Leptin action in the brain: How (and when) it makes fat burn

Molecular Metabolism

Volumn 2, Issue 2, 2013, Pages 63-64

  Yi, Chun Xia ^a   Meyer, Carola W ^a   Jastroch, Martin ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; LEPTIN; LEPTIN RECEPTOR; VESICULAR GLUTAMATE TRANSPORTER 2;

ANIMAL BEHAVIOR; BASAL METABOLIC RATE; BIOLOGICAL RHYTHM; BODY TEMPERATURE; BRAIN NERVE CELL; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY EXPENDITURE; ENERGY METABOLISM; GABAERGIC TRANSMISSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; NONHUMAN; NOTE; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; THERMOGENESIS; THERMOREGULATION;

EID: 84877640516     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2013.03.002     Document Type: Note

References (9)

1. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
2. van deWall E., Leshan R., Xu A.W., Balthasar N., Coppari R., Liu S.M., et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 2008, 149:1773-1785.
3. Vong L., Ye C., Yang Z., Choi B., Chua S., Lowell B.B. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 2011, 71:142-154.
4. Xu Y, Kim ER, Zhao R, Myers MG, Muenzberg-Gruening H, Tong Q.Glutamate release mediates leptin action on energy expenditure. Mol Metab, in this issue.
5. Moore R.Y., Eichler V.B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res 1972, 42:201-206.
6. Kalsbeek A., Foppen E., Schalij I., Van Heijningen C., van der Vliet J., Fliers E., et al. Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamate. PLoS One 2008, 3:e3194.
7. Kalsbeek A., Fliers E., Romijn J.A., La Fleur S.E., Wortel J., Bakker O., et al. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 2001, 142:2677-2685.
8. Enriori P.J., Sinnayah P., Simonds S.E., Garcia Rudaz C., Cowley M.A. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci 2011, 31:12189-12197.
9. Zhang Y., Kerman I.A., Laque A., Nguyen P., Faouzi M., Louis G.W., et al. Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci 2011, 31:1873-1884.