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Volumn 11, Issue 1, 2009, Pages 37-42

Combining radiation and immunotherapy for synergistic antitumor therapy

Author keywords

Cancer; Immunopotentiation; Radiotherapy; Therapeutic vaccine

Indexed keywords

CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; DENDRITIC CELL VACCINE; FLUOROURACIL; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; LC 9018; LEXIDRONAM SAMARIUM SM 153; METRONIDAZOLE; RECOMBINANT VACCINE; SAMARIUM 153; STRONTIUM 89;

EID: 58849107200     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (50)

References (30)
  • 1
    • 0034900416 scopus 로고    scopus 로고
    • The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma
    • von Mehren M, Arlen P, Gulley J, Rogatko A, Cooper HS, Meropol NJ, Alpaugh RK, Davey M, McLaughlin S, Beard MT, Tsang KY et al: The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma. Clin Cancer Res (2001) 7(5):1181-1191.
    • (2001) Clin Cancer Res , vol.7 , Issue.5 , pp. 1181-1191
    • von Mehren, M.1    Arlen, P.2    Gulley, J.3    Rogatko, A.4    Cooper, H.S.5    Meropol, N.J.6    Alpaugh, R.K.7    Davey, M.8    McLaughlin, S.9    Beard, M.T.10    Tsang, K.Y.11
  • 2
    • 34347221896 scopus 로고    scopus 로고
    • Modification of the tumor microenvironment to enhance immunity
    • Liao YP, Schaue D, McBride WH: Modification of the tumor microenvironment to enhance immunity. Front Biosci (2007) 12:3576-3600.
    • (2007) Front Biosci , vol.12 , pp. 3576-3600
    • Liao, Y.P.1    Schaue, D.2    McBride, W.H.3
  • 4
    • 0035988623 scopus 로고    scopus 로고
    • Immune modulation by ionizing radiation and its implications for cancer immunotherapy
    • Friedman EJ: Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr Pharm Des (2002) 8(19):1765-1780.
    • (2002) Curr Pharm Des , vol.8 , Issue.19 , pp. 1765-1780
    • Friedman, E.J.1
  • 6
    • 52649153457 scopus 로고    scopus 로고
    • Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges
    • This review focuses on phenotypic modulation of tumors by radiation, and the potential synergy of radiation and vaccine combination treatments, discussion 1075, 1080-1081, 1084. •
    • Hodge JW, Guha C, Neefjes J, Gulley JL: Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges. Oncology (2008) 22(9):1064-1070; discussion 1075, 1080-1081, 1084. • This review focuses on phenotypic modulation of tumors by radiation, and the potential synergy of radiation and vaccine combination treatments.
    • (2008) Oncology , vol.22 , Issue.9 , pp. 1064-1070
    • Hodge, J.W.1    Guha, C.2    Neefjes, J.3    Gulley, J.L.4
  • 7
    • 25844459044 scopus 로고    scopus 로고
    • Combining radiotherapy and immunotherapy: A revived partnership
    • A review of the potential synergy of radiation with immunotherapy, focusing on the ability of radiation to induce inflammation and kill tumor cells, thus releasing antigens to the immune system, •
    • Demaria S, Bhardwaj N, McBride WH, Formenti SC: Combining radiotherapy and immunotherapy: A revived partnership. Int J Radiat Oncol Biol Phys (2005) 63(3):655-666. • A review of the potential synergy of radiation with immunotherapy, focusing on the ability of radiation to induce inflammation and kill tumor cells, thus releasing antigens to the immune system.
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , Issue.3 , pp. 655-666
    • Demaria, S.1    Bhardwaj, N.2    McBride, W.H.3    Formenti, S.C.4
  • 9
    • 33947374421 scopus 로고    scopus 로고
    • Standard treatments induce antigen-specific immune responses in prostate cancer
    • A groundbreaking study that demonstrated radiation alone can induce or augment antitumor immune responses, ••
