The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 17, 2012, Pages 6662-6667

  Willingham, Stephen B ^a   Volkmer, Jens Peter ^a,b   Gentles, Andrew J ^b   Sahoo, Debashis ^a   Dalerba, Piero ^a   Mitra, Siddhartha S ^a   Wang, Jian ^c,d   Contreras Trujillo, Humberto ^a   Martin, Robin ^a   Cohen, Justin D ^a   Lovelace, Patricia ^a   Scheeren, Ferenc A ^a   Chao, Mark P ^a   Weiskopf, Kipp ^a   Tang, Chad ^a   Volkmer, Anne Kathrin ^a   Naik, Tejaswitha J ^a   Storm, Theresa A ^a   Mosley, Adriane R ^a   Edris, Badreddin ^a   Schmid, Seraina M ^e   Sun, Chris K ^b   Chua, Mei Sze ^b   Murillo, Oihana ^a   Rajendran, Pradeep ^a   Cha, Adriel C ^a   Chin, Robert K ^a,b   Kim, Dongkyoon ^a   Adorno, Maddalena ^a   Raveh, Tal ^a   Tseng, Diane ^a   Jaiswal, Siddhartha ^a   Enger, Per Øyvind ^c,d   Steinberg, Gary K ^b   Li, Gordon ^b   So, Samuel K ^b   Majeti, Ravindra ^a   Harsh, Griffith R ^b   Van Rijn, Matt De ^a   Teng, Nelson N H ^b   Sunwoo, John B ^a,b   Alizadeh, Ash A ^a   Clarke, Michael F ^a   Weissman, Irving L ^a   more..

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF BERGEN   (Norway)

^e UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD47 ANTIBODY; CD47 ANTIGEN; MONOCLONAL ANTIBODY; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MACROPHAGE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SOLID TUMOR; SURVIVAL TIME;

ANTIBODIES; ANTIGENS, CD47; ANTIGENS, DIFFERENTIATION; CELL DIVISION; FLOW CYTOMETRY; HUMANS; NEOPLASMS; PHAGOCYTOSIS; PROGNOSIS; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; SURVIVAL ANALYSIS;

EID: 84860174226     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121623109     Document Type: Article

References (48)

1. Jaiswal S, Chao MP, Majeti R, Weissman IL (2010) Macrophages as mediators of tumor immunosurveillance. Trends Immunol 31:212-219.
2. Oldenborg PA, Gresham HD, Lindberg FP (2001) CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J Exp Med 193:855-862.
3. Oldenborg PA (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma 45:1319-1327.
4. Blazar BR, et al. (2001) CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med 194:541-549. (Pubitemid 32835048)
5. Jaiswal S, et al. (2009) CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138:271-285.
6. Brown EJ, Frazier WA (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 11:130-135. (Pubitemid 32289443)
7. Jiang P, Lagenaur CF, Narayanan V (1999) Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274:559-562.
8. Oldenborg PA, et al. (2000) Role of CD47 as a marker of self on red blood cells. Science 288:2051-2054.
9. Kharitonenkov A, et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181-186. (Pubitemid 27131446)
10. Fujioka Y, et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2- domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 16:6887-6899. (Pubitemid 26389748)
11. Timms JF, et al. (1998) Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol Cell Biol 18: 3838-3850. (Pubitemid 28287907)
12. Tsai RK, Discher DE (2008) Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol 180:989-1003. (Pubitemid 351398424)
13. Mateo V, et al. (2002) Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cyto-skeleton organization. Blood 100:2882-2890.
14. Rosales C, Gresham HD, Brown EJ (1992) Expression of the 50-kDa integrin-associated protein on myeloid cells and erythrocytes. J Immunol 149:2759-2764.
15. Mawby WJ, Holmes CH, Anstee DJ, Spring FA, Tanner MJ (1994) Isolation and characterization of CD47 glycoprotein: A multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. Biochem J 304:525-530. (Pubitemid 24368233)
16. Chao MP, et al. (2010) Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 142:699-713.
17. Majeti R, et al. (2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138:286-299.
18. Tothill RW, et al.; Australian Ovarian Cancer Study Group (2008) Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 14:5198-5208.
19. Marchini S, et al. (2008) Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res 14:7850-7860.
20. Chung CH, et al. (2004) Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell 5:489-500. (Pubitemid 38610250)
21. Gravendeel LA, et al. (2009) Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res 69:9065-9072.
22. Nutt CL, et al. (2003) Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res 63:1602-1607. (Pubitemid 36373650)
23. Freije WA, et al. (2004) Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64:6503-6510. (Pubitemid 39297907)
24. Lee Y, et al. (2008) Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC Med Genomics 1:52.
25. Smith JJ, et al. (2010) Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology 138: 958-968.
26. Chan KS, et al. (2009) Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci USA 106:14016-14021.
27. Dalerba P, et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104:10158-10163. (Pubitemid 47175279)
28. Sica A, et al. (2008) Macrophage polarization in tumour progression. Semin Cancer Biol 18:349-355.
29. Allavena P, Sica A, Solinas G, Porta C, Mantovani A (2008) The inflammatory microenvironment in tumor progression: The role of tumor-associated macrophages. Crit Rev Oncol Hematol 66:1-9. (Pubitemid 351324128)
30. Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35.
31. Addison CL, et al. (1995) Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model. Proc Natl Acad Sci USA 92:8522-8526.
32. Han X, et al. (2000) CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. J Biol Chem 275:37984-37992. (Pubitemid 32004920)
33. Lindberg FP, Gresham HD, Schwarz E, Brown EJ (1993) Molecular cloning of integrin-associated protein: An immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol 123:485-496. (Pubitemid 23313971)
34. Ogden CA, et al. (2001) C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194:781-795. (Pubitemid 32983014)
35. Hoffmann PR, et al. (2001) Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 155:649-659. (Pubitemid 34289322)
36. Gardai SJ, et al. (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123:321-334. (Pubitemid 41457220)
37. Chao M, et al. (2010) Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med 2:63ra94.
38. Obeid M, et al. (2007) Calreticulin exposure is required for the immunogenicity of gamma-irradiation and UVC light-induced apoptosis. Cell Death Differ 14:1848-1850. (Pubitemid 47423653)
39. Obeid M, et al. (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13:54-61. (Pubitemid 46067386)
40. Clynes RA, Towers TL, Presta LG, Ravetch JV (2000) Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6:443-446. (Pubitemid 30208162)
41. Jemal A, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71-96. (Pubitemid 351521864)
42. Wyckoff JB, et al. (2007) Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67:2649-2656. (Pubitemid 46548952)
43. Wang XQ, Frazier WA (1998) The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell 9:865-874.
44. Brown E, Hooper L, Ho T, Gresham H (1990) Integrin-associated protein: A 50-kD plasma membrane antigen physically and functionally associated with integrins. J Cell Biol 111:2785-2794. (Pubitemid 120014559)
45. Condeelis J, Pollard JW (2006) Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 124:263-266. (Pubitemid 43121975)
46. Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4:71-78.
47. Hothorn T, Lausen B (2003) On the exact distribution of maximally selected rank statistics. Comput Stat Data Anal 43:121-137. (Pubitemid 36715216)
48. Dai M, et al. (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33:e175.