

  Kim, Taeho ^a   Vidal, George S ^a   Djurisic, Maja ^a   William, Christopher M ^b   Birnbaum, Michael E ^c   Garcia, K Christopher ^c   Hyman, Bradley T ^b   Shatz, Carla J ^a  

^a STANFORD UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMYLOID OLIGOMER; CALCINEURIN; COFILIN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR B1; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR B2; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR B3; OLIGOMER; PAIRED IMMUNOGLOBULIN LIKE RECEPTOR B; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG;

ADULT; BRAIN; HOMOLOGY; IMMUNOASSAY; MEMORY; NEUROLOGY; RODENT; SIGNAL;

ALZHEIMER DISEASE; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN CELL CULTURE; CELL LOSS; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HIPPOCAMPUS; HUMAN; HUMAN CELL; LONG TERM POTENTIATION; MOUSE; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VISUAL CORTEX; WILD TYPE;

MURINAE; MUS;

EID: 84884630099     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1242077     Document Type: Article

References (43)

1. M. Sheng, B. L. Sabatini, T. C. Südhof, Cold Spring Harb. Perspect. Biol. 4, a005777 (2012).
2. J. J. Palop, L. Mucke, Nat. Neurosci. 13, 812-818 (2010).
3. M. Faizi et al., Brain Behav 2, 142-154 (2012).
4. C. Perez-Cruz et al., J. Neurosci. 31, 3926-3934 (2011).
5. S. Knafo et al., Cereb. Cortex 19, 586-592 (2009).
6. M. Cissé et al., Nature 469, 47-52 (2011).
7. F. Kamenetz et al., Neuron 37, 925-937 (2003).
8. J. Wu et al., Cell 147, 615-628 (2011).
9. G. M. Shankar et al., J. Neurosci. 27, 2866-2875 (2007).
10. G. M. Shankar et al., Nat. Med. 14, 837-842 (2008).
11. H. Hsieh et al., Neuron 52, 831-843 (2006).
12. J. Laurén, D. A. Gimbel, H. B. Nygaard, J. W. Gilbert, S. M. Strittmatter, Nature 457, 1128-1132 (2009).
13. J. W. Um et al., Nat. Neurosci. 15, 1227-1235 (2012).
14. X. Wang et al., J. Alzheimers Dis. 30, 665-673 (2012).
15. J. L. Jankowsky et al., Hum. Mol. Genet. 13, 159-170 (2004).
16. M. Garcia-Alloza et al., Neurobiol. Dis. 24, 516-524 (2006).
17. C. M. William et al., J. Neurosci. 32, 8004-8011 (2012).
18. J. Syken, T. Grandpre, P. O. Kanold, C. J. Shatz, Science 313, 1795-1800 (2006).
19. T. Takai, Immunology 115, 433-440 (2005).
20. J. K. Atwal et al., Science 322, 967-970 (2008).
21. On the basis of size exclusion column chromatography (Fig. 1A) and Western blot analyses (Fig. 1B), as well as previous studies (7), the average degree of polymerization (DP) of oligomerized Aβ42 is estimated to be 60 (DPn ≈ 270 kD/4.5 kD). The mono-Aβ42 preparation consists almost exclusively of monomeric peptides with a small fraction (<5%) of low-n oligomers (dimer, trimer, or tetramer; Fig. 1, A and B).
22. See supplementary materials on Science Online.
23. H. D. VanGuilder Starkey et al., J. Mol. Neurosci. 48, 111-126 (2012).
24. d would be ∼1 nM.
25. T.-I. Kam et al., J. Clin. Invest. 123, 2791-2802 (2013).
26. J. Zheng et al., Nature 485, 656-660 (2012).
27. G. Ma et al., Immunity 34, 385-395 (2011).
28. The closest human homolog for murine PirB among the five members of the human leukocyte immunoglobulin (Ig)-like receptor B (LilrB) family has been considered to be LilrB3 based on overall amino acid sequence homology (Fig. 2A) (27). However, domain sequence analysis indicates that the D1D2 domain of LilrB2 aligns with the D1D2 domain of PirB, where Aβ oligomer binding occurs, whereas the D1D2 domain of LilrB3 aligns more closely with the D3D4 domain of PirB, which suggests that conservation present in the D1D2 domains, as well as tertiary structure surrounding Aβ binding site, is important for this binding.
29. M. Lindhagen-Persson, K. Brännström, M. Vestling, M. Steinitz, A. Olofsson, PLoS ONE 5, e13928 (2010).
30. H. W. Kessels, L. N. Nguyen, S. Nabavi, R. Malinow, Nature 466, E3-E4, discussion E4-E5 (2010).
31. S. J. Raiker et al., J. Neurosci. 30, 12432-12445 (2010).
32. P. L. McClean, V. Parthsarathy, E. Faivre, C. Hölscher, J. Neurosci. 31, 6587-6594 (2011).
33. A. W. McGee, Y. Yang, Q. S. Fischer, N. W. Daw, S. M. Strittmatter, Science 309, 2222-2226 (2005).
34. G. B. Smith, A. J. Heynen, M. F. Bear, Philos. Trans. R. Soc. London Ser. B 364, 357-367 (2009).
35. R. A. Crozier, Y. Wang, C. H. Liu, M. F. Bear, Proc. Natl. Acad. Sci. U.S.A. 104, 1383-1388 (2007).
36. S. Li et al., Neuron 62, 788-801 (2009).
37. H. Y. Wu et al., J. Neurosci. 30, 2636-2649 (2010).
38. M. B. Rust et al., EMBO J. 29, 1889-1902 (2010).
39. J. D. Adelson et al., Neuron 73, 1100-1107 (2012).
40. Y. Fujita, S. Endo, T. Takai, T. Yamashita, EMBO J. 30, 1389-1401 (2011).
41. S. Lesné et al., Nature 440, 352-357 (2006).
42. P. J. Meberg, S. Ono, L. S. Minamide, M. Takahashi, J. R. Bamburg, Cell Motil. Cytoskeleton 39, 172-190 (1998).
43. N. V. Oleinik, N. I. Krupenko, S. A. Krupenko, Oncogene 29, 6233-6244 (2010).