    • Nesslinger NJ, Sahota RA, Stone B, Johnson K, Chima N, King C, Rasmussen D, Bishop D, Rennie PS, Gleave M, Blood P et al: Standard treatments induce antigen-specific immune responses in prostate cancer. Clin Cancer Res (2007) 13(5):1493-1502. •• A groundbreaking study that demonstrated radiation alone can induce or augment antitumor immune responses.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1493-1502
    • Nesslinger, N.J.1    Sahota, R.A.2    Stone, B.3    Johnson, K.4    Chima, N.5    King, C.6    Rasmussen, D.7    Bishop, D.8    Rennie, P.S.9    Gleave, M.10    Blood, P.11
  • 11
    • 33745106605 scopus 로고    scopus 로고
    • Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma
    • An interesting clinical trial that showed the abscopal effect and regression of non-irradiated tumors, •
    • Wersall PJ, Blomgren H, Pisa P, Lax I, Kalkner KM, Svedman C: Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol (2006) 45(4):493-497. • An interesting clinical trial that showed the abscopal effect and regression of non-irradiated tumors.
    • (2006) Acta Oncol , vol.45 , Issue.4 , pp. 493-497
    • Wersall, P.J.1    Blomgren, H.2    Pisa, P.3    Lax, I.4    Kalkner, K.M.5    Svedman, C.6
  • 13
    • 4644308143 scopus 로고    scopus 로고
    • Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: Implications for intratumoral vaccine therapy
    • Slavin-Chiorini DC, Catalfamo M, Kudo-Saito C, Hodge JW, Schlom J, Sabzevari H: Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: Implications for intratumoral vaccine therapy. Cancer Gene Ther (2004) 11(10):665-680.
    • (2004) Cancer Gene Ther , vol.11 , Issue.10 , pp. 665-680
    • Slavin-Chiorini, D.C.1    Catalfamo, M.2    Kudo-Saito, C.3    Hodge, J.W.4    Schlom, J.5    Sabzevari, H.6
  • 14
    • 0037942745 scopus 로고    scopus 로고
    • Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    • Chakraborty M, Abrams SI, Camphausen K, Liu K, Scott T, Coleman CN, Hodge JW: Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol (2003) 170(12):6338-6347.
    • (2003) J Immunol , vol.170 , Issue.12 , pp. 6338-6347
    • Chakraborty, M.1    Abrams, S.I.2    Camphausen, K.3    Liu, K.4    Scott, T.5    Coleman, C.N.6    Hodge, J.W.7
  • 15
    • 7444258053 scopus 로고    scopus 로고
    • Garnett CT, Palena C, Chakraborty M, Tsang KY, Schlom J, Hodge JW: Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res (2004) 64(21):7985-7994. • A preclinical study that demonstrated human tumor cells subjected to sublethal radiation in vitro were more easily killed by T-cells.
    • Garnett CT, Palena C, Chakraborty M, Tsang KY, Schlom J, Hodge JW: Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res (2004) 64(21):7985-7994. • A preclinical study that demonstrated human tumor cells subjected to sublethal radiation in vitro were more easily killed by T-cells.
  • 16
    • 34250693120 scopus 로고    scopus 로고
    • Crucial role of SDF-1/CXCR4 interaction in the recruitment of transplanted dermal multipotent cells to sublethally irradiated bone marrow
    • Zong ZW, Cheng TM, Su YP, Ran XZ, Li N, Ai GP, Xu H: Crucial role of SDF-1/CXCR4 interaction in the recruitment of transplanted dermal multipotent cells to sublethally irradiated bone marrow. J Radiat Res (2006) 47(3-4):287-293.
    • (2006) J Radiat Res , vol.47 , Issue.3-4 , pp. 287-293
    • Zong, Z.W.1    Cheng, T.M.2    Su, Y.P.3    Ran, X.Z.4    Li, N.5    Ai, G.P.6    Xu, H.7
  • 17
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    • This study demonstrated that radiation markedly affected the phenotype of tumor cells, leading to improved antitumor immunotherapy, •
    • Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, Camphausen K, Luiten RM, de Ru AH, Neijssen J, Griekspoor A et al: Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 203(5):1259-1271. • This study demonstrated that radiation markedly affected the phenotype of tumor cells, leading to improved antitumor immunotherapy.
    • (2006) J Exp Med , vol.203 , Issue.5 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3    Groothuis, T.A.4    Chakraborty, M.5    Wansley, E.K.6    Camphausen, K.7    Luiten, R.M.8    de Ru, A.H.9    Neijssen, J.10    Griekspoor, A.11
  • 19
    • 3042569675 scopus 로고    scopus 로고
    • External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    • Chakraborty M, Abrams SI, Coleman CN, Camphausen K, Schlom J, Hodge JW: External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. Cancer Res (2004) 64(12):4328-4337.
    • (2004) Cancer Res , vol.64 , Issue.12 , pp. 4328-4337
    • Chakraborty, M.1    Abrams, S.I.2    Coleman, C.N.3    Camphausen, K.4    Schlom, J.5    Hodge, J.W.6
  • 20
    • 44249097814 scopus 로고    scopus 로고
    • Chakraborty M, Gelbard A, Carrasquillo JA, Yu S, Mamede M, Paik CH, Camphausen K, Schlom J, Hodge JW: Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects. Cancer Immunol Immunother (2008) 57(8):1173-1183. • A preclinical model that showed phenotypic changes and improved survival in a tumor therapy model following combination treatment with radiation and vaccine. This study also demonstrated that memory T-cells were not negatively affected by radiation.
    • Chakraborty M, Gelbard A, Carrasquillo JA, Yu S, Mamede M, Paik CH, Camphausen K, Schlom J, Hodge JW: Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects. Cancer Immunol Immunother (2008) 57(8):1173-1183. • A preclinical model that showed phenotypic changes and improved survival in a tumor therapy model following combination treatment with radiation and vaccine. This study also demonstrated that memory T-cells were not negatively affected by radiation.
  • 21
    • 16844362403 scopus 로고    scopus 로고
    • Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses
    • Kudo-Saito C, Schlom J, Hodge JW: Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses. Clin Cancer Res (2005) 11(6):2416-2426.
    • (2005) Clin Cancer Res , vol.11 , Issue.6 , pp. 2416-2426
    • Kudo-Saito, C.1    Schlom, J.2    Hodge, J.W.3
  • 22
    • 0038326676 scopus 로고    scopus 로고
    • Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells
    • Nowak AK, Lake RA, Marzo AL, Scott B, Heath WR, Collins EJ, Frelinger JA, Robinson BW: Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells. J Immunol (2003) 170(10):4905-4913.
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 4905-4913
    • Nowak, A.K.1    Lake, R.A.2    Marzo, A.L.3    Scott, B.4    Heath, W.R.5    Collins, E.J.6    Frelinger, J.A.7    Robinson, B.W.8
  • 23
    • 0036784603 scopus 로고    scopus 로고
    • Differential sensitivity of naïve and memory CD8+ T cells to apoptosis in vivo
    • Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R: Differential sensitivity of naïve and memory CD8+ T cells to apoptosis in vivo. J Immunol (2002) 169(7):3760-3770.
    • (2002) J Immunol , vol.169 , Issue.7 , pp. 3760-3770
    • Grayson, J.M.1    Harrington, L.E.2    Lanier, J.G.3    Wherry, E.J.4    Ahmed, R.5
  • 24
    • 43049167382 scopus 로고    scopus 로고
    • Low-dose radiation potentiates the therapeutic efficacy of folate receptor-targeted hapten therapy
    • Sega EI, Lu Y, Ringor M, Leamon CP, Low PS: Low-dose radiation potentiates the therapeutic efficacy of folate receptor-targeted hapten therapy. Int J Radiat Oncol Biol Phys (2008) 71(2):559-566.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , Issue.2 , pp. 559-566
