-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61(2): 69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, Issue.2
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
84918815964
-
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
-
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): E359-E386.
-
(2015)
Int J Cancer
, vol.136
, Issue.5
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
-
3
-
-
67449138207
-
International trends in colorectal cancer incidence rates
-
Center MM, Jemal A, Ward E. International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009; 18(6): 1688-1694.
-
(2009)
Cancer Epidemiol Biomarkers Prev
, vol.18
, Issue.6
, pp. 1688-1694
-
-
Center, M.M.1
Jemal, A.2
Ward, E.3
-
4
-
-
84908540607
-
Targeted therapies in metastatic colorectal cancer: A systematic review and assessment of currently available data
-
Kirstein MM, Lange A, Prenzler A, Manns MP, Kubicka S, Vogel A. Targeted therapies in metastatic colorectal cancer: a systematic review and assessment of currently available data. Oncologist. 2014; 19(11): 1156-1168.
-
(2014)
Oncologist
, vol.19
, Issue.11
, pp. 1156-1168
-
-
Kirstein, M.M.1
Lange, A.2
Prenzler, A.3
Manns, M.P.4
Kubicka, S.5
Vogel, A.6
-
5
-
-
0028175144
-
Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
-
Buroker TR, O'Connell MJ, Wieand HS, et al. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol. 1994; 12(1): 14-20.
-
(1994)
J Clin Oncol
, vol.12
, Issue.1
, pp. 14-20
-
-
Buroker, T.R.1
O'Connell, M.J.2
Wieand, H.S.3
-
6
-
-
0024347268
-
Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
-
Poon MA, O'Connell MJ, Moertel CG, et al. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol. 1989; 7(10): 1407-1418.
-
(1989)
J Clin Oncol
, vol.7
, Issue.10
, pp. 1407-1418
-
-
Poon, M.A.1
O'Connell, M.J.2
Moertel, C.G.3
-
7
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000; 355(9209): 1041-1047.
-
(2000)
Lancet
, vol.355
, Issue.9209
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
8
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
-
Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med. 2000; 343(13): 905-914.
-
(2000)
N Engl J Med
, vol.343
, Issue.13
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
9
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000; 18(16): 2938-2947.
-
(2000)
J Clin Oncol
, vol.18
, Issue.16
, pp. 2938-2947
-
-
de Gramont, A.1
Figer, A.2
Seymour, M.3
-
10
-
-
1842569206
-
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
-
Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004; 22(1): 23-30.
-
(2004)
J Clin Oncol
, vol.22
, Issue.1
, pp. 23-30
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
11
-
-
34848844379
-
Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC)
-
Orlando, FL
-
Grothey A, Deschler B, Kroening H, et al. Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC). Poster presented at: American Society of Clinical Oncology Annual Meeting; May 18-21, 2002; Orlando, FL.
-
(2002)
Poster presented at: American Society of Clinical Oncology Annual Meeting; May 18-21
-
-
Grothey, A.1
Deschler, B.2
Kroening, H.3
-
12
-
-
2142703727
-
Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
-
Grothey A, Sargent D, Goldberg RM, Schmoll HJ. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol. 2004; 22(7): 1209-1214.
-
(2004)
J Clin Oncol
, vol.22
, Issue.7
, pp. 1209-1214
-
-
Grothey, A.1
Sargent, D.2
Goldberg, R.M.3
Schmoll, H.J.4
-
13
-
-
84908573757
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial
-
Heinemann V, von Weikersthal LF, Decker T, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014; 15(10): 1065-1075.
-
(2014)
Lancet Oncol
, vol.15
, Issue.10
, pp. 1065-1075
-
-
Heinemann, V.1
von Weikersthal, L.F.2
Decker, T.3
-
14
-
-
84905870196
-
PEAK: A randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
-
Schwartzberg LS, Rivera F, Karthaus M, et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014; 32(21): 2240-2247.
-
(2014)
J Clin Oncol
, vol.32
, Issue.21
, pp. 2240-2247
-
-
Schwartzberg, L.S.1
Rivera, F.2
Karthaus, M.3
-
15
-
-
84925519646
-
Personalized treatment for colorectal cancer: Novel developments and putative therapeutic strategies
-
Akkad J, Bochum S, Martens UM. Personalized treatment for colorectal cancer: novel developments and putative therapeutic strategies. Langenbecks Arch Surg. 2015; 400(2): 129-143.
-
(2015)
Langenbecks Arch Surg
, vol.400
, Issue.2
, pp. 129-143
-
-
Akkad, J.1
Bochum, S.2
Martens, U.M.3
-
17
-
-
84962462057
-
Biologic agents in the treatment of colorectal cancer: An update
-
Raj N, Saltz L. Biologic agents in the treatment of colorectal cancer: an update. Colorectal Cancer. 2014; 3(4): 363-374.
-
(2014)
Colorectal Cancer
, vol.3
, Issue.4
, pp. 363-374
-
-
Raj, N.1
Saltz, L.2
-
18
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol. 2012; 30(28): 3499-3506.
-
(2012)
J Clin Oncol
, vol.30
, Issue.28
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
19
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26(12): 2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
20
-
-
84871720057
-
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial
-
Bennouna J, Sastre J, Arnold D, et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 2013; 14(1): 29-37.
-
(2013)
Lancet Oncol
, vol.14
, Issue.1
, pp. 29-37
-
-
Bennouna, J.1
Sastre, J.2
Arnold, D.3
-
21
-
-
84885021477
-
Drug rechallenge and treatment beyond progression-implications for drug resistance
-
Kuczynski EA, Sargent DJ, Grothey A, Kerbel RS. Drug rechallenge and treatment beyond progression-implications for drug resistance. Nat Rev Clin Oncol. 2013; 10(10): 571-587.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, Issue.10
, pp. 571-587
-
-
Kuczynski, E.A.1
Sargent, D.J.2
Grothey, A.3
Kerbel, R.S.4
-
22
-
-
84891831211
-
Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: Prespecified subgroup analyses from the VELOUR trial
-
Tabernero J, Van Cutsem E, Lakomy R, et al. Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial. Eur J Cancer. 2014; 50(2): 320-331.
-
(2014)
Eur J Cancer
, vol.50
, Issue.2
, pp. 320-331
-
-
Tabernero, J.1
Van Cutsem, E.2
Lakomy, R.3
-
23
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 2011; 129(1): 245-255.
-
(2011)
Int J Cancer
, vol.129
, Issue.1
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
-
24
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013; 381(9863): 303-312.
-
(2013)
Lancet
, vol.381
, Issue.9863
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
25
-
-
84898430937
-
An open-label phase II study evaluating the safety and efficacy of ramucirumab combined with mFOLFOX-6 as first-line therapy for metastatic colorectal cancer
-
Garcia-Carbonero R, Rivera F, Maurel J, et al. An open-label phase II study evaluating the safety and efficacy of ramucirumab combined with mFOLFOX-6 as first-line therapy for metastatic colorectal cancer. Oncologist. 2014; 19(4): 350-351.
-
(2014)
Oncologist
, vol.19
, Issue.4
, pp. 350-351
-
-
Garcia-Carbonero, R.1
Rivera, F.2
Maurel, J.3
-
26
-
-
84930437602
-
RAISE: A randomized, double-blind, multicenter phase III study of irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) plus ramucirumab (RAM) or placebo (PBO) in patients (pts) with metastatic colorectal carcinoma (CRC) progressive during or following first-line combination therapy with bevacizumab (bev), oxaliplatin (ox), and a fluoropyrimidine (fp)
-
Tabernero J, Cohn AL, Obermannova R, et al. RAISE: a randomized, double-blind, multicenter phase III study of irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) plus ramucirumab (RAM) or placebo (PBO) in patients (pts) with metastatic colorectal carcinoma (CRC) progressive during or following first-line combination therapy with bevacizumab (bev), oxaliplatin (ox), and a fluoropyrimidine (fp). J Clin Oncol. 2015; 33 Suppl 3: 512.
-
(2015)
J Clin Oncol
, vol.33
, pp. 512
-
-
Tabernero, J.1
Cohn, A.L.2
Obermannova, R.3
-
27
-
-
84930633659
-
A randomized, double-blind, parallel-group, placebo-controlled, multicenter, phase II clinical study of famitinib in the treatment of advanced metastatic colorectal cancer
-
Xu RH, Shen L, Wang KM, et al. A randomized, double-blind, parallel-group, placebo-controlled, multicenter, phase II clinical study of famitinib in the treatment of advanced metastatic colorectal cancer. J Clin Oncol. 2015; 33 Suppl 3: 513.
-
(2015)
J Clin Oncol
, vol.33
, pp. 513
-
-
Xu, R.H.1
Shen, L.2
Wang, K.M.3
-
28
-
-
84876089340
-
Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: A randomized, phase III trial
-
Carrato A, Swieboda-Sadlej A, Staszewska-Skurczynska M, et al. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trial. J Clin Oncol. 2013; 31(10): 1341-1347.
