-
1
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes, R., Spillantini, M. G., and Goedert, M. (1994) Identification of two distinct synucleins from human brain. FEBS Lett. 345, 27-32
-
(1994)
FEBS Lett.
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
2
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
3
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Gen. 18, 106-108
-
(1998)
Nature Gen.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
4
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B., et al. (2004) The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
-
5
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
6
-
-
4644290985
-
α-Synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) α-Synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364, 1167-1169
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
7
-
-
0032568534
-
Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95, 6469-6473
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
8
-
-
22244442489
-
The biochemistry of Parkinson's disease
-
Cookson, M. R. (2005) The biochemistry of Parkinson's disease. Annu. Rev. Biochem. 74, 29-52
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 29-52
-
-
Cookson, M.R.1
-
9
-
-
2542427689
-
Alpha-synuclein and the pathogenesis of Parkinson's disease
-
Martin, F. L., Williamson, S. J., Paleologou, K. E., Allsop, D., and El-Agnaf, O. M. A. (2004) Alpha-synuclein and the pathogenesis of Parkinson's disease. Protein Pept. Lett. 11, 229-237
-
(2004)
Protein Pept. Lett.
, vol.11
, pp. 229-237
-
-
Martin, F.L.1
Williamson, S.J.2
Paleologou, K.E.3
Allsop, D.4
El-Agnaf, O.M.A.5
-
10
-
-
0033616458
-
Science, medicine, and the future Parkinson's disease
-
Schapira, A. H. V. (1999) Science, medicine, and the future Parkinson's disease. Br. Med. J. 318, 311-314
-
(1999)
Br. Med. J.
, vol.318
, pp. 311-314
-
-
Schapira, A.H.V.1
-
11
-
-
0032497504
-
Parkinson's disease - First of two parts
-
Lang, A. E., and Lozano, A. M. (1998) Parkinson's disease - first of two parts. N. Engl. J. Med. 339, 1130-1143
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1130-1143
-
-
Lang, A.E.1
Lozano, A.M.2
-
12
-
-
0032497504
-
Parkinson's disease - Second of two parts
-
Lang, A. E., and Lozano, A. M. (1998) Parkinson's disease - second of two parts. N. Engl. J. Med. 339, 1144-1153
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1144-1153
-
-
Lang, A.E.1
Lozano, A.M.2
-
13
-
-
0032573289
-
53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease
-
53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease. FEBS Lett. 440, 67-70
-
(1998)
FEBS Lett.
, vol.440
, pp. 67-70
-
-
El-Agnaf, O.M.A.1
Jakes, R.2
Curran, M.D.3
Wallace, A.4
-
14
-
-
85109083933
-
α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
-
El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., Curran, M. D., Court, J. A., Mann, D. M. A., Ikeda, S. I., et al. (2003) α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 17, 1945-1947
-
(2003)
FASEB J.
, vol.17
, pp. 1945-1947
-
-
El-Agnaf, O.M.A.1
Salem, S.A.2
Paleologou, K.E.3
Cooper, L.J.4
Fullwood, N.J.5
Gibson, M.J.6
Curran, M.D.7
Court, J.A.8
Mann, D.M.A.9
Ikeda, S.I.10
-
15
-
-
0023898945
-
The relevance of the Lewy body to the pathogenesis of Parkinson's disease
-
Gibb, W. R., and Lees, A. J. (1988) The relevance of the Lewy body to the pathogenesis of Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 51, 745-752
-
(1988)
J. Neurol. Neurosurg. Psychiatry
, vol.51
, pp. 745-752
-
-
Gibb, W.R.1
Lees, A.J.2
-
16
-
-
0038038389
-
Soluble oligomers for the diagnosis of neurodegenerative diseases
-
El-Agnaf, O. M. A., Walsh, D. M., and Allsop, D. (2003) Soluble oligomers for the diagnosis of neurodegenerative diseases. Lancet Neurol. 2, 461-462
-
(2003)
Lancet Neurol.
, vol.2
, pp. 461-462
-
-
El-Agnaf, O.M.A.1
Walsh, D.M.2
Allsop, D.3
-
17
-
-
0034647786
-
Oligomerization and toxicity of β-amyloid-42 implicated in Alzheimer's disease
-
El-Agnaf, O. M. A., Mahil, D. S., Patel, B. P., and Austen, B. A. (2000) Oligomerization and toxicity of β-amyloid-42 implicated in Alzheimer's disease. Biochem. Biophys. Res. Commun. 237, 1003-1007
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.237
, pp. 1003-1007
-
-
El-Agnaf, O.M.A.1
Mahil, D.S.2
Patel, B.P.3
Austen, B.A.4
-
18
-
-
0037456578
-
The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon, R., Bar-Joseph, I., Frosch, M. P., Walsh, D. M., Hamilton, J. A., and Selkoe, D. J. (2003) The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37, 583-595
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
Bar-Joseph, I.2
Frosch, M.P.3
Walsh, D.M.4
Hamilton, J.A.5
Selkoe, D.J.6
-
19
-
-
0038038284
-
Alzheimer's disease, normal pressure hydrocephalus, and senescent changes in CSF circulatory physiology: A hypothesis
-
Silverberg, G. D., Mayo, M., Saul, T., Rubenstein, E., and McGuire, D. (2003) Alzheimer's disease, normal pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol. 2, 506-511
-
(2003)
Lancet Neurol.
