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Volumn 13, Issue 1, 2016, Pages

Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research

Author keywords

Adipocytokines; Central nervous system; Diabetes; Neurodegeneration; Neurogenesis; Neuroinflammation; Obesity; White adipose tissue

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AUTOTAXIN; INTERLEUKIN 6; LEPTIN; LYSOPHOSPHATIDIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

EID: 84961621666     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0530-x     Document Type: Review
Times cited : (138)

References (223)
  • 2
    • 84961577013 scopus 로고    scopus 로고
    • Accessed 22 Mar
    • World Health Organisation W: obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 22 Mar 2016.
    • (2016) W: obesity and overweight
  • 3
    • 84961588420 scopus 로고    scopus 로고
    • Accessed 22 Mar
    • World Health Organisation W: diabetes. http://www.who.int/mediacentre/factsheets/fs312/en/. Accessed 22 Mar 2016.
    • (2016) W: diabetes
  • 4
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-53.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 5
    • 24144472565 scopus 로고    scopus 로고
    • The burden of mortality attributable to diabetes: realistic estimates for the year 2000
    • Roglic G, Unwin N, Bennett PH, Mathers C, Tuomilehto J, Nag S, et al. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care. 2005;28:2130-5.
    • (2005) Diabetes Care , vol.28 , pp. 2130-2135
    • Roglic, G.1    Unwin, N.2    Bennett, P.H.3    Mathers, C.4    Tuomilehto, J.5    Nag, S.6
  • 6
    • 0031468381 scopus 로고    scopus 로고
    • Diagnosis of Alzheimer's disease. Report of an International Psychogeriatric Association Special Meeting Work Group under the cosponsorship of Alzheimer's Disease International, the European Federation of Neurological Societies, the World Health Organization, and the World Psychiatric Association
    • Reisberg B, Burns A, Brodaty H, Eastwood R, Rossor M, Sartorius N, et al. Diagnosis of Alzheimer's disease. Report of an International Psychogeriatric Association Special Meeting Work Group under the cosponsorship of Alzheimer's Disease International, the European Federation of Neurological Societies, the World Health Organization, and the World Psychiatric Association. Int Psychogeriatr. 1997;9 Suppl 1:11-38.
    • (1997) Int Psychogeriatr , Issue.9 , pp. 11-38
    • Reisberg, B.1    Burns, A.2    Brodaty, H.3    Eastwood, R.4    Rossor, M.5    Sartorius, N.6
  • 7
    • 84961644732 scopus 로고    scopus 로고
    • Accessed 22 Mar 2016.
    • World Health Organisation W: dementia. http://www.who.int/mediacentre/factsheets/fs362/en/. Accessed 22 Mar 2016.
    • W: dementia
  • 12
    • 85027946037 scopus 로고    scopus 로고
    • Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines
    • Letra L, Santana I, Seica R. Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines. Metab Brain Dis. 2014;29:563-8.
    • (2014) Metab Brain Dis , vol.29 , pp. 563-568
    • Letra, L.1    Santana, I.2    Seica, R.3
  • 13
    • 42249107660 scopus 로고    scopus 로고
    • Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis
    • Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev. 2008;9:204-18.
    • (2008) Obes Rev , vol.9 , pp. 204-218
    • Beydoun, M.A.1    Beydoun, H.A.2    Wang, Y.3
  • 16
    • 84887229354 scopus 로고    scopus 로고
    • Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort.
    • Tolppanen AM, Ngandu T, Kareholt I, Laatikainen T, Rusanen M, Soininen H, et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. J Alzheimers Dis. 2014;38:201-9.
    • (2014) J Alzheimers Dis. , vol.38 , pp. 201-209
    • Tolppanen, A.M.1    Ngandu, T.2    Kareholt, I.3    Laatikainen, T.4    Rusanen, M.5    Soininen, H.6
  • 17
    • 84873137994 scopus 로고    scopus 로고
    • The adipose tissue as an endocrine organ
    • Adamczak M, Wiecek A. The adipose tissue as an endocrine organ. Semin Nephrol. 2013;33:2-13.
    • (2013) Semin Nephrol , vol.33 , pp. 2-13
    • Adamczak, M.1    Wiecek, A.2
  • 18
    • 84858964200 scopus 로고    scopus 로고
    • Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders
    • Lehr S, Hartwig S, Sell H. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin Appl. 2012;6:91-101.
    • (2012) Proteomics Clin Appl , vol.6 , pp. 91-101
    • Lehr, S.1    Hartwig, S.2    Sell, H.3
  • 21
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92:347-55.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 23
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 24
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
    • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 2001;60:329-39.
    • (2001) Proc Nutr Soc , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 27
    • 84923994435 scopus 로고    scopus 로고
    • From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century
    • Bluher M, Mantzoros CS. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism. 2015;64:131-45.
    • (2015) Metabolism , vol.64 , pp. 131-145
    • Bluher, M.1    Mantzoros, C.S.2
  • 28
    • 84897114276 scopus 로고    scopus 로고
    • Adipokines-removing road blocks to obesity and diabetes therapy
    • Bluher M. Adipokines-removing road blocks to obesity and diabetes therapy. Mol Metab. 2014;3:230-40.
    • (2014) Mol Metab , vol.3 , pp. 230-240
    • Bluher, M.1
  • 29
    • 70350188297 scopus 로고    scopus 로고
    • Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
    • Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010;314:1-16.
    • (2010) Mol Cell Endocrinol , vol.314 , pp. 1-16
    • Maury, E.1    Brichard, S.M.2
  • 30
    • 79960700893 scopus 로고    scopus 로고
    • Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study
    • Ku IA, Farzaneh-Far R, Vittinghoff E, Zhang MH, Na B, Whooley MA. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study. Atherosclerosis. 2011;217:503-8.
    • (2011) Atherosclerosis , vol.217 , pp. 503-508
    • Ku, I.A.1    Farzaneh-Far, R.2    Vittinghoff, E.3    Zhang, M.H.4    Na, B.5    Whooley, M.A.6
  • 32
    • 33646401824 scopus 로고    scopus 로고
    • Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    • Herder C, Baumert J, Thorand B, Koenig W, de Jager W, Meisinger C, et al. Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002. Diabetologia. 2006;49:921-9.
    • (2006) Diabetologia , vol.49 , pp. 921-929
    • Herder, C.1    Baumert, J.2    Thorand, B.3    Koenig, W.4    de Jager, W.5    Meisinger, C.6
  • 33
    • 84255175411 scopus 로고    scopus 로고
    • Obesity, leptin, and Alzheimer's disease
    • Lee EB. Obesity, leptin, and Alzheimer's disease. Ann N Y Acad Sci. 2011;1243:15-29.
    • (2011) Ann N Y Acad Sci , vol.1243 , pp. 15-29
    • Lee, E.B.1
  • 34
    • 33745940760 scopus 로고    scopus 로고
    • Adiposity indices and dementia
    • Gustafson D. Adiposity indices and dementia. Lancet Neurol. 2006;5:713-20.
