Symmetric division versus asymmetric division: A tale of two coactivators

Future Medicinal Chemistry

Volumn 3, Issue 14, 2011, Pages 1745-1763

  Kahn, Michael ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BLEOMYCIN; CALVASCULIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; EPHRIN RECEPTOR B2; ICG 001; IMATINIB; IQ 1; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN INHIBITOR; PROTEIN P300; PROTEIN P53; RETINOIC ACID; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VITAMIN D; WNT PROTEIN;

AGING; ALZHEIMER DISEASE; ASYMMETRIC DIVISION; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER PREVENTION; CANCER RESISTANCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; COLON CANCER; DRUG DOSE ESCALATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG PROTEIN BINDING; EMBRYONIC STEM CELL; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; INTERMETHOD COMPARISON; INTERSTITIAL PNEUMONIA; LUNG FIBROSIS; NONHUMAN; PANCREAS CANCER; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SALIVARY GLAND TUMOR; SIGNAL TRANSDUCTION; SKIN CANCER; SYMMETRIC DIVISION;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; HOMEOSTASIS; HUMANS; MICE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 80054959395     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.11.126     Document Type: Review

References (68)

1. Nemeth MJ, Mak KK, Yang Y, Bodine DM. Β-catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells 27, 1109-1119 (2009).
2. Malhotra S, Kincade PW. Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell 4, 27-36 (2009).
3. Monga SP. Role of Wnt/Β-catenin signaling in liver metabolism and cancer. Int. J. Biochem. Cell. Biol. 43(7), 1021-1029 (2009).
4. Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nat. Rev. Neurosci. 11, 77-86 (2010).
5. de Lau W, Barker N, Clevers H. WNT signaling in the normal intestine and colorectal cancer. Front. Biosci. 12, 471-491 (2007). (Pubitemid 46852800)
6. Kohn AD, Moon RT. Wnt and calcium signaling: Β-catenin-independent pathways. Cell. Calcium 38, 439-446 (2005). (Pubitemid 41283282)
7. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Ann. Rev. Cell. Dev. Biol. 20, 781-810 (2004). (Pubitemid 39488658)
8. Angers S, Moon RT. Proximal events in Wnt signal transduction. Nat. Rev. Mol. Cell. Biol. 10, 468-477 (2009).
9. Kim YM, Ma H, Oehler VG et al. The γ-catenin/CBP complex maintains survivin transcription in Β-catenin deficient/depleted cancer cells. Curr. Cancer Drug Targets 11, 213-225 (2011).
10. Kung AL, Rebel VI, Bronson RY et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 14, 272-277 (2000). (Pubitemid 30106482)
11. Yamauchi T, Oike Y, Kamon H et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat. Genet. 30, 221-226 (2002).
12. Roth JF, Shikama N, Henzen C et al. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 22, 5186-5196 (2003). (Pubitemid 37222038)
13. Foley P, Bunyan D, Stratton J, Dillon M, Lynch SA. Further case of Rubinstein -Taybi syndrome due to a deletion in EP300. Am. J. Med. Genet. A. 149A, 997-1000 (2009).
14. Tanaka Y, Naruse I, Maekawa T et al. Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc. Natl Acad. Sci. USA 94, 10215-10220 (1997). (Pubitemid 27407021)
15. Yao TP, Oh SP, Fuchs M et al. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93, 361-372 (1998). (Pubitemid 28232081)
16. Teo JL, Ma H, Nguyen C, Lam C, Kahn M. Specific inhibition of CBP/Β-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc. Natl Acad. Sci. USA 102, 12171-12176 (2005). (Pubitemid 41291147)
17. Ma H, Nguyen C, Lee KS, Kahn M. Differential roles for the coactivators CBP and p300 on TCF/Β-catenin-mediated surviving gene expression. Oncogene 24, 3619-3631 (2005). (Pubitemid 40756231)
18. Kawasaki H, Eckner R, Yao TP et al. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393, 284-289 (1998). (Pubitemid 28261730)
19. Roth JF, Shikama N, Henzen C et al. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 22, 5186-5196 (2003). (Pubitemid 37222038)
20. Rebel VI, Kung AL, Tanner EA, Yang H, Bronson RT, Livingston DM. Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc. Natl Acad. Sci. USA 99, 14789-14794 (2002). (Pubitemid 35334562)
21. Ugai H, Uchida K, Kawasaki H, Yokoyama KK. The coactivators p300 and CBP have different functions during the differentiation of F9 cells. J. Mol. Med. 77, 481-494 (1999). (Pubitemid 29372580)
22. McMillan M, Kahn M. Wnt Signaling, a chemogenomic safari. Drug Discovery Today 10, 1467-1474 (2005).
23. Emami KH, Nguyen C, Ma H et al. A small molecule inhibitor of Β-catenin/CREB-binding protein transcription [corrected], Proc. Natl Acad. Sci. USA 101, 12682-12687 (2004). (Pubitemid 39122083)
24. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/Β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc. Natl Acad. Sci. USA 104, 5668-5673 (2007). (Pubitemid 47175738)
25. Bedford DC, Lawryn KH, Tomofusa F, Brindle PK. Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 5, 9-15 (2010).
26. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55-63 (2004). (Pubitemid 38524699)
27. Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. Β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell 8, 214-227 (2011).
28. Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297, 365-369 (2002). (Pubitemid 34790759)
29. Falk S, Wurdak H, Ittner LM et al. Brain area-specific effect of TGF-b signaling on Wnt-dependent neural stem cell expansion. Cell. Stem Cell 2, 427-483 (2008).
30. Piccin D, Morshead CM. Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury. Stem Cells 29, 528-538 (2011).