-
(2013)
J Clin Oncol
, vol.31
, Issue.10
, pp. 1341-1347
-
-
Carrato, A.1
Swieboda-Sadlej, A.2
Staszewska-Skurczynska, M.3
-
29
-
-
84877098937
-
Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: The RESPECT trial
-
Tabernero J, Garcia-Carbonero R, Cassidy J, et al. Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: the RESPECT trial. Clin Cancer Res. 2013; 19(9): 2541-2550.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.9
, pp. 2541-2550
-
-
Tabernero, J.1
Garcia-Carbonero, R.2
Cassidy, J.3
-
30
-
-
79956297102
-
Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma
-
Van Cutsem E, Bajetta E, Valle J, et al. Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol. 2011; 29(15): 2004-2010.
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 2004-2010
-
-
Van Cutsem, E.1
Bajetta, E.2
Valle, J.3
-
31
-
-
84879660334
-
Axitinib and/or bevacizumab with modified FOLFOX-6 as first-line therapy for metastatic colorectal cancer: A randomized phase 2 study
-
Infante JR, Reid TR, Cohn AL, et al. Axitinib and/or bevacizumab with modified FOLFOX-6 as first-line therapy for metastatic colorectal cancer: a randomized phase 2 study. Cancer. 2013; 119(14): 2555-2563.
-
(2013)
Cancer
, vol.119
, Issue.14
, pp. 2555-2563
-
-
Infante, J.R.1
Reid, T.R.2
Cohn, A.L.3
-
32
-
-
84867602281
-
Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: A randomized, double-blind, phase III study (HORIZON II)
-
Hoff PM, Hochhaus A, Pestalozzi BC, et al. Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II). J Clin Oncol. 2012; 30(29): 3596-3603.
-
(2012)
J Clin Oncol
, vol.30
, Issue.29
, pp. 3596-3603
-
-
Hoff, P.M.1
Hochhaus, A.2
Pestalozzi, B.C.3
-
33
-
-
84883074556
-
Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: The NCIC Clinical Trials Group and AGITG CO. 20 trial
-
Siu LL, Shapiro JD, Jonker DJ, et al. Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO. 20 trial. J Clin Oncol. 2013; 31(19): 2477-2484.
-
(2013)
J Clin Oncol
, vol.31
, Issue.19
, pp. 2477-2484
-
-
Siu, L.L.1
Shapiro, J.D.2
Jonker, D.J.3
-
35
-
-
84896705592
-
Plant-derived vascular disrupting agents: Compounds, actions, and clinical trials
-
Kretzschmann VK, Fürst R. Plant-derived vascular disrupting agents: compounds, actions, and clinical trials. Phytochem Rev. 2014; 13(1): 191-206.
-
(2014)
Phytochem Rev
, vol.13
, Issue.1
, pp. 191-206
-
-
Kretzschmann, V.K.1
Fürst, R.2
-
36
-
-
84858736660
-
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular
-
Buchanan CM, Shih JH, Astin JW, et al. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clin Sci (Lond). 2012; 122(10): 449-457.
-
(2012)
Clin Sci (Lond)
, vol.122
, Issue.10
, pp. 449-457
-
-
Buchanan, C.M.1
Shih, J.H.2
Astin, J.W.3
-
37
-
-
80051612685
-
Clinical development of vascular disrupting agents: What lessons can we learn from ASA404?
-
Lorusso PM, Boerner SA, Hunsberger S. Clinical development of vascular disrupting agents: what lessons can we learn from ASA404? J Clin Oncol. 2011; 29(22): 2952-2955.
-
(2011)
J Clin Oncol
, vol.29
, Issue.22
, pp. 2952-2955
-
-
Lorusso, P.M.1
Boerner, S.A.2
Hunsberger, S.3
-
38
-
-
0036875993
-
Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate
-
Holwell SE, Cooper PA, Thompson MJ, et al. Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate. Anticancer Res. 2002; 22(6C): 3933-3940.
-
(2002)
Anticancer Res
, vol.22
, Issue.6 C
, pp. 3933-3940
-
-
Holwell, S.E.1
Cooper, P.A.2
Thompson, M.J.3
-
39
-
-
0037096814
-
A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
-
Dowlati A, Robertson K, Cooney M, et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res. 2002; 62(12): 3408-3416.
-
(2002)
Cancer Res
, vol.62
, Issue.12
, pp. 3408-3416
-
-
Dowlati, A.1
Robertson, K.2
Cooney, M.3
-
40
-
-
0042386700
-
Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
-
Rustin GJ, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol. 2003; 21(15): 2815-2822.
-
(2003)
J Clin Oncol
, vol.21
, Issue.15
, pp. 2815-2822
-
-
Rustin, G.J.1
Galbraith, S.M.2
Anderson, H.3
-
41
-
-
0642307227
-
Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
-
Stevenson JP, Rosen M, Sun W, et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol. 2003; 21(23): 4428-4438.
-
(2003)
J Clin Oncol
, vol.21
, Issue.23
, pp. 4428-4438
-
-
Stevenson, J.P.1
Rosen, M.2
Sun, W.3
-
42
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res. 2006; 12(18): 5268-5272.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.18
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
43
-
-
77949435827
-
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
-
Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol. 2010; 28(7): 1254-1261.
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1254-1261
-
-
Bardelli, A.1
Siena, S.2
-
44
-
-
16844376315
-
Oncogenic Ras in tumour progression and metastasis
-
Giehl K. Oncogenic Ras in tumour progression and metastasis. Biol Chem. 2005; 386(3): 193-205.
-
(2005)
Biol Chem
, vol.386
, Issue.3
, pp. 193-205
-
-
Giehl, K.1
-
45
-
-
0032541650
-
Increasing complexity of Ras signaling
-
Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling. Oncogene. 1998; 17(11): 1395-1413.
-
(1998)
Oncogene
, vol.17
, Issue.11
, pp. 1395-1413
-
-
Campbell, S.L.1
Khosravi-Far, R.2
Rossman, K.L.3
Clark, G.J.4
Der, C.J.5
-
46
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008; 359(17): 1757-1765.
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
47
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009; 360(14): 1408-1417.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
48
-
-
33750905700
-
Phase III study of irinotecan/5FU/LV (FOLFIRI) or oxaliplatin/5FU/LV (FOLFOX){+/-} cetuximab for patients (pts) with untreated metastatic adenocarcinoma of the colon or rectum (MCRC): CALGB 80203 preliminary results
-
Venook A, Niedzwiecki D, Hollis D, et al. Phase III study of irinotecan/5FU/LV (FOLFIRI) or oxaliplatin/5FU/LV (FOLFOX){+/-} cetuximab for patients (pts) with untreated metastatic adenocarcinoma of the colon or rectum (MCRC): CALGB 80203 preliminary results. J Clin Oncol. 2006; 24(18 Suppl): 3509.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18
, pp. 3509
-
-
Venook, A.1
Niedzwiecki, D.2
Hollis, D.3
-
49
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
Bokemeyer C, Van Cutsem E, Rougier P, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer. 2012; 48(10): 1466-1475.
-
(2012)
Eur J Cancer
, vol.48
, Issue.10
, pp. 1466-1475
-
-
Bokemeyer, C.1
Van Cutsem, E.2
Rougier, P.3
-
50
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
-
Douillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010; 28(31): 4697-4705.
-
(2010)
J Clin Oncol
, vol.28
, Issue.31
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
51
-
-
84856717005
-
Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer
-
Montagut C, Dalmases A, Bellosillo B, et al. Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer. Nat Med. 2012; 18(2): 221-223.
-
(2012)
Nat Med
, vol.18
, Issue.2
, pp. 221-223
-
-
Montagut, C.1
Dalmases, A.2
Bellosillo, B.3
-
52
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004; 22(7): 1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, Issue.7
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
53
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004; 351(4): 337-345.
-
(2004)
N Engl J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
54
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol. 2005; 23(9): 1803-1810.
-
(2005)
J Clin Oncol
, vol.23
, Issue.9
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
55
-
-
25144491785
-
Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: An immunohistochemical and chromogenic in situ hybridization study
-
Shia J, Klimstra DS, Li AR, et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod Pathol. 2005; 18(10): 1350-1356.
-
(2005)
Mod Pathol
, vol.18
, Issue.10
, pp. 1350-1356
-
-
Shia, J.1
Klimstra, D.S.2
Li, A.R.3
-
56
-
-
42649094858
-
EGFR FISH in colorectal cancer: What is the current reality?
-
Moroni M, Sartore-Bianchi A, Veronese S, Siena S. EGFR FISH in colorectal cancer: what is the current reality? Lancet Oncol. 2008; 9(5): 402-403.
-
(2008)
Lancet Oncol
, vol.9
, Issue.5
, pp. 402-403
-
-
Moroni, M.1
Sartore-Bianchi, A.2
Veronese, S.3
Siena, S.4
-
57
-
-
51249089269
-
Potential value of PTEN in predicting cetuximab response in colorectal cancer: An exploratory study
-
Razis E, Briasoulis E, Vrettou E, et al. Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study. BMC Cancer. 2008; 8: 234.
-
(2008)
BMC Cancer
, vol.8
, pp. 234
-
-
Razis, E.1
Briasoulis, E.2
Vrettou, E.3
-
58
-
-
73349098041
-
Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
-
Jacobs B, De Roock W, Piessevaux H, et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J Clin Oncol. 2009; 27(30): 5068-5074.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5068-5074
-
-
Jacobs, B.1
De Roock, W.2
Piessevaux, H.3
-
59
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol. 2007; 25(22): 3230-3237.
