Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Nature Medicine

Volumn 18, Issue 2, 2012, Pages 221-223

  Montagut, Clara ^a   Dalmases, Alba ^a   Bellosillo, Beatriz ^a   Crespo, Marta ^b   Pairet, Silvia ^a   Iglesias, Mar ^a,c   Salido, Marta ^a   Gallen, Manuel ^a   Marsters, Scot ^d   Tsai, Siao Ping ^d   Minoche, André ^e   Somasekar, Seshagiri ^d   Serrano, Sergi ^a,c   Himmelbauer, Heinz ^e   Bellmunt, Joaquim ^a,f   Rovira, Ana ^a   Settleman, Jeff ^d   Bosch, Francesc ^b   Albanell, Joan ^a,c  

^a HOSPITAL DEL MAR   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d GENENTECH INC   (United States)

^e CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^f UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; DNA SEQUENCE; DRUG BINDING; DRUG MECHANISM; EXTRACELLULAR SPACE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

EID: 84856717005     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2609     Document Type: Article

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