    • (2006) Lancet Neurol , vol.5 , pp. 713-720
    • Gustafson, D.1
  • 35
    • 84901936702 scopus 로고    scopus 로고
    • Metabolic syndrome: an important risk factor for Parkinson's disease
    • Zhang P, Tian B. Metabolic syndrome: an important risk factor for Parkinson's disease. Oxid Med Cell Longev. 2014;2014:729194.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 729194
    • Zhang, P.1    Tian, B.2
  • 36
    • 84908049430 scopus 로고    scopus 로고
    • Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors.
    • Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, et al. Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract. 2014;8:e435-47.
    • (2014) Obes Res Clin Pract. , vol.8 , pp. e435-e447
    • Gianfrancesco, M.A.1    Acuna, B.2    Shen, L.3    Briggs, F.B.4    Quach, H.5    Bellesis, K.H.6
  • 39
    • 84949117755 scopus 로고    scopus 로고
    • Obesity and cognitive decline: role of inflammation and vascular changes
    • Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci. 2014;8:375.
    • (2014) Front Neurosci , vol.8 , pp. 375
    • Nguyen, J.C.1    Killcross, A.S.2    Jenkins, T.A.3
  • 42
    • 29144436439 scopus 로고    scopus 로고
    • The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
    • Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol. 2005;5:23.
    • (2005) BMC Neurol , vol.5 , pp. 23
    • Ward, M.A.1    Carlsson, C.M.2    Trivedi, M.A.3    Sager, M.A.4    Johnson, S.C.5
  • 46
    • 77952340870 scopus 로고    scopus 로고
    • A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.
    • Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010;107:8404-9.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8404-8409
    • Ho, A.J.1    Stein, J.L.2    Hua, X.3    Lee, S.4    Hibar, D.P.5    Leow, A.D.6
  • 47
    • 33749861878 scopus 로고    scopus 로고
    • Relation between body mass index and cognitive function in healthy middle-aged men and women.
    • Cournot M, Marquie JC, Ansiau D, Martinaud C, Fonds H, Ferrieres J, et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology. 2006;67:1208-14.
    • (2006) Neurology , vol.67 , pp. 1208-1214
    • Cournot, M.1    Marquie, J.C.2    Ansiau, D.3    Martinaud, C.4    Fonds, H.5    Ferrieres, J.6
  • 49
    • 59649103005 scopus 로고    scopus 로고
    • Body mass index over the adult life course and cognition in late midlife: the Whitehall II cohort study
    • Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A. Body mass index over the adult life course and cognition in late midlife: the Whitehall II cohort study. Am J Clin Nutr. 2009;89:601-7.
    • (2009) Am J Clin Nutr , vol.89 , pp. 601-607
    • Sabia, S.1    Kivimaki, M.2    Shipley, M.J.3    Marmot, M.G.4    Singh-Manoux, A.5
  • 50
    • 78149325368 scopus 로고    scopus 로고
    • High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task
    • McNeilly AD, Williamson R, Sutherland C, Balfour DJ, Stewart CA. High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task. Behav Brain Res. 2011;217:134-41.
    • (2011) Behav Brain Res , vol.217 , pp. 134-141
    • McNeilly, A.D.1    Williamson, R.2    Sutherland, C.3    Balfour, D.J.4    Stewart, C.A.5
  • 51
    • 72749106820 scopus 로고    scopus 로고
    • Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding.
    • Murray AJ, Knight NS, Cochlin LE, McAleese S, Deacon RM, Rawlins JN, et al. Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J. 2009;23:4353-60.
    • (2009) FASEB J. , vol.23 , pp. 4353-4360
    • Murray, A.J.1    Knight, N.S.2    Cochlin, L.E.3    McAleese, S.4    Deacon, R.M.5    Rawlins, J.N.6
  • 52
    • 84949537665 scopus 로고    scopus 로고
    • Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition.
    • Morris MJ, Beilharz JE, Maniam J, Reichelt AC, Westbrook RF. Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neurosci Biobehav Rev. 2015;58:36-45.
    • (2015) Neurosci Biobehav Rev. , vol.58 , pp. 36-45
    • Morris, M.J.1    Beilharz, J.E.2    Maniam, J.3    Reichelt, A.C.4    Westbrook, R.F.5
  • 53
    • 84888287660 scopus 로고    scopus 로고
    • Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity.
    • Lynch CM, Kinzenbaw DA, Chen X, Zhan S, Mezzetti E, Filosa J, et al. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke. 2013;44:3195-201.
    • (2013) Stroke , vol.44 , pp. 3195-3201
    • Lynch, C.M.1    Kinzenbaw, D.A.2    Chen, X.3    Zhan, S.4    Mezzetti, E.5    Filosa, J.6
  • 55
    • 84896888081 scopus 로고    scopus 로고
    • Relationship between [corrected] spatial memory in diabetic rats and protein kinase Cgamma, caveolin-1 in the hippocampus and neuroprotective effect of catalpol.
    • Zhou H, Liu J, Ren L, Liu W, Xing Q, Men L, et al. Relationship between [corrected] spatial memory in diabetic rats and protein kinase Cgamma, caveolin-1 in the hippocampus and neuroprotective effect of catalpol. Chin Med J (Engl). 2014;127:916-23.
    • (2014) Chin Med J (Engl) , vol.127 , pp. 916-923
    • Zhou, H.1    Liu, J.2    Ren, L.3    Liu, W.4    Xing, Q.5    Men, L.6
  • 56
    • 84862280143 scopus 로고    scopus 로고
    • Diabetes and cognitive dysfunction
    • McCrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet. 2012;379:2291-9.
    • (2012) Lancet , vol.379 , pp. 2291-2299
    • McCrimmon, R.J.1    Ryan, C.M.2    Frier, B.M.3
  • 57
    • 84922420531 scopus 로고    scopus 로고
    • Memory dysfunction in type 2 diabetes mellitus correlates with reduced hippocampal CA1 and subiculum volumes.
    • Zhang YW, Zhang JQ, Liu C, Wei P, Zhang X, Yuan QY, et al. Memory dysfunction in type 2 diabetes mellitus correlates with reduced hippocampal CA1 and subiculum volumes. Chin Med J (Engl). 2015;128:465-71.
    • (2015) Chin Med J (Engl) , vol.128 , pp. 465-471
    • Zhang, Y.W.1    Zhang, J.Q.2    Liu, C.3    Wei, P.4    Zhang, X.5    Yuan, Q.Y.6
  • 58
    • 38149065205 scopus 로고    scopus 로고
    • Cognition and diabetes: a lifespan perspective
    • Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol. 2008;7:184-90.
    • (2008) Lancet Neurol , vol.7 , pp. 184-190
    • Biessels, G.J.1    Deary, I.J.2    Ryan, C.M.3
  • 59
    • 33644585223 scopus 로고    scopus 로고
    • Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
    • Haan MN. Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nat Clin Pract Neurol. 2006;2:159-66.