-
(2007)
J Clin Oncol
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
60
-
-
0035256698
-
Untangling the ErbB signalling network
-
Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001; 2(2): 127-137.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, Issue.2
, pp. 127-137
-
-
Yarden, Y.1
Sliwkowski, M.X.2
-
61
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
-
Di Fiore F, Blanchard F, Charbonnier F, et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br J Cancer. 2007; 96(8): 1166-1169.
-
(2007)
Br J Cancer
, vol.96
, Issue.8
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
-
62
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006; 66(8): 3992-3995.
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
63
-
-
84964314170
-
Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer
-
Morris VK, Lucas FA, Overman MJ, et al. Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer. Ann Oncol. 2014; 25(10): 2008-2014.
-
(2014)
Ann Oncol
, vol.25
, Issue.10
, pp. 2008-2014
-
-
Morris, V.K.1
Lucas, F.A.2
Overman, M.J.3
-
64
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010; 11(8): 753-762.
-
(2010)
Lancet Oncol
, vol.11
, Issue.8
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
65
-
-
84925337082
-
Expanded RAS: Refining the patient population
-
Atreya CE, Corcoran RB, Kopetz S. Expanded RAS: refining the patient population. J Clin Oncol. 2015; 33(7): 682-685.
-
(2015)
J Clin Oncol
, vol.33
, Issue.7
, pp. 682-685
-
-
Atreya, C.E.1
Corcoran, R.B.2
Kopetz, S.3
-
66
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz LA Jr, Williams RT, Wu J, et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature. 2012; 486(7404): 537-540.
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 537-540
-
-
Diaz, L.A.1
Williams, R.T.2
Wu, J.3
-
67
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale S, Yaeger R, Hobor S, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012; 486(7404): 532-536.
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 532-536
-
-
Misale, S.1
Yaeger, R.2
Hobor, S.3
-
68
-
-
84891808183
-
The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies
-
Esposito C, Rachiglio AM, La Porta ML, et al. The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies. Cancer Biol Ther. 2013; 14(12): 1143-1146.
-
(2013)
Cancer Biol Ther
, vol.14
, Issue.12
, pp. 1143-1146
-
-
Esposito, C.1
Rachiglio, A.M.2
La Porta, M.L.3
-
69
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007; 67(6): 2643-2648.
-
(2007)
Cancer Res
, vol.67
, Issue.6
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
-
70
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 2008; 26(35): 5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, Issue.35
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
71
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
Jhawer M, Goel S, Wilson AJ, et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 2008; 68(6): 1953-1961.
-
(2008)
Cancer Res
, vol.68
, Issue.6
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
-
72
-
-
59049089201
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
-
Perrone F, Lampis A, Orsenigo M, et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol. 2009; 20(1): 84-90.
-
(2009)
Ann Oncol
, vol.20
, Issue.1
, pp. 84-90
-
-
Perrone, F.1
Lampis, A.2
Orsenigo, M.3
-
73
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini M, Saletti P, Romagnani E, et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer. 2007; 97(8): 1139-1145.
-
(2007)
Br J Cancer
, vol.97
, Issue.8
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
-
74
-
-
84878862323
-
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
-
Bardelli A, Corso S, Bertotti A, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 2013; 3(6): 658-673.
-
(2013)
Cancer Discov
, vol.3
, Issue.6
, pp. 658-673
-
-
Bardelli, A.1
Corso, S.2
Bertotti, A.3
-
75
-
-
84863152058
-
Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer
-
Huang F, Xu LA, Khambata-Ford S. Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer. Clin Cancer Res. 2012; 18(4): 1156-1166.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.4
, pp. 1156-1166
-
-
Huang, F.1
Xu, L.A.2
Khambata-Ford, S.3
-
76
-
-
80052591747
-
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
-
99ra86
-
Yonesaka K, Zejnullahu K, Okamoto I, et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011; 3(99): 99ra86.
-
(2011)
Sci Transl Med
, vol.3
, Issue.99
-
-
Yonesaka, K.1
Zejnullahu, K.2
Okamoto, I.3
-
77
-
-
84908441752
-
TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells
-
Hobor S, Van Emburgh BO, Crowley E, Misale S, Di Nicolantonio F, Bardelli A. TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells. Clin Cancer Res. 2014; 20(24): 6429-6438.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.24
, pp. 6429-6438
-
-
Hobor, S.1
Van Emburgh, B.O.2
Crowley, E.3
Misale, S.4
Di Nicolantonio, F.5
Bardelli, A.6
-
78
-
-
84885234293
-
Cell-autonomous and non-cell-autonomous mechanisms of HGF/MET-driven resistance to targeted therapies: From basic research to a clinical perspective
-
Corso S, Giordano S. Cell-autonomous and non-cell-autonomous mechanisms of HGF/MET-driven resistance to targeted therapies: from basic research to a clinical perspective. Cancer Discov. 2013; 3(9): 978-992.
-
(2013)
Cancer Discov
, vol.3
, Issue.9
, pp. 978-992
-
-
Corso, S.1
Giordano, S.2
-
79
-
-
84995743878
-
Markers of resistance to anti-EGFR therapy in colorectal cancer
-
Shaib W, Mahajan R, El-Rayes B. Markers of resistance to anti-EGFR therapy in colorectal cancer. J Gastrointest Oncol. 2013; 4(3): 308-318.
-
(2013)
J Gastrointest Oncol
, vol.4
, Issue.3
, pp. 308-318
-
-
Shaib, W.1
Mahajan, R.2
El-Rayes, B.3
-
80
-
-
84884343472
-
Proof-of-concept study of Sym004, an anti-EGFR monoclonal antibody (mAb) mixture, in patients (pts) with anti-EGFR mab-refractory KRAS wild-type (wt) metastatic colorectal cancer (mCRC)
-
Dienstmann R, Tabernero J, Van Cutsem E, et al. Proof-of-concept study of Sym004, an anti-EGFR monoclonal antibody (mAb) mixture, in patients (pts) with anti-EGFR mab-refractory KRAS wild-type (wt) metastatic colorectal cancer (mCRC). J Clin Oncol. 2013; 31 Suppl: 3551.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3551
-
-
Dienstmann, R.1
Tabernero, J.2
Van Cutsem, E.3
-
81
-
-
80054765331
-
A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
-
Schaefer G, Haber L, Crocker LM, et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell. 2011; 20(4): 472-486.
-
(2011)
Cancer Cell
, vol.20
, Issue.4
, pp. 472-486
-
-
Schaefer, G.1
Haber, L.2
Crocker, L.M.3
-
82
-
-
84872525097
-
Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
-
Huang S, Li C, Armstrong EA, et al. Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation. Cancer Res. 2013; 73(2): 824-833.
-
(2013)
Cancer Res
, vol.73
, Issue.2
, pp. 824-833
-
-
Huang, S.1
Li, C.2
Armstrong, E.A.3
-
83
-
-
84874541055
-
A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: Expansion cohorts
-
Cervantes-Ruiperez A, Juric D, Hidalgo M, et al. A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: expansion cohorts. J Clin Oncol. 2012; 30 Suppl: 2568.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2568
-
-
Cervantes-Ruiperez, A.1
Juric, D.2
Hidalgo, M.3
-
84
-
-
84874837435
-
GA201 (RG7160): A novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab
-
Gerdes CA, Nicolini VG, Herter S, et al. GA201 (RG7160): a novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab. Clin Cancer Res. 2013; 19(5): 1126-1138.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 1126-1138
-
-
Gerdes, C.A.1
Nicolini, V.G.2
Herter, S.3
-
85
-
-
84962441335
-
The GAIN-C study (BP25438): Randomized phase II trial of RG7160 (GA201) plus FOLFIRI, compared to cetuximab plus FOLFIRI or FOLFIRI alone in second-line KRAS wild type (WT) or mutant metastatic colorectal cancer (mCRC)
-
Cervantes-Ruiperez A, Markman B, Siena S, et al. The GAIN-C study (BP25438): randomized phase II trial of RG7160 (GA201) plus FOLFIRI, compared to cetuximab plus FOLFIRI or FOLFIRI alone in second-line KRAS wild type (WT) or mutant metastatic colorectal cancer (mCRC). J Clin Oncol. 2012; 30 Suppl: TPS3637.
-
(2012)
J Clin Oncol
, vol.30
-
-
Cervantes-Ruiperez, A.1
Markman, B.2
Siena, S.3
-
86
-
-
84962392532
-
Long-term efficacy and pharmacodynamic parameter analysis in pretreated KRAS-mutant metastatic colorectal carcinoma (mCRC) patients treated with RG7160 (GA201), an antibody-dependent cellular cytotoxicity (ADCC)-enhanced monoclonal anti-EGFR antibody
-
Delord JP, Tabernero J, Garcia-Carbonero R, et al. Long-term efficacy and pharmacodynamic parameter analysis in pretreated KRAS-mutant metastatic colorectal carcinoma (mCRC) patients treated with RG7160 (GA201), an antibody-dependent cellular cytotoxicity (ADCC)-enhanced monoclonal anti-EGFR antibody. J Clin Oncol. 2013; 31 Suppl 4: 379.