31. Otero JJ, Fu W, Kan L, Cuadra AE, Kessler JA. Β-catenin signaling is required for neural differentiation of embryonic stem cells. Development 131, 3545-3557 (2004). (Pubitemid 39199366)
32. Zechner D, Fujita Y, Hulsken J et al. Β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258, 406-418 (2003). (Pubitemid 36686723)
33. Kim WY, Wang X, Wu Y et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat. Neurosci. 12, 1390-1397 (2009).
34. McKinnon T, Ma H, Hasegawa K, Kahn M. Trophectoderm differentiation in mouse preimplantation embryos involves Wnt signaling and a switch to the transcriptional coactivator p300. Presented at: The ISSCR 7th Annual Meeting. Barcelona, Spain, 8-11 July 2009.
35. Hasegawa K, Teo JL, Suemori H, Nakatsuji N, Pera M, Kahn M. Development of a novel xeno-free human embryonic stem cell culture system using small molecules. Presented at: The ISSCR 7th Annual Meeting. Barcelona, Spain, 8-11 July 2009.
36. Marson A, Foreman R, Chevalier B et al. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 3, 132-135 (2008).
37. Batlle E, Henderson JT, Beghtel H et al. Β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111, 251-263 (2002). (Pubitemid 35292445)
38. Kumar SR, Scehnet JS, Ley EJ et al. Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. Cancer Res. 69, 3736-3745 (2009). Erratum in: Cancer Res. 69, 4554 (2009).
39. Creyghton MP, Rol G, Eichhorn PJ et al. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 19, 376-386 (2005). (Pubitemid 40189300)
40. Zeng W, Wharton KA Jr, Mack JA et al. Naked cuticle encodes an inducible antagonist of Wnt signalling. Nature 403, 789-795 (2000). (Pubitemid 30111842)
41. Hirota M, Watanabe K, Hamada S et al. Smad2 functions as a co-activator of canonical Wnt/Β-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300. Cell. Signal. 20, 1632-1641 (2008).
42. Kwon IK, Wang R, Thangaraju M et al. PKG inhibits TCF signaling in colon cancer cells by blocking Β-catenin expression and activating FOXO4. Oncogene 29, 3423-3434 (2010).
43. Beildeck ME, Islam M, Shah S, Welsh J, Byers SW. Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS One 4, e7872 (2009).
44. Lindvall C, Bu W, Williams BO, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev. 3, 157-168 (2007). (Pubitemid 350129718)
45. Nagahata T, Shimada T, Harada A et al. Amplification, up-regulation and over expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. Cancer Sci. 94, 515-518 (2003). (Pubitemid 36849715)
46. Ugolini F, Adélaïde J, Charafe-Jauffret E et al. Differential expression assay of chromosome arm 8p genes identifies frizzled-related (FRP1/ FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene 18, 1903-1910 (1999). (Pubitemid 29145858)
47. Roh MS, Hong SH, Jeong JS et al. Gene expression profiling of breast cancers with emphasis of Β-catenin regulation. J. Korean Med. Sci. 19, 275-282 (2004). (Pubitemid 38591804)
48. Mai M, Qian C, Yokomizo A, Smith DI, Liu W. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-24. Genomics 55, 341-344 (1999).
49. Jeannet G, Scheller M, Scarpellino L et al. Long-term, multilineage hematopoiesis occurs in the combined absence of Β-catenin and g-catenin. Blood 111, 142-149 (2008).
50. Giehl K, Menke A. Microenvironmental regulation of E-cadherin-mediated adherens junctions. Front. Biosci. 13, 3975-3985 (2008). (Pubitemid 351594675)
51. Ring A, Evgrafov O, Knowles J, Kahn M. Targeting B-catenin/CBP interaction in breast cancer. Presented at: American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 3-7 June 2011.
52. Szeto W, Jiang W, Tice DA et al. Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res. 61, 4197-4205 (2001). (Pubitemid 32724956)
53. LaBarge MA. The difficulty of targeting cancer stem cell niches. Clin. Cancer Res. 16, 3121-3129 (2010).
54. Merchant A, Watsui W. Targeting hedgehog - a cancer stem cell pathway. Clin. Cancer Res. 16, 3130-3140 (2010).
55. Pannuti A, Foreman K, Rizzo P et al. Targeting notch to target cancer stem cells. Clin. Cancer Res. 16, 3142-3152 (2010).
56. Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells. Curr. Opin. Genet. Dev. 14(1), 43-47 (2004). (Pubitemid 38167476)
57. Weinmann AS, Farnham PJ. Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation. Methods 26, 37-47 (2002). (Pubitemid 34969216)
58. Mani SA, Guo W, Liao MJ et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008). (Pubitemid 351636299)
59. Radich JP, Dai H, Mao M et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc. Natl Acad. Sci. USA 103, 2794-2799 (2006).
60. Henderson WR Jr, Chi EY, Ye X et al. Inhibition of Wnt/Β-catenin/ CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc. Natl Acad. Sci. USA 107, 14309-14314 (2010).
61. Cissé M, Halabisky B, Harris J et al. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 469, 47-52 (2011).
62. Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron 63, 189-202 (2009).
63. Schenke-Layland K, Nsair A, Van Handel B et al. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials 2, 2748-2756 (2011).
64. Yilmaz OH, Valdez R, Theisen BK et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482 (2006). (Pubitemid 44050144)
65. Cairns J. Mutation, selection and cancer. Nature 255, 197-200 (1975).
66. Hernandez L, Roux KJ, Wong ES et al. Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev. Cell 19, 413-425 (2010).
67. Liu H, Fergusson MM, Castilho RM et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317, 803-806 (2007). (Pubitemid 47257917)
68. Brack AS, Conboy MJ, Roy S et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317, 807-810 (2007). (Pubitemid 47257918)