    • Sega, E.I.1    Lu, Y.2    Ringor, M.3    Leamon, C.P.4    Low, P.S.5
  • 25
    • 20944441967 scopus 로고    scopus 로고
    • Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
    • A clinical trial that showed immune responses can be developed in patients receiving vaccine, despite their exposure to radiation therapy, •
    • Gulley JL, Arlen PM, Bastian A, Morin S, Marte J, Beetham P, Tsang KY, Yokokawa J, Hodge JW, Menard C, Camphausen K et al: Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer. Clin Cancer Res (2005) 11(9):3353-3362. • A clinical trial that showed immune responses can be developed in patients receiving vaccine, despite their exposure to radiation therapy.
    • (2005) Clin Cancer Res , vol.11 , Issue.9 , pp. 3353-3362
    • Gulley, J.L.1    Arlen, P.M.2    Bastian, A.3    Morin, S.4    Marte, J.5    Beetham, P.6    Tsang, K.Y.7    Yokokawa, J.8    Hodge, J.W.9    Menard, C.10    Camphausen, K.11
  • 26
    • 52649182085 scopus 로고    scopus 로고
    • Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant
    • Lechleider RJ, Arlen PM, Tsang KY, Steinberg SM, Yokokawa J, Cereda V, Camphausen K, Schlom J, Dahut WL, Gulley JL: Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clin Cancer Res (2008) 14(16):5284-5291.
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5284-5291
    • Lechleider, R.J.1    Arlen, P.M.2    Tsang, K.Y.3    Steinberg, S.M.4    Yokokawa, J.5    Cereda, V.6    Camphausen, K.7    Schlom, J.8    Dahut, W.L.9    Gulley, J.L.10
  • 27
    • 0024416085 scopus 로고
    • Phase II randomized clinical trial of LC9018 concurrently used with radiation in the treatment of carcinoma of the uterine cervix. Its effect on tumor reduction and histology
    • Okawa T, Kita M, Arai T, Iida K, Dokiya T, Takegawa Y, Hirokawa Y, Yamazaki K, Hashimoto S: Phase II randomized clinical trial of LC9018 concurrently used with radiation in the treatment of carcinoma of the uterine cervix. Its effect on tumor reduction and histology. Cancer (1989) 64(9):1769-1776.
    • (1989) Cancer , vol.64 , Issue.9 , pp. 1769-1776
    • Okawa, T.1    Kita, M.2    Arai, T.3    Iida, K.4    Dokiya, T.5    Takegawa, Y.6    Hirokawa, Y.7    Yamazaki, K.8    Hashimoto, S.9
  • 28
    • 14744275172 scopus 로고    scopus 로고
    • Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    • A clinical trial that showed immune responses can be generated when immunotherapy is administered in conjunction with local radiotherapy, •
    • Chi KH, Liu SJ, Li CP, Kuo HP, Wang YS, Chao Y, Hsieh SL: Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother (2005) 28(2):129-135. • A clinical trial that showed immune responses can be generated when immunotherapy is administered in conjunction with local radiotherapy.
    • (2005) J Immunother , vol.28 , Issue.2 , pp. 129-135
    • Chi, K.H.1    Liu, S.J.2    Li, C.P.3    Kuo, H.P.4    Wang, Y.S.5    Chao, Y.6    Hsieh, S.L.7
  • 29
    • 45049086553 scopus 로고    scopus 로고
    • Synergistic anti-tumor effect of combination radio- and immunotherapy by electro-gene therapy plus intra-tumor injection of dendritic cells
    • Wang YS, Tsang YW, Chi CH, Chang CC, Chu RM, Chi KH: Synergistic anti-tumor effect of combination radio- and immunotherapy by electro-gene therapy plus intra-tumor injection of dendritic cells. Cancer Lett (2008) 266(2):275-285.
    • (2008) Cancer Lett , vol.266 , Issue.2 , pp. 275-285
    • Wang, Y.S.1    Tsang, Y.W.2    Chi, C.H.3    Chang, C.C.4    Chu, R.M.5    Chi, K.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.