-
(2013)
J Clin Oncol
, vol.31
, pp. 379
-
-
Delord, J.P.1
Tabernero, J.2
Garcia-Carbonero, R.3
-
87
-
-
84862772839
-
A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
-
Bertotti A, Migliardi G, Galimi F, et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov. 2011; 1(6): 508-523.
-
(2011)
Cancer Discov
, vol.1
, Issue.6
, pp. 508-523
-
-
Bertotti, A.1
Migliardi, G.2
Galimi, F.3
-
88
-
-
78649723255
-
PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
-
Kopetz S, Desai J, Chan E, et al. PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. J Clin Oncol. 2010; 28(15 Suppl): 3534.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15
, pp. 3534
-
-
Kopetz, S.1
Desai, J.2
Chan, E.3
-
89
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012; 483(7387): 100-103.
-
(2012)
Nature
, vol.483
, Issue.7387
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
90
-
-
84861863158
-
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
-
Corcoran RB, Ebi H, Turke AB, et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov. 2012; 2(3): 227-235.
-
(2012)
Cancer Discov
, vol.2
, Issue.3
, pp. 227-235
-
-
Corcoran, R.B.1
Ebi, H.2
Turke, A.B.3
-
91
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P, Tsai J, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010; 467(7315): 596-599.
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
92
-
-
84863012433
-
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer
-
Yang H, Higgins B, Kolinsky K, et al. Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. Cancer Res. 2012; 72(3): 779-789.
-
(2012)
Cancer Res
, vol.72
, Issue.3
, pp. 779-789
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
-
93
-
-
84927604543
-
Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients
-
Yaeger R, Cercek A, O'Reilly EM, et al. Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients. Clin Cancer Res. 2015; 21(6): 1313-1320.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.6
, pp. 1313-1320
-
-
Yaeger, R.1
Cercek, A.2
O'Reilly, E.M.3
-
94
-
-
84919393400
-
Phase I study of the selective BRAFV600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced BRAF-mutant colorectal cancer
-
Van Geel R, Elez E, Bendell JC, et al. Phase I study of the selective BRAFV600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced BRAF-mutant colorectal cancer. J Clin Oncol. 2014; 32(5 Suppl): 3514.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
, pp. 3514
-
-
Van Geel, R.1
Elez, E.2
Bendell, J.C.3
-
95
-
-
84923100781
-
Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC)
-
Bendell JC, Atreya CE, André T, et al. Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC). J Clin Oncol. 2014; 32(5 Suppl): 3515.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
, pp. 3515
-
-
Bendell, J.C.1
Atreya, C.E.2
André, T.3
-
96
-
-
0031309169
-
Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases
-
Fujita S, Sugano K. Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases. Jpn J Clin Oncol. 1997; 27(6): 378-383.
-
(1997)
Jpn J Clin Oncol
, vol.27
, Issue.6
, pp. 378-383
-
-
Fujita, S.1
Sugano, K.2
-
97
-
-
43949111293
-
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
-
Zeng ZS, Weiser MR, Kuntz E, et al. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Lett. 2008; 265(2): 258-269.
-
(2008)
Cancer Lett
, vol.265
, Issue.2
, pp. 258-269
-
-
Zeng, Z.S.1
Weiser, M.R.2
Kuntz, E.3
-
98
-
-
0034131506
-
Functional expression of HGF and its receptor in human colorectal cancer
-
Otte JM, Schmitz F, Kiehne K, et al. Functional expression of HGF and its receptor in human colorectal cancer. Digestion. 2000; 61(4): 237-246.
-
(2000)
Digestion
, vol.61
, Issue.4
, pp. 237-246
-
-
Otte, J.M.1
Schmitz, F.2
Kiehne, K.3
-
99
-
-
0028946604
-
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
-
Di Renzo MF, Olivero M, Giacomini A, et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res. 1995; 1(2): 147-154.
-
(1995)
Clin Cancer Res
, vol.1
, Issue.2
, pp. 147-154
-
-
Di Renzo, M.F.1
Olivero, M.2
Giacomini, A.3
-
100
-
-
0034327340
-
Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma
-
Kataoka H, Hamasuna R, Itoh H, Kitamura N, Koono M. Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma. Cancer Res. 2000; 60(21): 6148-6159.
-
(2000)
Cancer Res
, vol.60
, Issue.21
, pp. 6148-6159
-
-
Kataoka, H.1
Hamasuna, R.2
Itoh, H.3
Kitamura, N.4
Koono, M.5
-
101
-
-
84922567957
-
Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model
-
Song EK, Tai WM, Messersmith WA, et al. Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model. Int J Cancer. 2015; 136(8): 1967-1975.
-
(2015)
Int J Cancer
, vol.136
, Issue.8
, pp. 1967-1975
-
-
Song, E.K.1
Tai, W.M.2
Messersmith, W.A.3
-
102
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008; 8(12): 915-928.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.12
, pp. 915-928
-
-
Pollak, M.1
-
103
-
-
84888125634
-
Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models
-
Flanigan SA, Pitts TM, Newton TP, et al. Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models. Clin Cancer Res. 2013; 19(22): 6219-6229.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.22
, pp. 6219-6229
-
-
Flanigan, S.A.1
Pitts, T.M.2
Newton, T.P.3
-
104
-
-
84920641580
-
A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours
-
Wilky BA, Rudek MA, Ahmed S, et al. A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours. Br J Cancer. 2015; 112(1): 24-31.
-
(2015)
Br J Cancer
, vol.112
, Issue.1
, pp. 24-31
-
-
Wilky, B.A.1
Rudek, M.A.2
Ahmed, S.3
-
105
-
-
34547209343
-
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
-
McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta. 2007; 1773(8): 1263-1284.
-
(2007)
Biochim Biophys Acta
, vol.1773
, Issue.8
, pp. 1263-1284
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
-
106
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2001; 17: 615-675.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
White, S.4
Timms, J.5
Waterfield, M.D.6
-
107
-
-
84920538174
-
First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors
-
Sarker D, Ang JE, Baird R, et al. First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2015; 21(1): 77-86.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.1
, pp. 77-86
-
-
Sarker, D.1
Ang, J.E.2
Baird, R.3
-
108
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012; 487(7407): 330-337.
-
(2012)
Nature
, vol.487
, Issue.7407
, pp. 330-337
-
-
Cancer Genome Atlas Network1
-
109
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004; 304(5670): 554.
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
110
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 2009; 69(5): 1851-1857.
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
111
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009; 9(8): 550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.8
, pp. 550-562
-
-
Engelman, J.A.1
-
112
-
-
77949881462
-
The PI3K pathway as drug target in human cancer
-
Courtney KD, Corcoran RB, Engelman JA. The PI3K pathway as drug target in human cancer. J Clin Oncol. 2010; 28(6): 1075-1083.
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1075-1083
-
-
Courtney, K.D.1
Corcoran, R.B.2
Engelman, J.A.3
-
113
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000; 103(2): 253-262.
-
(2000)
Cell
, vol.103
, Issue.2
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
114
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006; 66(3): 1500-1508.
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
115
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008; 118(9): 3065-3074.
-
(2008)
J Clin Invest
, vol.118
, Issue.9
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
-
117
-
-
73649112365
-
Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCα
-
Sturgill TW, Hall MN. Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCα. ACS Chem Biol. 2009; 4(12): 999-1015.
-
(2009)
ACS Chem Biol
, vol.4
, Issue.12
, pp. 999-1015
-
-
Sturgill, T.W.1
Hall, M.N.2
-
118
-
-
77953609118
-
Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
-
Zitzmann K, Ruden J, Brand S, et al. Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease. Cancer Lett. 2010; 295(1): 100-109.
-
(2010)
Cancer Lett
, vol.295
, Issue.1
, pp. 100-109
-
-
Zitzmann, K.1
Ruden, J.2
Brand, S.3
-
119
-
-
77954296394
-
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
-
She QB, Halilovic E, Ye Q, et al. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell. 2010; 18(1): 39-51.
-
(2010)
Cancer Cell
, vol.18
, Issue.1
, pp. 39-51
-
-
She, Q.B.1
Halilovic, E.2
Ye, Q.3
-
120
-
-
84863411136
-
The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models
-
Holt SV, Logie A, Odedra R, et al. The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models. Br J Cancer. 2012; 106(5): 858-866.
-
(2012)
Br J Cancer
, vol.106
, Issue.5
, pp. 858-866
-
-
Holt, S.V.1
Logie, A.2
Odedra, R.3
-
121
-
-
84874646171
-
A phase I dose escalation study of oral MK-2206 (allosteric Akt inhibitor) with oral selumetinib (AZD6244; ARRY-142866) (MEK 1/2 inhibitor) in patients with advanced or metastatic solid tumors
-
Khan KH, Yan L, Mezynski J, et al. A phase I dose escalation study of oral MK-2206 (allosteric Akt inhibitor) with oral selumetinib (AZD6244; ARRY-142866) (MEK 1/2 inhibitor) in patients with advanced or metastatic solid tumors. J Clin Oncol. 2012; 30 Suppl: e13599.
-
(2012)
J Clin Oncol
, vol.30
-
-
Khan, K.H.1
Yan, L.2
Mezynski, J.3
-
122
-
-
84891851458
-
MEK in cancer and cancer therapy
-
Neuzillet C, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S, Raymond E. MEK in cancer and cancer therapy. Pharmacol Ther. 2014; 141(2): 160-171.