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 159-166
    • Haan, M.N.1
  • 60
    • 84861450111 scopus 로고    scopus 로고
    • Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
    • Cheng G, Huang C, Deng H, Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J. 2012;42:484-91.
    • (2012) Intern Med J , vol.42 , pp. 484-491
    • Cheng, G.1    Huang, C.2    Deng, H.3    Wang, H.4
  • 61
    • 34548711907 scopus 로고    scopus 로고
    • Type 2 diabetes and risk of cognitive impairment and dementia
    • Whitmer RA. Type 2 diabetes and risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007;7:373-80.
    • (2007) Curr Neurol Neurosci Rep , vol.7 , pp. 373-380
    • Whitmer, R.A.1
  • 62
    • 0036973393 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging
    • MacKnight C, Rockwood K, Awalt E, McDowell I. Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord. 2002;14:77-83.
    • (2002) Dement Geriatr Cogn Disord , vol.14 , pp. 77-83
    • MacKnight, C.1    Rockwood, K.2    Awalt, E.3    McDowell, I.4
  • 63
    • 84879705689 scopus 로고    scopus 로고
    • Effects of diabetes on hippocampal neurogenesis: links to cognition and depression
    • Ho N, Sommers MS, Lucki I. Effects of diabetes on hippocampal neurogenesis: links to cognition and depression. Neurosci Biobehav Rev. 2013;37:1346-62.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 1346-1362
    • Ho, N.1    Sommers, M.S.2    Lucki, I.3
  • 65
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-70.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 66
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996;17:305-11.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 67
    • 0033944956 scopus 로고    scopus 로고
    • Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice
    • Banks WA, Clever CM, Farrell CL. Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice. Am J Physiol Endocrinol Metab. 2000;278:E1158-65.
    • (2000) Am J Physiol Endocrinol Metab , vol.278 , pp. E1158-E1165
    • Banks, W.A.1    Clever, C.M.2    Farrell, C.L.3
  • 69
    • 0034456535 scopus 로고    scopus 로고
    • Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier
    • Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000;141:1434-41.
    • (2000) Endocrinology , vol.141 , pp. 1434-1441
    • Zlokovic, B.V.1    Jovanovic, S.2    Miao, W.3    Samara, S.4    Verma, S.5    Farrell, C.L.6
  • 71
  • 72
    • 34547204416 scopus 로고    scopus 로고
    • Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
    • Brown R, Imran SA, Belsham DD, Ur E, Wilkinson M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology. 2007;85:232-41.
    • (2007) Neuroendocrinology , vol.85 , pp. 232-241
    • Brown, R.1    Imran, S.A.2    Belsham, D.D.3    Ur, E.4    Wilkinson, M.5
  • 73
    • 38749120585 scopus 로고    scopus 로고
    • Traumatic brain injury induces adipokine gene expression in rat brain
    • Brown R, Thompson HJ, Imran SA, Ur E, Wilkinson M. Traumatic brain injury induces adipokine gene expression in rat brain. Neurosci Lett. 2008;432:73-8.
    • (2008) Neurosci Lett , vol.432 , pp. 73-78
    • Brown, R.1    Thompson, H.J.2    Imran, S.A.3    Ur, E.4    Wilkinson, M.5
  • 75
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. The leptin receptor. J Biol Chem. 1997;272:6093-6.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 77
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 1996;387:113-6.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 78
    • 84877640516 scopus 로고    scopus 로고
    • Leptin action in the brain: How (and when) it makes fat burn
    • Yi CX, Meyer CW, Jastroch M. Leptin action in the brain: How (and when) it makes fat burn. Mol Metab. 2013;2:63-4.
    • (2013) Mol Metab , vol.2 , pp. 63-64
    • Yi, C.X.1    Meyer, C.W.2    Jastroch, M.3
  • 80
    • 0030768058 scopus 로고    scopus 로고
    • Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum
    • Savioz A, Charnay Y, Huguenin C, Graviou C, Greggio B, Bouras C. Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum. Neuroreport. 1997;8:3123-6.
    • (1997) Neuroreport , vol.8 , pp. 3123-3126
    • Savioz, A.1    Charnay, Y.2    Huguenin, C.3    Graviou, C.4    Greggio, B.5    Bouras, C.6
  • 81
    • 0037115192 scopus 로고    scopus 로고
    • Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels
    • Shanley LJ, O'Malley D, Irving AJ, Ashford ML, Harvey J. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. J Physiol. 2002;545:933-44.
    • (2002) J Physiol , vol.545 , pp. 933-944
    • Shanley, L.J.1    O'Malley, D.2    Irving, A.J.3    Ashford, M.L.4    Harvey, J.5
  • 82
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest. 2011;121:2413-21.
    • (2011) J Clin Invest , vol.121 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 85
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411:480-4.
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6
  • 87
    • 33847319765 scopus 로고    scopus 로고
    • Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.
    • Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, et al. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab. 2007;5:181-94.
    • (2007) Cell Metab. , vol.5 , pp. 181-194
    • Enriori, P.J.1    Evans, A.E.2    Sinnayah, P.3    Jobst, E.E.4    Tonelli-Lemos, L.5    Billes, S.K.6
  • 88
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong L, Ye C, Yang Z, Choi B, Chua Jr S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011;71:142-54.
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua, S.5    Lowell, B.B.6
  • 89
    • 84877677436 scopus 로고    scopus 로고
    • Glutamate release mediates leptin action on energy expenditure
    • Xu Y, Kim ER, Zhao R, Myers Jr MG, Munzberg H, Tong Q. Glutamate release mediates leptin action on energy expenditure. Mol Metab. 2013;2:109-15.
    • (2013) Mol Metab , vol.2 , pp. 109-115
    • Xu, Y.1    Kim, E.R.2    Zhao, R.3    Myers, M.G.4    Munzberg, H.5    Tong, Q.6
  • 90
    • 77956173468 scopus 로고    scopus 로고
    • Neurodevelopmental actions of leptin
    • Bouret SG. Neurodevelopmental actions of leptin. Brain Res. 2010;1350:2-9.
    • (2010) Brain Res , vol.1350 , pp. 2-9
    • Bouret, S.G.1
  • 91
    • 78649308474 scopus 로고    scopus 로고
    • The procognitive effects of leptin in the brain and their clinical implications
    • Paz-Filho G, Wong ML, Licinio J. The procognitive effects of leptin in the brain and their clinical implications. Int J Clin Pract. 2010;64:1808-12.
    • (2010) Int J Clin Pract , vol.64 , pp. 1808-1812
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 92
    • 77951150172 scopus 로고    scopus 로고
    • Leptin levels and Alzheimer disease
    • Paz-Filho G, Wong ML, Licinio J. Leptin levels and Alzheimer disease. JAMA. 2010;303:1478. author reply 1478-1479.
    • (2010) JAMA , vol.303 , pp. 1478
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 93
    • 84890806968 scopus 로고    scopus 로고
    • Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance
    • Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72.
