Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 16, 2015, Pages E1994-E2003

  Chen, Serene W ^a   Drakulic, Srdja ^b   Deas, Emma ^c   Ouberai, Myriam ^a   Aprile, Francesco A ^a   Arranz, Rocío ^b   Ness, Samuel ^a   Roodveldt, Cintia ^d   Guilliams, Tim ^a   De Genst, Erwin J ^a   Klenerman, David ^a   Wood, Nicholas W ^c   Knowles, Tuomas P J ^a   Alfonso, Carlos ^e   Rivas, Germán ^e   Abramov, Andrey Y ^c   Valpuesta, José María ^b   Dobson, Christopher M ^a   Cremades, Nunilo ^a,f  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^e CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^f UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Amyloid aggregation; Cryoelectron microscopy; Neurodegeneration; Protein misfolding; Toxic oligomer

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; OLIGOMER;

ARTICLE; BETA SHEET; CRYOELECTRON MICROSCOPY; HYDROPHOBICITY; IMAGE RECONSTRUCTION; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FOLDING; STRUCTURE ANALYSIS; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; MOLECULAR WEIGHT; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; AMYLOID; CRYOELECTRON MICROSCOPY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMAGING, THREE-DIMENSIONAL; MODELS, MOLECULAR; MOLECULAR WEIGHT; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84928170240     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421204112     Document Type: Article

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