-
(2014)
Pharmacol Ther
, vol.141
, Issue.2
, pp. 160-171
-
-
Neuzillet, C.1
Tijeras-Raballand, A.2
de Mestier, L.3
Cros, J.4
Faivre, S.5
Raymond, E.6
-
123
-
-
84887260065
-
Combination of a MEK inhibitor, pimasertib (MSC1936369B), and a PI3K/mTOR inhibitor, SAR245409, in patients with advanced solid tumors: Results of a phase IB dose-escalation trial
-
Heist RS, Gandhi L, Shapiro G, et al. Combination of a MEK inhibitor, pimasertib (MSC1936369B), and a PI3K/mTOR inhibitor, SAR245409, in patients with advanced solid tumors: Results of a phase IB dose-escalation trial. J Clin Oncol. 2013; 31 Suppl: 2530.
-
(2013)
J Clin Oncol
, vol.31
, pp. 2530
-
-
Heist, R.S.1
Gandhi, L.2
Shapiro, G.3
-
124
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(10): 1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
125
-
-
43749088703
-
KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature
-
author reply 2230-2231
-
de Reynies A, Boige V, Milano G, Faivre J, Laurent-Puig P. KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature. J Clin Oncol. 2008; 26(13): 2228-2230; author reply 2230-2231.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2228-2230
-
-
de Reynies, A.1
Boige, V.2
Milano, G.3
Faivre, J.4
Laurent-Puig, P.5
-
126
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A, Bachet JB, Boige V, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008; 26(3): 374-379.
-
(2008)
J Clin Oncol
, vol.26
, Issue.3
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
-
127
-
-
66249116702
-
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
-
Wee S, Jagani Z, Xiang KX, et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 2009; 69(10): 4286-4293.
-
(2009)
Cancer Res
, vol.69
, Issue.10
, pp. 4286-4293
-
-
Wee, S.1
Jagani, Z.2
Xiang, K.X.3
-
128
-
-
84880020762
-
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention
-
Rad R, Cadinanos J, Rad L, et al. A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell. 2013; 24(1): 15-29.
-
(2013)
Cancer Cell
, vol.24
, Issue.1
, pp. 15-29
-
-
Rad, R.1
Cadinanos, J.2
Rad, L.3
-
129
-
-
84873360893
-
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
-
Mao M, Tian F, Mariadason JM, et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res. 2013; 19(3): 657-667.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.3
, pp. 657-667
-
-
Mao, M.1
Tian, F.2
Mariadason, J.M.3
-
130
-
-
33846193290
-
The many ways of Wnt in cancer
-
Polakis P. The many ways of Wnt in cancer. Curr Opin Genet Dev. 2007; 17(1): 45-51.
-
(2007)
Curr Opin Genet Dev
, vol.17
, Issue.1
, pp. 45-51
-
-
Polakis, P.1
-
131
-
-
77956904030
-
Colorectal tumors are effectively eradicated by combined inhibition of β-catenin, KRAS, and the oncogenic transcription factor ITF2
-
Mologni L, Dekhil H, Ceccon M, et al. Colorectal tumors are effectively eradicated by combined inhibition of β-catenin, KRAS, and the oncogenic transcription factor ITF2. Cancer Res. 2010; 70(18): 7253-7263.
-
(2010)
Cancer Res
, vol.70
, Issue.18
, pp. 7253-7263
-
-
Mologni, L.1
Dekhil, H.2
Ceccon, M.3
-
132
-
-
77953715690
-
Targeting Wnt signaling: Can we safely eradicate cancer stem cells?
-
Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res. 2010; 16(12): 3153-3162.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.12
, pp. 3153-3162
-
-
Takahashi-Yanaga, F.1
Kahn, M.2
-
133
-
-
84903767326
-
Can we safely target the WNT pathway?
-
Kahn M. Can we safely target the WNT pathway? Nat Rev Drug Discov. 2014; 13(7): 513-532.
-
(2014)
Nat Rev Drug Discov
, vol.13
, Issue.7
, pp. 513-532
-
-
Kahn, M.1
-
134
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
-
Lepourcelet M, Chen YN, France DS, et al. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex. Cancer Cell. 2004; 5(1): 91-102.
-
(2004)
Cancer Cell
, vol.5
, Issue.1
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.N.2
France, D.S.3
-
135
-
-
4344587136
-
A small molecule inhibitor of β-catenin/CREB-binding protein transcription [corrected]
-
Emami KH, Nguyen C, Ma H, et al. A small molecule inhibitor of β-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A. 2004; 101(34): 12682-12687.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.34
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
-
136
-
-
28544444039
-
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis
-
Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis. Science. 2005; 310(5753): 1504-1510.
-
(2005)
Science
, vol.310
, Issue.5753
, pp. 1504-1510
-
-
Castellone, M.D.1
Teramoto, H.2
Williams, B.O.3
Druey, K.M.4
Gutkind, J.S.5
-
137
-
-
22544475938
-
Prostaglandin E2 stimulates the β-catenin/T cell factor-dependent transcription in colon cancer
-
Shao J, Jung C, Liu C, Sheng H. Prostaglandin E2 stimulates the β-catenin/T cell factor-dependent transcription in colon cancer. J Biol Chem. 2005; 280(28): 26565-26572.
-
(2005)
J Biol Chem
, vol.280
, Issue.28
, pp. 26565-26572
-
-
Shao, J.1
Jung, C.2
Liu, C.3
Sheng, H.4
-
138
-
-
84884194711
-
A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors
-
El-Khoueiry AB, Ning Y, Yang D, et al. A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors. J Clin Oncol. 2013; 31 Suppl: 2501.
-
(2013)
J Clin Oncol
, vol.31
, pp. 2501
-
-
El-Khoueiry, A.B.1
Ning, Y.2
Yang, D.3
-
139
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen B, Dodge ME, Tang W, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009; 5(2): 100-107.
-
(2009)
Nat Chem Biol
, vol.5
, Issue.2
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
-
140
-
-
58249105072
-
Novel Wnt antagonists target porcupine and Axin
-
Yeh JR, Peterson RT. Novel Wnt antagonists target porcupine and Axin. Nat Chem Biol. 2009; 5(2): 74-75.
-
(2009)
Nat Chem Biol
, vol.5
, Issue.2
, pp. 74-75
-
-
Yeh, J.R.1
Peterson, R.T.2
-
142
-
-
84861843671
-
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
-
Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012; 72(11): 2822-2832.
-
(2012)
Cancer Res
, vol.72
, Issue.11
, pp. 2822-2832
-
-
Waaler, J.1
Machon, O.2
Tumova, L.3
-
143
-
-
84863938543
-
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
-
Gurney A, Axelrod F, Bond CJ, et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A. 2012; 109(29): 11717-11722.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.29
, pp. 11717-11722
-
-
Gurney, A.1
Axelrod, F.2
Bond, C.J.3
-
144
-
-
84938196991
-
A first-in-human phase 1 study of anticancer stem cell agent OMP-54F28 (FZD8-Fc), decoy receptor for WNT ligands, in patients with advanced solid tumors
-
Jimeno A, Gordon MS, Chugh R, et al. A first-in-human phase 1 study of anticancer stem cell agent OMP-54F28 (FZD8-Fc), decoy receptor for WNT ligands, in patients with advanced solid tumors. J Clin Oncol. 2014; 32(5 Suppl): 2505.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
, pp. 2505
-
-
Jimeno, A.1
Gordon, M.S.2
Chugh, R.3
-
145
-
-
0034671686
-
Notch signaling: From the outside in
-
Mumm JS, Kopan R. Notch signaling: from the outside in. Dev Biol. 2000; 228(2): 151-165.
-
(2000)
Dev Biol
, vol.228
, Issue.2
, pp. 151-165
-
-
Mumm, J.S.1
Kopan, R.2
-
146
-
-
50849125368
-
More complicated than it looks: Assembly of Notch pathway transcription complexes
-
Kovall RA. More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene. 2008; 27(38): 5099-5109.
-
(2008)
Oncogene
, vol.27
, Issue.38
, pp. 5099-5109
-
-
Kovall, R.A.1
-
147
-
-
84859484685
-
A phase II study of RO4929097 in metastatic colorectal cancer
-
Strosberg JR, Yeatman T, Weber J, et al. A phase II study of RO4929097 in metastatic colorectal cancer. Eur J Cancer. 2012; 48(7): 997-1003.
-
(2012)
Eur J Cancer
, vol.48
, Issue.7
, pp. 997-1003
-
-
Strosberg, J.R.1
Yeatman, T.2
Weber, J.3
-
148
-
-
58349091690
-
γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
-
Meng RD, Shelton CC, Li YM, et al. γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009; 69(2): 573-582.
-
(2009)
Cancer Res
, vol.69
, Issue.2
, pp. 573-582
-
-
Meng, R.D.1
Shelton, C.C.2
Li, Y.M.3
-
149
-
-
84896391556
-
A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
-
Richter S, Bedard PL, Chen EX, et al. A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575). Invest New Drugs. 2014; 32(2): 243-249.
