Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice

Journal of Alzheimer's Disease

Volumn 21, Issue 4, 2010, Pages 1367-1381

  Balducci, Claudia ^a   Tonini, Raffaella ^b   Zianni, Elisa ^c   Nazzaro, Cristiano ^b   Fiordaliso, Fabio ^a   Salio, Monica ^a   Vismara, Lorenzo ^a   Gardoni, Fabrizio ^c   Di Luca, Monica ^c   Carli, Mirjana ^a   Forloni, Gianluigi ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Alzheimer's disease; amyloid oligomers; A PP23 Tg mice; NMDA glutamate receptors; spatial memory; synaptic plasticity

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DEXAMPHETAMINE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BRAIN REGION; CELLULAR DISTRIBUTION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; HIPPOCAMPUS; IN VIVO STUDY; LEARNING; MOTOR ACTIVITY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TASK PERFORMANCE; TRANSGENIC MOUSE; WORKING MEMORY;

EID: 78650505187     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100675     Document Type: Article

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