Axitinib and/or bevacizumab with modified FOLFOX-6 as first-line therapy for metastatic colorectal cancer: A randomized phase 2 study

Cancer

Volumn 119, Issue 14, 2013, Pages 2555-2563

  Infante, Jeffrey R ^a   Reid, Tony R ^b   Cohn, Allen L ^c   Edenfield, William J ^d   Cescon, Terrence P ^e   Hamm, John T ^f   Malik, Imtiaz A ^g   Rado, Thomas A ^h   McGee, Philip J ⁱ   Richards, Donald A ^j   Tarazi, Jamal ^k   Rosbrook, Brad ^k   Kim, Sinil ^k   Cartwright, Thomas H ^l  

^a SARAH CANNON RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ROCKY MOUNTAIN CANCER CENTERS   (United States)

^d Cancer Centers of the Carolinas   (United States)

^e Berks Hematology Oncology Associates Ltd   (United States)

^f Norton Cancer Institute   (United States)

^g Loma Linda Oncology Medical Group Inc   (United States)

^h Columbia Basin Hematology and Oncology Group ^*  (United States)

ⁱ Clearview Cancer Institute   (United States)

^j TEXAS ONCOLOGY   (United States)

^k PFIZER INC   (United States)

^l Ocala Oncology Center   (United States)

more..

Author keywords

axitinib; bevacizumab; colorectal cancer; FOLFOX

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; AXITINIB PLUS BEVACIZUMAB; BEVACIZUMAB; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ABSCESS; ADULT; AGED; ANEMIA; ARTICLE; ASTHENIA; BOLUS INJECTION; BRAIN HEMORRHAGE; CANCER SURVIVAL; CEREBROVASCULAR ACCIDENT; CHEMOTHERAPY INDUCED EMESIS; CONSTIPATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DECREASED APPETITE; DEEP VEIN THROMBOSIS; DEHYDRATION; DEPRESSION; DIARRHEA; DIGESTIVE SYSTEM PERFORATION; DIZZINESS; DOSE RESPONSE; DRUG CHOICE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSESTHESIA; DYSPHONIA; DYSPNEA; EPISTAXIS; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HEMORRHAGIC SHOCK; HUMAN; HYPERTENSION; HYPOTHYROIDISM; INSOMNIA; JUGULAR VEIN THROMBOSIS; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; METASTATIC COLORECTAL CANCER; MUCOSA INFLAMMATION; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OPEN STUDY; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; PHARYNGOLARYNGEAL DYSESTHESIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; RECTUM ABSCESS; SENSORY NEUROPATHY; SEPSIS; SIDE EFFECT; STOMATITIS; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; UPPER ABDOMINAL PAIN; WEIGHT REDUCTION;

AXITINIB; BEVACIZUMAB; COLORECTAL CANCER; FOLFOX;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; IMIDAZOLES; INDAZOLES; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; KAPLAN-MEIER ESTIMATE; LEUCOVORIN; MALE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; TREATMENT OUTCOME;

EID: 84879660334     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28112     Document Type: Article

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