-
(2014)
Invest New Drugs
, vol.32
, Issue.2
, pp. 243-249
-
-
Richter, S.1
Bedard, P.L.2
Chen, E.X.3
-
150
-
-
84861461140
-
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer
-
Arcaroli JJ, Powell RW, Varella-Garcia M, et al. ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer. Mol Oncol. 2012; 6(3): 370-381.
-
(2012)
Mol Oncol
, vol.6
, Issue.3
, pp. 370-381
-
-
Arcaroli, J.J.1
Powell, R.W.2
Varella-Garcia, M.3
-
151
-
-
84920509474
-
A phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014
-
Messersmith WA, Shapiro GI, Cleary JM, et al. A phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014. Clin Cancer Res. 2015; 21(1): 60-67.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.1
, pp. 60-67
-
-
Messersmith, W.A.1
Shapiro, G.I.2
Cleary, J.M.3
-
152
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001; 15(23): 3059-3087.
-
(2001)
Genes Dev
, vol.15
, Issue.23
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
153
-
-
0002452569
-
Developmental roles and clinical significance of Hedgehog signaling
-
McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of Hedgehog signaling. Curr Top Dev Biol. 2003; 53: 1-114.
-
(2003)
Curr Top Dev Biol
, vol.53
, pp. 1-114
-
-
McMahon, A.P.1
Ingham, P.W.2
Tabin, C.J.3
-
154
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004; 432(7015): 324-331.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
155
-
-
0023091971
-
Identification of an amplified, highly expressed gene in a human glioma
-
Kinzler KW, Bigner SH, Bigner DD, et al. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987; 236(4797): 70-73.
-
(1987)
Science
, vol.236
, Issue.4797
, pp. 70-73
-
-
Kinzler, K.W.1
Bigner, S.H.2
Bigner, D.D.3
-
156
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
-
Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res. 2004; 64(17): 6071-6074.
-
(2004)
Cancer Res
, vol.64
, Issue.17
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
-
157
-
-
27144541492
-
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
-
Ma X, Chen K, Huang S, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005; 26(10): 1698-1705.
-
(2005)
Carcinogenesis
, vol.26
, Issue.10
, pp. 1698-1705
-
-
Ma, X.1
Chen, K.2
Huang, S.3
-
158
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003; 425(6960): 851-856.
-
(2003)
Nature
, vol.425
, Issue.6960
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
-
159
-
-
29744463531
-
Deregulation of the Hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
-
Tostar U, Malm CJ, Meis-Kindblom JM, Kindblom LG, Toftgård R, Undén AB. Deregulation of the Hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol. 2006; 208(1): 17-25.
-
(2006)
J Pathol
, vol.208
, Issue.1
, pp. 17-25
-
-
Tostar, U.1
Malm, C.J.2
Meis-Kindblom, J.M.3
Kindblom, L.G.4
Toftgård, R.5
Undén, A.B.6
-
160
-
-
0033990220
-
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma
-
Zurawel RH, Allen C, Chiappa S, et al. Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma. Genes Chromosomes Cancer. 2000; 27(1): 44-51.
-
(2000)
Genes Chromosomes Cancer
, vol.27
, Issue.1
, pp. 44-51
-
-
Zurawel, R.H.1
Allen, C.2
Chiappa, S.3
-
161
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
di Magliano MP, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003; 3(12): 903-911.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.12
, pp. 903-911
-
-
di Magliano, M.P.1
Hebrok, M.2
-
162
-
-
0141728540
-
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
-
Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond PP. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol. 2003; 5(10): 907-913.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.10
, pp. 907-913
-
-
Ruel, L.1
Rodriguez, R.2
Gallet, A.3
Lavenant-Staccini, L.4
Therond, P.P.5
-
163
-
-
33646407865
-
Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer
-
Douard R, Moutereau S, Pernet P, et al. Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Surgery. 2006; 139(5): 665-670.
-
(2006)
Surgery
, vol.139
, Issue.5
, pp. 665-670
-
-
Douard, R.1
Moutereau, S.2
Pernet, P.3
-
164
-
-
78649307157
-
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas
-
Varnat F, Siegl-Cachedenier I, Malerba M, Gervaz P, Altaba AR. Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med. 2010; 2(11): 440-457.
-
(2010)
EMBO Mol Med
, vol.2
, Issue.11
, pp. 440-457
-
-
Varnat, F.1
Siegl-Cachedenier, I.2
Malerba, M.3
Gervaz, P.4
Altaba, A.R.5
-
165
-
-
77952911825
-
Hedgehog signalling in colon cancer and stem cells
-
Gulino A, Ferretti E, De Smaele E. Hedgehog signalling in colon cancer and stem cells. EMBO Mol Med. 2009; 1(6-7): 300-302.
-
(2009)
EMBO Mol Med
, vol.1
, Issue.6-7
, pp. 300-302
-
-
Gulino, A.1
Ferretti, E.2
De Smaele, E.3
-
166
-
-
84874453448
-
Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes
-
Iwasaki H, Nakano K, Shinkai K, et al. Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes. Cancer Sci. 2013; 104(3): 328-336.
-
(2013)
Cancer Sci
, vol.104
, Issue.3
, pp. 328-336
-
-
Iwasaki, H.1
Nakano, K.2
Shinkai, K.3
-
167
-
-
84899482439
-
Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39
-
Bassilana F, Carlson A, DaSilva JA, et al. Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nat Chem Biol. 2014; 10(5): 343-349.
-
(2014)
Nat Chem Biol
, vol.10
, Issue.5
, pp. 343-349
-
-
Bassilana, F.1
Carlson, A.2
DaSilva, J.A.3
-
168
-
-
84903216540
-
Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies
-
Banerjee U, Hadden MK. Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies. Expert Opin Drug Discov. 2014; 9(7): 751-771.
-
(2014)
Expert Opin Drug Discov
, vol.9
, Issue.7
, pp. 751-771
-
-
Banerjee, U.1
Hadden, M.K.2
-
169
-
-
78650493853
-
A phase 2, randomized, double-blind, placebo-controlled study of Hedgehog pathway inhibitor (HPI) GDC-0449 in patients with previously untreated metastatic colorectal cancer (mCRC)
-
Berlin J, Bendell J, Hart LL, et al. A phase 2, randomized, double-blind, placebo-controlled study of Hedgehog pathway inhibitor (HPI) GDC-0449 in patients with previously untreated metastatic colorectal cancer (mCRC). Ann Oncol. 2010; 21 Suppl 8: viii10.
-
(2010)
Ann Oncol
, vol.21
-
-
Berlin, J.1
Bendell, J.2
Hart, L.L.3
-
170
-
-
84865270456
-
The utility of Hedgehog signaling pathway inhibition for cancer
-
Sahebjam S, Siu LL, Razak AA. The utility of Hedgehog signaling pathway inhibition for cancer. Oncologist. 2012; 17(8): 1090-1099.
-
(2012)
Oncologist
, vol.17
, Issue.8
, pp. 1090-1099
-
-
Sahebjam, S.1
Siu, L.L.2
Razak, A.A.3
-
171
-
-
79551540949
-
Hedgehog signaling drives cellular survival in human colon carcinoma cells
-
Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011; 71(3): 1092-1102.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 1092-1102
-
-
Mazumdar, T.1
DeVecchio, J.2
Shi, T.3
Jones, J.4
Agyeman, A.5
Houghton, J.A.6
-
172
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science. 2009; 326(5952): 572-574.
-
(2009)
Science
, vol.326
, Issue.5952
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
-
173
-
-
78751520029
-
Small molecule inhibition of GDC-0449 refractory Smoothened mutants and downstream mechanisms of drug resistance
-
Dijkgraaf GJ, Alicke B, Weinmann L, et al. Small molecule inhibition of GDC-0449 refractory Smoothened mutants and downstream mechanisms of drug resistance. Cancer Res. 2011; 71(2): 435-444.
-
(2011)
Cancer Res
, vol.71
, Issue.2
, pp. 435-444
-
-
Dijkgraaf, G.J.1
Alicke, B.2
Weinmann, L.3
-
174
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
-
Buonamici S, Williams J, Morrissey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med. 2010; 2(51): 51ra70.
-
(2010)
Sci Transl Med
, vol.2
, Issue.51
-
-
Buonamici, S.1
Williams, J.2
Morrissey, M.3
-
176
-
-
0141750434
-
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
-
Aza-Blanc P, Cooper CL, Wagner K, Batalov S, Deveraux QL, Cooke MP. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol Cell. 2003; 12(3): 627-637.
-
(2003)
Mol Cell
, vol.12
, Issue.3
, pp. 627-637
-
-
Aza-Blanc, P.1
Cooper, C.L.2
Wagner, K.3
Batalov, S.4
Deveraux, Q.L.5
Cooke, M.P.6
-
177
-
-
81755161607
-
Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer
-
Soria JC, Mark Z, Zatloukal P, et al. Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer. J Clin Oncol. 2011; 29(33): 4442-4451.
-
(2011)
J Clin Oncol
, vol.29
, Issue.33
, pp. 4442-4451
-
-
Soria, J.C.1
Mark, Z.2
Zatloukal, P.3
-
178
-
-
42749092258
-
TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them
-
Thorburn A, Behbakht K, Ford H. TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them. Drug Resist Updat. 2008; 11(1-2): 17-24.
