Soluble a β oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

Journal of Neuroscience

Volumn 31, Issue 18, 2011, Pages 6627-6638

  Li, Shaomin ^a   Jin, Ming ^a   Koeglsperger, Thomas ^a   Shepardson, Nina E ^a   Shankar, Ganesh M ^a   Selkoe, Dennis J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AMYLOID BETA PROTEIN; ASPARTIC ACID DERIVATIVE; CALPAIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMATE RECEPTOR ANTAGONIST; IFENPRODIL; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; THREO BETA BENZYLOASPARTIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; HIPPOCAMPUS; LONG TERM POTENTIATION; MOUSE; NERVE CELL CULTURE; NEUROPATHOLOGY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SYNAPTIC INHIBITION; WILD TYPE;

AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CALCIUM; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LONG-TERM POTENTIATION; MICE; MICROSCOPY, CONFOCAL; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 79955769953     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0203-11.2011     Document Type: Article

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