, vol.2
, pp. 506-511
-
-
Silverberg, G.D.1
Mayo, M.2
Saul, T.3
Rubenstein, E.4
McGuire, D.5
-
20
-
-
0036319503
-
Plaque-associated disruption of CSF and plasma amyloid-beta (Aβ) equilibrium in a mouse model of Alzheimer's disease
-
DeMattos, R. B., Bales, K. R., Parsadanian, M., O'Dell, M. A., Foss, E. M., Paul, S. M., and Holtzman, D. M. (2002) Plaque-associated disruption of CSF and plasma amyloid-beta (Aβ) equilibrium in a mouse model of Alzheimer's disease. J. Neurochem. 81, 229-236
-
(2002)
J. Neurochem.
, vol.81
, pp. 229-236
-
-
DeMattos, R.B.1
Bales, K.R.2
Parsadanian, M.3
O'Dell, M.A.4
Foss, E.M.5
Paul, S.M.6
Holtzman, D.M.7
-
21
-
-
0037155581
-
Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., and Holtzman, D. M. (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Paul, S.M.4
Holtzman, D.M.5
-
22
-
-
0036669811
-
Platelet α- and γ-synucleins in Parkinson's disease and normal control subjects
-
Li, Q. X., Campbell, B. C., McLean, C. A., Thyagarajan, D., Gai, W. P., Kapsa, R. M., Beyreuther, K., Masters, C. L., and Culvenor, J. G. (2002) Platelet α- and γ-synucleins in Parkinson's disease and normal control subjects. J. Alzheimers Dis. 4, 309-315
-
(2002)
J. Alzheimers Dis.
, vol.4
, pp. 309-315
-
-
Li, Q.X.1
Campbell, B.C.2
McLean, C.A.3
Thyagarajan, D.4
Gai, W.P.5
Kapsa, R.M.6
Beyreuther, K.7
Masters, C.L.8
Culvenor, J.G.9
-
23
-
-
0031871740
-
Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy
-
Pitschke, M., Prior, R., Haupt, M., and Riesner, D. (1998) Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat. Med. 4, 832-834
-
(1998)
Nat. Med.
, vol.4
, pp. 832-834
-
-
Pitschke, M.1
Prior, R.2
Haupt, M.3
Riesner, D.4
-
24
-
-
0034625009
-
Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets
-
Bieschke, J., Giese, A., Schulz-Schaeffer, W., Zerr, I., Poser, S., Eigen, M., and Kretzschmar, H. (2000) Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets. Proc. Natl. Acad. Sci. USA 97, 5468-5473
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5468-5473
-
-
Bieschke, J.1
Giese, A.2
Schulz-Schaeffer, W.3
Zerr, I.4
Poser, S.5
Eigen, M.6
Kretzschmar, H.7
-
25
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl. Acad. Sci. USA 97, 571-576
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury Jr., P.T.6
-
26
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., and Stefani, M. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature (London) 416, 507-511
-
(2002)
Nature (London)
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
Baroni, F.4
Formigli, L.5
Zurdo, J.6
Taddei, N.7
Ramponi, G.8
Dobson, C.M.9
Stefani, M.10
-
27
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (London) 416, 535-539
-
(2002)
Nature (London)
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
28
-
-
0035967889
-
Nonfibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils
-
El-Agnaf, O. M. A., Nagala, S., Patel, B. P., and Austen, B. M. (2001) Nonfibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils. J. Mol. Biol. 310, 157-168
-
(2001)
J. Mol. Biol.
, vol.310
, pp. 157-168
-
-
El-Agnaf, O.M.A.1
Nagala, S.2
Patel, B.P.3
Austen, B.M.4
-
29
-
-
0034681471
-
Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
-
Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269
-
(2000)
Science
, vol.287
, pp. 1265-1269
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Mallory, M.4
Hashimoto, M.5
Takeda, A.6
Sagara, Y.7
Sisk, A.8
Mucke, L.9
-
30
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 5618, 486-489
-
(2003)
Science
, vol.5618
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
31
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel, H. A., Hartley, D., Petre, B. M., Walz, T., and Lansbury, P. T., Jr. (2002) Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature (London) 418, 291
-
(2002)
Nature (London)
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury Jr., P.T.5
-
32
-
-
2442700253
-
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
-
Miller, D. W., Hague, S. M., Clarimon, J., Baptista, M., Gwinn-Hardy, K., Cookson, M. R. and Singleton, A. B. (2004) Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 62, 1835-1838
-
(2004)
Neurology
, vol.62
, pp. 1835-1838
-
-
Miller, D.W.1
Hague, S.M.2
Clarimon, J.3
Baptista, M.4
Gwinn-Hardy, K.5
Cookson, M.R.6
Singleton, A.B.7
-
33
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294, 1346-1349
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury Jr., P.T.4
-
34
-
-
9444229299
-
A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders
-
El-Agnaf, O. M. A., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J. E., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., et al. (2004) A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders. FASEB J. 18, 1315-1317
-
(2004)
FASEB J.
, vol.18
, pp. 1315-1317
-
-
El-Agnaf, O.M.A.1
Paleologou, K.E.2
Greer, B.3
Abogrein, A.M.4
King, J.E.5
Salem, S.A.6
Fullwood, N.J.7
Benson, F.E.8
Hewitt, R.9
Ford, K.J.10
|