-
(2008)
Drug Resist Updat
, vol.11
, Issue.1-2
, pp. 17-24
-
-
Thorburn, A.1
Behbakht, K.2
Ford, H.3
-
179
-
-
77952893976
-
Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer
-
Rosevear HM, Lightfoot AJ, Griffith TS. Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer. Curr Opin Investig Drugs. 2010; 11(6): 688-698.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, Issue.6
, pp. 688-698
-
-
Rosevear, H.M.1
Lightfoot, A.J.2
Griffith, T.S.3
-
180
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013; 369(2): 122-133.
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
181
-
-
77955292303
-
Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
-
Chung KY, Gore I, Fong L, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol. 2010; 28(21): 3485-3490.
-
(2010)
J Clin Oncol
, vol.28
, Issue.21
, pp. 3485-3490
-
-
Chung, K.Y.1
Gore, I.2
Fong, L.3
-
182
-
-
84872514622
-
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
-
Lipson EJ, Sharfman WH, Drake CG, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res. 2013; 19(2): 462-468.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.2
, pp. 462-468
-
-
Lipson, E.J.1
Sharfman, W.H.2
Drake, C.G.3
-
183
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010; 28(19): 3167-3175.
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
184
-
-
84938313517
-
Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumours
-
Lieu C, Bendell J, Powderly JD, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumours. Ann Oncol. 2014; 25 Suppl 4: iv361-iv372.
-
(2014)
Ann Oncol
, vol.25
, pp. iv361-iv372
-
-
Lieu, C.1
Bendell, J.2
Powderly, J.D.3
-
185
-
-
85042893233
-
Imprime PGG plus cetuximab therapy for advanced KRAS mutant colorectal cancer
-
Segal NH, Senzer N, Gada P, et al. Imprime PGG plus cetuximab therapy for advanced KRAS mutant colorectal cancer. Annals of Oncology. 2011; 22 Suppl 5: v22.
-
(2011)
Annals of Oncology
, vol.22
-
-
Segal, N.H.1
Senzer, N.2
Gada, P.3
-
186
-
-
0030035119
-
Soluble β-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells
-
Vetvicka V, Thornton BP, Ross GD. Soluble β-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J Clin Invest. 1996; 98(1): 50-61.
-
(1996)
J Clin Invest
, vol.98
, Issue.1
, pp. 50-61
-
-
Vetvicka, V.1
Thornton, B.P.2
Ross, G.D.3
-
187
-
-
84902137525
-
Targeting CD137 enhances the efficacy of cetuximab
-
Kohrt HE, Colevas AD, Houot R, et al. Targeting CD137 enhances the efficacy of cetuximab. J Clin Invest. 2014; 124(6): 2668-2682.
-
(2014)
J Clin Invest
, vol.124
, Issue.6
, pp. 2668-2682
-
-
Kohrt, H.E.1
Colevas, A.D.2
Houot, R.3
-
188
-
-
84860174226
-
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
-
Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012; 109(17): 6662-6667.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.17
, pp. 6662-6667
-
-
Willingham, S.B.1
Volkmer, J.P.2
Gentles, A.J.3
-
189
-
-
84879733796
-
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response
-
Tseng D, Volkmer JP, Willingham SB, et al. Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc Natl Acad Sci U S A. 2013; 110(27): 11103-11108.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.27
, pp. 11103-11108
-
-
Tseng, D.1
Volkmer, J.P.2
Willingham, S.B.3
-
190
-
-
77950944395
-
Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
-
Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol. 2010; 22(2): 231-237.
-
(2010)
Curr Opin Immunol
, vol.22
, Issue.2
, pp. 231-237
-
-
Mantovani, A.1
Sica, A.2
-
191
-
-
31544441610
-
Distinct role of macrophages in different tumor microenvironments
-
Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006; 66(2): 605-612.
-
(2006)
Cancer Res
, vol.66
, Issue.2
, pp. 605-612
-
-
Lewis, C.E.1
Pollard, J.W.2
-
192
-
-
84876424760
-
Macrophage regulation of tumor responses to anticancer therapies
-
De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell. 2013; 23(3): 277-286.
-
(2013)
Cancer Cell
, vol.23
, Issue.3
, pp. 277-286
-
-
De Palma, M.1
Lewis, C.E.2
-
193
-
-
84921916858
-
Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside
-
Jinushi M, Komohara Y. Tumor-associated macrophages as an emerging target against tumors: creating a new path from bench to bedside. Biochim Biophys Acta. 2015; 1855(2): 123-130.
-
(2015)
Biochim Biophys Acta
, vol.1855
, Issue.2
, pp. 123-130
-
-
Jinushi, M.1
Komohara, Y.2
-
194
-
-
79955517032
-
TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice
-
Welford AF, Biziato D, Coffelt SB, et al. TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. J Clin Invest. 2011; 121(5): 1969-1973.
-
(2011)
J Clin Invest
, vol.121
, Issue.5
, pp. 1969-1973
-
-
Welford, A.F.1
Biziato, D.2
Coffelt, S.B.3
-
195
-
-
84930671005
-
Phase IB study of FOLFIRINOX plus PF-04136309 in patients with borderline resectable and locally advanced pancreatic adenocarcinoma (PC)
-
Wang-Gillam A, Nywening TM, Sanford DE, et al. Phase IB study of FOLFIRINOX plus PF-04136309 in patients with borderline resectable and locally advanced pancreatic adenocarcinoma (PC). J Clin Oncol. 2015; 33 Suppl 3: 338.
-
(2015)
J Clin Oncol
, vol.33
, pp. 338
-
-
Wang-Gillam, A.1
Nywening, T.M.2
Sanford, D.E.3
-
196
-
-
1242315588
-
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
-
Demaria S, Ng B, Devitt ML, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004; 58(3): 862-870.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, Issue.3
, pp. 862-870
-
-
Demaria, S.1
Ng, B.2
Devitt, M.L.3
-
197
-
-
75349083568
-
Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation
-
Garg AD, Nowis D, Golab J, Vandenabeele P, Krysko DV, Agostinis P. Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim Biophys Acta. 2010; 1805(1): 53-71.
-
(2010)
Biochim Biophys Acta
, vol.1805
, Issue.1
, pp. 53-71
-
-
Garg, A.D.1
Nowis, D.2
Golab, J.3
Vandenabeele, P.4
Krysko, D.V.5
Agostinis, P.6
-
198
-
-
84875039618
-
Combining radiotherapy and cancer immunotherapy: A paradigm shift
-
Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst. 2013; 105(4): 256-265.
-
(2013)
J Natl Cancer Inst
, vol.105
, Issue.4
, pp. 256-265
-
-
Formenti, S.C.1
Demaria, S.2
-
199
-
-
58849107200
-
Combining radiation and immunotherapy for synergistic antitumor therapy
-
Ferrara TA, Hodge JW, Gulley JL. Combining radiation and immunotherapy for synergistic antitumor therapy. Curr Opin Mol Ther. 2009; 11(1): 37-42.
-
(2009)
Curr Opin Mol Ther
, vol.11
, Issue.1
, pp. 37-42
-
-
Ferrara, T.A.1
Hodge, J.W.2
Gulley, J.L.3
-
200
-
-
69949085196
-
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
-
Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009; 15(17): 5379-5388.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.17
, pp. 5379-5388
-
-
Dewan, M.Z.1
Galloway, A.E.2
Kawashima, N.3
-
201
-
-
84887618161
-
Genome-wide association and sequencing studies on colorectal cancer
-
Wong SH, Sung JJ, Chan FK, et al. Genome-wide association and sequencing studies on colorectal cancer. Semin Cancer Biol. 2013; 23(6 Pt B): 502-511.
-
(2013)
Semin Cancer Biol
, vol.23
, Issue.6
, pp. 502-511
-
-
Wong, S.H.1
Sung, J.J.2
Chan, F.K.3
-
202
-
-
84877619075
-
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
-
Sadanandam A, Lyssiotis CA, Homicsko K, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med. 2013; 19(5): 619-625.
-
(2013)
Nat Med
, vol.19
, Issue.5
, pp. 619-625
-
-
Sadanandam, A.1
Lyssiotis, C.A.2
Homicsko, K.3
-
203
-
-
84871676568
-
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
-
Schlicker A, Beran G, Chresta CM, et al. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med Genomics. 2012; 5: 66.
-
(2012)
BMC Med Genomics
, vol.5
, pp. 66
-
-
Schlicker, A.1
Beran, G.2
Chresta, C.M.3
-
204
-
-
0023262535
-
Lung recurrence after curative surgery for colorectal cancer
-
Pihl E, Hughes ES, McDermott FT, Johnson WR, Katrivessis H. Lung recurrence after curative surgery for colorectal cancer. Dis Colon Rectum. 1987; 30(6): 417-419.
-
(1987)
Dis Colon Rectum
, vol.30
, Issue.6
, pp. 417-419
-
-
Pihl, E.1
Hughes, E.S.2
McDermott, F.T.3
Johnson, W.R.4
Katrivessis, H.5
-
205
-
-
0035185894
-
Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: Parallel pathways of tumorigenesis
-
Young J, Simms LA, Biden KG, et al. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol. 2001; 159(6): 2107-2116.