    • (2014) J Neurochem. , vol.128 , pp. 162-172
    • Bonda, D.J.1    Stone, J.G.2    Torres, S.L.3    Siedlak, S.L.4    Perry, G.5    Kryscio, R.6
  • 95
    • 0036335012 scopus 로고    scopus 로고
    • Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptin
    • Salbe AD, Weyer C, Lindsay RS, Ravussin E, Tataranni PA. Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptin. Pediatrics. 2002;110:299-306.
    • (2002) Pediatrics , vol.110 , pp. 299-306
    • Salbe, A.D.1    Weyer, C.2    Lindsay, R.S.3    Ravussin, E.4    Tataranni, P.A.5
  • 96
    • 0036075274 scopus 로고    scopus 로고
    • Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians
    • Wang H, Chu WS, Hemphill C, Elbein SC. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002;87:2520-4.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2520-2524
    • Wang, H.1    Chu, W.S.2    Hemphill, C.3    Elbein, S.C.4
  • 98
    • 13844253235 scopus 로고    scopus 로고
    • Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia
    • Lee JH, Bullen Jr JW, Stoyneva VL, Mantzoros CS. Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia. Am J Physiol Endocrinol Metab. 2005;288:E625-32.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E625-E632
    • Lee, J.H.1    Bullen, J.W.2    Stoyneva, V.L.3    Mantzoros, C.S.4
  • 99
    • 4644226667 scopus 로고    scopus 로고
    • Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity.
    • Vendrell J, Broch M, Vilarrasa N, Molina A, Gomez JM, Gutierrez C, et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res. 2004;12:962-71.
    • (2004) Obes Res. , vol.12 , pp. 962-971
    • Vendrell, J.1    Broch, M.2    Vilarrasa, N.3    Molina, A.4    Gomez, J.M.5    Gutierrez, C.6
  • 100
    • 84892185319 scopus 로고    scopus 로고
    • Resistin in rodents and humans
    • Park HK, Ahima RS. Resistin in rodents and humans. Diabetes Metab J. 2013;37:404-14.
    • (2013) Diabetes Metab J , vol.37 , pp. 404-414
    • Park, H.K.1    Ahima, R.S.2
  • 101
    • 24344443978 scopus 로고    scopus 로고
    • Hallmarks of a common forebrain vertebrate plan: specialized pallial areas for spatial, temporal and emotional memory in actinopterygian fish.
    • Broglio C, Gómez A, Durán E, Ocaña FM, Jiménez-Moya F, Rodríguez F, et al. Hallmarks of a common forebrain vertebrate plan: specialized pallial areas for spatial, temporal and emotional memory in actinopterygian fish. Brain Res Bull. 2005;66:277-81.
    • (2005) Brain Res Bull. , Issue.66 , pp. 277-281
    • Broglio, C.1    Gómez, A.2    Durán, E.3    Ocaña, F.M.4    Jiménez-Moya, F.5    Rodríguez, F.6
  • 102
    • 84884257529 scopus 로고    scopus 로고
    • ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue
    • Kosari S, Camera DM, Hawley JA, Stebbing M, Badoer E. ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. Int J Physiol Pathophysiol Pharmacol. 2013;5:184-9.
    • (2013) Int J Physiol Pathophysiol Pharmacol , vol.5 , pp. 184-189
    • Kosari, S.1    Camera, D.M.2    Hawley, J.A.3    Stebbing, M.4    Badoer, E.5
  • 103
    • 84867668791 scopus 로고    scopus 로고
    • Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2
    • Kosari S, Rathner JA, Badoer E. Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2. J Neuroendocrinol. 2012;24:1432-9.
    • (2012) J Neuroendocrinol , vol.24 , pp. 1432-1439
    • Kosari, S.1    Rathner, J.A.2    Badoer, E.3
  • 104
    • 84865525054 scopus 로고    scopus 로고
    • Brain-gut-adipose-tissue communication pathways at a glance
    • Yi CX, Tschop MH. Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech. 2012;5:583-7.
    • (2012) Dis Model Mech , vol.5 , pp. 583-587
    • Yi, C.X.1    Tschop, M.H.2
  • 105
    • 84855210399 scopus 로고    scopus 로고
    • Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor
    • Sanchez-Solana B, Laborda J, Baladron V. Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor. Mol Endocrinol. 2012;26:110-27.
    • (2012) Mol Endocrinol , vol.26 , pp. 110-127
    • Sanchez-Solana, B.1    Laborda, J.2    Baladron, V.3
  • 108
  • 109
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-46.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 110
    • 23044439100 scopus 로고    scopus 로고
    • Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway
    • Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun. 2005;334:1092-101.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 1092-1101
    • Silswal, N.1    Singh, A.K.2    Aruna, B.3    Mukhopadhyay, S.4    Ghosh, S.5    Ehtesham, N.Z.6
  • 111
    • 84872048527 scopus 로고    scopus 로고
    • Central resistin overexposure induces insulin resistance through Toll-like receptor 4
    • Benomar Y, Gertler A, De Lacy P, Crepin D, Ould Hamouda H, Riffault L, et al. Central resistin overexposure induces insulin resistance through Toll-like receptor 4. Diabetes. 2013;62:102-14.
    • (2013) Diabetes , vol.62 , pp. 102-114
    • Benomar, Y.1    Gertler, A.2    De Lacy, P.3    Crepin, D.4    Ould Hamouda, H.5    Riffault, L.6
  • 112
    • 20944445369 scopus 로고    scopus 로고
    • Pituitary resistin gene expression is upregulated in vitro and in vivo by dexamethasone but is unaffected by rosiglitazone
    • Brown R, Wiesner G, Ur E, Wilkinson M. Pituitary resistin gene expression is upregulated in vitro and in vivo by dexamethasone but is unaffected by rosiglitazone. Neuroendocrinology. 2005;81:41-8.
    • (2005) Neuroendocrinology , vol.81 , pp. 41-48
    • Brown, R.1    Wiesner, G.2    Ur, E.3    Wilkinson, M.4
  • 113
    • 0037189916 scopus 로고    scopus 로고
    • Resistin expression and regulation in mouse pituitary
    • Morash BA, Willkinson D, Ur E, Wilkinson M. Resistin expression and regulation in mouse pituitary. FEBS Lett. 2002;526:26-30.
    • (2002) FEBS Lett , vol.526 , pp. 26-30
    • Morash, B.A.1    Willkinson, D.2    Ur, E.3    Wilkinson, M.4
  • 114
    • 34547224236 scopus 로고    scopus 로고
    • Adipokine gene expression in brain and pituitary gland
    • Wilkinson M, Brown R, Imran SA, Ur E. Adipokine gene expression in brain and pituitary gland. Neuroendocrinology. 2007;86:191-209.
