메뉴 건너뛰기




Volumn 71, Issue 3, 2000, Pages 187-195

The long form of the leptin receptor (OB-Rh) is widely expressed in the human brain

Author keywords

Amygdala; Cerebellum; Human brain; Leptin receptor; Medulla; Ob gene; Obesity

Indexed keywords

ISOPROTEIN; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

EID: 0034014941     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054536     Document Type: Article
Times cited : (143)

References (56)
  • 4
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity to central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity to central neural networks. Science 1995;269: 546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 6
    • 0029932592 scopus 로고    scopus 로고
    • Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice
    • Lynn RB, Cao GY, Considine RV, Hyde TM, Caro JF: Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun 1996;219:884-889.
    • (1996) Biochem Biophys Res Commun , vol.219 , pp. 884-889
    • Lynn, R.B.1    Cao, G.Y.2    Considine, R.V.3    Hyde, T.M.4    Caro, J.F.5
  • 9
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA: The leptin receptor. J Biol Chem 1997;272:6093-6096.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 13
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto T, Taga T, Akira S: Cytokine signal transduction. Cell 1994;76:253-262.
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T.1    Taga, T.2    Akira, S.3
  • 15
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • Fei H,Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM: Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 1997;94:7001-7005.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.H.4    Zhao, C.5    Darnell, R.6    Friedman, J.M.7
  • 19
    • 0030590070 scopus 로고    scopus 로고
    • Substitution at codon 269 (glutamine-proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat
    • Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K: Substitution at codon 269 (glutamine-proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 1996;224:597-604.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 597-604
    • Iida, M.1    Murakami, T.2    Ishida, K.3    Mizuno, A.4    Kuwajima, M.5    Shima, K.6
  • 22
    • 0032010818 scopus 로고    scopus 로고
    • Leptin receptor gene in a large cohort of massively obese subjects: No indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity
    • Rolland V, Clement K, Dugail I, Guy-Grand B, Basdevant A, Froguel P, Lavau M: Leptin receptor gene in a large cohort of massively obese subjects: No indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity. Obes Res 1998;6: 122-127.
    • (1998) Obes Res , vol.6 , pp. 122-127
    • Rolland, V.1    Clement, K.2    Dugail, I.3    Guy-Grand, B.4    Basdevant, A.5    Froguel, P.6    Lavau, M.7
  • 26
    • 0032982438 scopus 로고    scopus 로고
    • Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
    • Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL: Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 1999;140:1630-1638.
    • (1999) Endocrinology , vol.140 , pp. 1630-1638
    • Thomas, T.1    Gori, F.2    Khosla, S.3    Jensen, M.D.4    Burguera, B.5    Riggs, B.L.6
  • 27
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake
    • Kennedy GC: The role of depot fat in the hypothalamic control of food intake. Proc R Soc 1952;140:578-592.
    • (1952) Proc R Soc , vol.140 , pp. 578-592
    • Kennedy, G.C.1
  • 28
    • 0025614453 scopus 로고
    • Role of set point theory in regulation of body weight
    • Harris RBS: Role of set point theory in regulation of body weight. FASEB J 1990;4:3310-3318.
    • (1990) FASEB J , vol.4 , pp. 3310-3318
    • Harris, R.B.S.1
  • 29
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mecer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P: Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996;387:113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mecer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 31
    • 0029949063 scopus 로고    scopus 로고
    • Leptin activation in hypothalamus
    • Woods AJ, Stock MJ: Leptin activation in hypothalamus. Nature 1996;381:745.
    • (1996) Nature , vol.381 , pp. 745
    • Woods, A.J.1    Stock, M.J.2
  • 33
    • 85011452023 scopus 로고    scopus 로고
    • Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain
    • Mercer JG, Moar KM, Hoggard N: Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 1998;139:29-34.
    • (1998) Endocrinology , vol.139 , pp. 29-34
    • Mercer, J.G.1    Moar, K.M.2    Hoggard, N.3
  • 36
    • 0030768058 scopus 로고    scopus 로고
    • Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum
    • Savioz A, Charnay Y, Huguenin C, Graviou C, Greggio B, Bouras C: Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum. Neuroreport 1997;8:3123-3126.