-
(2001)
Am J Pathol
, vol.159
, Issue.6
, pp. 2107-2116
-
-
Young, J.1
Simms, L.A.2
Biden, K.G.3
-
206
-
-
0033579863
-
Survival of patients with hereditary colorectal cancer: Comparison of HNPCC and colorectal cancer in FAP patients with sporadic colorectal cancer
-
Bertario L, Russo A, Sala P, et al. Survival of patients with hereditary colorectal cancer: comparison of HNPCC and colorectal cancer in FAP patients with sporadic colorectal cancer. Int J Cancer. 1999; 80(2): 183-187.
-
(1999)
Int J Cancer
, vol.80
, Issue.2
, pp. 183-187
-
-
Bertario, L.1
Russo, A.2
Sala, P.3
-
207
-
-
84941024773
-
Rectal and colon cancer: Not just a different anatomic site
-
Tamas K, Walenkamp AM, de Vries EG, et al. Rectal and colon cancer: not just a different anatomic site. Cancer Treat Rev. 2015; 41(8): 671-679.
-
(2015)
Cancer Treat Rev
, vol.41
, Issue.8
, pp. 671-679
-
-
Tamas, K.1
Walenkamp, A.M.2
de Vries, E.G.3
-
208
-
-
84927171452
-
Primary tumor location as a prognostic factor in metastatic colorectal cancer
-
pii: dju427
-
Loupakis F, Yang D, Yau L, et al. Primary tumor location as a prognostic factor in metastatic colorectal cancer. J Natl Cancer Inst. 2015; 107(3). pii: dju427.
-
(2015)
J Natl Cancer Inst
, vol.107
, Issue.3
-
-
Loupakis, F.1
Yang, D.2
Yau, L.3
-
209
-
-
3042656476
-
Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect-a histopathological and immunohistochemical study
-
Nagtegaal ID, Marijnen CA, Kranenbarg EK, et al. Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect-a histopathological and immunohistochemical study. BMC Cancer. 2001; 1: 7.
-
(2001)
BMC Cancer
, vol.1
, pp. 7
-
-
Nagtegaal, I.D.1
Marijnen, C.A.2
Kranenbarg, E.K.3
-
210
-
-
0031422881
-
Protein bound polysaccharide PSK abrogates more efficiently experimental metastases derived from H-2 negative than from H-2 positive fibrosarcoma tumor clones
-
Algarra I, Collado A, Garrido F. Protein bound polysaccharide PSK abrogates more efficiently experimental metastases derived from H-2 negative than from H-2 positive fibrosarcoma tumor clones. J Exp Clin Cancer Res. 1997; 16(4): 373-380.
-
(1997)
J Exp Clin Cancer Res
, vol.16
, Issue.4
, pp. 373-380
-
-
Algarra, I.1
Collado, A.2
Garrido, F.3
-
211
-
-
77951074212
-
Effects of preoperative immunochemoradiotherapy and chemoradiotherapy on immune responses in patients with rectal adenocarcinoma
-
Sadahiro S, Suzuki T, Maeda Y, et al. Effects of preoperative immunochemoradiotherapy and chemoradiotherapy on immune responses in patients with rectal adenocarcinoma. Anticancer Res. 2010; 30(3): 993-999.
-
(2010)
Anticancer Res
, vol.30
, Issue.3
, pp. 993-999
-
-
Sadahiro, S.1
Suzuki, T.2
Maeda, Y.3
-
212
-
-
10744221102
-
Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes
-
Kanazawa M, Mori Y, Yoshihara K, et al. Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes. Immunol Lett. 2004; 91(2-3): 229-238.
-
(2004)
Immunol Lett
, vol.91
, Issue.2-3
, pp. 229-238
-
-
Kanazawa, M.1
Mori, Y.2
Yoshihara, K.3
-
213
-
-
84929484187
-
CXCR4 and CXCL12 expression in rectal tumors of stage IV patients before and after local radiotherapy and systemic neoadjuvant treatment
-
Tamas K, Domanska UM, van Dijk TH, et al. CXCR4 and CXCL12 expression in rectal tumors of stage IV patients before and after local radiotherapy and systemic neoadjuvant treatment. Curr Pharm Des. 2015; 21(17): 2276-2283.
-
(2015)
Curr Pharm Des
, vol.21
, Issue.17
, pp. 2276-2283
-
-
Tamas, K.1
Domanska, U.M.2
van Dijk, T.H.3
-
215
-
-
84891852738
-
Self-renewal as a therapeutic target in human colorectal cancer
-
Kreso A, van Galen P, Pedley NM, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014; 20(1): 29-36.
-
(2014)
Nat Med
, vol.20
, Issue.1
, pp. 29-36
-
-
Kreso, A.1
van Galen, P.2
Pedley, N.M.3
-
216
-
-
80054959395
-
Symmetric division versus asymmetric division: A tale of two coactivators
-
Kahn M. Symmetric division versus asymmetric division: a tale of two coactivators. Future Med Chem. 2011; 3(14): 1745-1763.
-
(2011)
Future Med Chem
, vol.3
, Issue.14
, pp. 1745-1763
-
-
Kahn, M.1
-
217
-
-
84961288878
-
Molecular pathways: Novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells
-
Justilien V, Fields AP. Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res. 2015; 21(3): 505-513.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.3
, pp. 505-513
-
-
Justilien, V.1
Fields, A.P.2
-
218
-
-
80053385552
-
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
-
Bass AJ, Lawrence MS, Brace LE, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet. 2011; 43(10): 964-968.
-
(2011)
Nat Genet
, vol.43
, Issue.10
, pp. 964-968
-
-
Bass, A.J.1
Lawrence, M.S.2
Brace, L.E.3
-
219
-
-
84865459654
-
Recurrent R-spondin fusions in colon cancer
-
Seshagiri S, Stawiski EW, Durinck S, et al. Recurrent R-spondin fusions in colon cancer. Nature. 2012; 488(7413): 660-664.
-
(2012)
Nature
, vol.488
, Issue.7413
, pp. 660-664
-
-
Seshagiri, S.1
Stawiski, E.W.2
Durinck, S.3
-
220
-
-
84924407954
-
Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer
-
Yu J, Wu WK, Li X, et al. Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut. 2015; 64(4): 636-645.
-
(2015)
Gut
, vol.64
, Issue.4
, pp. 636-645
-
-
Yu, J.1
Wu, W.K.2
Li, X.3
-
221
-
-
84924279179
-
In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities
-
Rubio-Perez C, Tamborero D, Schroeder MP, et al. In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities. Cancer Cell. 2015; 27(3): 382-396.
-
(2015)
Cancer Cell
, vol.27
, Issue.3
, pp. 382-396
-
-
Rubio-Perez, C.1
Tamborero, D.2
Schroeder, M.P.3
-
222
-
-
84891757926
-
DriverDB: An exome sequencing database for cancer driver gene identification
-
Cheng WC, Chung IF, Chen CY, et al. DriverDB: an exome sequencing database for cancer driver gene identification. Nucleic Acids Res. 2014; 42(D1): D1048-D1054.
-
(2014)
Nucleic Acids Res
, vol.42
, Issue.D1
, pp. D1048-D1054
-
-
Cheng, W.C.1
Chung, I.F.2
Chen, C.Y.3
-
223
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391(6669): 806-811.
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
224
-
-
84877120847
-
First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
-
Tabernero J, Shapiro GI, LoRusso PM, et al. First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov. 2013; 3(4): 406-417.
-
(2013)
Cancer Discov
, vol.3
, Issue.4
, pp. 406-417
-
-
Tabernero, J.1
Shapiro, G.I.2
LoRusso, P.M.3
-
225
-
-
84927615838
-
Antibody-mediated delivery of anti-KRAS-siRNA in vivo overcomes therapy resistance in colon cancer
-
Baumer S, Baumer N, Appel N, et al. Antibody-mediated delivery of anti-KRAS-siRNA in vivo overcomes therapy resistance in colon cancer. Clin Cancer Res. 2015; 21(6): 1383-1394.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.6
, pp. 1383-1394
-
-
Baumer, S.1
Baumer, N.2
Appel, N.3
-
226
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2): 215-233.
-
(2009)
Cell
, vol.136
, Issue.2
, pp. 215-233
-
-
Bartel, D.P.1
-
227
-
-
84958534027
-
Concurrent targeting of KRAS and AKT by MiR-4689 is a novel treatment against mutant KRAS colorectal cancer
-
Hiraki M, Nishimura J, Takahashi H, et al. Concurrent targeting of KRAS and AKT by MiR-4689 is a novel treatment against mutant KRAS colorectal cancer. Mol Ther Nucleic Acids. 2015; 4: e231.
-
(2015)
Mol Ther Nucleic Acids
, vol.4
-
-
Hiraki, M.1
Nishimura, J.2
Takahashi, H.3
-
228
-
-
84923106217
-
Therapeutic genome editing: Prospects and challenges
-
Cox DB, Platt RJ, Zhang F. Therapeutic genome editing: prospects and challenges. Nat Med. 2015; 21(2): 121-131.
-
(2015)
Nat Med
, vol.21
, Issue.2
, pp. 121-131
-
-
Cox, D.B.1
Platt, R.J.2
Zhang, F.3
|