    • (2007) Neuroendocrinology , vol.86 , pp. 191-209
    • Wilkinson, M.1    Brown, R.2    Imran, S.A.3    Ur, E.4
  • 115
    • 33745931054 scopus 로고    scopus 로고
    • Increased expression of the adipokine genes resistin and fasting-induced adipose factor in hypoxic/ischaemic mouse brain
    • Wiesner G, Brown RE, Robertson GS, Imran SA, Ur E, Wilkinson M. Increased expression of the adipokine genes resistin and fasting-induced adipose factor in hypoxic/ischaemic mouse brain. Neuroreport. 2006;17:1195-8.
    • (2006) Neuroreport , vol.17 , pp. 1195-1198
    • Wiesner, G.1    Brown, R.E.2    Robertson, G.S.3    Imran, S.A.4    Ur, E.5    Wilkinson, M.6
  • 117
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270:26746-9.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 118
    • 17044375852 scopus 로고    scopus 로고
    • Adiponectin: identification, physiology and clinical relevance in metabolic and vascular disease
    • Matsuzawa Y. Adiponectin: identification, physiology and clinical relevance in metabolic and vascular disease. Atheroscler Suppl. 2005;6:7-14.
    • (2005) Atheroscler Suppl , vol.6 , pp. 7-14
    • Matsuzawa, Y.1
  • 120
    • 0141924849 scopus 로고    scopus 로고
    • Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.
    • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003;278:40352-63.
    • (2003) J Biol Chem. , vol.278 , pp. 40352-40363
    • Waki, H.1    Yamauchi, T.2    Kamon, J.3    Ito, Y.4    Uchida, S.5    Kita, S.6
  • 122
    • 24944468687 scopus 로고    scopus 로고
    • Adiponectin gene is expressed in multiple tissues in the chicken: food deprivation influences adiponectin messenger ribonucleic acid expression
    • Maddineni S, Metzger S, Ocon O, Hendricks 3rd G, Ramachandran R. Adiponectin gene is expressed in multiple tissues in the chicken: food deprivation influences adiponectin messenger ribonucleic acid expression. Endocrinology. 2005;146:4250-6.
    • (2005) Endocrinology , vol.146 , pp. 4250-4256
    • Maddineni, S.1    Metzger, S.2    Ocon, O.3    Hendricks, G.4    Ramachandran, R.5
  • 123
    • 0036511213 scopus 로고    scopus 로고
    • ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
    • Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002;13:84-9.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 84-89
    • Berg, A.H.1    Combs, T.P.2    Scherer, P.E.3
  • 124
    • 0037180472 scopus 로고    scopus 로고
    • Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.
    • Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767-70.
    • (2002) Circulation. , vol.106 , pp. 2767-2770
    • Okamoto, Y.1    Kihara, S.2    Ouchi, N.3    Nishida, M.4    Arita, Y.5    Kumada, M.6
  • 125
    • 0036750241 scopus 로고    scopus 로고
    • Adiponectin-its role in metabolism and beyond
    • Stefan N, Stumvoll M. Adiponectin-its role in metabolism and beyond. Horm Metab Res. 2002;34:469-74.
    • (2002) Horm Metab Res , vol.34 , pp. 469-474
    • Stefan, N.1    Stumvoll, M.2
  • 127
  • 128
    • 37249015602 scopus 로고    scopus 로고
    • Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus
    • Hoyda TD, Fry M, Ahima RS, Ferguson AV. Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus. J Physiol. 2007;585:805-16.
    • (2007) J Physiol , vol.585 , pp. 805-816
    • Hoyda, T.D.1    Fry, M.2    Ahima, R.S.3    Ferguson, A.V.4
  • 131
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
    • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9.
    • (2003) Nature. , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3    Tsuchida, A.4    Yokomizo, T.5    Kita, S.6
  • 132
    • 0026052670 scopus 로고
    • T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region
    • Ranscht B, Dours-Zimmermann MT. T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron. 1991;7:391-402.
    • (1991) Neuron , vol.7 , pp. 391-402
    • Ranscht, B.1    Dours-Zimmermann, M.T.2
  • 133
    • 84885446686 scopus 로고    scopus 로고
    • Differential cadherin expression in the developing postnatal telencephalon of a New World monkey
    • Matsunaga E, Nambu S, Oka M, Iriki A. Differential cadherin expression in the developing postnatal telencephalon of a New World monkey. J Comp Neurol. 2013;521:4027-60.
    • (2013) J Comp Neurol , vol.521 , pp. 4027-4060
    • Matsunaga, E.1    Nambu, S.2    Oka, M.3    Iriki, A.4
  • 134
    • 67949121952 scopus 로고    scopus 로고
    • Changes in serum adiponectin concentrations in critical illness: a preliminary investigation
    • Venkatesh B, Hickman I, Nisbet J, Cohen J, Prins J. Changes in serum adiponectin concentrations in critical illness: a preliminary investigation. Crit Care. 2009;13:R105.
    • (2009) Crit Care , vol.13 , pp. R105
    • Venkatesh, B.1    Hickman, I.2    Nisbet, J.3    Cohen, J.4    Prins, J.5
  • 137
  • 138
    • 33644748270 scopus 로고    scopus 로고
    • Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells.
    • Spranger J, Verma S, Gohring I, Bobbert T, Seifert J, Sindler AL, et al. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes. 2006;55:141-7.
    • (2006) Diabetes , vol.55 , pp. 141-147
    • Spranger, J.1    Verma, S.2    Gohring, I.3    Bobbert, T.4    Seifert, J.5    Sindler, A.L.6
  • 139
    • 79959544623 scopus 로고    scopus 로고
    • Adiponectin protects rat hippocampal neurons against excitotoxicity.
    • Qiu G, Wan R, Hu J, Mattson MP, Spangler E, Liu S, et al. Adiponectin protects rat hippocampal neurons against excitotoxicity. Age (Dordr). 2011;33:155-65.
    • (2011) Age (Dordr) , vol.33 , pp. 155-165
    • Qiu, G.1    Wan, R.2    Hu, J.3    Mattson, M.P.4    Spangler, E.5    Liu, S.6
  • 140
    • 38049178556 scopus 로고    scopus 로고
    • Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms.
    • Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation. 2008;117:216-23.
    • (2008) Circulation. , vol.117 , pp. 216-223
    • Nishimura, M.1    Izumiya, Y.2    Higuchi, A.3    Shibata, R.4    Qiu, J.5    Kudo, C.6
  • 142
    • 0024281428 scopus 로고
    • A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF
    • Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell. 1988;53:45-53.
    • (1988) Cell , vol.53 , pp. 45-53
    • Kriegler, M.1    Perez, C.2    DeFay, K.3    Albert, I.4    Lu, S.D.5
  • 143
    • 0028220362 scopus 로고
    • TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation
    • Tang P, Hung MC, Klostergaard J. TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation. Lymphokine Cytokine Res. 1994;13:117-23.
    • (1994) Lymphokine Cytokine Res , vol.13 , pp. 117-123
    • Tang, P.1    Hung, M.C.2    Klostergaard, J.3
  • 144
    • 8044257704 scopus 로고    scopus 로고
    • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
    • Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997;385:729-33.