    • (1997) Neuroreport , vol.8 , pp. 3123-3126
    • Savioz, A.1    Charnay, Y.2    Huguenin, C.3    Graviou, C.4    Greggio, B.5    Bouras, C.6
  • 38
    • 0031895877 scopus 로고    scopus 로고
    • Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting
    • Baskin DG, Seeley RJ, Kuijper JL, Lok S, Weigle DS, Erickson JC, Palmiter RD, Schwartz MW: Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 1998;47:538-543.
    • (1998) Diabetes , vol.47 , pp. 538-543
    • Baskin, D.G.1    Seeley, R.J.2    Kuijper, J.L.3    Lok, S.4    Weigle, D.S.5    Erickson, J.C.6    Palmiter, R.D.7    Schwartz, M.W.8
  • 39
    • 0030695064 scopus 로고    scopus 로고
    • Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain
    • Lin S, Huang XF: Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain. Neuroreport 1997;8: 3625-3629.
    • (1997) Neuroreport , vol.8 , pp. 3625-3629
    • Lin, S.1    Huang, X.F.2
  • 40
    • 0031975670 scopus 로고    scopus 로고
    • Differential expression and regulation of leptin receptor isoforms in the rat brain: Effects of fasting and oestrogen
    • Bennett PA, Lindell K, Karlsson C, Robinson IC, Carlsson LM, Carlsson B: Differential expression and regulation of leptin receptor isoforms in the rat brain: Effects of fasting and oestrogen. Neuroendocrinology 1998;67:29-36.
    • (1998) Neuroendocrinology , vol.67 , pp. 29-36
    • Bennett, P.A.1    Lindell, K.2    Karlsson, C.3    Robinson, I.C.4    Carlsson, L.M.5    Carlsson, B.6
  • 41
    • 0031665574 scopus 로고    scopus 로고
    • Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet
    • Boado RJ, Golden PL, Levin N, Pardridge WM: Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet. J Neurochem 1998;71: 1761-1764.
    • (1998) J Neurochem , vol.71 , pp. 1761-1764
    • Boado, R.J.1    Golden, P.L.2    Levin, N.3    Pardridge, W.M.4
  • 42
    • 0031794333 scopus 로고    scopus 로고
    • Hypothalamic expression of neuropeptide-Y in the New Zealand obese mouse
    • Rizk NM, Liu IS, Eckel J: Hypothalamic expression of neuropeptide-Y in the New Zealand obese mouse. Int J Obes 1998;22:1172-1177.
    • (1998) Int J Obes , vol.22 , pp. 1172-1177
    • Rizk, N.M.1    Liu, I.S.2    Eckel, J.3
  • 43
    • 0031587582 scopus 로고    scopus 로고
    • Quantification of the full-lenght leptin receptor (OB-Rb) in human brown and white adipose tissue
    • Kutoh E, Boss O, Levasseur F, Giacobino JP: Quantification of the full-lenght leptin receptor (OB-Rb) in human brown and white adipose tissue. Life Sci 1998;62:445-451.
    • (1998) Life Sci , vol.62 , pp. 445-451
    • Kutoh, E.1    Boss, O.2    Levasseur, F.3    Giacobino, J.P.4
  • 44
    • 0032159495 scopus 로고    scopus 로고
    • Monkey leptin receptor mRNA: Sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys
    • Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Hansen BC: Monkey leptin receptor mRNA: Sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys. Obes Res 1998;6:353-360.
    • (1998) Obes Res , vol.6 , pp. 353-360
    • Hotta, K.1    Gustafson, T.A.2    Ortmeyer, H.K.3    Bodkin, N.L.4    Hansen, B.C.5
  • 45
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab FF, Lim ME, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996:12:318-320.
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 50
    • 0031761830 scopus 로고    scopus 로고
    • Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone
    • Tannenbaum GS, Gurd W, Lapointe M: Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone. Endocrinology 1998;139:3871-3875.
    • (1998) Endocrinology , vol.139 , pp. 3871-3875
    • Tannenbaum, G.S.1    Gurd, W.2    Lapointe, M.3
  • 51
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord GM, Matarese G, Howard LK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, L.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 52
    • 0033325799 scopus 로고    scopus 로고
    • Leptin and leptin receptor expression in the normal and neoplastic human pituitary. Evidence of a regulatory role of leptin in pituitary cell proliferation
    • Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsam J, Eberhardt NL, Kulig E, Lloyd RV: Leptin and leptin receptor expression in the normal and neoplastic human pituitary. Evidence of a regulatory role of leptin in pituitary cell proliferation. J Endocrinol Metab 1999;84:2903-2911.
    • (1999) J Endocrinol Metab , vol.84 , pp. 2903-2911
    • Jin, L.1    Burguera, B.G.2    Couce, M.E.3    Scheithauer, B.W.4    Lamsam, J.5    Eberhardt, N.L.6    Kulig, E.7    Lloyd, R.V.8
  • 53
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D: Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nat Med 1996;2:589-593.
    • (1996) Nat Med , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.