    • (1997) Nature. , vol.385 , pp. 729-733
    • Black, R.A.1    Rauch, C.T.2    Kozlosky, C.J.3    Peschon, J.J.4    Slack, J.L.5    Wolfson, M.F.6
  • 145
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 147
    • 0025304816 scopus 로고
    • Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta
    • Chung IY, Benveniste EN. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta. J Immunol. 1990;144:2999-3007.
    • (1990) J Immunol , vol.144 , pp. 2999-3007
    • Chung, I.Y.1    Benveniste, E.N.2
  • 148
    • 0001139213 scopus 로고
    • Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
    • Lieberman AP, Pitha PM, Shin HS, Shin ML. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci U S A. 1989;86:6348-52.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 6348-6352
    • Lieberman, A.P.1    Pitha, P.M.2    Shin, H.S.3    Shin, M.L.4
  • 149
    • 84860122734 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system
    • Montgomery SL, Bowers WJ. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. J Neuroimmune Pharmacol. 2012;7:42-59.
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 42-59
    • Montgomery, S.L.1    Bowers, W.J.2
  • 150
    • 26044438460 scopus 로고    scopus 로고
    • Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system
    • Pickering M, Cumiskey D, O'Connor JJ. Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system. Exp Physiol. 2005;90:663-70.
    • (2005) Exp Physiol , vol.90 , pp. 663-670
    • Pickering, M.1    Cumiskey, D.2    O'Connor, J.J.3
  • 151
    • 84938614317 scopus 로고    scopus 로고
    • A neurologist's guide to TNF biology and to the principles behind the therapeutic removal of excess TNF in disease
    • Clark IA, Vissel B. A neurologist's guide to TNF biology and to the principles behind the therapeutic removal of excess TNF in disease. Neural Plast. 2015;2015:358263.
    • (2015) Neural Plast , vol.2015 , pp. 358263
    • Clark, I.A.1    Vissel, B.2
  • 152
    • 84925337188 scopus 로고    scopus 로고
    • Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF
    • Fischer R, Maier O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev. 2015;2015:610813.
    • (2015) Oxid Med Cell Longev , vol.2015 , pp. 610813
    • Fischer, R.1    Maier, O.2
  • 153
    • 39149118892 scopus 로고    scopus 로고
    • The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation
    • Harry GJ, Funk JA, Lefebvre d'Hellencourt C, McPherson CA, Aoyama M. The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. Brain Res. 2008;1194:8-20.
    • (2008) Brain Res , vol.1194 , pp. 8-20
    • Harry, G.J.1    Funk, J.A.2    Lefebvre d'Hellencourt, C.3    McPherson, C.A.4    Aoyama, M.5
  • 154
    • 84938285609 scopus 로고    scopus 로고
    • TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects
    • Probert L. TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects. Neuroscience. 2015;302:2-22.
    • (2015) Neuroscience , vol.302 , pp. 2-22
    • Probert, L.1
  • 155
    • 0029033167 scopus 로고
    • Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation
    • Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci U S A. 1995;92:9328-32.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9328-9332
    • Barger, S.W.1    Horster, D.2    Furukawa, K.3    Goodman, Y.4    Krieglstein, J.5    Mattson, M.P.6
  • 157
    • 3543046113 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
    • Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem. 2004;279:32869-81.
    • (2004) J Biol Chem , vol.279 , pp. 32869-32881
    • Marchetti, L.1    Klein, M.2    Schlett, K.3    Pfizenmaier, K.4    Eisel, U.L.5
  • 158
    • 26244461607 scopus 로고    scopus 로고
    • TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain
    • Heldmann U, Thored P, Claasen JH, Arvidsson A, Kokaia Z, Lindvall O. TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain. Exp Neurol. 2005;196:204-8.
    • (2005) Exp Neurol , vol.196 , pp. 204-208
    • Heldmann, U.1    Thored, P.2    Claasen, J.H.3    Arvidsson, A.4    Kokaia, Z.5    Lindvall, O.6
  • 160
    • 0024215195 scopus 로고
    • Tumor necrosis factor mediates myelin damage in organotypic cultures of nervous tissue
    • Selmaj K, Raine CS. Tumor necrosis factor mediates myelin damage in organotypic cultures of nervous tissue. Ann N Y Acad Sci. 1988;540:568-70.
    • (1988) Ann N Y Acad Sci , vol.540 , pp. 568-570
    • Selmaj, K.1    Raine, C.S.2
  • 161
    • 0034877451 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord
    • Hermann GE, Rogers RC, Bresnahan JC, Beattie MS. Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord. Neurobiol Dis. 2001;8:590-9.
    • (2001) Neurobiol Dis , vol.8 , pp. 590-599
    • Hermann, G.E.1    Rogers, R.C.2    Bresnahan, J.C.3    Beattie, M.S.4
  • 162
    • 1242339720 scopus 로고    scopus 로고
    • Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP
    • Butler MP, O'Connor JJ, Moynagh PN. Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP. Neuroscience. 2004;124:319-26.
    • (2004) Neuroscience , vol.124 , pp. 319-326
    • Butler, M.P.1    O'Connor, J.J.2    Moynagh, P.N.3
  • 163
    • 0029671172 scopus 로고    scopus 로고
    • Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
    • Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ. Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci Lett. 1996;203:17-20.
    • (1996) Neurosci Lett , vol.203 , pp. 17-20
    • Cunningham, A.J.1    Murray, C.A.2    O'Neill, L.A.3    Lynch, M.A.4    O'Connor, J.J.5
  • 164
    • 84870877683 scopus 로고    scopus 로고
    • TNF-alpha affects human cortical neural progenitor cell differentiation through the autocrine secretion of leukemia inhibitory factor.
    • Lan X, Chen Q, Wang Y, Jia B, Sun L, Zheng J, et al. TNF-alpha affects human cortical neural progenitor cell differentiation through the autocrine secretion of leukemia inhibitory factor. PLoS ONE. 2012;7:e50783.
    • (2012) PLoS ONE. , vol.7 , pp. e50783
    • Lan, X.1    Chen, Q.2    Wang, Y.3    Jia, B.4    Sun, L.5    Zheng, J.6
  • 165
    • 33748906248 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.
    • Iosif RE, Ekdahl CT, Ahlenius H, Pronk CJ, Bonde S, Kokaia Z, et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci. 2006;26:9703-12.
    • (2006) J Neurosci. , vol.26 , pp. 9703-9712
    • Iosif, R.E.1    Ekdahl, C.T.2    Ahlenius, H.3    Pronk, C.J.4    Bonde, S.5    Kokaia, Z.6
  • 167
    • 16644392588 scopus 로고    scopus 로고
    • Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators
    • Tokumura A. Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. J Cell Biochem. 2004;92:869-81.
    • (2004) J Cell Biochem , vol.92 , pp. 869-881
    • Tokumura, A.1
  • 169
    • 33745957774 scopus 로고    scopus 로고
    • Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.
    • Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, et al. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. J Pharmacol Exp Ther. 2006;318:619-28.
    • (2006) J Pharmacol Exp Ther. , vol.318 , pp. 619-628
    • Kotarsky, K.1    Boketoft, A.2    Bristulf, J.3    Nilsson, N.E.4    Norberg, A.5    Hansson, S.6
  • 170
    • 0038152846 scopus 로고    scopus 로고
    • Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    • Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003;278:25600-6.
    • (2003) J Biol Chem , vol.278 , pp. 25600-25606
    • Noguchi, K.1    Ishii, S.2    Shimizu, T.3
  • 171
    • 84927165214 scopus 로고
    • Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling
    • Zhao Y, Natarajan V. Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling. Biochim Biophys Acta. 1831;2013:86-92.
    • (1831) Biochim Biophys Acta , vol.2013 , pp. 86-92
    • Zhao, Y.1    Natarajan, V.2
  • 172
    • 84880398679 scopus 로고    scopus 로고
    • Regulation of angiogenesis by phospholipid lysophosphatidic acid
    • Chen Y, Ramakrishnan DP, Ren B. Regulation of angiogenesis by phospholipid lysophosphatidic acid. Front Biosci (Landmark Ed). 2013;18:852-61.
    • (2013) Front Biosci (Landmark Ed) , vol.18 , pp. 852-861
    • Chen, Y.1    Ramakrishnan, D.P.2    Ren, B.3
  • 173
    • 48749098088 scopus 로고    scopus 로고
    • Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    • Ye X, Skinner MK, Kennedy G, Chun J. Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling. Biol Reprod. 2008;79:328-36.
    • (2008) Biol Reprod , vol.79 , pp. 328-336
    • Ye, X.1    Skinner, M.K.2    Kennedy, G.3    Chun, J.4
  • 174
    • 18344397194 scopus 로고    scopus 로고
    • LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    • Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, et al. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature. 2005;435:104-8.
    • (2005) Nature , vol.435 , pp. 104-108
    • Ye, X.1    Hama, K.2    Contos, J.J.3    Anliker, B.4    Inoue, A.5    Skinner, M.K.6
  • 175
    • 73249146077 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) signaling in vertebrate reproduction
    • Ye X, Chun J. Lysophosphatidic acid (LPA) signaling in vertebrate reproduction. Trends Endocrinol Metab. 2010;21:17-24.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 17-24
    • Ye, X.1    Chun, J.2
  • 178
    • 77953036199 scopus 로고    scopus 로고
    • Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis
    • Dubin AE, Herr DR, Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010;30:7300-9.
    • (2010) J Neurosci , vol.30 , pp. 7300-7309
    • Dubin, A.E.1    Herr, D.R.2    Chun, J.3
  • 179
    • 0344011597 scopus 로고    scopus 로고
    • Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
    • Kingsbury MA, Rehen SK, Contos JJ, Higgins CM, Chun J. Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nat Neurosci. 2003;6:1292-9.
    • (2003) Nat Neurosci , vol.6 , pp. 1292-1299
    • Kingsbury, M.A.1    Rehen, S.K.2    Contos, J.J.3    Higgins, C.M.4    Chun, J.5
  • 180
    • 33846190244 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway
    • Fukushima N, Shano S, Moriyama R, Chun J. Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway. Neurochem Int. 2007;50:302-7.
    • (2007) Neurochem Int , vol.50 , pp. 302-307
    • Fukushima, N.1    Shano, S.2    Moriyama, R.3    Chun, J.4
  • 181
    • 11144247982 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors
    • Svetlov SI, Ignatova TN, Wang KK, Hayes RL, English D, Kukekov VG. Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors. Stem Cells Dev. 2004;13:685-93.
    • (2004) Stem Cells Dev , vol.13 , pp. 685-693
    • Svetlov, S.I.1    Ignatova, T.N.2    Wang, K.K.3    Hayes, R.L.4    English, D.5    Kukekov, V.G.6
  • 183
    • 33746715033 scopus 로고    scopus 로고
    • Neuroprotective effect of lysophosphatidic acid on AbetaP31-35-induced apoptosis in cultured cortical neurons
    • Zheng ZQ, Fang XJ, Zhang Y, Qiao JT. Neuroprotective effect of lysophosphatidic acid on AbetaP31-35-induced apoptosis in cultured cortical neurons. Sheng Li Xue Bao. 2005;57:289-94.
    • (2005) Sheng Li Xue Bao , vol.57 , pp. 289-294
    • Zheng, Z.Q.1    Fang, X.J.2    Zhang, Y.3    Qiao, J.T.4
  • 184
    • 3142687155 scopus 로고    scopus 로고
    • Dual action of lysophosphatidic acid in cultured cortical neurons: survival and apoptogenic
    • Zheng ZQ, Fang XJ, Qiao JT. Dual action of lysophosphatidic acid in cultured cortical neurons: survival and apoptogenic. Sheng Li Xue Bao. 2004;56:163-71.
    • (2004) Sheng Li Xue Bao , vol.56 , pp. 163-171
    • Zheng, Z.Q.1    Fang, X.J.2    Qiao, J.T.3
  • 186
    • 0035854770 scopus 로고    scopus 로고
    • Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells
    • Moller T, Contos JJ, Musante DB, Chun J, Ransom BR. Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J Biol Chem. 2001;276:25946-52.
    • (2001) J Biol Chem , vol.276 , pp. 25946-25952
    • Moller, T.1    Contos, J.J.2    Musante, D.B.3    Chun, J.4    Ransom, B.R.5
  • 188
    • 84926482464 scopus 로고    scopus 로고
    • Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production.
    • Awada R, Saulnier-Blache JS, Gres S, Bourdon E, Rondeau P, Parimisetty A, et al. Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production. J Cell Biochem. 2014;115:2123-32.
    • (2014) J Cell Biochem. , vol.115 , pp. 2123-2132
    • Awada, R.1    Saulnier-Blache, J.S.2    Gres, S.3    Bourdon, E.4    Rondeau, P.5    Parimisetty, A.6
  • 190
    • 0029836932 scopus 로고    scopus 로고
    • Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
    • Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996;135:1071-83.
    • (1996) J Cell Biol , vol.135 , pp. 1071-1083
    • Hecht, J.H.1    Weiner, J.A.2    Post, S.R.3    Chun, J.4
  • 191
    • 84914674938 scopus 로고    scopus 로고
    • Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin.
    • Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc Natl Acad Sci U S A. 2014;111:15810-5.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15810-15815
    • Yau, S.Y.1    Li, A.2    Hoo, R.L.3    Ching, Y.P.4    Christie, B.R.5    Lee, T.M.6
  • 193
    • 33644856005 scopus 로고    scopus 로고
    • Obesity and the role of adipose tissue in inflammation and metabolism
    • Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83:461S-5.
    • (2006) Am J Clin Nutr , vol.83 , pp. 461S-465S
    • Greenberg, A.S.1    Obin, M.S.2
  • 194
  • 195
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6:772-83.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 196
    • 7744226149 scopus 로고    scopus 로고
    • Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.
    • Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat CA, et al. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J. 2004;18:1657-69.
    • (2004) FASEB J. , vol.18 , pp. 1657-1669
    • Clement, K.1    Viguerie, N.2    Poitou, C.3    Carette, C.4    Pelloux, V.5    Curat, C.A.6
  • 197
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96:939-49.
    • (2005) Circ Res , vol.96 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 198
    • 84904654930 scopus 로고    scopus 로고
    • Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy
    • Takeda S, Sato N, Morishita R. Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci. 2014;6:171.
    • (2014) Front Aging Neurosci , vol.6 , pp. 171
    • Takeda, S.1    Sato, N.2    Morishita, R.3
  • 199
    • 85015355603 scopus 로고    scopus 로고
    • Metabolic syndrome and the immunological affair with the blood-brain barrier
    • Mauro C, De Rosa V, Marelli-Berg F, Solito E. Metabolic syndrome and the immunological affair with the blood-brain barrier. Front Immunol. 2014;5:677.
    • (2014) Front Immunol , vol.5 , pp. 677
    • Mauro, C.1    Rosa, V.2    Marelli-Berg, F.3    Solito, E.4
  • 201
    • 77954981010 scopus 로고    scopus 로고
    • The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    • Kanoski SE, Zhang Y, Zheng W, Davidson TL. The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis. 2010;21:207-19.
    • (2010) J Alzheimers Dis , vol.21 , pp. 207-219
    • Kanoski, S.E.1    Zhang, Y.2    Zheng, W.3    Davidson, T.L.4
  • 203
    • 84922580355 scopus 로고    scopus 로고
    • White matter disruption at the prodromal stage of Alzheimer's disease: relationships with hippocampal atrophy and episodic memory performance
    • Remy F, Vayssiere N, Saint-Aubert L, Barbeau E, Pariente J. White matter disruption at the prodromal stage of Alzheimer's disease: relationships with hippocampal atrophy and episodic memory performance. Neuroimage Clin. 2015;7:482-92.
    • (2015) Neuroimage Clin , vol.7 , pp. 482-492
    • Remy, F.1    Vayssiere, N.2    Saint-Aubert, L.3    Barbeau, E.4    Pariente, J.5
  • 204
    • 78049317979 scopus 로고    scopus 로고
    • Progression of atrophy in Alzheimer's disease and related disorders
    • Whitwell JL. Progression of atrophy in Alzheimer's disease and related disorders. Neurotox Res. 2010;18:339-46.
    • (2010) Neurotox Res , vol.18 , pp. 339-346
    • Whitwell, J.L.1
  • 205
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: stability and functional significance
    • Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF. Blood-brain barrier impairment in Alzheimer disease: stability and functional significance. Neurology. 2007;68:1809-14.
    • (2007) Neurology , vol.68 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 206
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation. 2003;10:463-70.
    • (2003) Microcirculation , vol.10 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 207
    • 84970917706 scopus 로고    scopus 로고
    • Diet and inflammation in Alzheimer's disease and related chronic diseases: a review
    • Gardener SL, Rainey-Smith SR, Martins RN. Diet and inflammation in Alzheimer's disease and related chronic diseases: a review. J Alzheimers Dis. 2015;50:301-34.
    • (2015) J Alzheimers Dis , vol.50 , pp. 301-334
    • Gardener, S.L.1    Rainey-Smith, S.R.2    Martins, R.N.3
  • 208
    • 84896315146 scopus 로고    scopus 로고
    • Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases
    • Matsuda M, Shimomura I. Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases. Rev Endocr Metab Disord. 2014;15:1-10.
    • (2014) Rev Endocr Metab Disord , vol.15 , pp. 1-10
    • Matsuda, M.1    Shimomura, I.2
  • 209
    • 84921938357 scopus 로고    scopus 로고
    • Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery.
    • Laurikka A, Vuolteenaho K, Toikkanen V, Rinne T, Leppanen T, Tarkka M, et al. Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery. Eur J Cardiothorac Surg. 2014;46:729-36.
    • (2014) Eur J Cardiothorac Surg. , vol.46 , pp. 729-736
    • Laurikka, A.1    Vuolteenaho, K.2    Toikkanen, V.3    Rinne, T.4    Leppanen, T.5    Tarkka, M.6
  • 211
    • 67650388375 scopus 로고    scopus 로고
    • Adipose tissue: a motor for the inflammation associated with obesity
    • Vachharajani V, Granger DN. Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life. 2009;61:424-30.
    • (2009) IUBMB Life , vol.61 , pp. 424-430
    • Vachharajani, V.1    Granger, D.N.2
  • 215
    • 29044447177 scopus 로고    scopus 로고
    • Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes
    • Pihl E, Zilmer K, Kullisaar T, Kairane C, Magi A, Zilmer M. Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes. Int J Obes (Lond). 2006;30:141-6.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 141-146
    • Pihl, E.1    Zilmer, K.2    Kullisaar, T.3    Kairane, C.4    Magi, A.5    Zilmer, M.6
  • 216
    • 84862297475 scopus 로고    scopus 로고
    • Mechanism of oxidative stress in neurodegeneration
    • Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:428010.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 428010
    • Gandhi, S.1    Abramov, A.Y.2
  • 217
    • 0037339931 scopus 로고    scopus 로고
    • Is oxidant stress a connection between obesity and atherosclerosis?
    • Morrow JD. Is oxidant stress a connection between obesity and atherosclerosis? Arterioscler Thromb Vasc Biol. 2003;23:368-70.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 368-370
    • Morrow, J.D.1
  • 219
    • 84930952984 scopus 로고    scopus 로고
    • Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.
    • Ruszkiewicz J, Albrecht J. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Neurochem Int. 2015;88:66-72.
    • (2015) Neurochem Int. , vol.88 , pp. 66-72
    • Ruszkiewicz, J.1    Albrecht, J.2
  • 221
    • 84898906711 scopus 로고
    • Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions
    • Freeman LR, Keller JN. Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions. Biochim Biophys Acta. 1822;2012:822-9.
    • (1822) Biochim Biophys Acta , vol.2012 , pp. 822-829
    • Freeman, L.R.1    Keller, J.N.2
  • 222
    • 77956247309 scopus 로고    scopus 로고
    • Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation.
    • Lochhead JJ, McCaffrey G, Quigley CE, Finch J, DeMarco KM, Nametz N, et al. Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J Cereb Blood Flow Metab. 2010;30:1625-36.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1625-1636
    • Lochhead, J.J.1    McCaffrey, G.2    Quigley, C.E.3    Finch, J.4    DeMarco, K.M.5    Nametz, N.6
  • 223
    • 84875513508 scopus 로고    scopus 로고
    • Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration
    • Enciu AM, Gherghiceanu M, Popescu BO. Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration. Oxid Med Cell Longev. 2013;2013:297512.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 297512
    • Enciu, A.M.1    Gherghiceanu, M.2    Popescu, B.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.